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The map label for this gene is emrA [H]

Identifier: 225686274

GI number: 225686274

Start: 438946

End: 439995

Strand: Direct

Name: emrA [H]

Synonym: BMEA_B0450

Alternate gene names: 225686274

Gene position: 438946-439995 (Clockwise)

Preceding gene: 225686273

Following gene: 225686277

Centisome position: 37.03

GC content: 56.76

Gene sequence:

>1050_bases
ATGTCCGTATCCAAGAAATATATCCGCGGTGGCTTTGCAATCCTGATTGGCCTTTTGGGTGTTTTCATCATCTTGTGGGC
TTGGCAGTTGCCGCCGTTCAAACACAGTGTCGAAACGACCGACAATGCCTATGTGCGCGGGCAGGTGACGGTTATGAGCC
CGCAGGTTTCAGGCTATATAACCAAAGTCAACGTGACCGATTACGAGCAGGTCAAAAAAGGCGATCTGCTTTTTGAGATC
GATAGCCGCAGCTATCAGCAAAAGCTGGATCAGGCGCTTGCCGCGTTGGACAGCAAGAAGGCGGCACTTGCCAATTCGGA
GCAGAGCCAGCGTTCCGCCGAGGCAACGATAAAGGCGCGAGAAGCCCAGATATCGGGGGCAAAGGCGGCGCTTGAAGTGG
CAAAAGCCAATACGGTTCGTGTCGATGCCCTGTTGCCGCGCGGTGTGACGACACAAAGCTCTGCCGATACGGCACATGGC
AATATGCTTCAGGCGCAGGCTGCGGTCGATCAGGCCGAAGCGGCACTGGCCGTTGCGAAGGAGGATTTGCGCACCATCAT
CGTCGCGCGTGAAGGGCTCAATGCCGACCTGCACAATGCAGAGGCTGCGGTGGCGCTGGCCAGGATCGACCTCCAGAACA
CGAAGATCCTTGCTCCAAGGGATGGCAAGCTTGGCGAAGTCGGTGTGCGGCTTGGCCAATATGTCACCGCAGGCACACAG
CTTGTTTCGCTCGTGCCGGCCGTCAAATGGATCATGGCCAATTTCAAGGAAACGCAACTTTATGGCATGAAGGTCGGCCA
GCCGGTTACGCTGACGGTCGATGCGCTCCGCCATGCGGAACTGAAGGGGCATATCGAGGCTTTTTCACCGGCAACCGGCT
CTGAATTCAGCGTCATCAAATCCGACAATGCGACCGGCAATTTCACCAAGATCACGCAGCGCTTGTCTGTCCGCATTTCC
ATCGACGAAGGGCAGCCGGATGCTGAATTGCTGGCGCCCGGCATGTCGGTGGTGGTGCGTGTCGATACTGCCTCCACGCC
GGATAAATAA

Upstream 100 bases:

>100_bases
GCTGTGCTGTCAGGTGACCTATCGCGTTTATGAAGCTTTCCGGGCAAGGCGCTCTGCGCTTGCCGTCATGAGTTGAACTG
TTCGATGAGTGTTTGAAGAA

Downstream 100 bases:

>100_bases
AAGCGGCCGACTTTCAAGTGCGTCGGTCGCAAGTCATCTTGTTATCGACGCCATTTCATCGAGAAACTGCTTTATCTCGG
CATAAGTCTCGAACCAGGCA

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSVSKKYIRGGFAILIGLLGVFIILWAWQLPPFKHSVETTDNAYVRGQVTVMSPQVSGYITKVNVTDYEQVKKGDLLFEI
DSRSYQQKLDQALAALDSKKAALANSEQSQRSAEATIKAREAQISGAKAALEVAKANTVRVDALLPRGVTTQSSADTAHG
NMLQAQAAVDQAEAALAVAKEDLRTIIVAREGLNADLHNAEAAVALARIDLQNTKILAPRDGKLGEVGVRLGQYVTAGTQ
LVSLVPAVKWIMANFKETQLYGMKVGQPVTLTVDALRHAELKGHIEAFSPATGSEFSVIKSDNATGNFTKITQRLSVRIS
IDEGQPDAELLAPGMSVVVRVDTASTPDK

Sequences:

>Translated_349_residues
MSVSKKYIRGGFAILIGLLGVFIILWAWQLPPFKHSVETTDNAYVRGQVTVMSPQVSGYITKVNVTDYEQVKKGDLLFEI
DSRSYQQKLDQALAALDSKKAALANSEQSQRSAEATIKAREAQISGAKAALEVAKANTVRVDALLPRGVTTQSSADTAHG
NMLQAQAAVDQAEAALAVAKEDLRTIIVAREGLNADLHNAEAAVALARIDLQNTKILAPRDGKLGEVGVRLGQYVTAGTQ
LVSLVPAVKWIMANFKETQLYGMKVGQPVTLTVDALRHAELKGHIEAFSPATGSEFSVIKSDNATGNFTKITQRLSVRIS
IDEGQPDAELLAPGMSVVVRVDTASTPDK
>Mature_348_residues
SVSKKYIRGGFAILIGLLGVFIILWAWQLPPFKHSVETTDNAYVRGQVTVMSPQVSGYITKVNVTDYEQVKKGDLLFEID
SRSYQQKLDQALAALDSKKAALANSEQSQRSAEATIKAREAQISGAKAALEVAKANTVRVDALLPRGVTTQSSADTAHGN
MLQAQAAVDQAEAALAVAKEDLRTIIVAREGLNADLHNAEAAVALARIDLQNTKILAPRDGKLGEVGVRLGQYVTAGTQL
VSLVPAVKWIMANFKETQLYGMKVGQPVTLTVDALRHAELKGHIEAFSPATGSEFSVIKSDNATGNFTKITQRLSVRISI
DEGQPDAELLAPGMSVVVRVDTASTPDK

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=342, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788711, Length=334, Percent_Identity=30.2395209580838, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790519, Length=340, Percent_Identity=27.0588235294118, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1790012, Length=290, Percent_Identity=24.4827586206897, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37421; Mature: 37290

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSKKYIRGGFAILIGLLGVFIILWAWQLPPFKHSVETTDNAYVRGQVTVMSPQVSGYI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCCEE
TKVNVTDYEQVKKGDLLFEIDSRSYQQKLDQALAALDSKKAALANSEQSQRSAEATIKAR
EEEECCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHH
EAQISGAKAALEVAKANTVRVDALLPRGVTTQSSADTAHGNMLQAQAAVDQAEAALAVAK
HHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
EDLRTIIVAREGLNADLHNAEAAVALARIDLQNTKILAPRDGKLGEVGVRLGQYVTAGTQ
HHHHEEEEEECCCCCCCCCHHHEEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHH
LVSLVPAVKWIMANFKETQLYGMKVGQPVTLTVDALRHAELKGHIEAFSPATGSEFSVIK
HHHHHHHHHHHHHCCCHHEEEEEECCCCEEEEHHHHHHHHHHCCCEECCCCCCCCEEEEE
SDNATGNFTKITQRLSVRISIDEGQPDAELLAPGMSVVVRVDTASTPDK
CCCCCCCHHHEEEEEEEEEEECCCCCCHHHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
SVSKKYIRGGFAILIGLLGVFIILWAWQLPPFKHSVETTDNAYVRGQVTVMSPQVSGYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCCEE
TKVNVTDYEQVKKGDLLFEIDSRSYQQKLDQALAALDSKKAALANSEQSQRSAEATIKAR
EEEECCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHH
EAQISGAKAALEVAKANTVRVDALLPRGVTTQSSADTAHGNMLQAQAAVDQAEAALAVAK
HHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
EDLRTIIVAREGLNADLHNAEAAVALARIDLQNTKILAPRDGKLGEVGVRLGQYVTAGTQ
HHHHEEEEEECCCCCCCCCHHHEEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHH
LVSLVPAVKWIMANFKETQLYGMKVGQPVTLTVDALRHAELKGHIEAFSPATGSEFSVIK
HHHHHHHHHHHHHCCCHHEEEEEECCCCEEEEHHHHHHHHHHCCCEECCCCCCCCEEEEE
SDNATGNFTKITQRLSVRISIDEGQPDAELLAPGMSVVVRVDTASTPDK
CCCCCCCHHHEEEEEEEEEEECCCCCCHHHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]