BacMap

Definition	Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession	NC_012442
Length	1,185,518

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The map label for this gene is livF [H]

Identifier: 225686918

GI number: 225686918

Start: 1156812

End: 1157516

Strand: Direct

Name: livF [H]

Synonym: BMEA_B1171

Alternate gene names: 225686918

Gene position: 1156812-1157516 (Clockwise)

Preceding gene: 225686917

Following gene: 225686932

Centisome position: 97.58

GC content: 62.7

Gene sequence:

>705_bases
ATGACGACATTCTCTGTCAAGGCGCTGCAAGTGGACCGTGCCAGCATTCCCGTCATTCGCGGCGTGGATGTGGAGGTCAG
GAGCGGCGAGATCAGCGTGCTTCTGGGCTCCAACGGCGCGGGCAAGACCACGTTTCTGGAAAGCCTTTCCGGCATCATCC
CGGCGCGTGCGGGAACAATCCGTCTGGACGAAACCGAACTTGCTAGATTGCGGCCCGGCGCGCGCACAAAGGCGGGGTTG
AGCCATGTCGAGCAGGGCCGCACGGTTTTCCCGGACATGACGACGGACGAGAATATCCGCGTTGCGCTTCACCCCGATGC
CGATCCGGGCGAGGCCTATGGTCTCTTCCCGGAACTTCTGCAACGGCGCGATGTGAAAGCGGGCATGTTGTCGGGCGGCG
AGCAGCAGATGGTCGTCATCGCCCGATCCATCGTCAACCGGCCCAAAGTGATGCTGATCGACGAAATGTCGTCGGGGCTT
GCCCCCGTCATCGTCAACCGCCTGATGCGCGCCGTGCGGCAACTGGCCGATAATGGTATGGCCATCGTGCTGGTCGAGCA
GTTCGCTGCGCTGGCGCTTTCCATCGGAAACCGCGCTTACGTGCTGCGCCGCGGCCAGATCGTCTATGATGGCAACAGCG
AGGCGCTGGCGCACGACCCCGCCCGCCTTCACCAGCTTTATCTGGGTGATGCCGCTGCCATTTAA

Upstream 100 bases:

>100_bases
ATTTCGGACAGGTGATCGCTTCGGGCGAACCGGCGGAAGTGCTGGACATGCCAGAAGTACAGAAAGCCTATATGGGCGTT
GATTTCGAGGAGGCTGCGGA

Downstream 100 bases:

>100_bases
CCGTTAGAGCGGTTCCGGTAAAAAGGAACGTCGGAGCCGCTCCATCTCTTTGTTTTAAGCATTATCCAACGCAAAACCGT
CACTTAATTCGTCATTACAG

Product: branched-chain amino acid transport ATP-binding protein livF

Products: ADP; phosphate; L-leucine [Cytoplasm]; ADP; L-valine [Cytoplasm]; L-iso-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein F [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTTFSVKALQVDRASIPVIRGVDVEVRSGEISVLLGSNGAGKTTFLESLSGIIPARAGTIRLDETELARLRPGARTKAGL
SHVEQGRTVFPDMTTDENIRVALHPDADPGEAYGLFPELLQRRDVKAGMLSGGEQQMVVIARSIVNRPKVMLIDEMSSGL
APVIVNRLMRAVRQLADNGMAIVLVEQFAALALSIGNRAYVLRRGQIVYDGNSEALAHDPARLHQLYLGDAAAI

Sequences:

>Translated_234_residues
MTTFSVKALQVDRASIPVIRGVDVEVRSGEISVLLGSNGAGKTTFLESLSGIIPARAGTIRLDETELARLRPGARTKAGL
SHVEQGRTVFPDMTTDENIRVALHPDADPGEAYGLFPELLQRRDVKAGMLSGGEQQMVVIARSIVNRPKVMLIDEMSSGL
APVIVNRLMRAVRQLADNGMAIVLVEQFAALALSIGNRAYVLRRGQIVYDGNSEALAHDPARLHQLYLGDAAAI
>Mature_233_residues
TTFSVKALQVDRASIPVIRGVDVEVRSGEISVLLGSNGAGKTTFLESLSGIIPARAGTIRLDETELARLRPGARTKAGLS
HVEQGRTVFPDMTTDENIRVALHPDADPGEAYGLFPELLQRRDVKAGMLSGGEQQMVVIARSIVNRPKVMLIDEMSSGLA
PVIVNRLMRAVRQLADNGMAIVLVEQFAALALSIGNRAYVLRRGQIVYDGNSEALAHDPARLHQLYLGDAAAI

Specific function: Component of the leucine-specific transport system [H]

COG id: COG0410

COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=215, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI27477115, Length=205, Percent_Identity=26.3414634146341, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592964, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592971, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592956, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592978, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592898, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592915, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4505771, Length=162, Percent_Identity=31.4814814814815, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI42741659, Length=162, Percent_Identity=32.7160493827161, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI9961252, Length=162, Percent_Identity=31.4814814814815, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI116734710, Length=209, Percent_Identity=27.7511961722488, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI171184400, Length=232, Percent_Identity=26.2931034482759, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI255708477, Length=166, Percent_Identity=28.9156626506024, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI9961250, Length=168, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI11967969, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082268, Length=232, Percent_Identity=36.2068965517241, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788225, Length=239, Percent_Identity=32.6359832635983, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789593, Length=238, Percent_Identity=31.0924369747899, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787792, Length=209, Percent_Identity=29.6650717703349, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786872, Length=203, Percent_Identity=32.0197044334975, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787029, Length=216, Percent_Identity=31.0185185185185, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789864, Length=252, Percent_Identity=28.968253968254, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081791, Length=211, Percent_Identity=32.2274881516588, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787370, Length=216, Percent_Identity=30.5555555555556, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1789672, Length=213, Percent_Identity=30.9859154929577, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI48995001, Length=229, Percent_Identity=29.2576419213974, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790190, Length=222, Percent_Identity=28.3783783783784, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788472, Length=203, Percent_Identity=29.064039408867, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081782, Length=209, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1787089, Length=227, Percent_Identity=26.8722466960352, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1787712, Length=215, Percent_Identity=27.4418604651163, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790525, Length=218, Percent_Identity=28.8990825688073, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786319, Length=208, Percent_Identity=25.9615384615385, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081709, Length=223, Percent_Identity=27.3542600896861, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786398, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788761, Length=216, Percent_Identity=28.7037037037037, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788644, Length=230, Percent_Identity=29.1304347826087, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788210, Length=197, Percent_Identity=26.9035532994924, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787105, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790467, Length=227, Percent_Identity=26.431718061674, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787547, Length=245, Percent_Identity=23.265306122449, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789873, Length=201, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87081834, Length=165, Percent_Identity=29.6969696969697, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786253, Length=205, Percent_Identity=26.3414634146341, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787500, Length=238, Percent_Identity=25.2100840336134, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788897, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789991, Length=219, Percent_Identity=24.6575342465753, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790162, Length=235, Percent_Identity=24.2553191489362, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994997, Length=214, Percent_Identity=27.1028037383178, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786698, Length=150, Percent_Identity=27.3333333333333, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789032, Length=223, Percent_Identity=26.0089686098655, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788450, Length=214, Percent_Identity=27.1028037383178, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787972, Length=229, Percent_Identity=25.764192139738, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786703, Length=203, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082267, Length=153, Percent_Identity=30.718954248366, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=234, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996809, Length=217, Percent_Identity=27.1889400921659, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193211015, Length=217, Percent_Identity=27.1889400921659, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558664, Length=219, Percent_Identity=24.6575342465753, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI193209708, Length=229, Percent_Identity=28.82096069869, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=217, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193211017, Length=225, Percent_Identity=27.1111111111111, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17541710, Length=163, Percent_Identity=31.2883435582822, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565586, Length=194, Percent_Identity=26.2886597938144, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71984940, Length=211, Percent_Identity=27.4881516587678, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212646699, Length=217, Percent_Identity=25.3456221198157, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569143, Length=161, Percent_Identity=34.1614906832298, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193208177, Length=218, Percent_Identity=24.7706422018349, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=236, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319856, Length=241, Percent_Identity=25.7261410788382, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322640, Length=230, Percent_Identity=25.6521739130435, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24643674, Length=203, Percent_Identity=29.064039408867, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574744, Length=223, Percent_Identity=26.9058295964126, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19920532, Length=207, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24580930, Length=207, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI161076682, Length=211, Percent_Identity=28.436018957346, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076684, Length=211, Percent_Identity=28.436018957346, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581617, Length=211, Percent_Identity=28.436018957346, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581615, Length=211, Percent_Identity=28.436018957346, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85724864, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24580555, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI85816269, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24580553, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666092, Length=209, Percent_Identity=26.7942583732057, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363262, Length=217, Percent_Identity=26.7281105990783, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24653245, Length=217, Percent_Identity=26.7281105990783, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574533, Length=222, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221512771, Length=213, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136662, Length=232, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581191, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581189, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581193, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581195, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357907, Length=211, Percent_Identity=26.5402843601896, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 25191; Mature: 25060

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFSVKALQVDRASIPVIRGVDVEVRSGEISVLLGSNGAGKTTFLESLSGIIPARAGTI
CCCEEEEEEEECCCCCCEEECCCEEEECCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEE
RLDETELARLRPGARTKAGLSHVEQGRTVFPDMTTDENIRVALHPDADPGEAYGLFPELL
EECHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHH
QRRDVKAGMLSGGEQQMVVIARSIVNRPKVMLIDEMSSGLAPVIVNRLMRAVRQLADNGM
HHCCCCHHHCCCCCHHHHHEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
AIVLVEQFAALALSIGNRAYVLRRGQIVYDGNSEALAHDPARLHQLYLGDAAAI
EEEEHHHHHHHHHHCCCEEEEEECCEEEECCCCCCCCCCHHHHHHHHHCHHCCC
>Mature Secondary Structure 
TTFSVKALQVDRASIPVIRGVDVEVRSGEISVLLGSNGAGKTTFLESLSGIIPARAGTI
CCEEEEEEEECCCCCCEEECCCEEEECCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEE
RLDETELARLRPGARTKAGLSHVEQGRTVFPDMTTDENIRVALHPDADPGEAYGLFPELL
EECHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHH
QRRDVKAGMLSGGEQQMVVIARSIVNRPKVMLIDEMSSGLAPVIVNRLMRAVRQLADNGM
HHCCCCHHHCCCCCHHHHHEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
AIVLVEQFAALALSIGNRAYVLRRGQIVYDGNSEALAHDPARLHQLYLGDAAAI
EEEEHHHHHHHHHHCCCEEEEEECCEEEECCCCCCCCCCHHHHHHHHHCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-leucine [Periplasm]; H2O; ATP; L-valine [Periplasm]; L-iso-leucine [Periplasm] [C]

Specific reaction: ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]