| Definition | Streptococcus pneumoniae 70585, complete genome. |
|---|---|
| Accession | NC_012468 |
| Length | 2,184,682 |
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The map label for this gene is idnO [C]
Identifier: 225859883
GI number: 225859883
Start: 2045699
End: 2046538
Strand: Reverse
Name: idnO [C]
Synonym: SP70585_2236
Alternate gene names: 225859883
Gene position: 2046538-2045699 (Counterclockwise)
Preceding gene: 225859884
Following gene: 225859882
Centisome position: 93.68
GC content: 41.9
Gene sequence:
>840_bases ATGACACGTGTTATTGAATTTAAAGACAAGGTTGTTGTTATTACCGGAGCTGGAGGCGTTCTTTGTGGTTATTTGGCAAA AGAATTTGCGAAGGCTGGTGCTAAAGTAGCTCTTTTGGACTTAAATGAGGTAGCTGCTCAAGTGTTTGTTGATGAAATTG AGTCAGTAGGTGGAGTTGCAAAGACCTATAAATCTAACGTTCTTTCTAAGGAAAATTTGGAAGAAGTTCGCCAACAAGTC TTAGCAGATTTTGGTCCAGTTGATATCTTGGTTAACGGTGCCGGAGGCAACAATCCGAAAGCAACGACGGACAATGAGTT TCATGAAATTGGACTTCCTGTGGACACCAAAACTTTCTTTGATTTGGACGAGGCGGGAATCAACTTTGTATTCAATTTGA ATTATTTAGGTACTCTCTTGCCAACTCAGGTATTTGCGCAGGATATGATTGGCCGTAGCGGAGCAAATATTATTAATATT TCTAGCATGAACGCCTTCACACCATTGACTAAAATTCCAGCATATTCAGGGGCCAAAGCTGCCATCAGCAATTTTACTCA GTGGTTAGCAGTGCATTTTTCAAAAGTTGGAATCCGTTGCAATGCCATTGCACCAGGTTTCTTTTTAACCAATCAGAACC GCGGCTTGTTATTTGATGAGTCAGGTCAACCGACAGCACGTGCCAACAAGATTTTGACCAATACACCGATGGGACGGTTT GGCGAAGCAGAAGAGCTAGTTGGAGGTGTCTTCTTCTTAGCAGATGAGAATCTGGCAAGTTTTGTAAATGGCGTTGTTTT ACCGATTGACGGTGGATTTTCAGCCTATTCAGGAGTCTAA
Upstream 100 bases:
>100_bases CCTATTTTAACGGTCTCTACGAAGCGAATATGCGAGCGGCAGGTAAGACACCAGATTTTGGAATTAAAGTAAAAACAGTT GGGAATAAGGAGGGCTAGTT
Downstream 100 bases:
>100_bases TCATGAAGACAGATTATGTATTTTGTGTGGACTCTGATGGCTGTGCAATGGACACCATGACCTACAAACATAAGCTCTTC TTTGGCCCCTTGGCAGCAGA
Product: D-mannonate oxidoreductase
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 279; Mature: 278
Protein sequence:
>279_residues MTRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEVAAQVFVDEIESVGGVAKTYKSNVLSKENLEEVRQQV LADFGPVDILVNGAGGNNPKATTDNEFHEIGLPVDTKTFFDLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINI SSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLFDESGQPTARANKILTNTPMGRF GEAEELVGGVFFLADENLASFVNGVVLPIDGGFSAYSGV
Sequences:
>Translated_279_residues MTRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEVAAQVFVDEIESVGGVAKTYKSNVLSKENLEEVRQQV LADFGPVDILVNGAGGNNPKATTDNEFHEIGLPVDTKTFFDLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINI SSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLFDESGQPTARANKILTNTPMGRF GEAEELVGGVFFLADENLASFVNGVVLPIDGGFSAYSGV >Mature_278_residues TRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEVAAQVFVDEIESVGGVAKTYKSNVLSKENLEEVRQQVL ADFGPVDILVNGAGGNNPKATTDNEFHEIGLPVDTKTFFDLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINIS SMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLFDESGQPTARANKILTNTPMGRFG EAEELVGGVFFLADENLASFVNGVVLPIDGGFSAYSGV
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI66933014, Length=268, Percent_Identity=30.5970149253731, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI40254992, Length=266, Percent_Identity=25.9398496240602, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI15277342, Length=277, Percent_Identity=27.4368231046931, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI7705925, Length=268, Percent_Identity=25.7462686567164, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI59889578, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI32483357, Length=272, Percent_Identity=24.6323529411765, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI10190704, Length=273, Percent_Identity=27.8388278388278, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI31542939, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=28.436018957346, Blast_Score=65, Evalue=9e-11, Organism=Escherichia coli, GI1790717, Length=273, Percent_Identity=27.8388278388278, Blast_Score=113, Evalue=2e-26, Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=31.3432835820896, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI1789208, Length=270, Percent_Identity=28.1481481481481, Blast_Score=107, Evalue=9e-25, Organism=Escherichia coli, GI1787335, Length=269, Percent_Identity=30.4832713754647, Blast_Score=98, Evalue=5e-22, Organism=Escherichia coli, GI1788459, Length=197, Percent_Identity=29.4416243654822, Blast_Score=81, Evalue=9e-17, Organism=Escherichia coli, GI87082160, Length=268, Percent_Identity=26.4925373134328, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=26.9662921348315, Blast_Score=78, Evalue=6e-16, Organism=Escherichia coli, GI1786812, Length=271, Percent_Identity=28.7822878228782, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.1828793774319, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1789378, Length=269, Percent_Identity=26.7657992565056, Blast_Score=69, Evalue=5e-13, Organism=Caenorhabditis elegans, GI115534694, Length=270, Percent_Identity=31.4814814814815, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI17560150, Length=285, Percent_Identity=28.0701754385965, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17559104, Length=294, Percent_Identity=27.5510204081633, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI71994604, Length=271, Percent_Identity=26.1992619926199, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17536025, Length=269, Percent_Identity=27.8810408921933, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17562990, Length=291, Percent_Identity=27.4914089347079, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560676, Length=278, Percent_Identity=25.5395683453237, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17551412, Length=285, Percent_Identity=27.719298245614, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538486, Length=278, Percent_Identity=27.3381294964029, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17560332, Length=286, Percent_Identity=29.020979020979, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI25147288, Length=269, Percent_Identity=27.5092936802974, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI71994600, Length=269, Percent_Identity=26.3940520446097, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=24.6268656716418, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17560220, Length=285, Percent_Identity=27.0175438596491, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17563726, Length=288, Percent_Identity=26.3888888888889, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562910, Length=273, Percent_Identity=27.1062271062271, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17536651, Length=268, Percent_Identity=28.7313432835821, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17562904, Length=290, Percent_Identity=27.2413793103448, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17508895, Length=219, Percent_Identity=29.2237442922374, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17561272, Length=255, Percent_Identity=28.6274509803922, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI72000259, Length=281, Percent_Identity=25.6227758007117, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17565030, Length=286, Percent_Identity=27.6223776223776, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17544670, Length=282, Percent_Identity=25.177304964539, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17538480, Length=281, Percent_Identity=25.9786476868327, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17562906, Length=288, Percent_Identity=24.3055555555556, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI193204405, Length=287, Percent_Identity=25.4355400696864, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17562908, Length=281, Percent_Identity=24.5551601423488, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538182, Length=217, Percent_Identity=31.3364055299539, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=210, Percent_Identity=30.4761904761905, Blast_Score=69, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=271, Percent_Identity=23.6162361623616, Blast_Score=63, Evalue=5e-11, Organism=Drosophila melanogaster, GI23397609, Length=273, Percent_Identity=30.03663003663, Blast_Score=111, Evalue=5e-25, Organism=Drosophila melanogaster, GI28571526, Length=276, Percent_Identity=29.7101449275362, Blast_Score=102, Evalue=4e-22, Organism=Drosophila melanogaster, GI21357041, Length=275, Percent_Identity=29.4545454545455, Blast_Score=101, Evalue=4e-22, Organism=Drosophila melanogaster, GI24644337, Length=269, Percent_Identity=30.4832713754647, Blast_Score=94, Evalue=7e-20, Organism=Drosophila melanogaster, GI24644339, Length=281, Percent_Identity=30.2491103202847, Blast_Score=94, Evalue=7e-20, Organism=Drosophila melanogaster, GI24639444, Length=267, Percent_Identity=29.5880149812734, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI21355319, Length=266, Percent_Identity=25.5639097744361, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24643142, Length=270, Percent_Identity=28.8888888888889, Blast_Score=77, Evalue=9e-15, Organism=Drosophila melanogaster, GI24649181, Length=209, Percent_Identity=29.6650717703349, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI24640492, Length=176, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=9e-14, Organism=Drosophila melanogaster, GI21355631, Length=181, Percent_Identity=27.6243093922652, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI221331218, Length=229, Percent_Identity=27.0742358078603, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24665243, Length=229, Percent_Identity=27.0742358078603, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 29740; Mature: 29609
Theoretical pI: Translated: 4.61; Mature: 4.61
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEVAAQVFVDEIESVGGVA CCCEEEECCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCHHH KTYKSNVLSKENLEEVRQQVLADFGPVDILVNGAGGNNPKATTDNEFHEIGLPVDTKTFF HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCCCHHC DLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINISSMNAFTPLTKIPAYSGAKA CCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCHHH AISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLFDESGQPTARANKILTNTPMGRF HHHHHHHHHHHHHHHHCEEEEEECCCEEEECCCCCEEECCCCCCHHHHCEEEECCCCCCC GEAEELVGGVFFLADENLASFVNGVVLPIDGGFSAYSGV CCHHHHHCEEEEEECCHHHHHHCCEEEEECCCCHHCCCC >Mature Secondary Structure TRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEVAAQVFVDEIESVGGVA CCEEEECCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCHHH KTYKSNVLSKENLEEVRQQVLADFGPVDILVNGAGGNNPKATTDNEFHEIGLPVDTKTFF HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCCCHHC DLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINISSMNAFTPLTKIPAYSGAKA CCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCHHH AISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLFDESGQPTARANKILTNTPMGRF HHHHHHHHHHHHHHHHCEEEEEECCCEEEECCCCCEEECCCCCCHHHHCEEEECCCCCCC GEAEELVGGVFFLADENLASFVNGVVLPIDGGFSAYSGV CCHHHHHCEEEEEECCHHHHHHCCEEEEECCCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 20 {D-gluconate}} 0.006 {NADPH}} 0.02 {NADP+}} 0.9 {5-keto-D-gluconate}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7542800; 10675023 [H]