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The map label for this gene is mutM

Identifier: 225853608

GI number: 225853608

Start: 2123112

End: 2123993

Strand: Direct

Name: mutM

Synonym: BMEA_A2244

Alternate gene names: 225853608

Gene position: 2123112-2123993 (Clockwise)

Preceding gene: 225853606

Following gene: 225853609

Centisome position: 99.88

GC content: 60.77

Gene sequence:

>882_bases
ATGCCGGAACTGCCAGAGGTCGAAACGGTTCGCCGTGGTCTGCAACCCTTCATGGAAGGGGCAACCGTTGTGCGGGTGGA
GCAGAATCGGCCCGACCTGCGCTTTGCCTTTCCTGAAAATTTTGCCGAACGCCTTTCCGGCAGGCGCATCGAGGCGCTTG
GCCGCCGTGCGAAATATCTGACCGTCCATCTCGATGACGGGCTTTCGATCATCAGCCATCTCGGCATGTCCGGCTCGTTT
CGCATTGAGGCGGAGGATGCGCAAGGTTTGCCGGGCGGGTTTCATCACGAGCGCTCCAAGAACAGCCTGCATGACCATGT
GGTCTTTCACCTCATGCGCCCGGACGGTGCGTCTGCACGCATTATTTATAATGATCCGCGCCGCTTCGGTTTCATGCTCT
TTGCCGAAAAGGGCGCGCTGGAGGAACATCCGCTCCTGAAAGACCTTGGTGTGGAGCCGACCGGCAATCTCCTGTCGGGC
GAGGTTCTGGCCGCGCTTTTCAAGGGACGCCGCACGCCCCTGAAGGCCGCCTTGCTCGACCAGAGGCTTATCGCGGGGCT
TGGCAATATCTATGTCTGCGAGGCGCTCTGGCGCCCAGGGCTTTCGCCGATGCGCGCGGCAGGCTCGGTTGCAGGCGAAA
TGGACGTGATGGAGCGGCTTGCCGGGGCCATTCGCTCCGTCATTGCGCAGGCGATTGCAGCCGGAGGCTCCAGCCTTAAG
GATTACATTCAGGCCGACGGTGCGCTCGGCTATTTCCAGCACTCTTTTTCCGTCTATGGCCGCGAGGGTAAGCCATGCAG
AAACCCCGCCTGCGGCGGCACTGTCGAGCGCGTGGTGCAATCTGGTCGTTCGACTTTTTTCTGTGCCTCTTGCCAGACAT
GA

Upstream 100 bases:

>100_bases
TGGCATTTGGGTTAACGGATGGCAAACGGACGTGGCGCGGTTTTCACCTGTGTTGAAAATGCCTATATGTGCCTCACCCT
TTTGAACGGAAAGAAACCCT

Downstream 100 bases:

>100_bases
GCCCTTGCCAAAGTCTGGATGCCGGTCCAATTTGCGCCACGGAATTTTAAGGCGGGGCAGCCTTGCCGGCACATTATCCC
GGATGAGCCGGGCTGTCACG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYLTVHLDDGLSIISHLGMSGSF
RIEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASARIIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSG
EVLAALFKGRRTPLKAALLDQRLIAGLGNIYVCEALWRPGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLK
DYIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT

Sequences:

>Translated_293_residues
MPELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYLTVHLDDGLSIISHLGMSGSF
RIEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASARIIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSG
EVLAALFKGRRTPLKAALLDQRLIAGLGNIYVCEALWRPGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLK
DYIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT
>Mature_292_residues
PELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYLTVHLDDGLSIISHLGMSGSFR
IEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASARIIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSGE
VLAALFKGRRTPLKAALLDQRLIAGLGNIYVCEALWRPGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLKD
YIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=292, Percent_Identity=41.0958904109589, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1786932, Length=300, Percent_Identity=27.6666666666667, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_BRUA1 (B2S9T2)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001936001.1
- ProteinModelPortal:   B2S9T2
- SMR:   B2S9T2
- GeneID:   6327605
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I20450
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32006; Mature: 31875

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 283-283 BINDING 104-104 BINDING 127-127 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYL
CCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCHHHHHHHCCCHHHHHCCCEEEE
TVHLDDGLSIISHLGMSGSFRIEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASAR
EEEECCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCEEEEEEECCCCCCEE
IIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSGEVLAALFKGRRTPLKAALLD
EEEECCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
QRLIAGLGNIYVCEALWRPGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLK
HHHHHCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DYIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT
HHHHCCCCHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
PELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYL
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCHHHHHHHCCCHHHHHCCCEEEE
TVHLDDGLSIISHLGMSGSFRIEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASAR
EEEECCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCEEEEEEECCCCCCEE
IIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSGEVLAALFKGRRTPLKAALLD
EEEECCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
QRLIAGLGNIYVCEALWRPGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLK
HHHHHCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DYIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT
HHHHCCCCHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA