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The map label for this gene is divL [H]

Identifier: 225853527

GI number: 225853527

Start: 2037233

End: 2039812

Strand: Direct

Name: divL [H]

Synonym: BMEA_A2160

Alternate gene names: 225853527

Gene position: 2037233-2039812 (Clockwise)

Preceding gene: 225853526

Following gene: 225853528

Centisome position: 95.84

GC content: 60.62

Gene sequence:

>2580_bases
ATGCCAGAGCTAGGCTTACTGGGCAGCGTGCGGAAAACTTCCGCTACCGTGAAAGGCAGGCCCGCCATGAAAGGCAAGCA
TAGGCTCGCTGCTTTCACCCTTGCCGCAAAGTCCTTGTGGCAAACCGCATTGAAAGCCTCGGTCTCGGTTTCCGCTCTCT
TTGCTGCTTCTCCTGCCTTTGCACAAGGTATGGACGGCGCACGCATTTCCATGCCGTTCGGAGGCAGTGTCGGCGCTTTC
GAGGTCATCCAGTTTTCCATTTTTCTGGGCGCCATGGGCGCGGCCCTGCTCTCGGCGGGCTGGCTGATCCGCGACCGTTC
CAAGATCGCCAATGAAAACAATGAGCTGCGTTCCAAATTTGCAGATCTTAATCTCATTGCGCAGCGCAACGAGGCGCTCC
TCAACATGAAGGACCAGCGCATTGTGGTCTGGGACGGCCATAATGTGCGCGCCGATGTGGTGGGGCAATTGCCGGATGCC
TGCGGCGCGCCGCAGGATCGGCCGGCTTTTCTCGCCTTCGGGCGCTGGCTGCGTCCGCAATCGGTGACGGCGCTGGAACG
CGCCATTTCGACCTTGCGCGAGCAGGCGCGCGCCTTTGATCTCACGGTCGAAACGGTCAATGGCTCGCTGCTCGATGTCC
ATGGCCGCACGTCCGGCGGCTTTGCGGTTGCCTGTTTCCAGAGCCTGCAAGGCGTGCAGGCCGAACGTGCAAGCCTTGAA
GCGCAGAACCGTGAGCTTGCCGACAGAATAGAGCTGATGCGCCGCCTTCTGGACCGCATCGAACAGCCGGCTTGGCTGCG
CGACGGCAATGGGCGCATCGAATGGGTCAATCTGGCCTATGCGCAGGCGGTCGATATGGCCAATGCGAGCCAGGTTATCA
GTGAAGGGCGCGAGCTTTTCGGCGCGCAGGCACGCCAGCGCCTGGAGCGCGACCGTTTTGCCGAGCCTGTTGTGCAGGAA
CAACTGACGGCGGTGGTGCATGGCGACCGACGCGTTTTCGACGTGATCGATGTGAGCGCGGAATCGGGTTCCGTCGGCCT
TGGCTTCGACCTGACCGAAGTGCAGGCCGTGCGCGACGAACTGAGCCGCACACTCAAAAGCCATGCCGAAACCCTGGACC
AGCTTTCGACCGCGGTGGCGATCTTCGACCCGGAGATGAAGCTGCAATTCTTCAATCAGGCCTTTGTGAAGCTCTGGGGT
CTGGATGTGGCGTGGCTGGAAACGCGGCCGAGCAACACGCTTATTTTCGACCGTCTGCGCGCGGAAGGAAAGCTTCCCGA
ACAGCCCGAATGGCGCAAATGGAAGGATTCGCTTCTCTCCGCCTATCGCGCGGTCGAGCCGGAAGAACATATGTGGCATC
TGCCCGATACGCGCACCATGCGCGTGGTGGCAAATCCGCACCCGCAAGGCGGCGTGACCTGGTTCTTCGAGAACATGACG
GAAAAATTCGAGCTTGAGGGCCGCTACAATACGCTCATCAAGGTGCAGGGCGAAACGCTCGACCATCTGGCCGAAGCCGT
GGCCGTCTTTGGATCCGACGGGCGGCTGCGCCTGTCCAATCCATCTTTCGCAGCACTTTGGTCGCTGCCCTCTGAAATGG
TTCGCGAAGGTACGCATATTTCGATCATTGCAAAGCTTTGCAACCAGCGCGGCGGCGATGGCCTTTGGGAAGATTTCGTG
TCCACCGTAACCGGCTTCCTCGATCAGCGCGATGGTCGCATGGGGCAGGTGGAACTGAGCGACGGCGCGATCCTTTCCTT
TGCCGTGGTGCCACTGCCCAAGGGGCAGACCATGCTCACCTTCATCGACGTTACCGATACGGTGCGCGTCGAGCGGGCGC
TGAAGGAAAAGAACGAGGCGCTGGAGCTTGCCGACCAGATCAAGAACGATTTTGTCCAGCACGTCTCCTACGAGCTTCGC
TCGCCGCTGACCAATATCATCGGCTTCACCGAGCTTTTGCAGACACCGGCCTTCGGCTCGCTCAACGAGCGCCAGCTTGA
ATATCTTGACCATATCAGCACCTCGTCGTCCGTGCTTCTCACCATCGTCAATGATATTCTCGACCTTGCGACCGTCGATG
CGGGCATCATGGAGCTGGAGATTGGCGACGTATCGGTGGTCGAAGCGATTTCAGCCGCGGCCTCGCGCGTGAGCGAGCGC
CTGCGCGACCATAATATCGGCCTTGATGTCGATATTGCCGACGATGTGGACGTGTTCAAGGCCGATGCCAACCGCGTGCG
GCAGGTGCTGTTCAACCTCCTGTCCAATGCCGTCAACTATGCGCCGGAAGGCTCCAACATCGTGCTTCAGGTGGCGCGTG
ACGGGGCGGATGTCGTCTTTGCGGTCCATGATGACGGCCACGGCATGCCGAGCGAAGTGCTGGACACGGTTTTCAAGCGT
TTCCAGTCCTATCCGAATGGCGGGCGCAGGCGCGGCGCGGGCCTTGGCCTTGCGATCGTGAAAAGCTTCGTGGAACTTCA
TGGCGGCCGGGTCGAGATCGACACCGGCGAGGAGAGGGGCACGACCGTCATTTGCCGCTTTCCATCCGAAGCGCGCAGCT
TCCGCGCTGCCGCCGAATAG

Upstream 100 bases:

>100_bases
CGCTCGATAGCGGGGCCGGTAACTGTTTGAAGTATTTTGAAAATACGGGTGTGCGTCCGTTCAGCGGATGGCGCGGCCGG
GTGGCGGAGAAAAGGGAAAC

Downstream 100 bases:

>100_bases
GGTAAACGGTGGCTATGAACGCCCCGATCAAGATTCTCGAAGCCTTTCTTCCCGACGAAGCCGCCACGCTGCGCTTTGGC
GAGGATTTCGCCCTTGCATT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 859; Mature: 858

Protein sequence:

>859_residues
MPELGLLGSVRKTSATVKGRPAMKGKHRLAAFTLAAKSLWQTALKASVSVSALFAASPAFAQGMDGARISMPFGGSVGAF
EVIQFSIFLGAMGAALLSAGWLIRDRSKIANENNELRSKFADLNLIAQRNEALLNMKDQRIVVWDGHNVRADVVGQLPDA
CGAPQDRPAFLAFGRWLRPQSVTALERAISTLREQARAFDLTVETVNGSLLDVHGRTSGGFAVACFQSLQGVQAERASLE
AQNRELADRIELMRRLLDRIEQPAWLRDGNGRIEWVNLAYAQAVDMANASQVISEGRELFGAQARQRLERDRFAEPVVQE
QLTAVVHGDRRVFDVIDVSAESGSVGLGFDLTEVQAVRDELSRTLKSHAETLDQLSTAVAIFDPEMKLQFFNQAFVKLWG
LDVAWLETRPSNTLIFDRLRAEGKLPEQPEWRKWKDSLLSAYRAVEPEEHMWHLPDTRTMRVVANPHPQGGVTWFFENMT
EKFELEGRYNTLIKVQGETLDHLAEAVAVFGSDGRLRLSNPSFAALWSLPSEMVREGTHISIIAKLCNQRGGDGLWEDFV
STVTGFLDQRDGRMGQVELSDGAILSFAVVPLPKGQTMLTFIDVTDTVRVERALKEKNEALELADQIKNDFVQHVSYELR
SPLTNIIGFTELLQTPAFGSLNERQLEYLDHISTSSSVLLTIVNDILDLATVDAGIMELEIGDVSVVEAISAAASRVSER
LRDHNIGLDVDIADDVDVFKADANRVRQVLFNLLSNAVNYAPEGSNIVLQVARDGADVVFAVHDDGHGMPSEVLDTVFKR
FQSYPNGGRRRGAGLGLAIVKSFVELHGGRVEIDTGEERGTTVICRFPSEARSFRAAAE

Sequences:

>Translated_859_residues
MPELGLLGSVRKTSATVKGRPAMKGKHRLAAFTLAAKSLWQTALKASVSVSALFAASPAFAQGMDGARISMPFGGSVGAF
EVIQFSIFLGAMGAALLSAGWLIRDRSKIANENNELRSKFADLNLIAQRNEALLNMKDQRIVVWDGHNVRADVVGQLPDA
CGAPQDRPAFLAFGRWLRPQSVTALERAISTLREQARAFDLTVETVNGSLLDVHGRTSGGFAVACFQSLQGVQAERASLE
AQNRELADRIELMRRLLDRIEQPAWLRDGNGRIEWVNLAYAQAVDMANASQVISEGRELFGAQARQRLERDRFAEPVVQE
QLTAVVHGDRRVFDVIDVSAESGSVGLGFDLTEVQAVRDELSRTLKSHAETLDQLSTAVAIFDPEMKLQFFNQAFVKLWG
LDVAWLETRPSNTLIFDRLRAEGKLPEQPEWRKWKDSLLSAYRAVEPEEHMWHLPDTRTMRVVANPHPQGGVTWFFENMT
EKFELEGRYNTLIKVQGETLDHLAEAVAVFGSDGRLRLSNPSFAALWSLPSEMVREGTHISIIAKLCNQRGGDGLWEDFV
STVTGFLDQRDGRMGQVELSDGAILSFAVVPLPKGQTMLTFIDVTDTVRVERALKEKNEALELADQIKNDFVQHVSYELR
SPLTNIIGFTELLQTPAFGSLNERQLEYLDHISTSSSVLLTIVNDILDLATVDAGIMELEIGDVSVVEAISAAASRVSER
LRDHNIGLDVDIADDVDVFKADANRVRQVLFNLLSNAVNYAPEGSNIVLQVARDGADVVFAVHDDGHGMPSEVLDTVFKR
FQSYPNGGRRRGAGLGLAIVKSFVELHGGRVEIDTGEERGTTVICRFPSEARSFRAAAE
>Mature_858_residues
PELGLLGSVRKTSATVKGRPAMKGKHRLAAFTLAAKSLWQTALKASVSVSALFAASPAFAQGMDGARISMPFGGSVGAFE
VIQFSIFLGAMGAALLSAGWLIRDRSKIANENNELRSKFADLNLIAQRNEALLNMKDQRIVVWDGHNVRADVVGQLPDAC
GAPQDRPAFLAFGRWLRPQSVTALERAISTLREQARAFDLTVETVNGSLLDVHGRTSGGFAVACFQSLQGVQAERASLEA
QNRELADRIELMRRLLDRIEQPAWLRDGNGRIEWVNLAYAQAVDMANASQVISEGRELFGAQARQRLERDRFAEPVVQEQ
LTAVVHGDRRVFDVIDVSAESGSVGLGFDLTEVQAVRDELSRTLKSHAETLDQLSTAVAIFDPEMKLQFFNQAFVKLWGL
DVAWLETRPSNTLIFDRLRAEGKLPEQPEWRKWKDSLLSAYRAVEPEEHMWHLPDTRTMRVVANPHPQGGVTWFFENMTE
KFELEGRYNTLIKVQGETLDHLAEAVAVFGSDGRLRLSNPSFAALWSLPSEMVREGTHISIIAKLCNQRGGDGLWEDFVS
TVTGFLDQRDGRMGQVELSDGAILSFAVVPLPKGQTMLTFIDVTDTVRVERALKEKNEALELADQIKNDFVQHVSYELRS
PLTNIIGFTELLQTPAFGSLNERQLEYLDHISTSSSVLLTIVNDILDLATVDAGIMELEIGDVSVVEAISAAASRVSERL
RDHNIGLDVDIADDVDVFKADANRVRQVLFNLLSNAVNYAPEGSNIVLQVARDGADVVFAVHDDGHGMPSEVLDTVFKRF
QSYPNGGRRRGAGLGLAIVKSFVELHGGRVEIDTGEERGTTVICRFPSEARSFRAAAE

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: COG2202

COG function: function code T; FOG: PAS/PAC domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=33.0708661417323, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=33.7662337662338, Blast_Score=109, Evalue=9e-25,
Organism=Escherichia coli, GI1789149, Length=316, Percent_Identity=28.4810126582279, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI1786600, Length=282, Percent_Identity=27.3049645390071, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=28.936170212766, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788713, Length=263, Percent_Identity=27.3764258555133, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=27.5109170305677, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI1790861, Length=264, Percent_Identity=30.3030303030303, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=28.0373831775701, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=29.3103448275862, Blast_Score=83, Evalue=8e-17,
Organism=Escherichia coli, GI1786783, Length=251, Percent_Identity=26.6932270916335, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=329, Percent_Identity=26.1398176291793, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=25.5060728744939, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 94732; Mature: 94601

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELGLLGSVRKTSATVKGRPAMKGKHRLAAFTLAAKSLWQTALKASVSVSALFAASPAF
CCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AQGMDGARISMPFGGSVGAFEVIQFSIFLGAMGAALLSAGWLIRDRSKIANENNELRSKF
HCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHCCCCHHHHHHH
ADLNLIAQRNEALLNMKDQRIVVWDGHNVRADVVGQLPDACGAPQDRPAFLAFGRWLRPQ
HHHHHHHHCCHHHCCCCCCEEEEECCCCCCHHHHHCCCHHCCCCCCCCHHHHHHHHCCCC
SVTALERAISTLREQARAFDLTVETVNGSLLDVHGRTSGGFAVACFQSLQGVQAERASLE
HHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHH
AQNRELADRIELMRRLLDRIEQPAWLRDGNGRIEWVNLAYAQAVDMANASQVISEGRELF
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEHHHHHHHHCHHHHHHHHHHHHH
GAQARQRLERDRFAEPVVQEQLTAVVHGDRRVFDVIDVSAESGSVGLGFDLTEVQAVRDE
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCEECCCCHHHHHHHHHH
LSRTLKSHAETLDQLSTAVAIFDPEMKLQFFNQAFVKLWGLDVAWLETRPSNTLIFDRLR
HHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHH
AEGKLPEQPEWRKWKDSLLSAYRAVEPEEHMWHLPDTRTMRVVANPHPQGGVTWFFENMT
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEECCCCCCCEEEEEHHCC
EKFELEGRYNTLIKVQGETLDHLAEAVAVFGSDGRLRLSNPSFAALWSLPSEMVREGTHI
HHEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCHHHHHCCCHH
SIIAKLCNQRGGDGLWEDFVSTVTGFLDQRDGRMGQVELSDGAILSFAVVPLPKGQTMLT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCEEEE
FIDVTDTVRVERALKEKNEALELADQIKNDFVQHVSYELRSPLTNIIGFTELLQTPAFGS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LNERQLEYLDHISTSSSVLLTIVNDILDLATVDAGIMELEIGDVSVVEAISAAASRVSER
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
LRDHNIGLDVDIADDVDVFKADANRVRQVLFNLLSNAVNYAPEGSNIVLQVARDGADVVF
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEE
AVHDDGHGMPSEVLDTVFKRFQSYPNGGRRRGAGLGLAIVKSFVELHGGRVEIDTGEERG
EEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCC
TTVICRFPSEARSFRAAAE
CEEEEECCHHHHHHHCCCC
>Mature Secondary Structure 
PELGLLGSVRKTSATVKGRPAMKGKHRLAAFTLAAKSLWQTALKASVSVSALFAASPAF
CCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AQGMDGARISMPFGGSVGAFEVIQFSIFLGAMGAALLSAGWLIRDRSKIANENNELRSKF
HCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHCCCCHHHHHHH
ADLNLIAQRNEALLNMKDQRIVVWDGHNVRADVVGQLPDACGAPQDRPAFLAFGRWLRPQ
HHHHHHHHCCHHHCCCCCCEEEEECCCCCCHHHHHCCCHHCCCCCCCCHHHHHHHHCCCC
SVTALERAISTLREQARAFDLTVETVNGSLLDVHGRTSGGFAVACFQSLQGVQAERASLE
HHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHH
AQNRELADRIELMRRLLDRIEQPAWLRDGNGRIEWVNLAYAQAVDMANASQVISEGRELF
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEHHHHHHHHCHHHHHHHHHHHHH
GAQARQRLERDRFAEPVVQEQLTAVVHGDRRVFDVIDVSAESGSVGLGFDLTEVQAVRDE
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCEECCCCHHHHHHHHHH
LSRTLKSHAETLDQLSTAVAIFDPEMKLQFFNQAFVKLWGLDVAWLETRPSNTLIFDRLR
HHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHH
AEGKLPEQPEWRKWKDSLLSAYRAVEPEEHMWHLPDTRTMRVVANPHPQGGVTWFFENMT
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEECCCCCCCEEEEEHHCC
EKFELEGRYNTLIKVQGETLDHLAEAVAVFGSDGRLRLSNPSFAALWSLPSEMVREGTHI
HHEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCHHHHHCCCHH
SIIAKLCNQRGGDGLWEDFVSTVTGFLDQRDGRMGQVELSDGAILSFAVVPLPKGQTMLT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCEEEE
FIDVTDTVRVERALKEKNEALELADQIKNDFVQHVSYELRSPLTNIIGFTELLQTPAFGS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LNERQLEYLDHISTSSSVLLTIVNDILDLATVDAGIMELEIGDVSVVEAISAAASRVSER
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
LRDHNIGLDVDIADDVDVFKADANRVRQVLFNLLSNAVNYAPEGSNIVLQVARDGADVVF
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEE
AVHDDGHGMPSEVLDTVFKRFQSYPNGGRRRGAGLGLAIVKSFVELHGGRVEIDTGEERG
EEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCC
TTVICRFPSEARSFRAAAE
CEEEEECCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]