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The map label for this gene is gyrA

Identifier: 225859001

GI number: 225859001

Start: 1174689

End: 1177157

Strand: Reverse

Name: gyrA

Synonym: SP70585_1266

Alternate gene names: 225859001

Gene position: 1177157-1174689 (Counterclockwise)

Preceding gene: 225859003

Following gene: 225859000

Centisome position: 53.88

GC content: 43.13

Gene sequence:

>2469_bases
ATGCAGGATAAAAATTTAGTGAATGTCAATCTGACAAAGGAGATGAAGGCAAGTTTTATCGACTACGCCATGAGTGTTAT
CGTAGCGCGAGCTCTTCCTGATGTTCGAGATGGCTTAAAACCTGTTCACCGTCGCATTCTCTACGGAATGAATGAATTGG
GTGTGACCCCAGACAAACCCCATAAAAAATCTGCTCGTATTACAGGGGATGTCATGGGTAAATATCACCCACACGGGGAT
TCCTCTATTTATGAAGCCATGGTCCGTATGGCTCAATGGTGGAGCTACCGTTACATGCTTGTAGATGGTCATGGGAATTT
TGGTTCCATGGATGGAGATAGTGCTGCCGCTCAACGTTATACCGAGGCACGTATGAGCAAGATTGCTCTGGAAATGCTTC
GTGATATCAACAAAAATACAGTTGATTTCGTTGATAACTATGATGCCAATGAACGGGAACCCTTGGTCTTGCCAGCGCGT
TTTCCAAACCTTTTGGTTAATGGAGCAACTGGTATCGCGGTTGGGATGGCAACCAATATTCCACCTCATAATCTGGGTGA
AACCATTGATGCAGTGAAGTTGGTCATGGATAATCCTGAAGTGACTACCAAGGACTTGATGGAAGTCTTGCCTGGACCAG
ATTTTCCAACTGGTGCTCTTGTCATGGGGAAATCAGGTATCCATAAGGCTTATGAAACAGGTAAAGGTTCGATTGTCCTA
CGTTCTCGTACAGAGATTGAAACGACTAAGACTGGTCGTGAGCGCATCGTTGTAACAGAATTTCCTTACATGGTCAATAA
AACCAAGGTGCATGAGCATATTGTTCGCTTGGTTCAGGAAAAACGCATTGAGGGTATCACAGCAGTACGTGATGAGTCAA
ACCGTGAAGGTGTTCGATTTGTTATTGAAGTCAAGCGCGACGCCTCAGCCAATGTTATTCTCAATAACCTCTTCAAAATG
ACCCAAATGCAAACCAATTTTGGTTTCAATATGCTCGCTATCCAAAATGGTATACCGAAAATTTTGTCTCTTCGTCAGAT
TTTGGATGCTTATATCGAGCACCAAAAAGAAGTGGTTGTTCGTCGTACACGTTTTGATAAGGAAAAAGCGGAAGCGCGCG
CTCATATCTTAGAAGGTCTCTTGATTGCGCTAGACCATATCGACGAAGTGATTCGTATCATCCGTGCTAGTGAAACGGAT
GCGGAAGCTCAAGCTGAGTTGATGAGCAAGTTTAAGCTTTCTGAACGTCAAAGTCAAGCTATCCTTGATATGCGTCTTCG
TCGTTTGACAGGTTTGGAACGCGATAAGATTCAATCTGAGTATGATGACCTCTTGGCTCTGATTGCGGATTTAGCAGATA
TTCTTGCTAAGCCTGAACGTGTTTCTCAAATTATCAAAGACGAATTGGATGAAGTTAAACGTAAATTTTCTGATAAACGC
CGTACAGAGTTGATGGTTGGACAGATCTTGAGTCTCGAGGATGAGGACTTGATTGAAGAATCGGATGTCTTGATTACCCT
TTCTAACAGAGGCTACATTAAGCGTTTGGATCAGGACGAGTTCACTGCTCAAAAACGTGGGGGTCGTGGTGTCCAAGGAA
CGGGAGTGAAAGATGATGACTTTGTTCGTGAGTTAGTGTCAACTAGCACCCATGATCATCTGCTCTTCTTCACAAACAAG
GGACGTGTCTATCGTCTTAAAGGTTATGAAATTCCTGAGTATGGTCGGACTGCCAAAGGGCTACCAGTAGTCAATCTCTT
GAAATTGGATGAAGACGAAAGTATTCAGACGGTTATCAATGTTGAGTCTGATCGCAGTGATGATGCTTATCTCTTCTTTA
CAACCCGTCACGGTATTGTGAAGAGAACCAGTGTTAAGGAGTTTGCCAATATTCGTCAAAATGGTCTCAAAGCGCTGAAT
TTAAAGGATGAAGATGAGTTAATCAATGTCTTGTTGGCAGAAGGAGATATGGATATTATCATTGGTACCAAGTTTGGTTA
TGCAGTTCGCTTTAATCAATCAGCCGTTCGTGGTATGAGTCGTATCGCCACTGGTGTGAAAGGTGTTAACCTTCGTGAAG
GAGACACAGTTGTTGGTGCCAGCTTGATTACTGATCAAGATGAGGTTCTTATTATCACAGAAAAAGGATATGGTAAGCGT
ACAGTCGCTACTGAATACCCAACAAAAGGTCGTGGTGGTAAGGGAATGCAGACAGCTAAAATTACCGAAAAAAATGGCTT
GCTGGCCGGTCTTATGACTGTTCAAGGGGATGAGGATTTGATGATTATCACTGATACAGGTGTCATGATTCGAACCAATC
TTGCCAATATTTCACAAACAGGACGTGCAACTATGGGAGTTAAAGTAATGCGCCTGGATCAAGATGCTCAGATAGTGACT
TTCACAACGGTTGCGGTGGCAGAAAAAGAAGAAGTTGGGACAGAAAACGAAACAGAAGGTGAAGCATAA

Upstream 100 bases:

>100_bases
AGTTCTCGATGTAAACGTTTTAGTGGTTTAGAGGCTGAAATAGATGGGAATTTATGGTATAATGTTGTTACTTACTAATT
GTGAAATGAGGCATTTATTA

Downstream 100 bases:

>100_bases
TGTCTCAAAAAAATAATAAAAAGAAAAACAAGCGAAAAAATCTGCTGACAAATATCCTAGCAGGATTTCTGATATTACTG
TCACTGGCTTTGATTTTTAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 822

Protein sequence:

>822_residues
MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGD
SSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVL
RSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKM
TQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETD
AEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKR
RTELMVGQILSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNK
GRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALN
LKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKR
TVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVT
FTTVAVAEKEEVGTENETEGEA

Sequences:

>Translated_822_residues
MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGD
SSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVL
RSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKM
TQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETD
AEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKR
RTELMVGQILSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNK
GRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALN
LKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKR
TVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVT
FTTVAVAEKEEVGTENETEGEA
>Mature_822_residues
MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGD
SSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVL
RSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKM
TQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETD
AEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKR
RTELMVGQILSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNK
GRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALN
LKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKR
TVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVT
FTTVAVAEKEEVGTENETEGEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=338, Percent_Identity=25.4437869822485, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=48.3985765124555, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=696, Percent_Identity=34.9137931034483, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=179, Percent_Identity=31.8435754189944, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=178, Percent_Identity=30.8988764044944, Blast_Score=73, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=475, Percent_Identity=22.7368421052632, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=373, Percent_Identity=22.7882037533512, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136538, Length=351, Percent_Identity=24.5014245014245, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92055; Mature: 92055

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKP
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCCCCCCC
HKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRY
CCCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHH
TEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCCCEEECCCCEEEEEECCC
PPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVL
CCCCCCHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCCEEE
RSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRF
ECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEE
VIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVV
EEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RTELMVGQILSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDD
HHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCEEECCCHHHHHHHCCCCCCCCCCCCCHH
FVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVIN
HHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEE
VESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDII
ECCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHCCCEEECCCCHHHHHHHHEECCCEEEE
IGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKR
EECCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCEEEEHEEECCCCCEEEEECCCCCCC
TVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQT
EEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEECCHHHHHC
GRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA
CCHHHCEEEEEECCCCEEEEEEEEEEECHHHCCCCCCCCCCC
>Mature Secondary Structure
MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKP
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCCCCCCC
HKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRY
CCCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHH
TEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCCCEEECCCCEEEEEECCC
PPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVL
CCCCCCHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCCEEE
RSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRF
ECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEE
VIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVV
EEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RTELMVGQILSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDD
HHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCEEECCCHHHHHHHCCCCCCCCCCCCCHH
FVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVIN
HHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEE
VESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDII
ECCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHCCCEEECCCCHHHHHHHHEECCCEEEE
IGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKR
EECCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCEEEEHEEECCCCCEEEEECCCCCCC
TVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQT
EEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEECCHHHHHC
GRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA
CCHHHCEEEEEECCCCEEEEEEEEEEECHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]