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The map label for this gene is msrB

Identifier: 225686252

GI number: 225686252

Start: 415499

End: 415939

Strand: Direct

Name: msrB

Synonym: BMEA_B0425

Alternate gene names: 225686252

Gene position: 415499-415939 (Clockwise)

Preceding gene: 225686251

Following gene: 225686256

Centisome position: 35.05

GC content: 56.24

Gene sequence:

>441_bases
ATGAAATATCAAAAAAGCGCCGAAGCGATTGCGAAGCTCTCCGCCGAGCAATATCGGGTGACACAGGAAAACGGCACGGA
GCGCCCCGGCACAGGCGAGTATCTCTACAACAAGGAACCCGGCATCTACGTGGATATTGTCTCTGGCGAACCGCTTTTCG
CTTCGTCGGACAAATATGAATCGCATTGTGGCTGGCCAAGCTTTACCAAGCCGATCGAGCGAGCCAACGTTACGGAACTG
ACGGATATGTCCCACGGCATGGTGCGTACCGAAGTCCGCTCGGCCCATGGCGACAGCCATCTGGGCCATGTTTTCCCGGA
CGGTCCGGTGGATCGTGGCGGCTTGCGCTATTGCATCAACTCCGCTTCCCTCCGTTTTGTGCCGAAAGACCGGATGGAAG
CGGAAGGTTATGGCGATTATCTCGATCAGGTCGAAGGCTGA

Upstream 100 bases:

>100_bases
GAGGGAATGCATATAATATGGAGACCACAGGTGCGGTCTTGCGAAGCGCTTGCCTCTGTTCCCATCTATAAGTTTATTGA
AATGACAGGGAGATGCCCGG

Downstream 100 bases:

>100_bases
TTATAGCCCGCGCGCGATGACGAGCCGCTGCACGTCGCTTGTGCCTTCATAAATCTGGCAGACGCGGACCTCGCGATAGA
TGCGCTCGACCGATAATCGG

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKYQKSAEAIAKLSAEQYRVTQENGTERPGTGEYLYNKEPGIYVDIVSGEPLFASSDKYESHCGWPSFTKPIERANVTEL
TDMSHGMVRTEVRSAHGDSHLGHVFPDGPVDRGGLRYCINSASLRFVPKDRMEAEGYGDYLDQVEG

Sequences:

>Translated_146_residues
MKYQKSAEAIAKLSAEQYRVTQENGTERPGTGEYLYNKEPGIYVDIVSGEPLFASSDKYESHCGWPSFTKPIERANVTEL
TDMSHGMVRTEVRSAHGDSHLGHVFPDGPVDRGGLRYCINSASLRFVPKDRMEAEGYGDYLDQVEG
>Mature_146_residues
MKYQKSAEAIAKLSAEQYRVTQENGTERPGTGEYLYNKEPGIYVDIVSGEPLFASSDKYESHCGWPSFTKPIERANVTEL
TDMSHGMVRTEVRSAHGDSHLGHVFPDGPVDRGGLRYCINSASLRFVPKDRMEAEGYGDYLDQVEG

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=119, Percent_Identity=49.5798319327731, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI301336162, Length=119, Percent_Identity=49.5798319327731, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI73089054, Length=119, Percent_Identity=49.5798319327731, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI37620216, Length=119, Percent_Identity=49.5798319327731, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI117606353, Length=130, Percent_Identity=44.6153846153846, Blast_Score=106, Evalue=9e-24,
Organism=Escherichia coli, GI1788077, Length=128, Percent_Identity=51.5625, Blast_Score=133, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17553450, Length=127, Percent_Identity=47.244094488189, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115532676, Length=127, Percent_Identity=47.244094488189, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=122, Percent_Identity=36.0655737704918, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221378664, Length=121, Percent_Identity=50.4132231404959, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45553335, Length=120, Percent_Identity=50, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356369, Length=120, Percent_Identity=50, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=128, Percent_Identity=47.65625, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645799, Length=120, Percent_Identity=50, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645801, Length=131, Percent_Identity=45.8015267175573, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24645804, Length=131, Percent_Identity=45.8015267175573, Blast_Score=106, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_BRUME (P65447)

Other databases:

- EMBL:   AE008918
- PIR:   AB3612
- RefSeq:   NP_541797.1
- ProteinModelPortal:   P65447
- SMR:   P65447
- GeneID:   1198591
- GenomeReviews:   AE008918_GR
- KEGG:   bme:BMEII0819
- HOGENOM:   HBG715255
- OMA:   EPLFASA
- PhylomeDB:   P65447
- ProtClustDB:   PRK00222
- BioCyc:   BMEL224914:BMEII0819-MONOMER
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 16281; Mature: 16281

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: ACT_SITE 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQKSAEAIAKLSAEQYRVTQENGTERPGTGEYLYNKEPGIYVDIVSGEPLFASSDKYE
CCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCC
SHCGWPSFTKPIERANVTELTDMSHGMVRTEVRSAHGDSHLGHVFPDGPVDRGGLRYCIN
CCCCCCCCCCCHHHCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
SASLRFVPKDRMEAEGYGDYLDQVEG
CCEEEECCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MKYQKSAEAIAKLSAEQYRVTQENGTERPGTGEYLYNKEPGIYVDIVSGEPLFASSDKYE
CCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCC
SHCGWPSFTKPIERANVTELTDMSHGMVRTEVRSAHGDSHLGHVFPDGPVDRGGLRYCIN
CCCCCCCCCCCHHHCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
SASLRFVPKDRMEAEGYGDYLDQVEG
CCEEEECCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688