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The map label for this gene is paaH [H]

Identifier: 225686850

GI number: 225686850

Start: 1065470

End: 1066990

Strand: Direct

Name: paaH [H]

Synonym: BMEA_B1090

Alternate gene names: 225686850

Gene position: 1065470-1066990 (Clockwise)

Preceding gene: 225686849

Following gene: 225686851

Centisome position: 89.87

GC content: 56.87

Gene sequence:

>1521_bases
ATGGTCATTGAAACAGTGACTTACGGTCAGATCGCAAAAGTCGCGATCATCGGCTCCGGTGTCATGGGAGCAGGCATCGC
CGAGACGATGGCAGCTGGCGGCATTGACGTCTTGCTCTTCGACCAGATGGCCGACAAGGCAAGTGCGGCCAAACTCGCCC
TCTCGCACCGTTTGCAAAGCCGCGTTGAGCGAGGCAAGCTCGGGGCCGATCGAGCGGCACAGATATTGGAACGGATTGTG
CCGGTACAGCAACTGGACGAGATCGTTTCAGCTGATCTAGTCGTCGAGGCGATCGTTGAAAATCTGACAGTCAAGAAAGA
TCTCGTTGCCGCTCTGGAAGCGATTTTACCCCGTCAAGCCGTGATAGCGACGAATACGTCGTCCCTTTCGGTGACGGCTA
TTGCAGCCAGCGCAAAATATCCCGAGCGGATCGCGGGCTTCCATTTTTTCAATCCCGTTCCGTTGATGCGCGTCGTGGAG
GTTATCAAGGGGGCGCTGACGGGTGATGCGGTGGTGGATGCCCTTAAGGAGCTTGCCGTCAGGGTCGGTCACAGGCCGGT
CAATGCGACCGATACGCCGGGTTTCATCATCAACCATGCAGGCCGTGCTTACGGAACGGAAGCTTTGGCGATGGTGAAGG
AAGGGGTAGCTGATTTTGCAACGATTGACACCATCCTGCGAGACGCGGCGGGATTTCGCATGGGGCCTTTCGAACTCTTC
GATCTGACAGGCCTTAATGTGTCCCATCTCGTCATGGAGGAGGTCTACCATCAATATTATGAGGAATCGCGCTATCGCCC
GTCGCTAATCACGCGCCGCCGTCTGGAGGCCGGTTTGCTGGGTCGCAAAACCGGGCGGGGCTTCTACGATTATCCAGACG
CCAGCGCCGGATCGAATGCAAACACCCAACCGGAAAAAGGGCCTTTGCCGAAGATTGTAAGGATCATCGATGATACGGCG
TCCGGGGACATTCACCGCCTCGCTGAGCAGGCAAAAGTTCAAATCGGGGAAAATGTCGGGCCGGATGGATTGGTTCTCGT
GGGATTGGTTGGAGACGATCTGACGTCCGCTGTTGTCAGACTGGGCCTCGATGCGACCAATGTCATCGGCTTTGATCCGC
TTTTCGGCTTTGATACGCACCGGACCCTCGTAGCGTCTCCAGCCAGTAGCGAGAATGCCCGCGCACAGGCCATGGCTCTG
GCGACTATCGATGGTGTCAACGCATCCATCGTGAATGACACGTGTGGCACGGTCTGCCAGCGCGTTCTGGCGATGATCGT
GAATATCGCTGCAGATATTATCCAGCAGAACATTACCTGTACTGACGATCTCGACGCAGCCGTCAAGCTCGGCCTGGGCT
ATCCACTTGGCCCGCTTGCATGGGGTGATCGTATCGGCGCAGACGTCATCGTCCATATTCTGGACAGCATTCACGCACGA
ACATTCGATCCACGATACCGGGCAAGCCTCTGGCTGCGGCGCCGGGCTGAACTTGGGTTGCGACTGGCAGACTACAATTA
G

Upstream 100 bases:

>100_bases
GAGCGCAAGGCATTTCAGCTCCTGTTCGATACGGAAGACAAGCGTGAAGGCATCGATGCATTTTTGACCAAGCGCAAGCC
GGCATTCAAAGGGCGCTGAA

Downstream 100 bases:

>100_bases
GGGAAACTCTCACAATGGCAGAGAAAATTGATCTGAAACCATCCGCACCCTGGTATCGGTTGAATACCACGGACGAGGAT
TGGCAAAATGCAGAAGCGGC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MVIETVTYGQIAKVAIIGSGVMGAGIAETMAAGGIDVLLFDQMADKASAAKLALSHRLQSRVERGKLGADRAAQILERIV
PVQQLDEIVSADLVVEAIVENLTVKKDLVAALEAILPRQAVIATNTSSLSVTAIAASAKYPERIAGFHFFNPVPLMRVVE
VIKGALTGDAVVDALKELAVRVGHRPVNATDTPGFIINHAGRAYGTEALAMVKEGVADFATIDTILRDAAGFRMGPFELF
DLTGLNVSHLVMEEVYHQYYEESRYRPSLITRRRLEAGLLGRKTGRGFYDYPDASAGSNANTQPEKGPLPKIVRIIDDTA
SGDIHRLAEQAKVQIGENVGPDGLVLVGLVGDDLTSAVVRLGLDATNVIGFDPLFGFDTHRTLVASPASSENARAQAMAL
ATIDGVNASIVNDTCGTVCQRVLAMIVNIAADIIQQNITCTDDLDAAVKLGLGYPLGPLAWGDRIGADVIVHILDSIHAR
TFDPRYRASLWLRRRAELGLRLADYN

Sequences:

>Translated_506_residues
MVIETVTYGQIAKVAIIGSGVMGAGIAETMAAGGIDVLLFDQMADKASAAKLALSHRLQSRVERGKLGADRAAQILERIV
PVQQLDEIVSADLVVEAIVENLTVKKDLVAALEAILPRQAVIATNTSSLSVTAIAASAKYPERIAGFHFFNPVPLMRVVE
VIKGALTGDAVVDALKELAVRVGHRPVNATDTPGFIINHAGRAYGTEALAMVKEGVADFATIDTILRDAAGFRMGPFELF
DLTGLNVSHLVMEEVYHQYYEESRYRPSLITRRRLEAGLLGRKTGRGFYDYPDASAGSNANTQPEKGPLPKIVRIIDDTA
SGDIHRLAEQAKVQIGENVGPDGLVLVGLVGDDLTSAVVRLGLDATNVIGFDPLFGFDTHRTLVASPASSENARAQAMAL
ATIDGVNASIVNDTCGTVCQRVLAMIVNIAADIIQQNITCTDDLDAAVKLGLGYPLGPLAWGDRIGADVIVHILDSIHAR
TFDPRYRASLWLRRRAELGLRLADYN
>Mature_506_residues
MVIETVTYGQIAKVAIIGSGVMGAGIAETMAAGGIDVLLFDQMADKASAAKLALSHRLQSRVERGKLGADRAAQILERIV
PVQQLDEIVSADLVVEAIVENLTVKKDLVAALEAILPRQAVIATNTSSLSVTAIAASAKYPERIAGFHFFNPVPLMRVVE
VIKGALTGDAVVDALKELAVRVGHRPVNATDTPGFIINHAGRAYGTEALAMVKEGVADFATIDTILRDAAGFRMGPFELF
DLTGLNVSHLVMEEVYHQYYEESRYRPSLITRRRLEAGLLGRKTGRGFYDYPDASAGSNANTQPEKGPLPKIVRIIDDTA
SGDIHRLAEQAKVQIGENVGPDGLVLVGLVGDDLTSAVVRLGLDATNVIGFDPLFGFDTHRTLVASPASSENARAQAMAL
ATIDGVNASIVNDTCGTVCQRVLAMIVNIAADIIQQNITCTDDLDAAVKLGLGYPLGPLAWGDRIGADVIVHILDSIHAR
TFDPRYRASLWLRRRAELGLRLADYN

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=37.9790940766551, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=35.8552631578947, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI20127408, Length=295, Percent_Identity=28.8135593220339, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI68989263, Length=300, Percent_Identity=27.3333333333333, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI261878539, Length=300, Percent_Identity=27.3333333333333, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI115430219, Length=237, Percent_Identity=25.7383966244726, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787661, Length=488, Percent_Identity=37.7049180327869, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1790281, Length=277, Percent_Identity=32.129963898917, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788682, Length=253, Percent_Identity=32.8063241106719, Blast_Score=119, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=38.0952380952381, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=35.8885017421603, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=32.9861111111111, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=320, Percent_Identity=27.1875, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71985923, Length=327, Percent_Identity=27.217125382263, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508951, Length=295, Percent_Identity=29.1525423728814, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25144276, Length=295, Percent_Identity=29.1525423728814, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508953, Length=295, Percent_Identity=29.1525423728814, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17558304, Length=305, Percent_Identity=27.5409836065574, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24583077, Length=293, Percent_Identity=29.0102389078498, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24583079, Length=293, Percent_Identity=29.0102389078498, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI19921000, Length=293, Percent_Identity=29.0102389078498, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45549573, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=27.0042194092827, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54149; Mature: 54149

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIETVTYGQIAKVAIIGSGVMGAGIAETMAAGGIDVLLFDQMADKASAAKLALSHRLQS
CEEEEECCCCCEEEEEEECCCHHCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
RVERGKLGADRAAQILERIVPVQQLDEIVSADLVVEAIVENLTVKKDLVAALEAILPRQA
HHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VIATNTSSLSVTAIAASAKYPERIAGFHFFNPVPLMRVVEVIKGALTGDAVVDALKELAV
EEEECCCCEEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
RVGHRPVNATDTPGFIINHAGRAYGTEALAMVKEGVADFATIDTILRDAAGFRMGPFELF
HHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEE
DLTGLNVSHLVMEEVYHQYYEESRYRPSLITRRRLEAGLLGRKTGRGFYDYPDASAGSNA
EECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
NTQPEKGPLPKIVRIIDDTASGDIHRLAEQAKVQIGENVGPDGLVLVGLVGDDLTSAVVR
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHH
LGLDATNVIGFDPLFGFDTHRTLVASPASSENARAQAMALATIDGVNASIVNDTCGTVCQ
HCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHH
RVLAMIVNIAADIIQQNITCTDDLDAAVKLGLGYPLGPLAWGDRIGADVIVHILDSIHAR
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
TFDPRYRASLWLRRRAELGLRLADYN
CCCCHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MVIETVTYGQIAKVAIIGSGVMGAGIAETMAAGGIDVLLFDQMADKASAAKLALSHRLQS
CEEEEECCCCCEEEEEEECCCHHCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
RVERGKLGADRAAQILERIVPVQQLDEIVSADLVVEAIVENLTVKKDLVAALEAILPRQA
HHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VIATNTSSLSVTAIAASAKYPERIAGFHFFNPVPLMRVVEVIKGALTGDAVVDALKELAV
EEEECCCCEEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
RVGHRPVNATDTPGFIINHAGRAYGTEALAMVKEGVADFATIDTILRDAAGFRMGPFELF
HHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEE
DLTGLNVSHLVMEEVYHQYYEESRYRPSLITRRRLEAGLLGRKTGRGFYDYPDASAGSNA
EECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
NTQPEKGPLPKIVRIIDDTASGDIHRLAEQAKVQIGENVGPDGLVLVGLVGDDLTSAVVR
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHH
LGLDATNVIGFDPLFGFDTHRTLVASPASSENARAQAMALATIDGVNASIVNDTCGTVCQ
HCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHH
RVLAMIVNIAADIIQQNITCTDDLDAAVKLGLGYPLGPLAWGDRIGADVIVHILDSIHAR
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
TFDPRYRASLWLRRRAELGLRLADYN
CCCCHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]