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The map label for this gene is gltA [H]

Identifier: 225852646

GI number: 225852646

Start: 1146599

End: 1147891

Strand: Direct

Name: gltA [H]

Synonym: BMEA_A1192

Alternate gene names: 225852646

Gene position: 1146599-1147891 (Clockwise)

Preceding gene: 225852645

Following gene: 225852662

Centisome position: 53.94

GC content: 57.31

Gene sequence:

>1293_bases
ATGTCAGATAAGACAGCCAGCTTTACCCTCGACGGCAAAACGTTCGATCTGCCTGTGCGAAAAGGCACTGTCGGGCCGGA
TGTCGTTGATATTGGTCCACTTTACAAGAATTCCCACGCATTCACCTACGACCCTGGCTTCACTTCCACCGCTTCGTGCG
AATCCAAAATCACCTATATCGATGGTGACGAAGGCGTCCTGCTTTATCGCGGCTACCCGATCGACCAGCTTGCCGAGCAT
GGCGACTTCCTCGAAACCTGCTATCTGCTTCTTTACGGCGAACTGCCGACCGCAACCCAGAAGGCCGATTTCGACTATCG
TGTAACCCGCCACACCATGCTGCACGAGCAGATGACGAAGTTCTTCACCGGCTTCCGTCGTGATGCCCACCCGATGGCTG
TCATGGTGGGTTGCCTGGGCGCCATGTCCGCCTTCTACCACGACTCGACCGATATCACCGATCCGCATCAGCGCATGGTC
GCTTCGATCCGCCTGATCGCCAAGGTGCCGACGCTTGCAGCCATGGCCTACAAGTACCATATCGGCCAGCCGTTCGTATA
TCCGAAGAACGACCTCGATTTCGCGTCGAACTTCCTGCACATGTGCTTCACCGTGCCTTGCGAAGAGTACAAGGTGAACC
CGGTTCTGGCGCGCGCCATGGACCGCATTTTCATCCTGCATGCTGATCACGAACAGAATGCCTCCACCTCGACCGTCCGC
CTCGCCGGCTCGTCGGGTGCAAACCCGTTTGCCTGCATTGCCGCTGGCGTGGCCTGCCTCTGGGGCCCGGCTCATGGCGG
CGCCAATGAAGCTGCGCTCAACATGCTTTCGGAAATCGGCTCGGTTGACCGTATCCCGGAATATATCGCCAGGGCTAAAG
ACAAGAACGATCCGTTCCGTTTGATGGGCTTCGGCCATCGCGTTTACAAGAACTACGATCCGCGCGCCAAGATCATGCAG
AAGACCTGCCATGAAGTCCTCGGCGAGCTGGGCATCAAGGATGATCCGCTGCTTGACGTTGCAATGGAACTGGAAAGGAT
TGCCCTGACCGACGAATATTTCATCGAAAAGAAGCTCTACCCGAACATCGACTTCTATTCGGGCATCACGCTGAAGGCGC
TGGGCTTCCCGACCGAAATGTTCACCGTCCTGTTCGCCCTTGCCCGCACCGTTGGCTGGGTCGCCCAGTGGAAGGAAATG
ATCGAAGATCCGCAGCAGAAAATCGGCCGTCCGCGCCAGCTCTACACCGGCGCAACCGAACGCGATTACGTGCCGCTTGC
AAAGCGCAAGTAA

Upstream 100 bases:

>100_bases
GTTCCATCGGAAACCCCGATCGAAGATAAGAAACAAGTTATAAGACGATTGCAAATTCTGCCGTCGTGCAGGCGGCGAAG
TGGACATGAAAGGAAAAACG

Downstream 100 bases:

>100_bases
CCTTCTGTGTGAGCACAAAAGAAACCCCGGCAGCGAAGGCTGCCGGGGTTTTTCTTTGTCCAGAAAGAGCATCCCTCCCG
AAAGTGGGAACCGGTTTTCG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSDKTASFTLDGKTFDLPVRKGTVGPDVVDIGPLYKNSHAFTYDPGFTSTASCESKITYIDGDEGVLLYRGYPIDQLAEH
GDFLETCYLLLYGELPTATQKADFDYRVTRHTMLHEQMTKFFTGFRRDAHPMAVMVGCLGAMSAFYHDSTDITDPHQRMV
ASIRLIAKVPTLAAMAYKYHIGQPFVYPKNDLDFASNFLHMCFTVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGVACLWGPAHGGANEAALNMLSEIGSVDRIPEYIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQ
KTCHEVLGELGIKDDPLLDVAMELERIALTDEYFIEKKLYPNIDFYSGITLKALGFPTEMFTVLFALARTVGWVAQWKEM
IEDPQQKIGRPRQLYTGATERDYVPLAKRK

Sequences:

>Translated_430_residues
MSDKTASFTLDGKTFDLPVRKGTVGPDVVDIGPLYKNSHAFTYDPGFTSTASCESKITYIDGDEGVLLYRGYPIDQLAEH
GDFLETCYLLLYGELPTATQKADFDYRVTRHTMLHEQMTKFFTGFRRDAHPMAVMVGCLGAMSAFYHDSTDITDPHQRMV
ASIRLIAKVPTLAAMAYKYHIGQPFVYPKNDLDFASNFLHMCFTVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGVACLWGPAHGGANEAALNMLSEIGSVDRIPEYIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQ
KTCHEVLGELGIKDDPLLDVAMELERIALTDEYFIEKKLYPNIDFYSGITLKALGFPTEMFTVLFALARTVGWVAQWKEM
IEDPQQKIGRPRQLYTGATERDYVPLAKRK
>Mature_429_residues
SDKTASFTLDGKTFDLPVRKGTVGPDVVDIGPLYKNSHAFTYDPGFTSTASCESKITYIDGDEGVLLYRGYPIDQLAEHG
DFLETCYLLLYGELPTATQKADFDYRVTRHTMLHEQMTKFFTGFRRDAHPMAVMVGCLGAMSAFYHDSTDITDPHQRMVA
SIRLIAKVPTLAAMAYKYHIGQPFVYPKNDLDFASNFLHMCFTVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGVACLWGPAHGGANEAALNMLSEIGSVDRIPEYIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQK
TCHEVLGELGIKDDPLLDVAMELERIALTDEYFIEKKLYPNIDFYSGITLKALGFPTEMFTVLFALARTVGWVAQWKEMI
EDPQQKIGRPRQLYTGATERDYVPLAKRK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=398, Percent_Identity=26.6331658291457, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786939, Length=430, Percent_Identity=68.8372093023256, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1786527, Length=365, Percent_Identity=30.6849315068493, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555174, Length=385, Percent_Identity=26.7532467532467, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=330, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324328, Length=366, Percent_Identity=25.9562841530055, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325257, Length=363, Percent_Identity=26.1707988980716, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24640124, Length=407, Percent_Identity=26.5356265356265, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24640126, Length=407, Percent_Identity=26.5356265356265, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356863, Length=398, Percent_Identity=25.8793969849246, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48243; Mature: 48112

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKTASFTLDGKTFDLPVRKGTVGPDVVDIGPLYKNSHAFTYDPGFTSTASCESKITYI
CCCCCCEEEECCCEEECCCCCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCCCEEEEE
DGDEGVLLYRGYPIDQLAEHGDFLETCYLLLYGELPTATQKADFDYRVTRHTMLHEQMTK
ECCCCEEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FFTGFRRDAHPMAVMVGCLGAMSAFYHDSTDITDPHQRMVASIRLIAKVPTLAAMAYKYH
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
IGQPFVYPKNDLDFASNFLHMCFTVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGVACLWGPAHGGANEAALNMLSEIGSVDRIPEYIARAKDKNDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
LMGFGHRVYKNYDPRAKIMQKTCHEVLGELGIKDDPLLDVAMELERIALTDEYFIEKKLY
EEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCC
PNIDFYSGITLKALGFPTEMFTVLFALARTVGWVAQWKEMIEDPQQKIGRPRQLYTGATE
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEECCCCCC
RDYVPLAKRK
CCCCCCCCCC
>Mature Secondary Structure 
SDKTASFTLDGKTFDLPVRKGTVGPDVVDIGPLYKNSHAFTYDPGFTSTASCESKITYI
CCCCCEEEECCCEEECCCCCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCCCEEEEE
DGDEGVLLYRGYPIDQLAEHGDFLETCYLLLYGELPTATQKADFDYRVTRHTMLHEQMTK
ECCCCEEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FFTGFRRDAHPMAVMVGCLGAMSAFYHDSTDITDPHQRMVASIRLIAKVPTLAAMAYKYH
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
IGQPFVYPKNDLDFASNFLHMCFTVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGVACLWGPAHGGANEAALNMLSEIGSVDRIPEYIARAKDKNDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
LMGFGHRVYKNYDPRAKIMQKTCHEVLGELGIKDDPLLDVAMELERIALTDEYFIEKKLY
EEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCC
PNIDFYSGITLKALGFPTEMFTVLFALARTVGWVAQWKEMIEDPQQKIGRPRQLYTGATE
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEECCCCCC
RDYVPLAKRK
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8526514 [H]