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The map label for this gene is yhxA [H]

Identifier: 225686909

GI number: 225686909

Start: 1143742

End: 1145100

Strand: Reverse

Name: yhxA [H]

Synonym: BMEA_B1161

Alternate gene names: 225686909

Gene position: 1145100-1143742 (Counterclockwise)

Preceding gene: 225686910

Following gene: 225686908

Centisome position: 96.59

GC content: 59.97

Gene sequence:

>1359_bases
ATGCGTGATTCCAATTTCCTGATCGAGAACAATGCCCGCCACCTGTGGCACCCCATGGCGCATCCGGCGGAGATGCAGGC
CAATCCGCCCCGCATCGTCAATGGTGGCGAGGGCGTCGAGGTGATCGACATTCACGGCAAGAAGGTTCTCGATGCGGTGG
GCGGTCTGTGGAACGTCAATCTGGGCTATTCCTGCGAGCCGGTGAAGAAGGCGATCCGCGACCAGCTCGACAGCCTGCCT
TATTATTCGACCTTTCGCGGCACGACCAATTCGCCTCTGATCGAGCTTTCCTATGAGCTGGCCGAATTCTTCAAGGAAGA
CGGGCTGACGCGTGCTTTCTTCACGTCCGGCGGATCGGATTCGGTCGAAACGGCGCTGCGGCTTGCCCGCCAGTTCCACA
AGATCAACGGACAGCCGGAACGCACGAAATTCGTTTCGCTGAAAAAGGGCTATCACGGCACGCATTTTGGCGGCGCTTCG
GTCAATGGCAATGCCAATTTCCGCCGCAACTATGAGCCGCTTCTGCCGGGCGTGTTCCATCTGGCGGCACCCTATCCCTA
TCGCAACCCGTTCAATATGGACGACCCGGCGGCGATTGCTGCGGCCATTGCGCGCCAGTTTGAGGATGAAATCGCGTTTC
AGGGTGCGGACACCATTGCCGCCTTCATCATGGAGCCGGTTCTGGGAGCAGGGGGCGTGATCGTGCCGCATGAAAGCTTC
ATGCCGCTGATGCGTGAAATCTGCGACCGGCACGGCATTCTCCTGATTGCCGATGAGGTCATCACGGCTTTCGGGCGCAC
CGGCGCATGGACCGGCTCGCGCGGCTGGGGCGTGAAACCCGATATGATGACGACCGCCAAGGCGATCACCAATGGCTATT
TCCCCTTCGGTGCGGTGATGATTTCCGACAAGGTGGCAAGCGTTTTTGAGGCGAACAAAAATTCGCTTGGCGCAATCGGC
CATGGCTACACCTATTCCGGCCATCCGGTGGGTGCCGCAGCCGCCCTTGCCACGCTGAAGGAAACGGCGCGCGCCAACAC
GGCGGCCAATGCCGGGGCGCGCGGTGTCGAACTTATGGCGGGGCTCAATCAACTGAAGGAAAAGCACGAGCTTGTGGGTG
ACGTGCGCGGCAAGGGCCTGATGGCGGCGCTGGAACTCGTTTCCGATCGGGAAAAGAAAAGTGCTGCCGCCAAGACCGTG
GTGCAGAAGGTTTATGACGTCGCCTATGAGGAAGGCGTCATGGTGCGCACTTCCGGCGCCAATGTCATCATTTCGCCGCC
GCTTGTCATCACGCCTGCCGATGTGAACCGCATTGTTTCTGCGCTCGATGCTGGCCTTTCCGCCGCGAAGGGACAATGA

Upstream 100 bases:

>100_bases
GGAGGCAGTCCACCTGCCGCATGTGCACTTCGACGTGACCCGGCCTGCGGAAAGCTATGCGCAGGCGCTGAAAATGCTCG
GAATTTGAAAGGTTATCGTC

Downstream 100 bases:

>100_bases
CATGAGCGGAAATCAGGAAATGATTGCCCGCAGGGAGCGGCTGCTTGGCCGCAACATGTCCCTATTTTATCAGGACCCGG
TGCATCTGGTGAAGGGTGAG

Product: hypothetical protein

Products: L-Glutamate; L-Glutamate 5-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVNLGYSCEPVKKAIRDQLDSLP
YYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSDSVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGAS
VNGNANFRRNYEPLLPGVFHLAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVMISDKVASVFEANKNSLGAIG
HGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMAGLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTV
VQKVYDVAYEEGVMVRTSGANVIISPPLVITPADVNRIVSALDAGLSAAKGQ

Sequences:

>Translated_452_residues
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVNLGYSCEPVKKAIRDQLDSLP
YYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSDSVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGAS
VNGNANFRRNYEPLLPGVFHLAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVMISDKVASVFEANKNSLGAIG
HGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMAGLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTV
VQKVYDVAYEEGVMVRTSGANVIISPPLVITPADVNRIVSALDAGLSAAKGQ
>Mature_452_residues
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVNLGYSCEPVKKAIRDQLDSLP
YYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSDSVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGAS
VNGNANFRRNYEPLLPGVFHLAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVMISDKVASVFEANKNSLGAIG
HGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMAGLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTV
VQKVYDVAYEEGVMVRTSGANVIISPPLVITPADVNRIVSALDAGLSAAKGQ

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=433, Percent_Identity=27.7136258660508, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=29.6983758700696, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=27.0454545454545, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=29.7674418604651, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI226442709, Length=393, Percent_Identity=30.5343511450382, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI284507298, Length=316, Percent_Identity=30.6962025316456, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=28.9044289044289, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI145693181, Length=411, Percent_Identity=30.4136253041363, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786991, Length=441, Percent_Identity=29.9319727891156, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=32.1596244131455, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=30.2211302211302, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789759, Length=422, Percent_Identity=28.436018957346, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1787560, Length=447, Percent_Identity=27.2930648769575, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786349, Length=341, Percent_Identity=26.9794721407625, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=30.2222222222222, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=26.0340632603406, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=221, Percent_Identity=28.9592760180996, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=473, Percent_Identity=26.4270613107822, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=26.7281105990783, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=25.8992805755396, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=27.6255707762557, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI161085790, Length=439, Percent_Identity=26.879271070615, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=26.6666666666667, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21356575, Length=432, Percent_Identity=28.0092592592593, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.13 [C]

Molecular weight: Translated: 48585; Mature: 48585

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVN
CCCCCEEEECCCHHHHCCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHCCEEECC
LGYSCEPVKKAIRDQLDSLPYYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCH
SVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGASVNGNANFRRNYEPLLPGVFH
HHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHH
LAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCHHH
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVM
HHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEE
ISDKVASVFEANKNSLGAIGHGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHH
GLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTVVQKVYDVAYEEGVMVRTSGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
NVIISPPLVITPADVNRIVSALDAGLSAAKGQ
CEEECCCEEEECCHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MRDSNFLIENNARHLWHPMAHPAEMQANPPRIVNGGEGVEVIDIHGKKVLDAVGGLWNVN
CCCCCEEEECCCHHHHCCCCCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHCCEEECC
LGYSCEPVKKAIRDQLDSLPYYSTFRGTTNSPLIELSYELAEFFKEDGLTRAFFTSGGSD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCH
SVETALRLARQFHKINGQPERTKFVSLKKGYHGTHFGGASVNGNANFRRNYEPLLPGVFH
HHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHH
LAAPYPYRNPFNMDDPAAIAAAIARQFEDEIAFQGADTIAAFIMEPVLGAGGVIVPHESF
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCHHH
MPLMREICDRHGILLIADEVITAFGRTGAWTGSRGWGVKPDMMTTAKAITNGYFPFGAVM
HHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEE
ISDKVASVFEANKNSLGAIGHGYTYSGHPVGAAAALATLKETARANTAANAGARGVELMA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHH
GLNQLKEKHELVGDVRGKGLMAALELVSDREKKSAAAKTVVQKVYDVAYEEGVMVRTSGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
NVIISPPLVITPADVNRIVSALDAGLSAAKGQ
CEEECCCEEEECCHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; Ornithine [C]

Specific reaction: 2-Oxoglutarate + Ornithine --> L-Glutamate + L-Glutamate 5-semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]