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The map label for this gene is fabG [H]

Identifier: 225853474

GI number: 225853474

Start: 1985134

End: 1985898

Strand: Reverse

Name: fabG [H]

Synonym: BMEA_A2104

Alternate gene names: 225853474

Gene position: 1985898-1985134 (Counterclockwise)

Preceding gene: 225853475

Following gene: 225853472

Centisome position: 93.42

GC content: 60.39

Gene sequence:

>765_bases
ATGAGCCGTCAAAGACCTGTAGCGCTGGTGACTGGCGGGCGGCGGGGGATCGGGCTTGGCATTGCCCGCGCTCTGGCTGC
CAAGGGGTTTGATCTGGCGATCACCGACCGCGAAAGCGACGAGGCCGTCATCCACGAATTGCGCGGGCTTGGTGGAAAAG
TGGCTTTCTTTAAAAGTGATCTCGCTGCCGTGGAAACCCATGAGGCGACGGTTTTTGCCGTGCTGGATGCGTTCGGCGGC
ATTGATTGTCTGGTCAATAATGCGGGTATGGGTGCGGTCGAGCGCGGCGATTTTCTTGCCCTGAAGCCTGAAAATTTCGA
CACGATCATGGATGTGAACCTGCGCGGCACGGTGTTTTTCACGCAGGCCGTGGTGAAGGCCATGCTGGCCGCAGACGAAG
TGCGCTTTCCACGCTCCATCGTGACGATCAGTTCGGTTTCTTCCGTGATGACATCGCCGGAGCGGCTTGATTACTGCATC
AGCAAGGCGGGGCTGACCGCCTTCGTGCAAGGGCTGGCACTGCGTCTGGCCGAAGCGCGGATCGGTGTCTTCGAGGTGCG
CCCCGGCATTATCCGCACCGATATGACGGCAAAGGTTGCCGCGCGTTATGACGCGCTGATCGAAGGCGGGTTGGTGCCGA
TGAAGCGCTGGGGCGAGGCGAGCGATGTTGGCGCCATCGTGGCCGGGCTTGCCGGTGGCGATTTCATCTTTGCGACCGGC
TCGGCAATCCATGCCGATGGCGGCCTGTCGATTGCAAAATTATAA

Upstream 100 bases:

>100_bases
ATGCGTCGTTCCTGCCAACAGCGGCAGCGGTCAATCCGGCGCTGACCATCGCCGCGCAAGCCTTGCGCGTCGCAGACCGT
ATCAAGCGGGAGGGTTTTGC

Downstream 100 bases:

>100_bases
GGGTAGCGCGATGCATTACGATTATATCATCGTTGGAGGCGGGCCTGCCGGTTGCGTTCTCGCCAATCGCCTGAGCGAAG
ATGCATCGATAAAAGTGTTG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSRQRPVALVTGGRRGIGLGIARALAAKGFDLAITDRESDEAVIHELRGLGGKVAFFKSDLAAVETHEATVFAVLDAFGG
IDCLVNNAGMGAVERGDFLALKPENFDTIMDVNLRGTVFFTQAVVKAMLAADEVRFPRSIVTISSVSSVMTSPERLDYCI
SKAGLTAFVQGLALRLAEARIGVFEVRPGIIRTDMTAKVAARYDALIEGGLVPMKRWGEASDVGAIVAGLAGGDFIFATG
SAIHADGGLSIAKL

Sequences:

>Translated_254_residues
MSRQRPVALVTGGRRGIGLGIARALAAKGFDLAITDRESDEAVIHELRGLGGKVAFFKSDLAAVETHEATVFAVLDAFGG
IDCLVNNAGMGAVERGDFLALKPENFDTIMDVNLRGTVFFTQAVVKAMLAADEVRFPRSIVTISSVSSVMTSPERLDYCI
SKAGLTAFVQGLALRLAEARIGVFEVRPGIIRTDMTAKVAARYDALIEGGLVPMKRWGEASDVGAIVAGLAGGDFIFATG
SAIHADGGLSIAKL
>Mature_253_residues
SRQRPVALVTGGRRGIGLGIARALAAKGFDLAITDRESDEAVIHELRGLGGKVAFFKSDLAAVETHEATVFAVLDAFGGI
DCLVNNAGMGAVERGDFLALKPENFDTIMDVNLRGTVFFTQAVVKAMLAADEVRFPRSIVTISSVSSVMTSPERLDYCIS
KAGLTAFVQGLALRLAEARIGVFEVRPGIIRTDMTAKVAARYDALIEGGLVPMKRWGEASDVGAIVAGLAGGDFIFATGS
AIHADGGLSIAKL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=31.3953488372093, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=30.8300395256917, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=30.241935483871, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI5031737, Length=241, Percent_Identity=30.7053941908714, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706318, Length=201, Percent_Identity=29.8507462686567, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=28.6885245901639, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=27.4809160305344, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=33.1578947368421, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=31.7948717948718, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4504505, Length=223, Percent_Identity=29.5964125560538, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=29.7979797979798, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=34.5238095238095, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=31.3725490196078, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=28.8, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=32.1285140562249, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=30.1255230125523, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=26.5873015873016, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=25.7028112449799, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=31.3008130081301, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=29.3436293436293, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=29.0076335877863, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=27.3408239700375, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=28.0632411067194, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=275, Percent_Identity=29.8181818181818, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=28.1368821292776, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=29.3436293436293, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=25.9541984732824, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=26.1029411764706, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=32.156862745098, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=32.2709163346614, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=32, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=32.6693227091633, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=29.5546558704453, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=26.953125, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=29.5918367346939, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26672; Mature: 26541

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQRPVALVTGGRRGIGLGIARALAAKGFDLAITDRESDEAVIHELRGLGGKVAFFKSD
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCC
LAAVETHEATVFAVLDAFGGIDCLVNNAGMGAVERGDFLALKPENFDTIMDVNLRGTVFF
HHHHCCCCHHHEEEHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEEECCCCEEHH
TQAVVKAMLAADEVRFPRSIVTISSVSSVMTSPERLDYCISKAGLTAFVQGLALRLAEAR
HHHHHHHHHHHHHHCCCHHEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVFEVRPGIIRTDMTAKVAARYDALIEGGLVPMKRWGEASDVGAIVAGLAGGDFIFATG
CCEEEECCCEEECCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHCCCCCEEEECC
SAIHADGGLSIAKL
CEEECCCCEEEECC
>Mature Secondary Structure 
SRQRPVALVTGGRRGIGLGIARALAAKGFDLAITDRESDEAVIHELRGLGGKVAFFKSD
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCC
LAAVETHEATVFAVLDAFGGIDCLVNNAGMGAVERGDFLALKPENFDTIMDVNLRGTVFF
HHHHCCCCHHHEEEHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEEECCCCEEHH
TQAVVKAMLAADEVRFPRSIVTISSVSSVMTSPERLDYCISKAGLTAFVQGLALRLAEAR
HHHHHHHHHHHHHHCCCHHEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVFEVRPGIIRTDMTAKVAARYDALIEGGLVPMKRWGEASDVGAIVAGLAGGDFIFATG
CCEEEECCCEEECCHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHCCCCCEEEECC
SAIHADGGLSIAKL
CEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]