Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 225853526

GI number: 225853526

Start: 2035448

End: 2036848

Strand: Direct

Name: ahcY [H]

Synonym: BMEA_A2159

Alternate gene names: 225853526

Gene position: 2035448-2036848 (Clockwise)

Preceding gene: 225853525

Following gene: 225853527

Centisome position: 95.75

GC content: 58.32

Gene sequence:

>1401_bases
ATGACCGCAAGCCAAGATTTTGTTGTCAAGGATATTAGCCTGGCCGATTGGGGCCGCAGGGAACTCGACATCGCAGAAAC
CGAAATGCCGGGCCTGATGGCTGCCCGCGAGGAATTCGGCAAGTCGCAGCCGCTGAAGGGCGCGCGCATTTCCGGCTCGC
TGCACATGACCATTCAAACTGCCGTTCTCATTGAGACGCTGAAGGTTCTGGGTGCCGAAGTGCGCTGGGCTTCCTGCAAC
ATTTTCTCCACGCAGGATCACGCGGCGGCGGCGATTGCGGCAACCGGCACCCCGGTTTTCGCCGTCAAGGGCGAGACGCT
TGAAGAATACTGGACCTATACCGACCAGATCTTCCAGTGGCCGGATGGCGAGCCGTCCAACATGATCCTCGATGATGGCG
GCGACGCCACCATGTATATTCTCATCGGCGCGCGCGCCGAGGCTGGCGAGGACGTCCTGTCCAATCCGCAGAGCGAGGAA
GAAGAAGTTCTTTTCGCGCAGATCAAGAAGCGCATGGCCGCAACGCCGGGCTTCTTCACGAAGCAGCGCGCCGCAATCAA
GGGCGTGACGGAAGAAACGACCACCGGCGTCAACCGCCTCTATCAGTTGCAGAAGAAGGGTCTCCTGCCCTTCCCCGCCA
TCAACGTCAATGACAGTGTGACCAAGTCGAAGTTCGACAACAAGTATGGCTGCAAGGAATCGCTGGTGGATGGCATTCGT
CGCGGCACCGACGTCATGATGGCCGGCAAGGTTGCCGTCGTCTGCGGCTATGGTGATGTCGGCAAAGGCTCTGCCCAGTC
GCTCGCCGGTGCCGGCGCTCGCGTCAAGGTCACGGAAGTCGATCCGATCTGCGCGCTTCAGGCCGCGATGGACGGCTTCG
AGGTCGTGACCCTTGATGATGCCGCCTCCACCGCCGATATCGTCGTGACGACCACCGGCAACAAGGACGTCATCACGATC
GACCATATGCGCAAGATGAAAGACATGTGCATCGTCGGCAATATCGGCCACTTCGACAATGAAATTCAGGTCGCAGCCCT
GCGCAACCTGAAATGGACCAATGTGAAGCCGCAGGTCGATCTGATCGAGTTCCCCGACGGCAAGCGCCTCATCCTTCTTT
CGGAAGGCCGCCTGCTCAATCTGGGCAATGCGACGGGCCATCCAAGCTTTGTCATGTCGGCTTCCTTCACCAATCAGGTG
TTGGGCCAGATCGAACTTTTCACCCGCACCGATGCCTATAAGAACGAAGTCTATGTGCTGCCGAAGCACCTTGATGAAAA
GGTCGCTCGTCTTCATCTCGACAAGCTTGGCGCAAAGCTGACGGTACTTTCCGAGGAACAGGCTGCCTATATCGGCGTCA
CTCCACAGGGTCCGTTCAAGTCGGAACACTACAGGTATTAA

Upstream 100 bases:

>100_bases
GCCAGCCGGAGTGGTTTGACCGTTTTAGAAAATCCGCTCCAGAACCAATTTTTTCATGCAATTTTGCCTTCAGGCGAATT
GCCCTGGATTGGAGCACGCG

Downstream 100 bases:

>100_bases
CCATAGGTTAAGCATTCCACTACATCTTGAGGCCGGATGGTTGACAAGCCATCCGGTCTTTCTTTTTGCGCGCGAGATGC
TTCACGCGGATTCGCCGGAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTASQDFVVKDISLADWGRRELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQTAVLIETLKVLGAEVRWASCN
IFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQWPDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEE
EEVLFAQIKKRMAATPGFFTKQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAASTADIVVTTTGNKDVITI
DHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVDLIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQV
LGQIELFTRTDAYKNEVYVLPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY

Sequences:

>Translated_466_residues
MTASQDFVVKDISLADWGRRELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQTAVLIETLKVLGAEVRWASCN
IFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQWPDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEE
EEVLFAQIKKRMAATPGFFTKQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
RGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAASTADIVVTTTGNKDVITI
DHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVDLIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQV
LGQIELFTRTDAYKNEVYVLPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY
>Mature_465_residues
TASQDFVVKDISLADWGRRELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQTAVLIETLKVLGAEVRWASCNI
FSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQWPDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEE
EVLFAQIKKRMAATPGFFTKQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRR
GTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAASTADIVVTTTGNKDVITID
HMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVDLIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVL
GQIELFTRTDAYKNEVYVLPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=57.9059829059829, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.1818181818182, Blast_Score=477, Evalue=1e-135,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=50.4291845493562, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=50.8583690987124, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=50.8583690987124, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=50.4291845493562, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=48.9270386266094, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.7096774193548, Blast_Score=516, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=55.625, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=61.038961038961, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=467, Percent_Identity=51.1777301927195, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=51.8358531317495, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=51.7316017316017, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50820; Mature: 50688

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASQDFVVKDISLADWGRRELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQT
CCCCCCEEEEECCCCCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEEEEHH
AVLIETLKVLGAEVRWASCNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQW
HHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCEEEEEECCHHHHHHCCCHHEEEC
PDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEVLFAQIKKRMAATPGFFT
CCCCCCCEEEECCCCEEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
KQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDD
CCCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEECC
AASTADIVVTTTGNKDVITIDHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVD
CCCCCCEEEEECCCCCEEEHHHHHHHHCEEEECCCCCCCCCEEEEEECCCEECCCCCCEE
LIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTRTDAYKNEVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHHEEEEEEECCCCCCCEEEE
PKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY
CCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TASQDFVVKDISLADWGRRELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQT
CCCCCEEEEECCCCCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEEEEHH
AVLIETLKVLGAEVRWASCNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQW
HHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCEEEEEECCHHHHHHCCCHHEEEC
PDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEVLFAQIKKRMAATPGFFT
CCCCCCCEEEECCCCEEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
KQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIR
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHH
RGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDD
CCCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEECC
AASTADIVVTTTGNKDVITIDHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVD
CCCCCCEEEEECCCCCEEEHHHHHHHHCEEEECCCCCCCCCEEEEEECCCEECCCCCCEE
LIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTRTDAYKNEVYVL
EEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHHEEEEEEECCCCCCCEEEE
PKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY
CCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA