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The map label for this gene is 225859003

Identifier: 225859003

GI number: 225859003

Start: 1178597

End: 1179370

Strand: Reverse

Name: 225859003

Synonym: SP70585_1268

Alternate gene names: NA

Gene position: 1179370-1178597 (Counterclockwise)

Preceding gene: 225859004

Following gene: 225859001

Centisome position: 53.98

GC content: 31.01

Gene sequence:

>774_bases
TTGAAGAAAAAATGGTTTTTTGCAGATTATTATGATACAACAATTATTTTACTTGCTTTAATCTCTGTTATTCTGGTATT
ACTTGGATTTGCTGAGATGATTGATTTGGACAATCCGCCTTATAGTATTATTGATTTAGTAATCTGGGGTGTTTTTGTAA
TTGATTATAGTTGGCGCTTTTTTACGACTAAAAGAAAATGGCGCTTTATTCTTGAAAATATTTTTGATTTATTGGCTATT
CTCCCTTTAAATGCTATTTTTACAGTGTTTCGATTAGGGCGTATCTTTCGTTTAGTTAAACTAACAAAATTACTGAAACT
GACTCGTTTACTTAGAATAATTGGACTTACAGGTAAATTAGAAAGAAAAATTAGTAGATTCTTACGGACAAATGGCTTGA
TTTATATCTTGTATGTTAATATCTTTATCGTGCTAGTAGGAAGTTCAATTTTATCTGTAGTTGAAGAAAAATCCTTCTCA
GATAGTCTTTGGTGGGCTCTTGTAACGGTAACGACTGTTGGATATGGGGATATTGTTCCTGCTTCCATTTTTGGGAAATG
GCTAGCAGTTTTACTGATGCTTGTCGGTATTGGAACAATAGGGATGTTAACAAGTGCTTTGACGAACTTTTTTGTAAAGG
ATAATCCAGATGAACAGATAAAACTTGATAAACTCCAAGATGAATTATCTAGTCAGAGAATATTACTAGAGAAACAATCT
AAAAAGATAGAAGAACTACATAAAATGATACAAGATTTGATTGAAAAAACATAA

Upstream 100 bases:

>100_bases
GATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGGAGAGATATTTATTGAATTAAAGCTGAGTAATAACAATATAG
AAAGTAAGGAGAGTAAAAAT

Downstream 100 bases:

>100_bases
TAAAAATAAAGATGAGAAAAAGTTTGAACTGAGGAGAAATCAAGTAAGTTTTGACACAATAGAACGCATATTATCAGGTA
TAAAAACTTGATACTATGCG

Product: potassium/ion channel protein

Products: NA

Alternate protein names: KvAP [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRFFTTKRKWRFILENIFDLLAI
LPLNAIFTVFRLGRIFRLVKLTKLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
KKIEELHKMIQDLIEKT

Sequences:

>Translated_257_residues
MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRFFTTKRKWRFILENIFDLLAI
LPLNAIFTVFRLGRIFRLVKLTKLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
KKIEELHKMIQDLIEKT
>Mature_257_residues
MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRFFTTKRKWRFILENIFDLLAI
LPLNAIFTVFRLGRIFRLVKLTKLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
KKIEELHKMIQDLIEKT

Specific function: Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassi

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family [H]

Homologues:

Organism=Homo sapiens, GI4826784, Length=281, Percent_Identity=28.8256227758007, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI20070166, Length=224, Percent_Identity=31.6964285714286, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI27436974, Length=259, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4826782, Length=217, Percent_Identity=29.4930875576037, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI27436996, Length=253, Percent_Identity=26.4822134387352, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI119395748, Length=216, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI27436984, Length=231, Percent_Identity=25.5411255411255, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI27436986, Length=231, Percent_Identity=25.5411255411255, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504817, Length=218, Percent_Identity=27.0642201834862, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI25952087, Length=244, Percent_Identity=27.0491803278689, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI88758565, Length=214, Percent_Identity=28.9719626168224, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI5031819, Length=145, Percent_Identity=32.4137931034483, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7657289, Length=259, Percent_Identity=30.1158301158301, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI25952092, Length=148, Percent_Identity=31.0810810810811, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71989381, Length=232, Percent_Identity=26.2931034482759, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71989361, Length=232, Percent_Identity=26.2931034482759, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71989376, Length=232, Percent_Identity=26.2931034482759, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71989369, Length=232, Percent_Identity=26.2931034482759, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17544122, Length=192, Percent_Identity=23.9583333333333, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281365536, Length=226, Percent_Identity=27.8761061946903, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI116007764, Length=226, Percent_Identity=27.8761061946903, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656289, Length=226, Percent_Identity=27.8761061946903, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656294, Length=226, Percent_Identity=27.8761061946903, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642916, Length=247, Percent_Identity=28.7449392712551, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642914, Length=247, Percent_Identity=28.7449392712551, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45555859, Length=247, Percent_Identity=29.1497975708502, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45549143, Length=247, Percent_Identity=29.1497975708502, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642910, Length=247, Percent_Identity=29.1497975708502, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013099 [H]

Pfam domain/function: PF07885 Ion_trans_2 [H]

EC number: NA

Molecular weight: Translated: 29716; Mature: 29716

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRF
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
FTTKRKWRFILENIFDLLAILPLNAIFTVFRLGRIFRLVKLTKLLKLTRLLRIIGLTGKL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFSDSLWWALVTVTTVGYGDIVP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCH
ASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KKIEELHKMIQDLIEKT
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSIIDLVIWGVFVIDYSWRF
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
FTTKRKWRFILENIFDLLAILPLNAIFTVFRLGRIFRLVKLTKLLKLTRLLRIIGLTGKL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFSDSLWWALVTVTTVGYGDIVP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCH
ASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDEQIKLDKLQDELSSQRILLEKQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KKIEELHKMIQDLIEKT
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]