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The map label for this gene is betA [C]

Identifier: 225853475

GI number: 225853475

Start: 1985895

End: 1987379

Strand: Reverse

Name: betA [C]

Synonym: BMEA_A2105

Alternate gene names: 225853475

Gene position: 1987379-1985895 (Counterclockwise)

Preceding gene: 225853476

Following gene: 225853474

Centisome position: 93.49

GC content: 59.26

Gene sequence:

>1485_bases
TTGGGAGGACAGCCGGATATTGTCATCATCGGATCGGGGATCGGCGGCGCGACAATGGCCGCAGGTCTTGCCGCATCGGG
TGCCGACATTCTCATTCTGGAGGCGGGCGGGCGCCTGGCTGACAGGCCGGAAAACCGTGACCCGCGCGCCATTTTCCAGC
GCGGGTTCTTTCGTCCGAAGGAGTTGTGGTACGAGACCAGTGGAGCGCCGTTCAATCCCGGCAATTATTACAATGTCGGC
GGCAATTCCAAATTCTACGGCGCGGTGCTGATCCGCTATCGGCGTGAGGATTTTGAAGAGCTTGCGCATCTGGAAGGCGT
GTCGCCCGCATGGCCCTTTTCCTATGACGAACTGGAGCCGTGGTATTGCAAGGCGGAAGAACTGTTTCAGGTGCGCGGTG
AATTGGGCGACGACCCGACCGAGCCGCATCATTCAAAGCCTTATCCTTATGCGGCTATCCGTGATGAGCGCCCGATTGCC
GATATGCGGGCACGGCTGAAGAAGGCGGGATTGCATCCGGCCTCCTTGCCATTGGGTGTTGATATTGAGCGTTGGCTGGC
AAAGGCCAGAACGCCATGGGATGCGCATCCCAATTGCGACGATGGCAAGATGGATGCGGAAACCTGTCCGCTTGCGCAAG
CACTTCAATATGCCAATGTCCGGCTGGAAACGTCCGCGCAGGTGAGGCGGCTGGAAGCCGGGCCGGATGGAAAAGCAATC
ACGGCAGTCCATTATGTGAAGAACGGCGAGGCGCTGGTCCTGCGCCCAAAGCTCGTTATTCTATCGGCTGGCGCCGTGCA
GTCGGCGGCACTTTTGCTGCGTTCGGGACTGGCCAATCGCTCCGATCAGGTCGGGCGCAATTTCATGAACCACAACGCAA
GCGCCGTGATTGCCTTCGATCCGCGCTATCGCAATGACAGCGTCTACCAGAAGACTTTTGGTTTCAATGATTACTATCTG
TCGGATGGGGCAGGCGGGCCGCCGCTTGGCAATGTGCAATTGCTGGGGCGGGTGTCGGGCGCAATCCTGAAATCCAATAT
GCGCCACGTGCCCGAATGGCTTTTGAACCGCATCGCCGGGCACACAATTGATTTTTACGCCATGAGCGAAGACCTACCAT
CGCCGGAAAGCCGCGTGAGTGTGGATGGCGACCGCATCATTCTGCATTGGGTGCGCAGTAACTGGAAAGCGCATCTGATG
CTGGTGGAAAAACTCAAATCCGCGCTTCGGGCGGTGGGTTTTCCGGTGGTTCTGTCTCGGGCCTTCGACCGGCGCACGCC
ATCGCATCAATGCGGCACGGCGCGCATCGGCAATGATCCGGCGACAGCGCCGCTCGATCCTTATTGCCGCGCTTACGATC
ACCCCAATCTCTACGTGGTCGATGCGTCGTTCCTGCCAACAGCGGCAGCGGTCAATCCGGCGCTGACCATCGCCGCGCAA
GCCTTGCGCGTCGCAGACCGTATCAAGCGGGAGGGTTTTGCATGA

Upstream 100 bases:

>100_bases
TCATGCGGTGGAGGATTACACCGAAACCAAAACGCTCAACATGCATATCGGCGCGCGCACGGGCTGGTGGATGCCGCAAG
CGAAATAGGAGGAGGCGGCT

Downstream 100 bases:

>100_bases
GCCGTCAAAGACCTGTAGCGCTGGTGACTGGCGGGCGGCGGGGGATCGGGCTTGGCATTGCCCGCGCTCTGGCTGCCAAG
GGGTTTGATCTGGCGATCAC

Product: glucose-methanol-choline oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: FAD Dependent Oxidoreductase; Choline Dehydrogenase; Oxidoreductase; Dehydrogenase; GMC Oxidoreductase; Gluconate 2-Dehydrogenase; Gluconate Dehydrogenase; Flavoprotein Related Choline Dehydrogenase; Dehydrogenase Subunit-Like Protein; GMC Family Oxidoreductase; GMC Oxidoreductase Family Protein; Glucose Dehydrogenase; Dehydrogenase Subunit; Oxidoreductase GMC Family; Glucose-Methanol-Choline Family Oxidoreductase; Dehydrogenase Protein; GMC Oxidoreductase Family; Oxidoreductase-Like Protein; Dehydrogenase Large Subunit Protein; Dehydrogenase-Like Protein; L-Sorbose Dehydrogenase; 2-Keto-Gluconate Dehydrogenase; FAD-Dependent Pyridine Nucleotide-Disulfide Oxidoreductase; Dehydrogluconate Dehydrogenase; Sugar-Alcohol Dehydrogenase; Glucoside 3-Dehydrogenase; Dehydrogenase Flavoprotein Subunit; Glucase Dehydrogenase Subunit Alpha; Transmembrane Dehydrogenase Protein; Dehydrogenase Subunit I; Choline Dehydrogenase-Like Flavoprotein; 2-Keto-Gluconate Dehydrogenase Subunit; Gluconate 2-Dehydrogenase Flavoprotein; Quinoprotein Glucose Dehydrogenase; Flavoproteins Oxidoreductases; Oxidoreductase Chain; N-Terminal Membrane-Anchored Dehydrogenase; Oxidoreductase GMC Family Protein; Gluconate Dehydrogenase Subunit; Dehydrogenase Transmembrane Protein

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MGGQPDIVIIGSGIGGATMAAGLAASGADILILEAGGRLADRPENRDPRAIFQRGFFRPKELWYETSGAPFNPGNYYNVG
GNSKFYGAVLIRYRREDFEELAHLEGVSPAWPFSYDELEPWYCKAEELFQVRGELGDDPTEPHHSKPYPYAAIRDERPIA
DMRARLKKAGLHPASLPLGVDIERWLAKARTPWDAHPNCDDGKMDAETCPLAQALQYANVRLETSAQVRRLEAGPDGKAI
TAVHYVKNGEALVLRPKLVILSAGAVQSAALLLRSGLANRSDQVGRNFMNHNASAVIAFDPRYRNDSVYQKTFGFNDYYL
SDGAGGPPLGNVQLLGRVSGAILKSNMRHVPEWLLNRIAGHTIDFYAMSEDLPSPESRVSVDGDRIILHWVRSNWKAHLM
LVEKLKSALRAVGFPVVLSRAFDRRTPSHQCGTARIGNDPATAPLDPYCRAYDHPNLYVVDASFLPTAAAVNPALTIAAQ
ALRVADRIKREGFA

Sequences:

>Translated_494_residues
MGGQPDIVIIGSGIGGATMAAGLAASGADILILEAGGRLADRPENRDPRAIFQRGFFRPKELWYETSGAPFNPGNYYNVG
GNSKFYGAVLIRYRREDFEELAHLEGVSPAWPFSYDELEPWYCKAEELFQVRGELGDDPTEPHHSKPYPYAAIRDERPIA
DMRARLKKAGLHPASLPLGVDIERWLAKARTPWDAHPNCDDGKMDAETCPLAQALQYANVRLETSAQVRRLEAGPDGKAI
TAVHYVKNGEALVLRPKLVILSAGAVQSAALLLRSGLANRSDQVGRNFMNHNASAVIAFDPRYRNDSVYQKTFGFNDYYL
SDGAGGPPLGNVQLLGRVSGAILKSNMRHVPEWLLNRIAGHTIDFYAMSEDLPSPESRVSVDGDRIILHWVRSNWKAHLM
LVEKLKSALRAVGFPVVLSRAFDRRTPSHQCGTARIGNDPATAPLDPYCRAYDHPNLYVVDASFLPTAAAVNPALTIAAQ
ALRVADRIKREGFA
>Mature_493_residues
GGQPDIVIIGSGIGGATMAAGLAASGADILILEAGGRLADRPENRDPRAIFQRGFFRPKELWYETSGAPFNPGNYYNVGG
NSKFYGAVLIRYRREDFEELAHLEGVSPAWPFSYDELEPWYCKAEELFQVRGELGDDPTEPHHSKPYPYAAIRDERPIAD
MRARLKKAGLHPASLPLGVDIERWLAKARTPWDAHPNCDDGKMDAETCPLAQALQYANVRLETSAQVRRLEAGPDGKAIT
AVHYVKNGEALVLRPKLVILSAGAVQSAALLLRSGLANRSDQVGRNFMNHNASAVIAFDPRYRNDSVYQKTFGFNDYYLS
DGAGGPPLGNVQLLGRVSGAILKSNMRHVPEWLLNRIAGHTIDFYAMSEDLPSPESRVSVDGDRIILHWVRSNWKAHLML
VEKLKSALRAVGFPVVLSRAFDRRTPSHQCGTARIGNDPATAPLDPYCRAYDHPNLYVVDASFLPTAAAVNPALTIAAQA
LRVADRIKREGFA

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 54308; Mature: 54177

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGQPDIVIIGSGIGGATMAAGLAASGADILILEAGGRLADRPENRDPRAIFQRGFFRPK
CCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCHH
ELWYETSGAPFNPGNYYNVGGNSKFYGAVLIRYRREDFEELAHLEGVSPAWPFSYDELEP
HHHEECCCCCCCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
WYCKAEELFQVRGELGDDPTEPHHSKPYPYAAIRDERPIADMRARLKKAGLHPASLPLGV
CEECHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCC
DIERWLAKARTPWDAHPNCDDGKMDAETCPLAQALQYANVRLETSAQVRRLEAGPDGKAI
CHHHHHHHCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHCEEEECCHHHHEECCCCCCCEE
TAVHYVKNGEALVLRPKLVILSAGAVQSAALLLRSGLANRSDQVGRNFMNHNASAVIAFD
EEEEEEECCCEEEEECEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEC
PRYRNDSVYQKTFGFNDYYLSDGAGGPPLGNVQLLGRVSGAILKSNMRHVPEWLLNRIAG
CCCCCCCHHHHHCCCCCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
HTIDFYAMSEDLPSPESRVSVDGDRIILHWVRSNWKAHLMLVEKLKSALRAVGFPVVLSR
CEEEEEEECCCCCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHH
AFDRRTPSHQCGTARIGNDPATAPLDPYCRAYDHPNLYVVDASFLPTAAAVNPALTIAAQ
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHCCHHHHHHHH
ALRVADRIKREGFA
HHHHHHHHHHCCCC
>Mature Secondary Structure 
GGQPDIVIIGSGIGGATMAAGLAASGADILILEAGGRLADRPENRDPRAIFQRGFFRPK
CCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCHH
ELWYETSGAPFNPGNYYNVGGNSKFYGAVLIRYRREDFEELAHLEGVSPAWPFSYDELEP
HHHEECCCCCCCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
WYCKAEELFQVRGELGDDPTEPHHSKPYPYAAIRDERPIADMRARLKKAGLHPASLPLGV
CEECHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCC
DIERWLAKARTPWDAHPNCDDGKMDAETCPLAQALQYANVRLETSAQVRRLEAGPDGKAI
CHHHHHHHCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHCEEEECCHHHHEECCCCCCCEE
TAVHYVKNGEALVLRPKLVILSAGAVQSAALLLRSGLANRSDQVGRNFMNHNASAVIAFD
EEEEEEECCCEEEEECEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEC
PRYRNDSVYQKTFGFNDYYLSDGAGGPPLGNVQLLGRVSGAILKSNMRHVPEWLLNRIAG
CCCCCCCHHHHHCCCCCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
HTIDFYAMSEDLPSPESRVSVDGDRIILHWVRSNWKAHLMLVEKLKSALRAVGFPVVLSR
CEEEEEEECCCCCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHH
AFDRRTPSHQCGTARIGNDPATAPLDPYCRAYDHPNLYVVDASFLPTAAAVNPALTIAAQ
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHCCHHHHHHHH
ALRVADRIKREGFA
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA