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The map label for this gene is uvrD [H]

Identifier: 225852895

GI number: 225852895

Start: 1385889

End: 1388465

Strand: Direct

Name: uvrD [H]

Synonym: BMEA_A1461

Alternate gene names: 225852895

Gene position: 1385889-1388465 (Clockwise)

Preceding gene: 225852894

Following gene: 225852898

Centisome position: 65.2

GC content: 59.41

Gene sequence:

>2577_bases
ATGTCCGATTTTCCCGACGATATGCCGTTTTTCGGCGATGACGACGCTCCGGCTGGCCGCGCGCCCGCTCCCGGCAGCAT
TGCCGCACGCGCCATGGCCGCACGCAACCAGCAGCATGGCGAGCCCGATTACCTCAAGGGCCTGAACCCGAAGCAGAAAC
AGGCGGTGCTCACCACCGAGGGCCCGGTTCTGGTGCTGGCGGGTGCTGGCACCGGCAAGACGCGCGTGCTCACCACGCGC
ATTGCACATATTCTTTCGACCGGCCTTGCCTATCCGAGCCAGATTTTGGCCGTGACCTTCACCAACAAGGCCGCGCGCGA
AATGAAGGAGCGTATCGGCCATCTGGTCGGCGGTGCTGTTGAAGGCATGCCCTGGCTTGGCACATTCCACTCCATCGGCG
TCAAGCTTTTGCGCCGCCACGCCGAACTGGTCAATCTTACCTCCAGCTTCACCATCCTCGATACGGACGATGTGATCCGG
CTCATCAAGCAGCTTATTCAGGCCGAAGGACTGGATGACAAACGCTGGCCTGCCCGCACCTTCGCCAATATGATCGACGG
CTGGAAGAATAAGGGTTTCAGTCCCGCCGATATTCCCGAAGGGGATGCGCGCTCGTTCGGCAACGGGCGGGGCCGTGAGC
TTTATCAGGCCTATCAGGAACGGTTGCGCACACTGAACGCCTGTGATTTTGGCGATCTTCTGCTGCATCCGATCCGCATC
TTCCGCAACCACCCGGATATCCTGCGCGAATATCATGCAAAATTCCGCTACATTCTGGTGGACGAATATCAGGACACCAA
CACCGCACAATATCTCTGGCTGCGTCTGCTAGCACAGCGACCAAAATCACGAACGACAGCGCCAACGCAGGCCGGAGGCT
CGCCAGTACAGCCCGCTAGGGCGTCCGAAGGCCCCTGCGGAGCCGGTGAGCGCAGCGAACTCGGCGTGAGCGAAGACAAA
GTAAACTTGTGTTGTGTGGGCGATGACGACCAGTCGATCTATGGCTGGCGCGGAGCGGAAGTGGACAATATCTTGCGCTT
TGAGAAGGACTTTCCGGGCGCGGTCGTTATCAAGCTTGAGCGCAATTATCGCTCCACGGCGCATATTCTGGGCACTGCCG
CGCATCTGATCGCGCATAATGAAGGCCGTTTGGGCAAGACGCTTTTCACCGAGGCACCCAATCCGGATGACCCGCGCGTC
AAGGTCCATGCGGCCTGGGACTCGGAAGAGGAAGCGCGTGCGGTTGGCGAAGCCATCGAGCAGGCGCAGCGTCAGGGGCA
CCTTCTCAACAATATGGCGATCCTTGTGCGCGCCTCCTTCCAGATGCGTGAGTTTGAAGACCGTTTTGTCACGCTCGGCC
TCAATTATCGCGTCATAGGCGGCCCGCGCTTCTATGAGCGCCTCGAAATTCGCGATGCCATGGCATATCTGCGCGTCGTC
GCGCAACCCGCCGACGATCTGGCGCTGGAGCGCATCATCAACACGCCAAAGCGCGGCCTTGGCGAAGCAGCCATCCGCCA
GATTCATGACTATGCGCGCGCGCGCGACATTTCCATGTTCGCTGCGGCCTGCGACCTCATAGAAACCGAGGAGCTGAAAC
CCAAGCCACGCTCTGCCCTGCGTGAGGTGGTGGAGAATTTCCTGCGCTGGCAGTCGCTGATCGACACCACGCCGCATACG
GAACTGGCGGAAACCATTCTTGATGAATCCGGCTACACCGCCATGTGGCAGAACGACAAATCAGCGGAAGCGCCGGGCCG
GCTTGAAAACCTCAAGGAACTGATCCGTTCCATGGAGGAATATGAAAGCCTGCGTGGTTTCCTCGAACATGTCACGCTCG
TCATGGATGCCGAGCAGAATGAGGATATGGATGCCGTCAACATCATGACGCTGCATTCGGCCAAGGGGCTGGAGTTTGAA
ACCGTCTTCCTTCCCGGCTGGGAGGAAGGCCTGTTTCCACACCAGCGCGCGCTTGATGAAGGCGGACGTTCGGGGCTGGA
GGAAGAGCGCCGCCTCGCCTATGTCGGCGTCACCCGCGCCAAGAAAAACCTGCATATCTGGTTCGTGTCCAACCGCCGCA
TCCACGGCATGTGGCAATCGACCATCCCGTCGCGCTTTCTGGAAGAGCTTCCCGAAGCACATGTGGAGGTGGCCGAACTG
GAAGGTAATTATGGTGGTTATGGCGGCGGCTATGGACAGTCCCGTTTCGACAAGGCCGACCCCTTCCAGAACTCCTATTC
CACACCCGGCTGGCAGCGTGCGCAGCAGAACCGTTCGGATGCAACGCGCAACAACTGGGGTTCGCGCTCGGGCAGCCGCG
TGGAGCGCATTGGCTATGGCGAGACCGATTCCGGCTTCGGTGCGGGGCGTGGATCGGTAAAAGGCCGCACGATTGAAGGC
GAACTGGTGGCAAAATCAGTGGCCGACAAACCATCGGCCTTCAAGCTTGGCGACCGCGTATTCCATATCAAATTCGGAAA
CGGCACGATTTCGCTTATCGACGGCAACAAGCTGACGATCAATTTCGACAAGGCCGGACAAAAGCGCGTTCTCGATAGTT
TCGTCCAGCCGATCTAA

Upstream 100 bases:

>100_bases
CGGCTGAACTTCACCGACCGGCGCGTTACGCAATTAGAGTAGTCGAATATTTTAACCCTTTCGCTGGTCTTTCAGCCACG
AATCATTACATTCGGGCGAG

Downstream 100 bases:

>100_bases
AGAGGGTGAAGCGCCGGAATGCAGGCAAATTGCTCTTTGCAGCCCGGCCTCATGAAGAATGCAACAGGAATGTTTATTCC
GGCTTGCCATTCTGCCAGGT

Product: ATP-dependent DNA helicase PcrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 858; Mature: 857

Protein sequence:

>858_residues
MSDFPDDMPFFGDDDAPAGRAPAPGSIAARAMAARNQQHGEPDYLKGLNPKQKQAVLTTEGPVLVLAGAGTGKTRVLTTR
IAHILSTGLAYPSQILAVTFTNKAAREMKERIGHLVGGAVEGMPWLGTFHSIGVKLLRRHAELVNLTSSFTILDTDDVIR
LIKQLIQAEGLDDKRWPARTFANMIDGWKNKGFSPADIPEGDARSFGNGRGRELYQAYQERLRTLNACDFGDLLLHPIRI
FRNHPDILREYHAKFRYILVDEYQDTNTAQYLWLRLLAQRPKSRTTAPTQAGGSPVQPARASEGPCGAGERSELGVSEDK
VNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAVVIKLERNYRSTAHILGTAAHLIAHNEGRLGKTLFTEAPNPDDPRV
KVHAAWDSEEEARAVGEAIEQAQRQGHLLNNMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYLRVV
AQPADDLALERIINTPKRGLGEAAIRQIHDYARARDISMFAAACDLIETEELKPKPRSALREVVENFLRWQSLIDTTPHT
ELAETILDESGYTAMWQNDKSAEAPGRLENLKELIRSMEEYESLRGFLEHVTLVMDAEQNEDMDAVNIMTLHSAKGLEFE
TVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGVTRAKKNLHIWFVSNRRIHGMWQSTIPSRFLEELPEAHVEVAEL
EGNYGGYGGGYGQSRFDKADPFQNSYSTPGWQRAQQNRSDATRNNWGSRSGSRVERIGYGETDSGFGAGRGSVKGRTIEG
ELVAKSVADKPSAFKLGDRVFHIKFGNGTISLIDGNKLTINFDKAGQKRVLDSFVQPI

Sequences:

>Translated_858_residues
MSDFPDDMPFFGDDDAPAGRAPAPGSIAARAMAARNQQHGEPDYLKGLNPKQKQAVLTTEGPVLVLAGAGTGKTRVLTTR
IAHILSTGLAYPSQILAVTFTNKAAREMKERIGHLVGGAVEGMPWLGTFHSIGVKLLRRHAELVNLTSSFTILDTDDVIR
LIKQLIQAEGLDDKRWPARTFANMIDGWKNKGFSPADIPEGDARSFGNGRGRELYQAYQERLRTLNACDFGDLLLHPIRI
FRNHPDILREYHAKFRYILVDEYQDTNTAQYLWLRLLAQRPKSRTTAPTQAGGSPVQPARASEGPCGAGERSELGVSEDK
VNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAVVIKLERNYRSTAHILGTAAHLIAHNEGRLGKTLFTEAPNPDDPRV
KVHAAWDSEEEARAVGEAIEQAQRQGHLLNNMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYLRVV
AQPADDLALERIINTPKRGLGEAAIRQIHDYARARDISMFAAACDLIETEELKPKPRSALREVVENFLRWQSLIDTTPHT
ELAETILDESGYTAMWQNDKSAEAPGRLENLKELIRSMEEYESLRGFLEHVTLVMDAEQNEDMDAVNIMTLHSAKGLEFE
TVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGVTRAKKNLHIWFVSNRRIHGMWQSTIPSRFLEELPEAHVEVAEL
EGNYGGYGGGYGQSRFDKADPFQNSYSTPGWQRAQQNRSDATRNNWGSRSGSRVERIGYGETDSGFGAGRGSVKGRTIEG
ELVAKSVADKPSAFKLGDRVFHIKFGNGTISLIDGNKLTINFDKAGQKRVLDSFVQPI
>Mature_857_residues
SDFPDDMPFFGDDDAPAGRAPAPGSIAARAMAARNQQHGEPDYLKGLNPKQKQAVLTTEGPVLVLAGAGTGKTRVLTTRI
AHILSTGLAYPSQILAVTFTNKAAREMKERIGHLVGGAVEGMPWLGTFHSIGVKLLRRHAELVNLTSSFTILDTDDVIRL
IKQLIQAEGLDDKRWPARTFANMIDGWKNKGFSPADIPEGDARSFGNGRGRELYQAYQERLRTLNACDFGDLLLHPIRIF
RNHPDILREYHAKFRYILVDEYQDTNTAQYLWLRLLAQRPKSRTTAPTQAGGSPVQPARASEGPCGAGERSELGVSEDKV
NLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAVVIKLERNYRSTAHILGTAAHLIAHNEGRLGKTLFTEAPNPDDPRVK
VHAAWDSEEEARAVGEAIEQAQRQGHLLNNMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYLRVVA
QPADDLALERIINTPKRGLGEAAIRQIHDYARARDISMFAAACDLIETEELKPKPRSALREVVENFLRWQSLIDTTPHTE
LAETILDESGYTAMWQNDKSAEAPGRLENLKELIRSMEEYESLRGFLEHVTLVMDAEQNEDMDAVNIMTLHSAKGLEFET
VFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGVTRAKKNLHIWFVSNRRIHGMWQSTIPSRFLEELPEAHVEVAELE
GNYGGYGGGYGQSRFDKADPFQNSYSTPGWQRAQQNRSDATRNNWGSRSGSRVERIGYGETDSGFGAGRGSVKGRTIEGE
LVAKSVADKPSAFKLGDRVFHIKFGNGTISLIDGNKLTINFDKAGQKRVLDSFVQPI

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=690, Percent_Identity=42.1739130434783, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI48994965, Length=686, Percent_Identity=37.3177842565598, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1787196, Length=380, Percent_Identity=26.8421052631579, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322369, Length=787, Percent_Identity=27.0648030495553, Blast_Score=186, Evalue=9e-48,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 95726; Mature: 95595

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFPDDMPFFGDDDAPAGRAPAPGSIAARAMAARNQQHGEPDYLKGLNPKQKQAVLTTE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCHHCEEEECC
GPVLVLAGAGTGKTRVLTTRIAHILSTGLAYPSQILAVTFTNKAAREMKERIGHLVGGAV
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHH
EGMPWLGTFHSIGVKLLRRHAELVNLTSSFTILDTDDVIRLIKQLIQAEGLDDKRWPART
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCCHHHH
FANMIDGWKNKGFSPADIPEGDARSFGNGRGRELYQAYQERLRTLNACDFGDLLLHPIRI
HHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FRNHPDILREYHAKFRYILVDEYQDTNTAQYLWLRLLAQRPKSRTTAPTQAGGSPVQPAR
HCCCHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
ASEGPCGAGERSELGVSEDKVNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAVVIKLE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEE
RNYRSTAHILGTAAHLIAHNEGRLGKTLFTEAPNPDDPRVKVHAAWDSEEEARAVGEAIE
CCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
QAQRQGHLLNNMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYLRVV
HHHHCCHHHHCEEEEEECHHHHHHHCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHH
AQPADDLALERIINTPKRGLGEAAIRQIHDYARARDISMFAAACDLIETEELKPKPRSAL
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
REVVENFLRWQSLIDTTPHTELAETILDESGYTAMWQNDKSAEAPGRLENLKELIRSMEE
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
YESLRGFLEHVTLVMDAEQNEDMDAVNIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDE
HHHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHH
GGRSGLEEERRLAYVGVTRAKKNLHIWFVSNRRIHGMWQSTIPSRFLEELPEAHVEVAEL
CCCCCCHHHHHEEEEEEEECCCCEEEEEEECCEEECHHHHHHHHHHHHHCCHHHEEEEEE
EGNYGGYGGGYGQSRFDKADPFQNSYSTPGWQRAQQNRSDATRNNWGSRSGSRVERIGYG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCCCCCCCHHHCCCC
ETDSGFGAGRGSVKGRTIEGELVAKSVADKPSAFKLGDRVFHIKFGNGTISLIDGNKLTI
CCCCCCCCCCCCCCCCEECHHHHHHHHCCCCCCEECCCEEEEEEECCCEEEEEECCEEEE
NFDKAGQKRVLDSFVQPI
EECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDFPDDMPFFGDDDAPAGRAPAPGSIAARAMAARNQQHGEPDYLKGLNPKQKQAVLTTE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCHHCEEEECC
GPVLVLAGAGTGKTRVLTTRIAHILSTGLAYPSQILAVTFTNKAAREMKERIGHLVGGAV
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHH
EGMPWLGTFHSIGVKLLRRHAELVNLTSSFTILDTDDVIRLIKQLIQAEGLDDKRWPART
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCCHHHH
FANMIDGWKNKGFSPADIPEGDARSFGNGRGRELYQAYQERLRTLNACDFGDLLLHPIRI
HHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FRNHPDILREYHAKFRYILVDEYQDTNTAQYLWLRLLAQRPKSRTTAPTQAGGSPVQPAR
HCCCHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
ASEGPCGAGERSELGVSEDKVNLCCVGDDDQSIYGWRGAEVDNILRFEKDFPGAVVIKLE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEE
RNYRSTAHILGTAAHLIAHNEGRLGKTLFTEAPNPDDPRVKVHAAWDSEEEARAVGEAIE
CCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
QAQRQGHLLNNMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYLRVV
HHHHCCHHHHCEEEEEECHHHHHHHCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHH
AQPADDLALERIINTPKRGLGEAAIRQIHDYARARDISMFAAACDLIETEELKPKPRSAL
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
REVVENFLRWQSLIDTTPHTELAETILDESGYTAMWQNDKSAEAPGRLENLKELIRSMEE
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
YESLRGFLEHVTLVMDAEQNEDMDAVNIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDE
HHHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHH
GGRSGLEEERRLAYVGVTRAKKNLHIWFVSNRRIHGMWQSTIPSRFLEELPEAHVEVAEL
CCCCCCHHHHHEEEEEEEECCCCEEEEEEECCEEECHHHHHHHHHHHHHCCHHHEEEEEE
EGNYGGYGGGYGQSRFDKADPFQNSYSTPGWQRAQQNRSDATRNNWGSRSGSRVERIGYG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCCCCCCCHHHCCCC
ETDSGFGAGRGSVKGRTIEGELVAKSVADKPSAFKLGDRVFHIKFGNGTISLIDGNKLTI
CCCCCCCCCCCCCCCCEECHHHHHHHHCCCCCCEECCCEEEEEEECCCEEEEEECCEEEE
NFDKAGQKRVLDSFVQPI
EECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA