| Definition | Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence. |
|---|---|
| Accession | NC_012442 |
| Length | 1,185,518 |
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The map label for this gene is kduD [H]
Identifier: 225686737
GI number: 225686737
Start: 946648
End: 947397
Strand: Reverse
Name: kduD [H]
Synonym: BMEA_B0965
Alternate gene names: 225686737
Gene position: 947397-946648 (Counterclockwise)
Preceding gene: 225686739
Following gene: 225686736
Centisome position: 79.91
GC content: 60.13
Gene sequence:
>750_bases ATGACTGACGATCAGCTTTTTTCGGTTAGAGGCAAGGTCATTGCCGTGACGGGGGGATCTTCCGGGTTGGGCCTGCGCAT GGTGCATGTGCTGGCCGGTCATGGCGCCCGGGTGATATCGATTTCGCGCACCCATGCGGGCGAAAGCCTGTGCCCATCGG GCGGGGAAGTGCTGGAAATCATGGCAGATGTAACGCGCCCGGAAGAAATTGCGCGCGCCTTCGATGAAGGCGAAAGCCGC TTCGGGCCGATCAGCGCCTTGTTCAACAATGCCGGAGTTGCCCATATGGCCCGCGCTCTTGATACCACTCGCGATATGCT GGAGCATATTTTCGAGGTGAATGTCGCGGGTGCTTTCTTCACTGCGCAGGAGGTTGCGCGCCGGATGATCGCACAGGGGC AGGGCGGATCGATCATCAATGTCACGAGTATTCTGGGTGAGCGCCCGCAAAAGGGTGCGGCTGCCTATTCGATGTCGAAA GCCTGTGTGAGCCAGATGACGCGGGCACTGGCGCTGGAATGGGCGGCGCATGATATTCGCGTCAATGCAATCTCGCCCGG ATGGTTTCCAACCCGAATCAACGAAGAGCAGTTACAGGGGCCGGCTGCGGGCTATCTCAAGGGGCGCAACCCCATGCGGC GGCTTGGTGATCCGAACGACCTCGACGGGGTTGTGCTGCTGCTGGCCTCGGATGCGAGCCGGTATATGACTGGGTCGATC ATTACGGTCGATGGTGGCCACCAGCTCTGA
Upstream 100 bases:
>100_bases GATTCAAAGCGTTTTTTACGCCTCACCATGGTTCAAATGGCAAATTTTATCCTTTACGGTGACAGCAAACAAAGGATGGA TTGGCAGTTTGAGGGGATGA
Downstream 100 bases:
>100_bases CGGAAACCTGCCCGTTCATAATCCAAAGACGGCAATGGTTGCCGGGGTTTTCGCTATTGTTGGGGATGGTTCCTTGCCAT TATCCGCTTTTTATGTGCGT
Product: glucose 1-dehydrogenase 3
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 249; Mature: 248
Protein sequence:
>249_residues MTDDQLFSVRGKVIAVTGGSSGLGLRMVHVLAGHGARVISISRTHAGESLCPSGGEVLEIMADVTRPEEIARAFDEGESR FGPISALFNNAGVAHMARALDTTRDMLEHIFEVNVAGAFFTAQEVARRMIAQGQGGSIINVTSILGERPQKGAAAYSMSK ACVSQMTRALALEWAAHDIRVNAISPGWFPTRINEEQLQGPAAGYLKGRNPMRRLGDPNDLDGVVLLLASDASRYMTGSI ITVDGGHQL
Sequences:
>Translated_249_residues MTDDQLFSVRGKVIAVTGGSSGLGLRMVHVLAGHGARVISISRTHAGESLCPSGGEVLEIMADVTRPEEIARAFDEGESR FGPISALFNNAGVAHMARALDTTRDMLEHIFEVNVAGAFFTAQEVARRMIAQGQGGSIINVTSILGERPQKGAAAYSMSK ACVSQMTRALALEWAAHDIRVNAISPGWFPTRINEEQLQGPAAGYLKGRNPMRRLGDPNDLDGVVLLLASDASRYMTGSI ITVDGGHQL >Mature_248_residues TDDQLFSVRGKVIAVTGGSSGLGLRMVHVLAGHGARVISISRTHAGESLCPSGGEVLEIMADVTRPEEIARAFDEGESRF GPISALFNNAGVAHMARALDTTRDMLEHIFEVNVAGAFFTAQEVARRMIAQGQGGSIINVTSILGERPQKGAAAYSMSKA CVSQMTRALALEWAAHDIRVNAISPGWFPTRINEEQLQGPAAGYLKGRNPMRRLGDPNDLDGVVLLLASDASRYMTGSII TVDGGHQL
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=35.5371900826446, Blast_Score=121, Evalue=7e-28, Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=32.7868852459016, Blast_Score=119, Evalue=3e-27, Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=30.8300395256917, Blast_Score=117, Evalue=8e-27, Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=31.4741035856574, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=30.1652892561983, Blast_Score=98, Evalue=9e-21, Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=30.9322033898305, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI4758504, Length=252, Percent_Identity=30.952380952381, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=29.3388429752066, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI4503301, Length=251, Percent_Identity=27.4900398406374, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI66933014, Length=248, Percent_Identity=28.2258064516129, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=28.968253968254, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI20149619, Length=232, Percent_Identity=25.8620689655172, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI33667109, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI126723750, Length=245, Percent_Identity=26.1224489795918, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI31542939, Length=256, Percent_Identity=26.5625, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=27.5303643724696, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=37.5510204081633, Blast_Score=145, Evalue=2e-36, Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=32.5301204819277, Blast_Score=131, Evalue=4e-32, Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=34, Blast_Score=125, Evalue=4e-30, Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=32.2709163346614, Blast_Score=123, Evalue=1e-29, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=34.8178137651822, Blast_Score=121, Evalue=4e-29, Organism=Escherichia coli, GI2367175, Length=242, Percent_Identity=29.7520661157025, Blast_Score=105, Evalue=4e-24, Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=29.7959183673469, Blast_Score=104, Evalue=5e-24, Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=29.0836653386454, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=28.8, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=28.75, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=29.5019157088123, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=30.5220883534137, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1786701, Length=199, Percent_Identity=28.643216080402, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=34.8547717842324, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=4e-26, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=31.0204081632653, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=29.9212598425197, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17561272, Length=219, Percent_Identity=30.5936073059361, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=32.8, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=29.3650793650794, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=30.6772908366534, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.5546558704453, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=30.6513409961686, Blast_Score=90, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=27.5720164609054, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=31.25, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=29.3893129770992, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=28.2442748091603, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=26.8199233716475, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=28.7878787878788, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=27.9693486590038, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=29.5019157088123, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=27.2030651340996, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=29.277566539924, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=28.6792452830189, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=29.0076335877863, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=23.2209737827715, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=27.4436090225564, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=29.1187739463602, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=25, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI193203115, Length=190, Percent_Identity=26.8421052631579, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6322067, Length=189, Percent_Identity=31.2169312169312, Blast_Score=70, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=24, Blast_Score=63, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6320089, Length=185, Percent_Identity=28.6486486486486, Blast_Score=62, Evalue=6e-11, Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=31.3725490196078, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.1587301587302, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=31.7460317460317, Blast_Score=106, Evalue=1e-23, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=30.1587301587302, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=31.6872427983539, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=8e-22, Organism=Drosophila melanogaster, GI24644337, Length=250, Percent_Identity=30.4, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=27.3092369477912, Blast_Score=97, Evalue=7e-21, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=28.2352941176471, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI24584752, Length=201, Percent_Identity=30.8457711442786, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24663911, Length=226, Percent_Identity=27.8761061946903, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI24584748, Length=229, Percent_Identity=27.5109170305677, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI161076933, Length=229, Percent_Identity=27.5109170305677, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI21358495, Length=207, Percent_Identity=28.0193236714976, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24584744, Length=232, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI28574402, Length=232, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI21355631, Length=191, Percent_Identity=27.2251308900524, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 26514; Mature: 26382
Theoretical pI: Translated: 6.63; Mature: 6.63
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 4.0 %Met (Translated Protein) 4.8 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTDDQLFSVRGKVIAVTGGSSGLGLRMVHVLAGHGARVISISRTHAGESLCPSGGEVLEI CCCCCEEEECCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHH MADVTRPEEIARAFDEGESRFGPISALFNNAGVAHMARALDTTRDMLEHIFEVNVAGAFF HHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH TAQEVARRMIAQGQGGSIINVTSILGERPQKGAAAYSMSKACVSQMTRALALEWAAHDIR HHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEE VNAISPGWFPTRINEEQLQGPAAGYLKGRNPMRRLGDPNDLDGVVLLLASDASRYMTGSI EEEECCCCCCCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCHHEECEE ITVDGGHQL EEECCCCCC >Mature Secondary Structure TDDQLFSVRGKVIAVTGGSSGLGLRMVHVLAGHGARVISISRTHAGESLCPSGGEVLEI CCCCEEEECCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHH MADVTRPEEIARAFDEGESRFGPISALFNNAGVAHMARALDTTRDMLEHIFEVNVAGAFF HHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH TAQEVARRMIAQGQGGSIINVTSILGERPQKGAAAYSMSKACVSQMTRALALEWAAHDIR HHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEE VNAISPGWFPTRINEEQLQGPAAGYLKGRNPMRRLGDPNDLDGVVLLLASDASRYMTGSI EEEECCCCCCCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCHHEECEE ITVDGGHQL EEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386 [H]