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The map label for this gene is parE [H]

Identifier: 225686377

GI number: 225686377

Start: 557275

End: 559374

Strand: Direct

Name: parE [H]

Synonym: BMEA_B0566

Alternate gene names: 225686377

Gene position: 557275-559374 (Clockwise)

Preceding gene: 225686375

Following gene: 225686383

Centisome position: 47.01

GC content: 60.1

Gene sequence:

>2100_bases
ATGGACGACAGCAACGATCTCTTTTCAAGAGTAGTGAACAACGCCAGGGAACGGCAGATGGAGCGCCAAACGGGTGAAAA
CACCGTGGCGCAACCGGTCGTGCAGCCGGCACCATCCGCGCCCAAGCCTGTGCCTGCCGCTGCCAAGGCGCCGCCTGCTG
CATCAGGCGGCGACGATTACAACGCCTCCTCCATCCGCGTTCTTGAAGGCCTGGAGCCGGTGCGCCTGCGCCCCGGCATG
TATATCGGCGGCACGGACGAAAAAGCACTGCACCACCTGTTTGCCGAAGTCATCGACAATTCGATGGACGAAGCGGTTGC
TGGCCACGCGAATTTCATCGAAGTCACCGTGGATAAGGAAGGTTTTGTCACCGTTTCCGATAACGGGCGCGGCATTCCCG
TGGACGAGCATCCGCAGGTGCCGGGCAAATCCACGCTCGAAGTCATCATGACCAAGCTTCATGCGGGCGGAAAATTCGAC
GGCAAAGCCTATGAAACCTCCGGTGGCCTGCATGGCGTTGGCGTGTCGGTGGTCAATGCGCTTTCGGATGTGCTTGAGGT
GGAAGTGGCGCGCAATCGCCGGCTTTACCGCCAGTGTTTTTCACGCGGCATTCCGCAGGGAGGCCTCGAAGAACTGGGCG
AGGTTCATAATCGCCGCGGAACGCGGGTGCGCTTTCATCCCGACCCGGAAATTTTTGGCAAGAATGCCCATTTCGACCCG
CACCGGCTTTATCGGATGGCGCGCTCGAAGGCCTATCTGTTCGGTGGTGTGGAAATTCGCTGGAACTGCGATCCCTCGCT
GCTCGACCCCAAGAAGGAAACGCCGGAAAAGGCCGTTTTCCACTTTCCCGGCGGGTTGAAGGATTATCTGGAGGCCTCGC
TCGGCAAGGAACATCAGGTTACGCGCGAGGTTTTTGCAGGCCGCACGGAGAAGCAGGGCGGGCATGGCGCGGTTGAATGG
GCCGTTGCATGGTTCGGCGGCGATGGTTTTGTCCATTCCTATTGCAATACCATCCCGACCGGCGATGGCGGCACGCATGA
AGCGGGCCTGCGCATCGCGCTCACGCGCGGCCTCAAGGCCTATGCGGAACTGACCAATAACAAGCGCGCTTCTATCATCA
CCACAGACGATGTGATGGTGTCGGCGGCTGGTATGCTGTCTGTTTTCATCCGCGAGCCGGAATTCGTCGGCCAGACCAAA
GACAAGCTTGCGACCGTGGAAGCACAACGCCTCGTGGAAAACGCAATCCGCGATCCGTTTGATCACTGGCTTGCCGCTTC
CCCGCAGGAGGCTTCGCGCCTTCTGGAATGGGTGATCGACCGTGCCGATGAACGCCTGCGCCGCCGTCAGGAAAAAGAGA
CCGTACGCAAGAGCGCGACGCGCAAACTGCGCCTGCCCGGCAAACTTGCCGATTGCACGCAGAATGCGGCAGCAGGTGCG
GAATTGTTCATCGTGGAGGGCGATTCGGCTGGCGGTTCCGCCAAGCAGGCGCGCAACCGCGCCAATCAGGCCATTCTGCC
GCTACGGGGCAAGATTCTGAATGTCGCCAGTGCCGGACGCGAAAAACTGACTGCCAACCAGCAGATTGCCGATCTCGTTC
AGGCGCTTGGTTGCGGCACGCGGAAGAATTACCGCGAGGATGACCTGCGTTATGACCGCGTGATCGTGATGACCGACGCG
GACGTGGACGGTGCGCATATCGCCTCGCTTCTCATTACGTTCTTCTATCAGGAAATGCCGGAGCTCATCCGCAATGGCCA
TCTCTATCTGGCCGTACCGCCGCTCTATCGCCTGAGCCAGGGCGGCAAGACCGCCTATGCTCGCGACGACGCGCATAAGG
AAGAACTGCTGCGCACCGTGTTCACCGGACGCGGCAAGATCGAAATCGGACGTTTCAAGGGGCTTGGCGAGATGCGCGCC
GACCAGCTCAAGGAAACGACGATGGACCCGGCCAAACGTACGCTGTTGCGCGTTCAGGTGGATGAGGAATATGGCGATGA
GACGCGCAATACGGTGGATGACCTGATGGGGACAAAGCCGGAAGCCCGCTTCCGCTTTATTCAGGACCGCGCGGCCTTCG
TGGAGGAGCTGGATATCTGA

Upstream 100 bases:

>100_bases
CATCATCCATGTGATTCGCAGGCACTTTATTTTGGAGCGATACCGGGCTTTGCGCCCGGCACTTCCTTGAAAAATTCTGA
CAGAAAGCTTTTCAGGCACG

Downstream 100 bases:

>100_bases
TAAAGCTATTCCCTCACTTTGATACCCAGTCTCGTCTCGATTTCCTCGGTCGATTCCCGCACAAAAAATGTGAGATCCGC
GCTTAGCGTTACAAGGCGCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MDDSNDLFSRVVNNARERQMERQTGENTVAQPVVQPAPSAPKPVPAAAKAPPAASGGDDYNASSIRVLEGLEPVRLRPGM
YIGGTDEKALHHLFAEVIDNSMDEAVAGHANFIEVTVDKEGFVTVSDNGRGIPVDEHPQVPGKSTLEVIMTKLHAGGKFD
GKAYETSGGLHGVGVSVVNALSDVLEVEVARNRRLYRQCFSRGIPQGGLEELGEVHNRRGTRVRFHPDPEIFGKNAHFDP
HRLYRMARSKAYLFGGVEIRWNCDPSLLDPKKETPEKAVFHFPGGLKDYLEASLGKEHQVTREVFAGRTEKQGGHGAVEW
AVAWFGGDGFVHSYCNTIPTGDGGTHEAGLRIALTRGLKAYAELTNNKRASIITTDDVMVSAAGMLSVFIREPEFVGQTK
DKLATVEAQRLVENAIRDPFDHWLAASPQEASRLLEWVIDRADERLRRRQEKETVRKSATRKLRLPGKLADCTQNAAAGA
ELFIVEGDSAGGSAKQARNRANQAILPLRGKILNVASAGREKLTANQQIADLVQALGCGTRKNYREDDLRYDRVIVMTDA
DVDGAHIASLLITFFYQEMPELIRNGHLYLAVPPLYRLSQGGKTAYARDDAHKEELLRTVFTGRGKIEIGRFKGLGEMRA
DQLKETTMDPAKRTLLRVQVDEEYGDETRNTVDDLMGTKPEARFRFIQDRAAFVEELDI

Sequences:

>Translated_699_residues
MDDSNDLFSRVVNNARERQMERQTGENTVAQPVVQPAPSAPKPVPAAAKAPPAASGGDDYNASSIRVLEGLEPVRLRPGM
YIGGTDEKALHHLFAEVIDNSMDEAVAGHANFIEVTVDKEGFVTVSDNGRGIPVDEHPQVPGKSTLEVIMTKLHAGGKFD
GKAYETSGGLHGVGVSVVNALSDVLEVEVARNRRLYRQCFSRGIPQGGLEELGEVHNRRGTRVRFHPDPEIFGKNAHFDP
HRLYRMARSKAYLFGGVEIRWNCDPSLLDPKKETPEKAVFHFPGGLKDYLEASLGKEHQVTREVFAGRTEKQGGHGAVEW
AVAWFGGDGFVHSYCNTIPTGDGGTHEAGLRIALTRGLKAYAELTNNKRASIITTDDVMVSAAGMLSVFIREPEFVGQTK
DKLATVEAQRLVENAIRDPFDHWLAASPQEASRLLEWVIDRADERLRRRQEKETVRKSATRKLRLPGKLADCTQNAAAGA
ELFIVEGDSAGGSAKQARNRANQAILPLRGKILNVASAGREKLTANQQIADLVQALGCGTRKNYREDDLRYDRVIVMTDA
DVDGAHIASLLITFFYQEMPELIRNGHLYLAVPPLYRLSQGGKTAYARDDAHKEELLRTVFTGRGKIEIGRFKGLGEMRA
DQLKETTMDPAKRTLLRVQVDEEYGDETRNTVDDLMGTKPEARFRFIQDRAAFVEELDI
>Mature_699_residues
MDDSNDLFSRVVNNARERQMERQTGENTVAQPVVQPAPSAPKPVPAAAKAPPAASGGDDYNASSIRVLEGLEPVRLRPGM
YIGGTDEKALHHLFAEVIDNSMDEAVAGHANFIEVTVDKEGFVTVSDNGRGIPVDEHPQVPGKSTLEVIMTKLHAGGKFD
GKAYETSGGLHGVGVSVVNALSDVLEVEVARNRRLYRQCFSRGIPQGGLEELGEVHNRRGTRVRFHPDPEIFGKNAHFDP
HRLYRMARSKAYLFGGVEIRWNCDPSLLDPKKETPEKAVFHFPGGLKDYLEASLGKEHQVTREVFAGRTEKQGGHGAVEW
AVAWFGGDGFVHSYCNTIPTGDGGTHEAGLRIALTRGLKAYAELTNNKRASIITTDDVMVSAAGMLSVFIREPEFVGQTK
DKLATVEAQRLVENAIRDPFDHWLAASPQEASRLLEWVIDRADERLRRRQEKETVRKSATRKLRLPGKLADCTQNAAAGA
ELFIVEGDSAGGSAKQARNRANQAILPLRGKILNVASAGREKLTANQQIADLVQALGCGTRKNYREDDLRYDRVIVMTDA
DVDGAHIASLLITFFYQEMPELIRNGHLYLAVPPLYRLSQGGKTAYARDDAHKEELLRTVFTGRGKIEIGRFKGLGEMRA
DQLKETTMDPAKRTLLRVQVDEEYGDETRNTVDDLMGTKPEARFRFIQDRAAFVEELDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=628, Percent_Identity=26.5923566878981, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI19913408, Length=627, Percent_Identity=23.7639553429027, Blast_Score=135, Evalue=2e-31,
Organism=Escherichia coli, GI48994957, Length=561, Percent_Identity=45.9893048128342, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789408, Length=641, Percent_Identity=41.3416536661466, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17535065, Length=630, Percent_Identity=23.3333333333333, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=560, Percent_Identity=24.1071428571429, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324241, Length=673, Percent_Identity=24.2199108469539, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136538, Length=642, Percent_Identity=25.7009345794392, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 77209; Mature: 77209

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDSNDLFSRVVNNARERQMERQTGENTVAQPVVQPAPSAPKPVPAAAKAPPAASGGDDY
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NASSIRVLEGLEPVRLRPGMYIGGTDEKALHHLFAEVIDNSMDEAVAGHANFIEVTVDKE
CCCCEEHCCCCCCCEECCCEEECCCCHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCC
GFVTVSDNGRGIPVDEHPQVPGKSTLEVIMTKLHAGGKFDGKAYETSGGLHGVGVSVVNA
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHH
LSDVLEVEVARNRRLYRQCFSRGIPQGGLEELGEVHNRRGTRVRFHPDPEIFGKNAHFDP
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCH
HRLYRMARSKAYLFGGVEIRWNCDPSLLDPKKETPEKAVFHFPGGLKDYLEASLGKEHQV
HHHHHHHHCCEEEEECEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCHHHH
TREVFAGRTEKQGGHGAVEWAVAWFGGDGFVHSYCNTIPTGDGGTHEAGLRIALTRGLKA
HHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHH
YAELTNNKRASIITTDDVMVSAAGMLSVFIREPEFVGQTKDKLATVEAQRLVENAIRDPF
HHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCH
DHWLAASPQEASRLLEWVIDRADERLRRRQEKETVRKSATRKLRLPGKLADCTQNAAAGA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCC
ELFIVEGDSAGGSAKQARNRANQAILPLRGKILNVASAGREKLTANQQIADLVQALGCGT
EEEEEECCCCCCHHHHHHHHHCCCEECCCCHHHHHHHCCHHHHHCHHHHHHHHHHHCCCC
RKNYREDDLRYDRVIVMTDADVDGAHIASLLITFFYQEMPELIRNGHLYLAVPPLYRLSQ
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCC
GGKTAYARDDAHKEELLRTVFTGRGKIEIGRFKGLGEMRADQLKETTMDPAKRTLLRVQV
CCCEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHEEEEEEE
DEEYGDETRNTVDDLMGTKPEARFRFIQDRAAFVEELDI
CHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDSNDLFSRVVNNARERQMERQTGENTVAQPVVQPAPSAPKPVPAAAKAPPAASGGDDY
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NASSIRVLEGLEPVRLRPGMYIGGTDEKALHHLFAEVIDNSMDEAVAGHANFIEVTVDKE
CCCCEEHCCCCCCCEECCCEEECCCCHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCC
GFVTVSDNGRGIPVDEHPQVPGKSTLEVIMTKLHAGGKFDGKAYETSGGLHGVGVSVVNA
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHH
LSDVLEVEVARNRRLYRQCFSRGIPQGGLEELGEVHNRRGTRVRFHPDPEIFGKNAHFDP
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCH
HRLYRMARSKAYLFGGVEIRWNCDPSLLDPKKETPEKAVFHFPGGLKDYLEASLGKEHQV
HHHHHHHHCCEEEEECEEEEECCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCHHHH
TREVFAGRTEKQGGHGAVEWAVAWFGGDGFVHSYCNTIPTGDGGTHEAGLRIALTRGLKA
HHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHH
YAELTNNKRASIITTDDVMVSAAGMLSVFIREPEFVGQTKDKLATVEAQRLVENAIRDPF
HHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCH
DHWLAASPQEASRLLEWVIDRADERLRRRQEKETVRKSATRKLRLPGKLADCTQNAAAGA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCC
ELFIVEGDSAGGSAKQARNRANQAILPLRGKILNVASAGREKLTANQQIADLVQALGCGT
EEEEEECCCCCCHHHHHHHHHCCCEECCCCHHHHHHHCCHHHHHCHHHHHHHHHHHCCCC
RKNYREDDLRYDRVIVMTDADVDGAHIASLLITFFYQEMPELIRNGHLYLAVPPLYRLSQ
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCC
GGKTAYARDDAHKEELLRTVFTGRGKIEIGRFKGLGEMRADQLKETTMDPAKRTLLRVQV
CCCEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHEEEEEEE
DEEYGDETRNTVDDLMGTKPEARFRFIQDRAAFVEELDI
CHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9797224 [H]