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The map label for this gene is yqgN [H]

Identifier: 225859850

GI number: 225859850

Start: 2008313

End: 2008852

Strand: Reverse

Name: yqgN [H]

Synonym: SP70585_2201

Alternate gene names: 225859850

Gene position: 2008852-2008313 (Counterclockwise)

Preceding gene: 225859851

Following gene: 225859849

Centisome position: 91.95

GC content: 42.04

Gene sequence:

>540_bases
ATGAAATCGGAATTACGCAAGCAAGTCTTGCATGAAATGAAGACTTTATCTCAAGAACAAAAACAGGCTATAGACCAAGC
TTTAACCGAGCGAATTTTACAACACCCCTTTTATCAAGAAGCCAAGGTCATCGCAACCTACCTCTCTTTTTCTCATGAGT
TTCAAACGCGGGAACTGATTGAGCAGGCGCTGAAGGACGGCAAGAAGGTTTTGACACCTAAGACCTATCCCAAGGGGCGC
ATGGATTTTGTGGTCTATGATCCGCAACAGTTGGTAAAAACTTCCTTTGCCTTACTGGAGCTACAGGGAGATTTGGAAGT
AGTGGATGCATCTCAGATTGATTTGATTCATGTTCCTGGTCTGGCTTTTACGACGAAAGGATATCGGATAGGATACGGTG
GAGGCTATTATGACCGCTATCTGGAACATTTTTCTGGTCGTACTTTGAGTACGATATATCCTTGTCAAATTCAGGACTTT
ATACCTGAAAACCATGATATTCCTGTTCAGGAGGTATTAATTGATGAAGGAAATCTTTGA

Upstream 100 bases:

>100_bases
ATCACCCTCAAATGAGTCCTAAGGAAGAAGTCTTAGCTATTGGGGTGGCTGCGGTGTCTAGTTTCCTGAAAAAGAAGGCA
GCAGAATAGAGGGCTTGTCT

Downstream 100 bases:

>100_bases
TAGACGTTACCCTGTGACGAGTTTCTTCCTCTTAGTGACGGCCTTGGTATTTTTACTAATGTTGGTCACTGCAGGCGGAA
ACTTTGACAGGGCAGATACA

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKSELRKQVLHEMKTLSQEQKQAIDQALTERILQHPFYQEAKVIATYLSFSHEFQTRELIEQALKDGKKVLTPKTYPKGR
MDFVVYDPQQLVKTSFALLELQGDLEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDF
IPENHDIPVQEVLIDEGNL

Sequences:

>Translated_179_residues
MKSELRKQVLHEMKTLSQEQKQAIDQALTERILQHPFYQEAKVIATYLSFSHEFQTRELIEQALKDGKKVLTPKTYPKGR
MDFVVYDPQQLVKTSFALLELQGDLEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDF
IPENHDIPVQEVLIDEGNL
>Mature_179_residues
MKSELRKQVLHEMKTLSQEQKQAIDQALTERILQHPFYQEAKVIATYLSFSHEFQTRELIEQALKDGKKVLTPKTYPKGR
MDFVVYDPQQLVKTSFALLELQGDLEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDF
IPENHDIPVQEVLIDEGNL

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=192, Percent_Identity=30.7291666666667, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1789278, Length=168, Percent_Identity=33.9285714285714, Blast_Score=92, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17510857, Length=150, Percent_Identity=34, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161077430, Length=182, Percent_Identity=29.1208791208791, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 20624; Mature: 20624

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSELRKQVLHEMKTLSQEQKQAIDQALTERILQHPFYQEAKVIATYLSFSHEFQTRELI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHH
EQALKDGKKVLTPKTYPKGRMDFVVYDPQQLVKTSFALLELQGDLEVVDASQIDLIHVPG
HHHHHCCCEECCCCCCCCCCEEEEEECHHHHHHHHHHHHEECCCEEEECCCCCCEEEECC
LAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDFIPENHDIPVQEVLIDEGNL
EEEECCCEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHCCCCCCCCHHHHHCCCCCC
>Mature Secondary Structure
MKSELRKQVLHEMKTLSQEQKQAIDQALTERILQHPFYQEAKVIATYLSFSHEFQTRELI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHH
EQALKDGKKVLTPKTYPKGRMDFVVYDPQQLVKTSFALLELQGDLEVVDASQIDLIHVPG
HHHHHCCCEECCCCCCCCCCEEEEEECHHHHHHHHHHHHEECCCEEEECCCCCCEEEECC
LAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDFIPENHDIPVQEVLIDEGNL
EEEECCCEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHCCCCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]