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The map label for this gene is mdtG [H]

Identifier: 225686543

GI number: 225686543

Start: 734251

End: 735726

Strand: Direct

Name: mdtG [H]

Synonym: BMEA_B0754

Alternate gene names: 225686543

Gene position: 734251-735726 (Clockwise)

Preceding gene: 225686542

Following gene: 225686545

Centisome position: 61.94

GC content: 59.96

Gene sequence:

>1476_bases
ATGCAGGTGCTTCGGTTTCGATCGCGACACTACCCCCTCGCGTGTGGCTTCCACATCACAACGATCCGGCATCGCCACAA
TCGGCGCCACACGGCTGTGATTTTCCAATGCGCAGGCGCTTTTTCTGATATTCCACACTGGAATAGAAAAACAATCGCAT
TGAATCACAGGCATGACATGAGCACCACCCAAGCTGCTGCCGGGGACGCTTCGCAGATGGAGACGCCGCATCCAAACGGC
TCCTTCACCCAATCGAACGCGGATGAAAATCACGAGCAGTACTGGAAGCAAAACCTCGTGATCTGCCTTCTTGGCTCATT
CACAACCCTCATTGCCATGTCACTGCTTTTGCCTTTCCTGCCGCTTTACGTGGAACAGCTCGGCGTCATCAGCCATGCGG
CCATCGTGCAATGGTCGGGCATCGCCTATGGTGCGACCTTTCTGGCTGCCGCCTTTGTCGCGCCGCTCTGGGGCAGGCTC
GGCGACCGTTACGGGCGCAAGCTGATGCTGATCCGCGCCAGCCTCGGCATGGCTGTGGCCATGTCGCTGATCGGCATGGT
CACATGCGTTTGGCAATTGGTGGCGCTGCGGCTTTTCGTCGGCATTGCCGGCGGTTATTCGTCCGGATCGATGATCCTCG
TCGCCACACAGACGCCAAAAGACAAAACCGGCTGGGCGCTCGGCGCACTTTCGGCAGGCATCATGGCGGGCATCATGGCG
GGCAATCTGGCCGGGCCGCTGCTTGGCGGTGCACTGCCGCCGCTGATCGGCATTCGCGCCACGTTCTGGCTTGCGGGCGG
CGTGATCTTCCTGACATTCCTCGCCACAACCTTTCTGATCCGCGAGGAGCGCAAGCCGCCCAAGCCCACGAGGGAAGAGA
AAACGCAATCCATCTGGGCCGCAATTCCCGATAAAGGCCCGGTCGTTGCGATGCTGGTGACGGGCATATTGCTGCTCTTC
GCCAATATGTCCATCGAACCGATCCTCACCATTTATGTGATGCAGTTGATGGACGACCAGACCAAGGTAACGCTGGTTTC
CGGCGTGGTAATGGCCGCCGCAGCCCTTGGCAGCATCCTGTCATCGTCACGGCTGGGGCAACTTGCCGACCGCATCGGCC
ATACGCGCGTCATTATCGGAGCACTCGCCGTCTCGGCGCTGCTTCTGGTCCCGCAGGCTTTTGTGACCGATGCCTGGCAA
CTGATCGGCCTGCGCTTCCTGATGGGATTGGCGCTCGGTGGTCTTCTGCCCTGTATCACCAGCGTCATCCGGCATAATGT
GCCAGATCGTGTCGCAGGTGGCATTCTGGGCTATTCCGTCTCGGCGCAATATGTGGGGCAAGTCGCAGGGCCGGTGGCGG
GAGGCTTTGTCGGCGGCCATTTCGGCATGCGCGCCGTCTTCCTCGGCACCTGCCTGATGATGGCGGCAGGCGCGATTTAT
AACTGGGCCGTGTTGCGCAATAGCAAAACCCGATGA

Upstream 100 bases:

>100_bases
GCTACGCGCTTTTCCATGCTGCCGACCGTACTGATCGGCATGGGGGCGGCCAGTATCTGCCGTTATCTCATCGACTGAAC
CGAACGAAGCACCTGCATCA

Downstream 100 bases:

>100_bases
GCTTGCCTCATCGGGTTTTGGTTAAGTCCGTGCCGCGATTGAGCCTTTTCAGGGCGTGGATCGCGTCGGAATCTTGAATG
CTTTTCGATCAGATCGAATA

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MQVLRFRSRHYPLACGFHITTIRHRHNRRHTAVIFQCAGAFSDIPHWNRKTIALNHRHDMSTTQAAAGDASQMETPHPNG
SFTQSNADENHEQYWKQNLVICLLGSFTTLIAMSLLLPFLPLYVEQLGVISHAAIVQWSGIAYGATFLAAAFVAPLWGRL
GDRYGRKLMLIRASLGMAVAMSLIGMVTCVWQLVALRLFVGIAGGYSSGSMILVATQTPKDKTGWALGALSAGIMAGIMA
GNLAGPLLGGALPPLIGIRATFWLAGGVIFLTFLATTFLIREERKPPKPTREEKTQSIWAAIPDKGPVVAMLVTGILLLF
ANMSIEPILTIYVMQLMDDQTKVTLVSGVVMAAAALGSILSSSRLGQLADRIGHTRVIIGALAVSALLLVPQAFVTDAWQ
LIGLRFLMGLALGGLLPCITSVIRHNVPDRVAGGILGYSVSAQYVGQVAGPVAGGFVGGHFGMRAVFLGTCLMMAAGAIY
NWAVLRNSKTR

Sequences:

>Translated_491_residues
MQVLRFRSRHYPLACGFHITTIRHRHNRRHTAVIFQCAGAFSDIPHWNRKTIALNHRHDMSTTQAAAGDASQMETPHPNG
SFTQSNADENHEQYWKQNLVICLLGSFTTLIAMSLLLPFLPLYVEQLGVISHAAIVQWSGIAYGATFLAAAFVAPLWGRL
GDRYGRKLMLIRASLGMAVAMSLIGMVTCVWQLVALRLFVGIAGGYSSGSMILVATQTPKDKTGWALGALSAGIMAGIMA
GNLAGPLLGGALPPLIGIRATFWLAGGVIFLTFLATTFLIREERKPPKPTREEKTQSIWAAIPDKGPVVAMLVTGILLLF
ANMSIEPILTIYVMQLMDDQTKVTLVSGVVMAAAALGSILSSSRLGQLADRIGHTRVIIGALAVSALLLVPQAFVTDAWQ
LIGLRFLMGLALGGLLPCITSVIRHNVPDRVAGGILGYSVSAQYVGQVAGPVAGGFVGGHFGMRAVFLGTCLMMAAGAIY
NWAVLRNSKTR
>Mature_491_residues
MQVLRFRSRHYPLACGFHITTIRHRHNRRHTAVIFQCAGAFSDIPHWNRKTIALNHRHDMSTTQAAAGDASQMETPHPNG
SFTQSNADENHEQYWKQNLVICLLGSFTTLIAMSLLLPFLPLYVEQLGVISHAAIVQWSGIAYGATFLAAAFVAPLWGRL
GDRYGRKLMLIRASLGMAVAMSLIGMVTCVWQLVALRLFVGIAGGYSSGSMILVATQTPKDKTGWALGALSAGIMAGIMA
GNLAGPLLGGALPPLIGIRATFWLAGGVIFLTFLATTFLIREERKPPKPTREEKTQSIWAAIPDKGPVVAMLVTGILLLF
ANMSIEPILTIYVMQLMDDQTKVTLVSGVVMAAAALGSILSSSRLGQLADRIGHTRVIIGALAVSALLLVPQAFVTDAWQ
LIGLRFLMGLALGGLLPCITSVIRHNVPDRVAGGILGYSVSAQYVGQVAGPVAGGFVGGHFGMRAVFLGTCLMMAAGAIY
NWAVLRNSKTR

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=405, Percent_Identity=40.4938271604938, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI87082404, Length=324, Percent_Identity=25, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52639; Mature: 52639

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLRFRSRHYPLACGFHITTIRHRHNRRHTAVIFQCAGAFSDIPHWNRKTIALNHRHDM
CCCHHHHCCCCCEEECEEEHHHHHHCCCCHHEEEEEEHHHHHCCCCCCCEEEEECCCCCC
STTQAAAGDASQMETPHPNGSFTQSNADENHEQYWKQNLVICLLGSFTTLIAMSLLLPFL
CHHHHCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
PLYVEQLGVISHAAIVQWSGIAYGATFLAAAFVAPLWGRLGDRYGRKLMLIRASLGMAVA
HHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHH
MSLIGMVTCVWQLVALRLFVGIAGGYSSGSMILVATQTPKDKTGWALGALSAGIMAGIMA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
GNLAGPLLGGALPPLIGIRATFWLAGGVIFLTFLATTFLIREERKPPKPTREEKTQSIWA
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AIPDKGPVVAMLVTGILLLFANMSIEPILTIYVMQLMDDQTKVTLVSGVVMAAAALGSIL
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SSSRLGQLADRIGHTRVIIGALAVSALLLVPQAFVTDAWQLIGLRFLMGLALGGLLPCIT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVIRHNVPDRVAGGILGYSVSAQYVGQVAGPVAGGFVGGHFGMRAVFLGTCLMMAAGAIY
HHHHCCCCHHHHCCHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
NWAVLRNSKTR
HHHHHCCCCCC
>Mature Secondary Structure
MQVLRFRSRHYPLACGFHITTIRHRHNRRHTAVIFQCAGAFSDIPHWNRKTIALNHRHDM
CCCHHHHCCCCCEEECEEEHHHHHHCCCCHHEEEEEEHHHHHCCCCCCCEEEEECCCCCC
STTQAAAGDASQMETPHPNGSFTQSNADENHEQYWKQNLVICLLGSFTTLIAMSLLLPFL
CHHHHCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
PLYVEQLGVISHAAIVQWSGIAYGATFLAAAFVAPLWGRLGDRYGRKLMLIRASLGMAVA
HHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHH
MSLIGMVTCVWQLVALRLFVGIAGGYSSGSMILVATQTPKDKTGWALGALSAGIMAGIMA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
GNLAGPLLGGALPPLIGIRATFWLAGGVIFLTFLATTFLIREERKPPKPTREEKTQSIWA
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AIPDKGPVVAMLVTGILLLFANMSIEPILTIYVMQLMDDQTKVTLVSGVVMAAAALGSIL
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SSSRLGQLADRIGHTRVIIGALAVSALLLVPQAFVTDAWQLIGLRFLMGLALGGLLPCIT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVIRHNVPDRVAGGILGYSVSAQYVGQVAGPVAGGFVGGHFGMRAVFLGTCLMMAAGAIY
HHHHCCCCHHHHCCHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
NWAVLRNSKTR
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA