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The map label for this gene is upp [H]

Identifier: 225686819

GI number: 225686819

Start: 1031326

End: 1031952

Strand: Direct

Name: upp [H]

Synonym: BMEA_B1054

Alternate gene names: 225686819

Gene position: 1031326-1031952 (Clockwise)

Preceding gene: 225686815

Following gene: 225686820

Centisome position: 86.99

GC content: 57.58

Gene sequence:

>627_bases
ATGGGCGTTACAGTCGTCAGCCATCCGCTTGTCCAGCACAAGCTTACCATCATGCGCAAGAAGGAGACGTCCACGGCCAG
CTTCCGGCGGTTGCTGAAGGAGATTTCGCTGTTGCTGTGCTACGAAGTGACGCGCAATCTCGAACTTACCACCATGTCTA
TTGAAACCCCGCTGATGCCGATGGAAGCCCCGGTGCTGGAAGGCAAGAAGCTTGTGTTCGCTTCCATCCTGCGTGCAGGT
AACGGCCTTCTGGAAGGGATGCTCGATCTGGTGCCTGCCGCGCGCGTCGCCCATATCGGCCTCTACCGCGACCACGACAC
GCTTCAGCCGATCGAATATTACTTCAAGGCACCGGAAGATATCGTCAATCGCCTCGTTATCGTTGTCGATCCGATGCTTG
CCACCGCCAACTCGGCCATTGCCGCTATCGACAAGCTGAAAGAGCGCGGCGCAACCAATATCCGCTTCCTCTGCCTGCTG
GCCGCACCCGAAGGCATTGAACGCTTCACCAAGGCGCATCCGGATGTCGAGGTCTTCACCGCCTCCATCGATGAATGCCT
TGATGAAAAAGGCTATATTGTTCCGGGCCTCGGCGACGCGGGCGACCGCATGTACGGCACGAAATAA

Upstream 100 bases:

>100_bases
CCAAAGAGACATAAAACTGTGGGCGCGCGCCTGGCCCGGCATTTCCTCCGGCGCAATCCGCCGCTAAAGTCAAAAAGATA
ACAAGAAAAGTGGAAAAATC

Downstream 100 bases:

>100_bases
ATGCCATTGCCTCAATCTGCGCCGGCCCCTATCTTTTTTGGGACACTGGCGCGGATTGCGTGACGCCTCGCCTCCAATTC
CATCATGGCCACACAAACGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MGVTVVSHPLVQHKLTIMRKKETSTASFRRLLKEISLLLCYEVTRNLELTTMSIETPLMPMEAPVLEGKKLVFASILRAG
NGLLEGMLDLVPAARVAHIGLYRDHDTLQPIEYYFKAPEDIVNRLVIVVDPMLATANSAIAAIDKLKERGATNIRFLCLL
AAPEGIERFTKAHPDVEVFTASIDECLDEKGYIVPGLGDAGDRMYGTK

Sequences:

>Translated_208_residues
MGVTVVSHPLVQHKLTIMRKKETSTASFRRLLKEISLLLCYEVTRNLELTTMSIETPLMPMEAPVLEGKKLVFASILRAG
NGLLEGMLDLVPAARVAHIGLYRDHDTLQPIEYYFKAPEDIVNRLVIVVDPMLATANSAIAAIDKLKERGATNIRFLCLL
AAPEGIERFTKAHPDVEVFTASIDECLDEKGYIVPGLGDAGDRMYGTK
>Mature_207_residues
GVTVVSHPLVQHKLTIMRKKETSTASFRRLLKEISLLLCYEVTRNLELTTMSIETPLMPMEAPVLEGKKLVFASILRAGN
GLLEGMLDLVPAARVAHIGLYRDHDTLQPIEYYFKAPEDIVNRLVIVVDPMLATANSAIAAIDKLKERGATNIRFLCLLA
APEGIERFTKAHPDVEVFTASIDECLDEKGYIVPGLGDAGDRMYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=50.4807692307692, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.8756218905473, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.8756218905473, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.5833333333333, Blast_Score=124, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21358379, Length=175, Percent_Identity=26.2857142857143, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22994; Mature: 22863

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVTVVSHPLVQHKLTIMRKKETSTASFRRLLKEISLLLCYEVTRNLELTTMSIETPLMP
CCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
MEAPVLEGKKLVFASILRAGNGLLEGMLDLVPAARVAHIGLYRDHDTLQPIEYYFKAPED
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCHHH
IVNRLVIVVDPMLATANSAIAAIDKLKERGATNIRFLCLLAAPEGIERFTKAHPDVEVFT
HHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCHHHHH
ASIDECLDEKGYIVPGLGDAGDRMYGTK
HHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GVTVVSHPLVQHKLTIMRKKETSTASFRRLLKEISLLLCYEVTRNLELTTMSIETPLMP
CCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
MEAPVLEGKKLVFASILRAGNGLLEGMLDLVPAARVAHIGLYRDHDTLQPIEYYFKAPED
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCHHH
IVNRLVIVVDPMLATANSAIAAIDKLKERGATNIRFLCLLAAPEGIERFTKAHPDVEVFT
HHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCHHHHH
ASIDECLDEKGYIVPGLGDAGDRMYGTK
HHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA