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The map label for this gene is hemL [H]

Identifier: 225686831

GI number: 225686831

Start: 1041326

End: 1042531

Strand: Reverse

Name: hemL [H]

Synonym: BMEA_B1069

Alternate gene names: 225686831

Gene position: 1042531-1041326 (Counterclockwise)

Preceding gene: 225686836

Following gene: 225686830

Centisome position: 87.94

GC content: 62.44

Gene sequence:

>1206_bases
ATGGACGCACAATTGCGGGAGCGCGCAGAGCGCGTCATTCCCAACGGCATGTGGGGACATCAGCGGGCTTCATCGCTTCC
GCAGGGCTATCCGCAATATTTCGCCAGCGGCAAGGATGCTTGCGTCACGGACGTCGACGGCAACAGCTATATCGATTTCA
TGTGCGCCTGGGGGCCGATCATCCTGGGCCATCGCAATCCGCTGGTCGATGCGGCAGCGCTGTCTCAGATTGAGCTTGGC
GACAGCTTGAACGGCCCAACCGCCCATGCCGTGGAGCTGGCCGAACTTCTGGTCGCCACCATACCCCATGCCGACTGGGC
CCTGTTCCAGAAGAACGGAACCGACGCCACCACAAGCTGCGTCACCATTGCGCGCGGCACCACGAAACGCCGCAAGGTCC
TGGTGGCCAAAGGCGCCTATCATGGCGCAGCGCCCTGGTGCACCCCCTCGCTGGTTGGCGTCACCGCCGAGGATCGCGTC
CACCTCATTCATTATGTCTATAACGATGTCGAAAGCCTCACCGCAGCGGCGCGCGAAGCCGGTGACGATCTGGCGGCAAT
CCTCGTTTCGGCATTCAAGCACGATCTCGCCATTCCGCAGGAATCGCCAACGAAGGAATTTGCGCAAGCCGCAAGGGCGC
TTTGCGATGCGGCAGGCGCGGCGCTCATTCTCGATGACGTTCGCGGCGGGTTCCGTATCGACCTCGGCGGAAGTTGGCGC
GGCACAGGTATCGAACCGGACATGGCCGCCTATTCGAAGGCTATCGCGAATGGTTATGCCCTGGCGGCAGTGACCGGAAG
CGACCGTTTCCGCGAAGCGGCGCGACAGGCCTATATGACGGGCTCTTTCTGGTATGGCGGCGCGTCGATGGCCGCAGCGG
TTGCGACCATCAAGGAATTGCGGCGCATCGATGGCCCCGCGCTCATGAAACATGCGGGCGAACGCCTTCGCAGCGGCCTT
GACGCGCAGGCCGCCCGATACGGGTTCGACCTGCTTCAAACCGGCCCGGCGGTCATGCCGCTGGTGCAGTTCGCCGGCGA
CAGCGATGCCGCGCTTGGCGCGCGTTTTTGCCAGGAGGCGTTGAAGCGGGGCGTCTATCTGCACCACAAGCACAACATGT
TCATCTCCTGTGCACACACCGATGACGTGATCGACGACGCACTCTCCAGAACAGAGGACGCTTTCAAGGCTATTTCCACC
AAATAG

Upstream 100 bases:

>100_bases
CTCTTATTGATATATCATATTTCTTATTTGGCGCCAGCTTTGGGCCCGCCGTTTTCGGGGAGCGTTGAAAATGAACACGC
ATTCAGTTCCAGTCACAACG

Downstream 100 bases:

>100_bases
CGAACGGGAAGGCGAACGGTCGATCGACAATGGGGCATAATCCGACAGGCGTGAAACGGTTATCGGACAAGATGCACGGA
AAAACACATATTGCGAGCGC

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDAQLRERAERVIPNGMWGHQRASSLPQGYPQYFASGKDACVTDVDGNSYIDFMCAWGPIILGHRNPLVDAAALSQIELG
DSLNGPTAHAVELAELLVATIPHADWALFQKNGTDATTSCVTIARGTTKRRKVLVAKGAYHGAAPWCTPSLVGVTAEDRV
HLIHYVYNDVESLTAAAREAGDDLAAILVSAFKHDLAIPQESPTKEFAQAARALCDAAGAALILDDVRGGFRIDLGGSWR
GTGIEPDMAAYSKAIANGYALAAVTGSDRFREAARQAYMTGSFWYGGASMAAAVATIKELRRIDGPALMKHAGERLRSGL
DAQAARYGFDLLQTGPAVMPLVQFAGDSDAALGARFCQEALKRGVYLHHKHNMFISCAHTDDVIDDALSRTEDAFKAIST
K

Sequences:

>Translated_401_residues
MDAQLRERAERVIPNGMWGHQRASSLPQGYPQYFASGKDACVTDVDGNSYIDFMCAWGPIILGHRNPLVDAAALSQIELG
DSLNGPTAHAVELAELLVATIPHADWALFQKNGTDATTSCVTIARGTTKRRKVLVAKGAYHGAAPWCTPSLVGVTAEDRV
HLIHYVYNDVESLTAAAREAGDDLAAILVSAFKHDLAIPQESPTKEFAQAARALCDAAGAALILDDVRGGFRIDLGGSWR
GTGIEPDMAAYSKAIANGYALAAVTGSDRFREAARQAYMTGSFWYGGASMAAAVATIKELRRIDGPALMKHAGERLRSGL
DAQAARYGFDLLQTGPAVMPLVQFAGDSDAALGARFCQEALKRGVYLHHKHNMFISCAHTDDVIDDALSRTEDAFKAIST
K
>Mature_401_residues
MDAQLRERAERVIPNGMWGHQRASSLPQGYPQYFASGKDACVTDVDGNSYIDFMCAWGPIILGHRNPLVDAAALSQIELG
DSLNGPTAHAVELAELLVATIPHADWALFQKNGTDATTSCVTIARGTTKRRKVLVAKGAYHGAAPWCTPSLVGVTAEDRV
HLIHYVYNDVESLTAAAREAGDDLAAILVSAFKHDLAIPQESPTKEFAQAARALCDAAGAALILDDVRGGFRIDLGGSWR
GTGIEPDMAAYSKAIANGYALAAVTGSDRFREAARQAYMTGSFWYGGASMAAAVATIKELRRIDGPALMKHAGERLRSGL
DAQAARYGFDLLQTGPAVMPLVQFAGDSDAALGARFCQEALKRGVYLHHKHNMFISCAHTDDVIDDALSRTEDAFKAIST
K

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786349, Length=421, Percent_Identity=29.2161520190024, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789016, Length=353, Percent_Identity=28.6118980169972, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693181, Length=358, Percent_Identity=25.1396648044693, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788044, Length=381, Percent_Identity=26.509186351706, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789759, Length=294, Percent_Identity=25.1700680272109, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 42906; Mature: 42906

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAQLRERAERVIPNGMWGHQRASSLPQGYPQYFASGKDACVTDVDGNSYIDFMCAWGPI
CCCHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHCCCCCCEEEECCCCCEEEEEECCCCE
ILGHRNPLVDAAALSQIELGDSLNGPTAHAVELAELLVATIPHADWALFQKNGTDATTSC
EECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
VTIARGTTKRRKVLVAKGAYHGAAPWCTPSLVGVTAEDRVHLIHYVYNDVESLTAAAREA
EEEECCCCCHHEEEEEECCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GDDLAAILVSAFKHDLAIPQESPTKEFAQAARALCDAAGAALILDDVRGGFRIDLGGSWR
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCC
GTGIEPDMAAYSKAIANGYALAAVTGSDRFREAARQAYMTGSFWYGGASMAAAVATIKEL
CCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHH
RRIDGPALMKHAGERLRSGLDAQAARYGFDLLQTGPAVMPLVQFAGDSDAALGARFCQEA
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
LKRGVYLHHKHNMFISCAHTDDVIDDALSRTEDAFKAISTK
HHCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDAQLRERAERVIPNGMWGHQRASSLPQGYPQYFASGKDACVTDVDGNSYIDFMCAWGPI
CCCHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHCCCCCCEEEECCCCCEEEEEECCCCE
ILGHRNPLVDAAALSQIELGDSLNGPTAHAVELAELLVATIPHADWALFQKNGTDATTSC
EECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHH
VTIARGTTKRRKVLVAKGAYHGAAPWCTPSLVGVTAEDRVHLIHYVYNDVESLTAAAREA
EEEECCCCCHHEEEEEECCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GDDLAAILVSAFKHDLAIPQESPTKEFAQAARALCDAAGAALILDDVRGGFRIDLGGSWR
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCC
GTGIEPDMAAYSKAIANGYALAAVTGSDRFREAARQAYMTGSFWYGGASMAAAVATIKEL
CCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHH
RRIDGPALMKHAGERLRSGLDAQAARYGFDLLQTGPAVMPLVQFAGDSDAALGARFCQEA
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
LKRGVYLHHKHNMFISCAHTDDVIDDALSRTEDAFKAISTK
HHCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA