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The map label for this gene is gppA [H]

Identifier: 225686459

GI number: 225686459

Start: 643625

End: 645211

Strand: Direct

Name: gppA [H]

Synonym: BMEA_B0656

Alternate gene names: 225686459

Gene position: 643625-645211 (Clockwise)

Preceding gene: 225686458

Following gene: 225686460

Centisome position: 54.29

GC content: 63.26

Gene sequence:

>1587_bases
TTGAAGCGCCTTGCTTGCGTCCTCACCGGTTCGCGCGGCGCCATAAGGATCAGAACCTTGAAGAACCCCGAGGAGCGCAC
CGCCGATACGGTGCACCAGGGGGCGTCTGGCGGACAATCCGGCACTATTCAGGCCCGGAATCCGTCCGAAGGCGGCAAGC
GCAAGTTGCGCAAGAATGCCGCTGCAGAAGCCGGGAATGCGCGTAGCGCCCCCGATTCAGGACGCCCAAAAACCCAAAAT
GAAGCGGAAGCCAAGGGCTCTCCCGGCCAGCGTAAGCGTGCGCGCCGCCGCCACCGCGGCAAGGCGAGCCGTGGAACAGA
GGCGGCAAGCGCAAAGCCTCCCGCTGCCGAAGCCGCCCATGCGGAAGCACGCCCCTGCGGTAAAATCTCGAATCGCCGCC
GCCGCGCACGCAAGAAAAAGCAGCAGGCCTGCCAGCAAAACGGCCAGCCGGCACATGTTGCAGAAAGCGCAGCCAAGGCT
GCGCATCACACGCCGCGCACCGAAAACCATGCGCCTGCACCACAGGCCAAGCGCAAGGCCGGAACACCTCAGCCCGCGCG
CCATGCCCATGGTGAAGCGCCACTTTATGCAGCCCTTGATCTTGGCACCAATAATTGCCGCCTTCTGGTGGCCTCGCCCA
CACGCCCCGGCCAGTTTCGTGTCGTGGATGCCTTTTCGCGCATCGTACGGCTTGGCGAAGGCTTGAGCACCACCGGCGCT
TTGAGCGACAACGCCATGCATCGTGCGGTAGAGGCGCTGAAAATCTGCCGCGACAAGCTGGCAGGCAAGAAAATCCGCCG
CTCACGCCTGATCGCGACCGAGGCTTGCCGTTCGGCAGCCAATGGCGAGGAATTTCTGGCGCGCGTGCGTGAGGAAACCG
GGCTGGAACTGGAAATCGTGGACCGCCAGACCGAAGCGCGGCTGGCCGTATCCGGTTGCGGCACGCTCGTCACCCCCGAT
ACGGACGCCGTGGTACTGTTCGATATCGGCGGCGGCTCCTCGGAAATCGCGCTGATAGACGTATCGCAACGCCGCTCACC
GCGCCTTACCGAACATATCACGGCCTGGACTTCACTGCCGGTCGGCGTGGTGACGCTTGCCGAACGCTTTGGCGGGCGCA
ACGTGACCGAGGAAAGTTTTGGCGCGATGGTCGATCACGTTACCGAATTGCTGTCGCGCTTTGCGGAGCGCAATTGCCTC
GGCCCGCTTGCGGCAAGCCCTCGCTTTCACCTTCTCGGCACCTCCGGCACGGTAACGACGCTTGCCGGTATTCACCTCGG
CCTTGAACGCTACGACCGCCGCCGCGTGGACGGAATGTGGATGGGCGCGGATGACGTGACCCAGATGACCAACCGTCTGC
TTTCGTGGGATTTTGAGGCGCGGGTGGCCAATCCATGCATTGGCGCGGACAGGGCCGATCTGGTATTGGCAGGCTGCGCC
ATTCTCGATGCCATTCGCAAAGTGTGGCCAAGTGAAAAACTTCTCGTTGCCGATCGCGGTTTGCGCGAAGGCATTCTGAC
CGAACTGATGTCACGCGACGGCGCATGGCGCCATAACCGGGCATCCGGCGCTAGAAACAGGCACTAA

Upstream 100 bases:

>100_bases
CCGTAAAATTCTTTGGTGCTTCAAAATTTTCCGGCGACACTTCACAGCCTGCCCCTTGGTAAAACCAAAAACCACTGTTA
CATTATGCACAACGTAAAAA

Downstream 100 bases:

>100_bases
GATGAGCAAAGCAGGCGGAAACAAGGGTGGCAGCAGGACGGGCGGCCGCGGCGGCGCGGGCAGCAGCAACCTGCATGTGC
GGGTGAAGAAAAAGGCCGGC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKRLACVLTGSRGAIRIRTLKNPEERTADTVHQGASGGQSGTIQARNPSEGGKRKLRKNAAAEAGNARSAPDSGRPKTQN
EAEAKGSPGQRKRARRRHRGKASRGTEAASAKPPAAEAAHAEARPCGKISNRRRRARKKKQQACQQNGQPAHVAESAAKA
AHHTPRTENHAPAPQAKRKAGTPQPARHAHGEAPLYAALDLGTNNCRLLVASPTRPGQFRVVDAFSRIVRLGEGLSTTGA
LSDNAMHRAVEALKICRDKLAGKKIRRSRLIATEACRSAANGEEFLARVREETGLELEIVDRQTEARLAVSGCGTLVTPD
TDAVVLFDIGGGSSEIALIDVSQRRSPRLTEHITAWTSLPVGVVTLAERFGGRNVTEESFGAMVDHVTELLSRFAERNCL
GPLAASPRFHLLGTSGTVTTLAGIHLGLERYDRRRVDGMWMGADDVTQMTNRLLSWDFEARVANPCIGADRADLVLAGCA
ILDAIRKVWPSEKLLVADRGLREGILTELMSRDGAWRHNRASGARNRH

Sequences:

>Translated_528_residues
MKRLACVLTGSRGAIRIRTLKNPEERTADTVHQGASGGQSGTIQARNPSEGGKRKLRKNAAAEAGNARSAPDSGRPKTQN
EAEAKGSPGQRKRARRRHRGKASRGTEAASAKPPAAEAAHAEARPCGKISNRRRRARKKKQQACQQNGQPAHVAESAAKA
AHHTPRTENHAPAPQAKRKAGTPQPARHAHGEAPLYAALDLGTNNCRLLVASPTRPGQFRVVDAFSRIVRLGEGLSTTGA
LSDNAMHRAVEALKICRDKLAGKKIRRSRLIATEACRSAANGEEFLARVREETGLELEIVDRQTEARLAVSGCGTLVTPD
TDAVVLFDIGGGSSEIALIDVSQRRSPRLTEHITAWTSLPVGVVTLAERFGGRNVTEESFGAMVDHVTELLSRFAERNCL
GPLAASPRFHLLGTSGTVTTLAGIHLGLERYDRRRVDGMWMGADDVTQMTNRLLSWDFEARVANPCIGADRADLVLAGCA
ILDAIRKVWPSEKLLVADRGLREGILTELMSRDGAWRHNRASGARNRH
>Mature_528_residues
MKRLACVLTGSRGAIRIRTLKNPEERTADTVHQGASGGQSGTIQARNPSEGGKRKLRKNAAAEAGNARSAPDSGRPKTQN
EAEAKGSPGQRKRARRRHRGKASRGTEAASAKPPAAEAAHAEARPCGKISNRRRRARKKKQQACQQNGQPAHVAESAAKA
AHHTPRTENHAPAPQAKRKAGTPQPARHAHGEAPLYAALDLGTNNCRLLVASPTRPGQFRVVDAFSRIVRLGEGLSTTGA
LSDNAMHRAVEALKICRDKLAGKKIRRSRLIATEACRSAANGEEFLARVREETGLELEIVDRQTEARLAVSGCGTLVTPD
TDAVVLFDIGGGSSEIALIDVSQRRSPRLTEHITAWTSLPVGVVTLAERFGGRNVTEESFGAMVDHVTELLSRFAERNCL
GPLAASPRFHLLGTSGTVTTLAGIHLGLERYDRRRVDGMWMGADDVTQMTNRLLSWDFEARVANPCIGADRADLVLAGCA
ILDAIRKVWPSEKLLVADRGLREGILTELMSRDGAWRHNRASGARNRH

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=323, Percent_Identity=29.1021671826625, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788848, Length=329, Percent_Identity=25.8358662613982, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 57013; Mature: 57013

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLACVLTGSRGAIRIRTLKNPEERTADTVHQGASGGQSGTIQARNPSEGGKRKLRKNA
CCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHH
AAEAGNARSAPDSGRPKTQNEAEAKGSPGQRKRARRRHRGKASRGTEAASAKPPAAEAAH
HHCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHC
AEARPCGKISNRRRRARKKKQQACQQNGQPAHVAESAAKAAHHTPRTENHAPAPQAKRKA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
GTPQPARHAHGEAPLYAALDLGTNNCRLLVASPTRPGQFRVVDAFSRIVRLGEGLSTTGA
CCCCCHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCC
LSDNAMHRAVEALKICRDKLAGKKIRRSRLIATEACRSAANGEEFLARVREETGLELEIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
DRQTEARLAVSGCGTLVTPDTDAVVLFDIGGGSSEIALIDVSQRRSPRLTEHITAWTSLP
CCCCHHEEEEECCCEEECCCCCEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCC
VGVVTLAERFGGRNVTEESFGAMVDHVTELLSRFAERNCLGPLAASPRFHLLGTSGTVTT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHH
LAGIHLGLERYDRRRVDGMWMGADDVTQMTNRLLSWDFEARVANPCIGADRADLVLAGCA
HHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHH
ILDAIRKVWPSEKLLVADRGLREGILTELMSRDGAWRHNRASGARNRH
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRLACVLTGSRGAIRIRTLKNPEERTADTVHQGASGGQSGTIQARNPSEGGKRKLRKNA
CCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHH
AAEAGNARSAPDSGRPKTQNEAEAKGSPGQRKRARRRHRGKASRGTEAASAKPPAAEAAH
HHCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHC
AEARPCGKISNRRRRARKKKQQACQQNGQPAHVAESAAKAAHHTPRTENHAPAPQAKRKA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
GTPQPARHAHGEAPLYAALDLGTNNCRLLVASPTRPGQFRVVDAFSRIVRLGEGLSTTGA
CCCCCHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCC
LSDNAMHRAVEALKICRDKLAGKKIRRSRLIATEACRSAANGEEFLARVREETGLELEIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
DRQTEARLAVSGCGTLVTPDTDAVVLFDIGGGSSEIALIDVSQRRSPRLTEHITAWTSLP
CCCCHHEEEEECCCEEECCCCCEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCC
VGVVTLAERFGGRNVTEESFGAMVDHVTELLSRFAERNCLGPLAASPRFHLLGTSGTVTT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHH
LAGIHLGLERYDRRRVDGMWMGADDVTQMTNRLLSWDFEARVANPCIGADRADLVLAGCA
HHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHH
ILDAIRKVWPSEKLLVADRGLREGILTELMSRDGAWRHNRASGARNRH
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA