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The map label for this gene is mltA [H]

Identifier: 225853506

GI number: 225853506

Start: 2017996

End: 2019105

Strand: Direct

Name: mltA [H]

Synonym: BMEA_A2137

Alternate gene names: 225853506

Gene position: 2017996-2019105 (Clockwise)

Preceding gene: 225853505

Following gene: 225853507

Centisome position: 94.93

GC content: 60.09

Gene sequence:

>1110_bases
ATGGAAACGGCAGTGAACGACTTGGCGAGGATTTTCCGCCCGGCGAGCTTTGGCGATTGCCCCGGCTGGGATCGGGACGA
TCAGGCTTTGGCATTTGCCGCTTTTCGCCGTTCCGCCGACTATGCCGAAAATAACAGCTATGGGAGCGGCAGTCTTGGCC
TGTCTTTCGAGGCCCTGAAGCCGATCTTTGCTGCTGCCCGCGCGCTTGACCGTCCTGACAGGGGCGAAGCGCGGCGCTTT
TTCGAGGCGCATTTCGTGCCCTGCCGCGTGGAGCCTGAACAGGGCAAGGGCTTCGTGACCGGATTTTATGAGCCGGAAAT
AGAAGCATCGCGCATTGCGGATGCGCGGTTCAAAGTGCCTTTTCTGCGCAAGCACGCCGATCTTGTGAAAGTGAGCGATG
AAAATCGCCCGGCCGGCCTCGATCCGTCTTTTGCTTTTGCCCGCCAGACAGAAAGCGGCCTTGAGGAATATGCCGACCGC
CGCGCCATTGAGCAGGGTGCGCTTTCGGGCCATGGGCTGGAGATTGCCTTCGTGGCTGACCGCGTTGATGCATTTTTCGC
CCATGTGCAGGGGGCGGCACGCCTGAAACTGACCGACGGTGAAACCCTGCGCGTGACTTATGCGGCAAAAACCGGCCATC
CATTCACGGGTATCGGCCGCATTCTGGTTGATGAGGGCGAGATAGCGGCTGCGGAAATTTCGATGCAGTCGATCCGCCGC
TGGCTCAGCGCCCATCCGGACAGGGCCGACGAACTTATCTGGAAAAACCGCTCCTATATTTTCTTCCGCGAAGCACCTGT
CGATGATCCGGCCGCCGGTCCGGTTGCCGCGGCCAAGGTTCCGCTTACTGCCGGGCGTTCCATGGCGGTGGATAGATTAC
TGCATACGTTCGGAACGCCATTTTATGTCAGTGCTCCGACGCTTTGCGCTTTTGGCGGCGAGCCTTTTGCCCGCCTGATG
ATAGCGCAGGACACAGGAACGGCAATTGTCGGGCCTGCGCGCGGCGATCTTTTCACCGGTTCGGGCGATGAGGCGGGCAA
GATTGCCGGCGGCATCAAGGATGAGGCGGATTTCTACGTGCTTGTGCCGCGCAATATGGTCGGGGGGTGA

Upstream 100 bases:

>100_bases
GAACTGGAAGCTTGTTGCAACCGAAGCGGAAGATTAAAGATATTTCCTGGAAAGTGCCGCTTACCTTTCGTCGGAAGGCC
GCTCTTTCTTAATAATTGAA

Downstream 100 bases:

>100_bases
AGCCCATGCCCCCCAGATCCGAAAAGCCGGGCAAGGATTATCTGCGGGCCGAAGACCGCATCCTCTGGGAGACAGTGGCA
AAAACTGCGCGCCCGCTTGC

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
METAVNDLARIFRPASFGDCPGWDRDDQALAFAAFRRSADYAENNSYGSGSLGLSFEALKPIFAAARALDRPDRGEARRF
FEAHFVPCRVEPEQGKGFVTGFYEPEIEASRIADARFKVPFLRKHADLVKVSDENRPAGLDPSFAFARQTESGLEEYADR
RAIEQGALSGHGLEIAFVADRVDAFFAHVQGAARLKLTDGETLRVTYAAKTGHPFTGIGRILVDEGEIAAAEISMQSIRR
WLSAHPDRADELIWKNRSYIFFREAPVDDPAAGPVAAAKVPLTAGRSMAVDRLLHTFGTPFYVSAPTLCAFGGEPFARLM
IAQDTGTAIVGPARGDLFTGSGDEAGKIAGGIKDEADFYVLVPRNMVGG

Sequences:

>Translated_369_residues
METAVNDLARIFRPASFGDCPGWDRDDQALAFAAFRRSADYAENNSYGSGSLGLSFEALKPIFAAARALDRPDRGEARRF
FEAHFVPCRVEPEQGKGFVTGFYEPEIEASRIADARFKVPFLRKHADLVKVSDENRPAGLDPSFAFARQTESGLEEYADR
RAIEQGALSGHGLEIAFVADRVDAFFAHVQGAARLKLTDGETLRVTYAAKTGHPFTGIGRILVDEGEIAAAEISMQSIRR
WLSAHPDRADELIWKNRSYIFFREAPVDDPAAGPVAAAKVPLTAGRSMAVDRLLHTFGTPFYVSAPTLCAFGGEPFARLM
IAQDTGTAIVGPARGDLFTGSGDEAGKIAGGIKDEADFYVLVPRNMVGG
>Mature_369_residues
METAVNDLARIFRPASFGDCPGWDRDDQALAFAAFRRSADYAENNSYGSGSLGLSFEALKPIFAAARALDRPDRGEARRF
FEAHFVPCRVEPEQGKGFVTGFYEPEIEASRIADARFKVPFLRKHADLVKVSDENRPAGLDPSFAFARQTESGLEEYADR
RAIEQGALSGHGLEIAFVADRVDAFFAHVQGAARLKLTDGETLRVTYAAKTGHPFTGIGRILVDEGEIAAAEISMQSIRR
WLSAHPDRADELIWKNRSYIFFREAPVDDPAAGPVAAAKVPLTAGRSMAVDRLLHTFGTPFYVSAPTLCAFGGEPFARLM
IAQDTGTAIVGPARGDLFTGSGDEAGKIAGGIKDEADFYVLVPRNMVGG

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=270, Percent_Identity=32.2222222222222, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40041; Mature: 40041

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METAVNDLARIFRPASFGDCPGWDRDDQALAFAAFRRSADYAENNSYGSGSLGLSFEALK
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
PIFAAARALDRPDRGEARRFFEAHFVPCRVEPEQGKGFVTGFYEPEIEASRIADARFKVP
HHHHHHHHHCCCCCHHHHHHHHHHEEEEEECCCCCCEEEEEEECCCCCHHHHCCCCCCCH
FLRKHADLVKVSDENRPAGLDPSFAFARQTESGLEEYADRRAIEQGALSGHGLEIAFVAD
HHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHH
RVDAFFAHVQGAARLKLTDGETLRVTYAAKTGHPFTGIGRILVDEGEIAAAEISMQSIRR
HHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCCCCCCCEEEEECCCEEHHHHHHHHHHH
WLSAHPDRADELIWKNRSYIFFREAPVDDPAAGPVAAAKVPLTAGRSMAVDRLLHTFGTP
HHHCCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCC
FYVSAPTLCAFGGEPFARLMIAQDTGTAIVGPARGDLFTGSGDEAGKIAGGIKDEADFYV
EEEECCEEEECCCCCCEEEEEEECCCCEEEECCCCCEEECCCCCCCHHCCCCCCCCCEEE
LVPRNMVGG
EECCCCCCC
>Mature Secondary Structure
METAVNDLARIFRPASFGDCPGWDRDDQALAFAAFRRSADYAENNSYGSGSLGLSFEALK
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
PIFAAARALDRPDRGEARRFFEAHFVPCRVEPEQGKGFVTGFYEPEIEASRIADARFKVP
HHHHHHHHHCCCCCHHHHHHHHHHEEEEEECCCCCCEEEEEEECCCCCHHHHCCCCCCCH
FLRKHADLVKVSDENRPAGLDPSFAFARQTESGLEEYADRRAIEQGALSGHGLEIAFVAD
HHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHH
RVDAFFAHVQGAARLKLTDGETLRVTYAAKTGHPFTGIGRILVDEGEIAAAEISMQSIRR
HHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCCCCCCCEEEEECCCEEHHHHHHHHHHH
WLSAHPDRADELIWKNRSYIFFREAPVDDPAAGPVAAAKVPLTAGRSMAVDRLLHTFGTP
HHHCCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCC
FYVSAPTLCAFGGEPFARLMIAQDTGTAIVGPARGDLFTGSGDEAGKIAGGIKDEADFYV
EEEECCEEEECCCCCCEEEEEEECCCCEEEECCCCCEEECCCCCCCHHCCCCCCCCCEEE
LVPRNMVGG
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]