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The map label for this gene is cobH [H]

Identifier: 225852779

GI number: 225852779

Start: 1268316

End: 1268942

Strand: Direct

Name: cobH [H]

Synonym: BMEA_A1334

Alternate gene names: 225852779

Gene position: 1268316-1268942 (Clockwise)

Preceding gene: 225852778

Following gene: 225852780

Centisome position: 59.67

GC content: 62.04

Gene sequence:

>627_bases
ATGACAGACTATATCCGTGACGGACAGGCCATTTACGACCGATCCTTCGCTATTATCCGCGCCGAAGCCGATCTCCGTCA
CATTCCAGCCGATCTTGAAAAGCTTGCCGTTCGCGTGATTCACGCCTGCGGCATGGTGGATGTGGCAAACGATCTTGCCT
TCTCGGAAGGTGCAGGCAAAGCCGGGCGCAATGCTCTTCTGGCAGGCGCGCCGATCCTCTGCGATGCGCGCATGGTGGCC
GAAGGCATCACCCGCTCGCGCCTTCCCGCCGATAATCGCGTGATCTACACCCTGGGCGACCCATCCGTGCCGGAACTTGC
AAAAAAGATCGGCAACACCCGCTCCGCAGCCGCGCTTGATCTCTGGCTCCCGCATATTGAAGGCAGCATTGTCGCCATCG
GCAATGCGCCGACCGCCCTCTTCCGCCTGTTCGAGCTTCTCGATGCAGGGGCACCGAAGCCCGCACTTATCATTGGAATG
CCGGTGGGCTTTGTGGGAGCGGCGGAATCGAAGGACGAGCTTGCCGCCAACAGCCGCGGCGTGCCTTACGTGATCGTGCG
CGGGCGACGCGGCGGCAGCGCCATGACGGCAGCCGCGGTCAACGCGCTTGCTTCGGAGCGTGAATAA

Upstream 100 bases:

>100_bases
CGGGGCTGGACCATCGCGGTTCGGACAGCTATTGGCGTCGGATATCACCCTTGAGGAAGCGGCGCATATTCTGAACGCCC
GACATCAATAAGAGCGGCCC

Downstream 100 bases:

>100_bases
TGGCGGCGAAAGGCAGATTGTTCGGCCTGGGCGTCGGCCCCGGCGACCCCGAACTGATTACTCTGAAAGCCCTGCGGCTC
CTCAAATCCGCACCGGTCGT

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTDYIRDGQAIYDRSFAIIRAEADLRHIPADLEKLAVRVIHACGMVDVANDLAFSEGAGKAGRNALLAGAPILCDARMVA
EGITRSRLPADNRVIYTLGDPSVPELAKKIGNTRSAAALDLWLPHIEGSIVAIGNAPTALFRLFELLDAGAPKPALIIGM
PVGFVGAAESKDELAANSRGVPYVIVRGRRGGSAMTAAAVNALASERE

Sequences:

>Translated_208_residues
MTDYIRDGQAIYDRSFAIIRAEADLRHIPADLEKLAVRVIHACGMVDVANDLAFSEGAGKAGRNALLAGAPILCDARMVA
EGITRSRLPADNRVIYTLGDPSVPELAKKIGNTRSAAALDLWLPHIEGSIVAIGNAPTALFRLFELLDAGAPKPALIIGM
PVGFVGAAESKDELAANSRGVPYVIVRGRRGGSAMTAAAVNALASERE
>Mature_207_residues
TDYIRDGQAIYDRSFAIIRAEADLRHIPADLEKLAVRVIHACGMVDVANDLAFSEGAGKAGRNALLAGAPILCDARMVAE
GITRSRLPADNRVIYTLGDPSVPELAKKIGNTRSAAALDLWLPHIEGSIVAIGNAPTALFRLFELLDAGAPKPALIIGMP
VGFVGAAESKDELAANSRGVPYVIVRGRRGGSAMTAAAVNALASERE

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 21855; Mature: 21724

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYIRDGQAIYDRSFAIIRAEADLRHIPADLEKLAVRVIHACGMVDVANDLAFSEGAGK
CCCCCCCCCHHHCCCEEEEEECCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
AGRNALLAGAPILCDARMVAEGITRSRLPADNRVIYTLGDPSVPELAKKIGNTRSAAALD
CCCCEEEECCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCHHHE
LWLPHIEGSIVAIGNAPTALFRLFELLDAGAPKPALIIGMPVGFVGAAESKDELAANSRG
EECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHCCCC
VPYVIVRGRRGGSAMTAAAVNALASERE
CCEEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDYIRDGQAIYDRSFAIIRAEADLRHIPADLEKLAVRVIHACGMVDVANDLAFSEGAGK
CCCCCCCCHHHCCCEEEEEECCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
AGRNALLAGAPILCDARMVAEGITRSRLPADNRVIYTLGDPSVPELAKKIGNTRSAAALD
CCCCEEEECCCCEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCHHHE
LWLPHIEGSIVAIGNAPTALFRLFELLDAGAPKPALIIGMPVGFVGAAESKDELAANSRG
EECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHCCCC
VPYVIVRGRRGGSAMTAAAVNALASERE
CCEEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]