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The map label for this gene is gyaR [H]

Identifier: 225686739

GI number: 225686739

Start: 948555

End: 949529

Strand: Reverse

Name: gyaR [H]

Synonym: BMEA_B0967

Alternate gene names: 225686739

Gene position: 949529-948555 (Counterclockwise)

Preceding gene: 225686740

Following gene: 225686737

Centisome position: 80.09

GC content: 59.18

Gene sequence:

>975_bases
ATGACCAAACGTGATACGACTATACTAGTGCTTGGCAATTTTGATGATTATGCCGTGCAGCGGCTTTCGGACGAGTTCAA
TGTTCAGCGCATGGCGCGTGGCGACACCGCGCTTCTGGGGAGCGACTGGGTAAAGGACGTGAAAGGCATTGCCAGCATGT
CCAAGGTCAGCGCCGACTTGATCGATGCCTTGCCCAATCTCGAAATCATCGGGAATTTCGGCGTCGGCTATGATGCGGTC
GATGCCAGACATGCGGGCGCAAACAATGTCATGGTTACGAATACGCCGGATGTGCTGACCGAGGAAGTGGCCGATACGAC
CATTGGTCTCCTGATCGATACCGTGCGCGAATTGTCAAAGGCGCAGGAATTTCTGCGTCGCGGCGAGTGGGGAAAACAGG
TGCGCTATCCGCTGTCGAAGCTGTCGCTGCGCGGGCGCAAGGTCGGTATTTTCGGGCTTGGCCGCATCGGCAAGGCTGTC
GCCCGCCGTATCGAAGCCTTCGGCCTGCCGATCGCCTATCACAATCGCCGCAAGGCCGCCGATGTGGCTTATGATTATTA
TCCGAGCCTCAAGGAACTTGCCGGAGCGGTGGATACGCTCATTCTCGTTGCCCCCGGCGGGGCGGAAACCACCAGGGCGG
TCAATACGGAAGTGTTGCAGGCACTTGGGCCGGAAGGCGTGCTCATCAATATCGGGCGAGGCTCGGTCGTGGATGAGGAG
GCGCTTGCGCAAGCCCTGAAGGACGGTACGATTGCTGCTGCGGGCCTCGATGTTTTCGCCAACGAACCGCATGTGCCACA
GGCGCTTCTCGATGCGCCGAACACGGTGTTGCTGCCGCATATCGGCTCGGCCTCGGTCAAGACACGCCGCGCCATGGCCG
ATCTCGTGGTCGATAATCTCATTGCATGGTTCGACAGCGGTACGGCGATTACGCCCGTGCCGGAGACGGTGGGGGTTAAA
GCGGTAAGGCAGTAA

Upstream 100 bases:

>100_bases
CCGAAACACGCTTGATTCTTCCGCCCCATCCGTCAATCCTGCCGGACGGCTCCCCGGAGTGATTTTGAATTGCTGGAATT
GCTCGTGAGATGACGCACCT

Downstream 100 bases:

>100_bases
GGCAATAGGGCAGTAAGGCAGTATGTTAAGGGAATAGGGTAGGGGAGTATGTTTTGGTTGCGCATGAGCGCAGCGACCAT
ATTCTTCACTGCCCCACTGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTKRDTTILVLGNFDDYAVQRLSDEFNVQRMARGDTALLGSDWVKDVKGIASMSKVSADLIDALPNLEIIGNFGVGYDAV
DARHAGANNVMVTNTPDVLTEEVADTTIGLLIDTVRELSKAQEFLRRGEWGKQVRYPLSKLSLRGRKVGIFGLGRIGKAV
ARRIEAFGLPIAYHNRRKAADVAYDYYPSLKELAGAVDTLILVAPGGAETTRAVNTEVLQALGPEGVLINIGRGSVVDEE
ALAQALKDGTIAAAGLDVFANEPHVPQALLDAPNTVLLPHIGSASVKTRRAMADLVVDNLIAWFDSGTAITPVPETVGVK
AVRQ

Sequences:

>Translated_324_residues
MTKRDTTILVLGNFDDYAVQRLSDEFNVQRMARGDTALLGSDWVKDVKGIASMSKVSADLIDALPNLEIIGNFGVGYDAV
DARHAGANNVMVTNTPDVLTEEVADTTIGLLIDTVRELSKAQEFLRRGEWGKQVRYPLSKLSLRGRKVGIFGLGRIGKAV
ARRIEAFGLPIAYHNRRKAADVAYDYYPSLKELAGAVDTLILVAPGGAETTRAVNTEVLQALGPEGVLINIGRGSVVDEE
ALAQALKDGTIAAAGLDVFANEPHVPQALLDAPNTVLLPHIGSASVKTRRAMADLVVDNLIAWFDSGTAITPVPETVGVK
AVRQ
>Mature_323_residues
TKRDTTILVLGNFDDYAVQRLSDEFNVQRMARGDTALLGSDWVKDVKGIASMSKVSADLIDALPNLEIIGNFGVGYDAVD
ARHAGANNVMVTNTPDVLTEEVADTTIGLLIDTVRELSKAQEFLRRGEWGKQVRYPLSKLSLRGRKVGIFGLGRIGKAVA
RRIEAFGLPIAYHNRRKAADVAYDYYPSLKELAGAVDTLILVAPGGAETTRAVNTEVLQALGPEGVLINIGRGSVVDEEA
LAQALKDGTIAAAGLDVFANEPHVPQALLDAPNTVLLPHIGSASVKTRRAMADLVVDNLIAWFDSGTAITPVPETVGVKA
VRQ

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=243, Percent_Identity=38.2716049382716, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI23308577, Length=248, Percent_Identity=32.6612903225806, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580578, Length=281, Percent_Identity=29.8932384341637, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557499, Length=281, Percent_Identity=29.8932384341637, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=247, Percent_Identity=31.9838056680162, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI61743967, Length=247, Percent_Identity=31.9838056680162, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=30.5454545454545, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082289, Length=303, Percent_Identity=35.3135313531353, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1789279, Length=275, Percent_Identity=29.0909090909091, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787645, Length=220, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=257, Percent_Identity=24.5136186770428, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=28.3018867924528, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=253, Percent_Identity=28.4584980237154, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=278, Percent_Identity=31.6546762589928, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=334, Percent_Identity=27.8443113772455, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=332, Percent_Identity=27.710843373494, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=25.8992805755396, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=33.8983050847458, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=281, Percent_Identity=22.7758007117438, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571528, Length=264, Percent_Identity=35.6060606060606, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585516, Length=269, Percent_Identity=31.2267657992565, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=31.2252964426877, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=30.3030303030303, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=30.3030303030303, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=31.2252964426877, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=31.2252964426877, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=30.9433962264151, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=34.2741935483871, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=34.2741935483871, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=34.2741935483871, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=34.2741935483871, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472511, Length=242, Percent_Identity=35.1239669421488, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19921140, Length=293, Percent_Identity=28.3276450511945, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34681; Mature: 34550

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRDTTILVLGNFDDYAVQRLSDEFNVQRMARGDTALLGSDWVKDVKGIASMSKVSADL
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDALPNLEIIGNFGVGYDAVDARHAGANNVMVTNTPDVLTEEVADTTIGLLIDTVRELSK
HHHCCCCEEEECCCCCCCCCCHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AQEFLRRGEWGKQVRYPLSKLSLRGRKVGIFGLGRIGKAVARRIEAFGLPIAYHNRRKAA
HHHHHHCCCCCHHHHCCHHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCEEECCCCHHH
DVAYDYYPSLKELAGAVDTLILVAPGGAETTRAVNTEVLQALGPEGVLINIGRGSVVDEE
HHHHHHCCCHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
ALAQALKDGTIAAAGLDVFANEPHVPQALLDAPNTVLLPHIGSASVKTRRAMADLVVDNL
HHHHHHHCCCEEEECHHHHCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
IAWFDSGTAITPVPETVGVKAVRQ
HHHHCCCCEECCCCHHHCHHHHCC
>Mature Secondary Structure 
TKRDTTILVLGNFDDYAVQRLSDEFNVQRMARGDTALLGSDWVKDVKGIASMSKVSADL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDALPNLEIIGNFGVGYDAVDARHAGANNVMVTNTPDVLTEEVADTTIGLLIDTVRELSK
HHHCCCCEEEECCCCCCCCCCHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AQEFLRRGEWGKQVRYPLSKLSLRGRKVGIFGLGRIGKAVARRIEAFGLPIAYHNRRKAA
HHHHHHCCCCCHHHHCCHHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCEEECCCCHHH
DVAYDYYPSLKELAGAVDTLILVAPGGAETTRAVNTEVLQALGPEGVLINIGRGSVVDEE
HHHHHHCCCHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
ALAQALKDGTIAAAGLDVFANEPHVPQALLDAPNTVLLPHIGSASVKTRRAMADLVVDNL
HHHHHHHCCCEEEECHHHHCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
IAWFDSGTAITPVPETVGVKAVRQ
HHHHCCCCEECCCCHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA