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The map label for this gene is zwf [H]

Identifier: 225686545

GI number: 225686545

Start: 736835

End: 738310

Strand: Direct

Name: zwf [H]

Synonym: BMEA_B0756

Alternate gene names: 225686545

Gene position: 736835-738310 (Clockwise)

Preceding gene: 225686543

Following gene: 225686546

Centisome position: 62.15

GC content: 60.43

Gene sequence:

>1476_bases
ATGACCAGTCAGACAATTCCGGTAGATCCCTTCGACTGCATCGTTTTTGGTGGCACCGGCGATCTTGCCGAGCGCAAGCT
TATTCCGGCGCTTTATCAGCGCCAGCGCGCAGGCCAGCTTTCCGACCCCACACGCATCATCGGCGCCTCGCGCAGCCAGA
TGACCGACGACGAATATCGCACCTTCGCCGGCAATGCGATCAAGGAACATGTGAAACCGGAAGAGGTGGATCAGGCCGAA
GTTGAAATCTTCCTCAAGCGGCTGCACTATGTGGCGGTGGACGCCAAGTCCGACGAGGGCTGGGATGCGCTGAAGACCCT
GATCGGCAAGAAGCCGGAAAAGATCCGAGCCTTTTATCTGGCCGTCAGCCCGACCCTGTTCGGCGATATCGCCACGCGGC
TCAAGGCGCATGGCCTCATCACGCGCGATACGCGCATCGTCGTGGAAAAGCCGATTGGCCGCGATCTCGATTCCGCCAAG
GCGCTCAACGACACGCTGGGCAGTGTGTTCCGCGAAGACCAGATTTTCCGCATAGACCACTATCTCGGCAAGGAAACGGT
GCAGAACCTGATGGCGCTGCGCTTTGCCAATGCGCTCTACGAGCCGCTGTGGAACTCCGCCCATATCGACCATGTGCAGA
TCACGGTGGCGGAAGCCGTGGGCCTTGAAGGCCGCGCAGGCTATTACGACAAGGCGGGCGCGCTGCGCGACATGGTGCAG
AACCACATTCTCCAGCTTCTCTGCCTTGTTGCCATGGAACCGCCATCCTCGATTGAGGCCGACGCCGTACACGACGAGAA
GGTAAAGGTTCTGCGCTCCCTGCAGCCGATCTCCACGCATAATGTCGAGGAACTGACGGTCCGCGGACAATATCGCGCGG
GCGCTTCCGCAGGCGGGCCGGTCAAGGGCTATCTGGAAGACCTTGAAAGCGACACCAGCAATACGGAAACATTCGTGGCG
CTGAAGGCGGAAATCGCCAACTGGCGCTGGGCGGGTGTGCCGTTCTATCTGCGCACCGGCAAGCGCCTTGCCACGCGTGT
TTCGGAAATCGTCATCACGTTCAAGCCCATTCCGCATTCCATCTTTGGCGAAAGCGCGGGCAAGGTGATTGCCAATCAGC
TTGTCATCCGCCTGCAACCGGACGAAGGCGTGAAGCAATGGCTGATGATCAAGGATCCCGGTCCGGGTGGAATGCGCCTG
CGCCACATGCCGCTCGACATGAGCTTTGCGGAATCCTTCGAGGATCGCAACCCGGATGCCTATGAGCGCCTCATCATGGA
TGTGGTGCGCGGCAACCAGACCCTGTTCATGCGCCGCGACGAAGTGGAAGCGGCCTGGCGCTGGATCGACCCGATCCTTC
AGGCATGGGAGTTCAACAGCCAGCCCGTGCAGGGCTATACGGCTGGCACATGGGGGCCTTCGTCCTCCATCGCGCTCATT
GAGCGCGATGGCCGCACCTGGCACGAAAGCCTCTAA

Upstream 100 bases:

>100_bases
TGGTTGAATTTAAATCGATTAGATATTAGACAAGTCCAGCCTGAAAATCGCATGCTGCAACTGGCAGACTGATTTGCGCA
AAACATAAAGAGAGCGATAG

Downstream 100 bases:

>100_bases
AGCATTTCCAGCAAAAAATGCGAAGCGGTTTTTTGCGCCGGATAATGCATAAAAACAAATGGTTAGAGCAGCTTCGGCGA
TTCTGTTAAAACAGAAACCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTSQTIPVDPFDCIVFGGTGDLAERKLIPALYQRQRAGQLSDPTRIIGASRSQMTDDEYRTFAGNAIKEHVKPEEVDQAE
VEIFLKRLHYVAVDAKSDEGWDALKTLIGKKPEKIRAFYLAVSPTLFGDIATRLKAHGLITRDTRIVVEKPIGRDLDSAK
ALNDTLGSVFREDQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
NHILQLLCLVAMEPPSSIEADAVHDEKVKVLRSLQPISTHNVEELTVRGQYRAGASAGGPVKGYLEDLESDTSNTETFVA
LKAEIANWRWAGVPFYLRTGKRLATRVSEIVITFKPIPHSIFGESAGKVIANQLVIRLQPDEGVKQWLMIKDPGPGGMRL
RHMPLDMSFAESFEDRNPDAYERLIMDVVRGNQTLFMRRDEVEAAWRWIDPILQAWEFNSQPVQGYTAGTWGPSSSIALI
ERDGRTWHESL

Sequences:

>Translated_491_residues
MTSQTIPVDPFDCIVFGGTGDLAERKLIPALYQRQRAGQLSDPTRIIGASRSQMTDDEYRTFAGNAIKEHVKPEEVDQAE
VEIFLKRLHYVAVDAKSDEGWDALKTLIGKKPEKIRAFYLAVSPTLFGDIATRLKAHGLITRDTRIVVEKPIGRDLDSAK
ALNDTLGSVFREDQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
NHILQLLCLVAMEPPSSIEADAVHDEKVKVLRSLQPISTHNVEELTVRGQYRAGASAGGPVKGYLEDLESDTSNTETFVA
LKAEIANWRWAGVPFYLRTGKRLATRVSEIVITFKPIPHSIFGESAGKVIANQLVIRLQPDEGVKQWLMIKDPGPGGMRL
RHMPLDMSFAESFEDRNPDAYERLIMDVVRGNQTLFMRRDEVEAAWRWIDPILQAWEFNSQPVQGYTAGTWGPSSSIALI
ERDGRTWHESL
>Mature_490_residues
TSQTIPVDPFDCIVFGGTGDLAERKLIPALYQRQRAGQLSDPTRIIGASRSQMTDDEYRTFAGNAIKEHVKPEEVDQAEV
EIFLKRLHYVAVDAKSDEGWDALKTLIGKKPEKIRAFYLAVSPTLFGDIATRLKAHGLITRDTRIVVEKPIGRDLDSAKA
LNDTLGSVFREDQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQN
HILQLLCLVAMEPPSSIEADAVHDEKVKVLRSLQPISTHNVEELTVRGQYRAGASAGGPVKGYLEDLESDTSNTETFVAL
KAEIANWRWAGVPFYLRTGKRLATRVSEIVITFKPIPHSIFGESAGKVIANQLVIRLQPDEGVKQWLMIKDPGPGGMRLR
HMPLDMSFAESFEDRNPDAYERLIMDVVRGNQTLFMRRDEVEAAWRWIDPILQAWEFNSQPVQGYTAGTWGPSSSIALIE
RDGRTWHESL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=478, Percent_Identity=40.5857740585774, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI109389365, Length=478, Percent_Identity=40.5857740585774, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI52145310, Length=477, Percent_Identity=30.188679245283, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=49.0644490644491, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=38.7295081967213, Blast_Score=328, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=470, Percent_Identity=38.2978723404255, Blast_Score=306, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24643350, Length=475, Percent_Identity=38.9473684210526, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24643352, Length=475, Percent_Identity=38.9473684210526, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI221513548, Length=511, Percent_Identity=32.2896281800391, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55079; Mature: 54948

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQTIPVDPFDCIVFGGTGDLAERKLIPALYQRQRAGQLSDPTRIIGASRSQMTDDEYR
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHH
TFAGNAIKEHVKPEEVDQAEVEIFLKRLHYVAVDAKSDEGWDALKTLIGKKPEKIRAFYL
HHHCHHHHHCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCHHEEEEE
AVSPTLFGDIATRLKAHGLITRDTRIVVEKPIGRDLDSAKALNDTLGSVFREDQIFRIDH
EECCHHHHHHHHHHHHCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEHHH
YLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCHHHHHHHHHHH
NHILQLLCLVAMEPPSSIEADAVHDEKVKVLRSLQPISTHNVEELTVRGQYRAGASAGGP
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
VKGYLEDLESDTSNTETFVALKAEIANWRWAGVPFYLRTGKRLATRVSEIVITFKPIPHS
HHHHHHHHCCCCCCCEEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHEEEEEECCCHH
IFGESAGKVIANQLVIRLQPDEGVKQWLMIKDPGPGGMRLRHMPLDMSFAESFEDRNPDA
HHCCHHHHHEEEEEEEEECCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHCCCCCHH
YERLIMDVVRGNQTLFMRRDEVEAAWRWIDPILQAWEFNSQPVQGYTAGTWGPSSSIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEE
ERDGRTWHESL
ECCCCHHHHCC
>Mature Secondary Structure 
TSQTIPVDPFDCIVFGGTGDLAERKLIPALYQRQRAGQLSDPTRIIGASRSQMTDDEYR
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHH
TFAGNAIKEHVKPEEVDQAEVEIFLKRLHYVAVDAKSDEGWDALKTLIGKKPEKIRAFYL
HHHCHHHHHCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCHHEEEEE
AVSPTLFGDIATRLKAHGLITRDTRIVVEKPIGRDLDSAKALNDTLGSVFREDQIFRIDH
EECCHHHHHHHHHHHHCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEHHH
YLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAEAVGLEGRAGYYDKAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCHHHHHHHHHHH
NHILQLLCLVAMEPPSSIEADAVHDEKVKVLRSLQPISTHNVEELTVRGQYRAGASAGGP
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
VKGYLEDLESDTSNTETFVALKAEIANWRWAGVPFYLRTGKRLATRVSEIVITFKPIPHS
HHHHHHHHCCCCCCCEEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHEEEEEECCCHH
IFGESAGKVIANQLVIRLQPDEGVKQWLMIKDPGPGGMRLRHMPLDMSFAESFEDRNPDA
HHCCHHHHHEEEEEEEEECCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHCCCCCHH
YERLIMDVVRGNQTLFMRRDEVEAAWRWIDPILQAWEFNSQPVQGYTAGTWGPSSSIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEE
ERDGRTWHESL
ECCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]