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The map label for this gene is pdhA [H]

Identifier: 225686851

GI number: 225686851

Start: 1067005

End: 1069182

Strand: Direct

Name: pdhA [H]

Synonym: BMEA_B1091

Alternate gene names: 225686851

Gene position: 1067005-1069182 (Clockwise)

Preceding gene: 225686850

Following gene: 225686852

Centisome position: 90.0

GC content: 58.03

Gene sequence:

>2178_bases
ATGGCAGAGAAAATTGATCTGAAACCATCCGCACCCTGGTATCGGTTGAATACCACGGACGAGGATTGGCAAAATGCAGA
AGCGGCCGATCTGCTGAAATGGTATAGCCAGATGAAGCTGATCCGCCGGTTCGAAGAAAAGATACTCGATTTTGAAAAGG
CGGGTCTGGTCCATGGACCGGCCCATGCAAGCATTGGTCAGGAGGCTGCTGCGGTCGGCGCCATGTCGGTGCTGAAAACC
GATGACCAGATCAATGGCACGCACCGCGCCCACCATCAGGTCCTGACAAAACTGATCAATGCCCAGACGCCATCGGATTT
CGATATTCTTCAGTCCGATTTCACCGATGGCATGCATGACGCGGTTTATCGCCTCATGGCCGAAATCATGGGGCTGAATA
CGGGCTATTGCGGCGGGCGCGGCGGCTCGATGCATATGCGCGATGCGGCTTCGGGCATTGCCGGAACCAGCGCGATCGTC
GGCGGCAATATTCCCCATGCCGCCGGTTATGCCCTCGCAGACAAGATCCTCAACCGGAAGGGAATTTCTGTTGCCTTCTT
CGGCGATGGCCCTTCCTTGCAGGGCGCGACCTATGAAGCGATGAACATCGCCGCGCTCTACCGCCTGCCGGTCATTTTTT
ACGTGGAGAATAATCTCTACGCCGTATCGACCCATATTCAGGATGCAACGCGCGAGACGCGCATTGCCTCGCGCTGTCCC
ATGCTCGGCTTTACCGGCATCGAATGCGACGGCATGGACATTCTTTCCGTCCATCAGGCGATGCGTGAAGCCTGCCGCAT
TATCGAGGAAGAGGGCGGTCCGGTCGTCATCGAGGCGCAGTGCTACAGATATCTGCATCAAAGCGGCAGCAAATCGGGCA
GCGATTTCGGTTATCGCACGCGTGAGGAAGAAGAGGAATGGAAAAGCCGCGATCCGATTGCGCTTGCCGAGCGGCGCCTG
AAGGAACTGGGGATCGCGGGAGATGCCGAGTTTTTGAAGATTGACGAGCGTGTGACCGCCGCCGTTCAAGCGGCTGGAGA
GCGCCTGACCGAAACGGCCGCCGGCAGCAATGTTCTGCGTATTCCCGATGCGCTTTGGCCGTCGGCATCCAGTGTGGACG
ACGGGATTTTGGGAGATGGCAGCGAATTTTCCGGTGCGGAATTTCGCGAGATCGAGGATTATCAGCCCGATGAGCTGGAA
AAGATGCGCTTTGCCGCGGCGGCTTCGGATGTGCTCGGGCGGGCGATGGAAAAGGACCCGACGATCATCGTCATAGGGGA
GGATGTCCATCGTTTTGCAGGCGGTGTCAGCGGCTTTACCAGAAACGCGCTTGAGCTTTTTCCCGACCGGGTTCTCGCCA
TGCCCATCGCCGAAAACGGCTTTACCGGCGTAGTGCTTGGTGCAGCCCTGCGGGGCCTGCGCCCGGTGGTGGAAATCATG
TTCGGTGATTTCTGCTTTGTCGCGGCCGACCAGATCGCGAACGGGATTTCAAAAGTGCGTCATATGTTCGGCGACGGTTT
TCCAGTCCCCATCGTCATGCGTGTGCGCGTTTCGCCCCACACCGGCTATGGTTCGCAGCATTCCGGCGATCCCTCGGCAC
TGTTCGGCATGTTTCCCGGATGGCGCGTCGTCTCGCCCACAAATGCCTTTGATTATATCGGCCTGATGAACAGCGCGCTG
AAATCGGACGATCCCGTCGCGGTTATTGAGCATGTCGAGTTTTACCAGCGCGAAAGCTTAGTTCCGAGGAATGACAGGGA
TTATTGCATCCCGCTCGGCAAGGCGAAGATCGTGCGTCCGGGGTCGGCCTGCACCGTTCTTGCCACATCCGTCATGGTAC
AGGCTTCCATCAAGGCTGCGGAAGAGGCGGGCATCGATGCCGAAATCATCGATATGCGCAGCCTCGACATGTTCGGGATC
GACTGGGCCTTGATTGGCGCTTCCATCGGCAAAACCAACCGGGTGGTGATTGCCGAGCAGGTTGCAAGCGGCTTGTCGCT
CGGACGGCATTGGATCGCCGAAATCCAGAAGCGCTTCTTCAACGATCTCGACCATGAAGTCCTGCATGTGACGGGAAGCA
TGGCCTCGCCGGTCGTGTCGCTGGTTTTAAACAAGGCCGCCCTCGGATCGGCCGACAAGGTCCGGTCGGCCCTTGAGCAG
ATTACGCATTCCGCATGA

Upstream 100 bases:

>100_bases
CACGAACATTCGATCCACGATACCGGGCAAGCCTCTGGCTGCGGCGCCGGGCTGAACTTGGGTTGCGACTGGCAGACTAC
AATTAGGGGAAACTCTCACA

Downstream 100 bases:

>100_bases
CAAAAAACGTAAAATACGAGGAGGACAAAATGCTATTCAAGACAACGGGAACAAGGTCTGGATCATTGAAAACATTGCGA
AGCCTGATGATGGCGGCAAC

Product: 2-oxoisovalerate dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 725; Mature: 724

Protein sequence:

>725_residues
MAEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKT
DDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHDAVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIV
GGNIPHAAGYALADKILNRKGISVAFFGDGPSLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRCP
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRTREEEEEWKSRDPIALAERRL
KELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLRIPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELE
KMRFAAAASDVLGRAMEKDPTIIVIGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVVLGAALRGLRPVVEIM
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPGWRVVSPTNAFDYIGLMNSAL
KSDDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRPGSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGI
DWALIGASIGKTNRVVIAEQVASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
ITHSA

Sequences:

>Translated_725_residues
MAEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKT
DDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHDAVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIV
GGNIPHAAGYALADKILNRKGISVAFFGDGPSLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRCP
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRTREEEEEWKSRDPIALAERRL
KELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLRIPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELE
KMRFAAAASDVLGRAMEKDPTIIVIGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVVLGAALRGLRPVVEIM
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPGWRVVSPTNAFDYIGLMNSAL
KSDDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRPGSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGI
DWALIGASIGKTNRVVIAEQVASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
ITHSA
>Mature_724_residues
AEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKTD
DQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHDAVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVG
GNIPHAAGYALADKILNRKGISVAFFGDGPSLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRCPM
LGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRTREEEEEWKSRDPIALAERRLK
ELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLRIPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELEK
MRFAAAASDVLGRAMEKDPTIIVIGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVVLGAALRGLRPVVEIMF
GDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPGWRVVSPTNAFDYIGLMNSALK
SDDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRPGSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGID
WALIGASIGKTNRVVIAEQVASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQI
THSA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=285, Percent_Identity=35.7894736842105, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4505685, Length=322, Percent_Identity=35.0931677018634, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI4885543, Length=323, Percent_Identity=32.8173374613003, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI291084742, Length=319, Percent_Identity=35.1097178683386, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI291084744, Length=329, Percent_Identity=34.3465045592705, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI291084858, Length=285, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI4557353, Length=363, Percent_Identity=29.2011019283747, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI34101272, Length=363, Percent_Identity=29.2011019283747, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI291084757, Length=319, Percent_Identity=31.974921630094, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI11386135, Length=285, Percent_Identity=27.719298245614, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI258645172, Length=285, Percent_Identity=27.719298245614, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538422, Length=324, Percent_Identity=34.5679012345679, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=34.7003154574132, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=34.7003154574132, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17506935, Length=302, Percent_Identity=30.4635761589404, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI86563355, Length=359, Percent_Identity=27.5766016713092, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86563357, Length=359, Percent_Identity=27.5766016713092, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=35.1851851851852, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319698, Length=306, Percent_Identity=31.0457516339869, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24639744, Length=315, Percent_Identity=36.5079365079365, Blast_Score=163, Evalue=5e-40,
Organism=Drosophila melanogaster, GI28571106, Length=315, Percent_Identity=36.5079365079365, Blast_Score=163, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24639740, Length=315, Percent_Identity=36.5079365079365, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI21358145, Length=300, Percent_Identity=35, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24650940, Length=300, Percent_Identity=35, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=32.6086956521739, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24639746, Length=309, Percent_Identity=35.9223300970874, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI160714832, Length=312, Percent_Identity=29.8076923076923, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI160714828, Length=309, Percent_Identity=30.0970873786408, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21355903, Length=326, Percent_Identity=27.6073619631902, Blast_Score=96, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 78729; Mature: 78598

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGP
CCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AHASIGQEAAAVGAMSVLKTDDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHD
CHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
AVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVGGNIPHAAGYALADKILNRK
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCHHEECCCCCCHHHHHHHHHHHCCC
GISVAFFGDGPSLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRCP
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEEECHHHHHHHHHHHHHCC
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCC
REEEEEWKSRDPIALAERRLKELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLR
CCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
IPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELEKMRFAAAASDVLGRAMEKDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TIIVIGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVVLGAALRGLRPVVEIM
EEEEECCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPG
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCC
WRVVSPTNAFDYIGLMNSALKSDDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRP
CEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECC
GSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGIDWALIGASIGKTNRVVIAEQ
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEEEHHH
VASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
ITHSA
HHCCC
>Mature Secondary Structure 
AEKIDLKPSAPWYRLNTTDEDWQNAEAADLLKWYSQMKLIRRFEEKILDFEKAGLVHGP
CCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AHASIGQEAAAVGAMSVLKTDDQINGTHRAHHQVLTKLINAQTPSDFDILQSDFTDGMHD
CHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
AVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVGGNIPHAAGYALADKILNRK
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCHHEECCCCCCHHHHHHHHHHHCCC
GISVAFFGDGPSLQGATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRCP
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEEECHHHHHHHHHHHHHCC
MLGFTGIECDGMDILSVHQAMREACRIIEEEGGPVVIEAQCYRYLHQSGSKSGSDFGYRT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCC
REEEEEWKSRDPIALAERRLKELGIAGDAEFLKIDERVTAAVQAAGERLTETAAGSNVLR
CCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
IPDALWPSASSVDDGILGDGSEFSGAEFREIEDYQPDELEKMRFAAAASDVLGRAMEKDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TIIVIGEDVHRFAGGVSGFTRNALELFPDRVLAMPIAENGFTGVVLGAALRGLRPVVEIM
EEEEECCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FGDFCFVAADQIANGISKVRHMFGDGFPVPIVMRVRVSPHTGYGSQHSGDPSALFGMFPG
HCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCC
WRVVSPTNAFDYIGLMNSALKSDDPVAVIEHVEFYQRESLVPRNDRDYCIPLGKAKIVRP
CEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECC
GSACTVLATSVMVQASIKAAEEAGIDAEIIDMRSLDMFGIDWALIGASIGKTNRVVIAEQ
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEEEHHH
VASGLSLGRHWIAEIQKRFFNDLDHEVLHVTGSMASPVVSLVLNKAALGSADKVRSALEQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
ITHSA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]