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The map label for this gene is uppS

Identifier: 225852655

GI number: 225852655

Start: 1157355

End: 1158119

Strand: Reverse

Name: uppS

Synonym: BMEA_A1201

Alternate gene names: 225852655

Gene position: 1158119-1157355 (Counterclockwise)

Preceding gene: 225852656

Following gene: 225852654

Centisome position: 54.48

GC content: 59.74

Gene sequence:

>765_bases
ATGTCCGATCCGCGCCACATAGCCATTATCATGGATGGCAACGGCCGTTGGGCTAAGGCGCGCGGCTTGCCGCGCAGCGC
GGGGCACCGCGCGGGCGTGGAGGCCTTGCGGGAGATCGTGCGGGCCGCGGGAGATCGCGGCCTCGGCTATCTTACGCTTT
TTGCTTTCTCTTCCGAAAACTGGACCCGTCCGAGCGGCGAGGTCAGCGATCTTCTGGGGCTTTTGAAGCTCTTCATCCGG
CGCGATCTGGCAGAGCTTCACCGCAACAATGTGCGTGTCAATATTATCGGCGAGCGGGCGGAGCTCGCAGCCAATATCCG
TGCACTGTTGAACGAAGCGGAATCGCTTACCCATCGCAATACCGGCCTCAATCTCGTGATTGCCTTCAATTACGGTTCAC
GCGATGAGATTGTTCGTGCGGTCAGAAGCCTTGCGCGCGATGTCGCCGCCGGGCTTCTTGATCCATCCTCGATCTCGGCG
GAGCTTGTTTCCGCTAATCTTGATACGGCGGGAATACCTGATCCCGACCTCATCATCCGCACCAGTGGCGAGATGCGGCT
TTCCAACTTTCTTCTCTGGCAGGCTGCCTATTCCGAGTTTCTCTTTCTGCCATGTCACTGGCCGGATTTCCGGCCGGCCG
ACCTTGATGCGGCCTATGAAACGTTCCGGCAGCGCGAGCGTCGTTTTGGCGGTGTGGAGCCGCGCGCCAGTGCGGATGCC
GAAGAAGAAATATTATGCCCTTCGACCAAGGGAGCGGCAGTCTAG

Upstream 100 bases:

>100_bases
TCGCCGAGATGGATAAGATCGTTGCTGTCAAGGAGGGGGAGATCATGCAGGTTTAGGCCCTGGGCCTGGCATTGCATGAT
TTTAAAAGGAGAGCTGCGCC

Downstream 100 bases:

>100_bases
AGTGGTTCCCGTTTTAACAGAATCGCCGGAACCGCTCTCAGTGATGCGAATTTCAGATAAGCCATACTAGCGCGCTATAA
GTGTCGTTCCGCCGAAAGGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSENWTRPSGEVSDLLGLLKLFIR
RDLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRNTGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISA
ELVSANLDTAGIPDPDLIIRTSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADA
EEEILCPSTKGAAV

Sequences:

>Translated_254_residues
MSDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSENWTRPSGEVSDLLGLLKLFIR
RDLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRNTGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISA
ELVSANLDTAGIPDPDLIIRTSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADA
EEEILCPSTKGAAV
>Mature_253_residues
SDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSENWTRPSGEVSDLLGLLKLFIRR
DLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRNTGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISAE
LVSANLDTAGIPDPDLIIRTSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADAE
EEILCPSTKGAAV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=39.4618834080717, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=39.4618834080717, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=48.2608695652174, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=34.6491228070175, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=36.2790697674419, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=29.7674418604651, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18857969, Length=208, Percent_Identity=38.4615384615385, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_BRUAB (Q57CY1)

Other databases:

- EMBL:   AE017223
- RefSeq:   YP_221864.1
- ProteinModelPortal:   Q57CY1
- SMR:   Q57CY1
- GeneID:   3339838
- GenomeReviews:   AE017223_GR
- KEGG:   bmb:BruAb1_1164
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q57CY1
- ProtClustDB:   PRK14834
- BioCyc:   BABO262698:BRUAB1_1164-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28005; Mature: 27874

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSEN
CCCCEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
WTRPSGEVSDLLGLLKLFIRRDLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
TGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISAELVSANLDTAGIPDPDLIIR
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
TSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADA
CCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
EEEILCPSTKGAAV
CCCEECCCCCCCCC
>Mature Secondary Structure 
SDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSEN
CCCEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
WTRPSGEVSDLLGLLKLFIRRDLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
TGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISAELVSANLDTAGIPDPDLIIR
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEE
TSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADA
CCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
EEEILCPSTKGAAV
CCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA