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The map label for this gene is hisI

Identifier: 225852577

GI number: 225852577

Start: 1065024

End: 1065443

Strand: Direct

Name: hisI

Synonym: BMEA_A1117

Alternate gene names: 225852577

Gene position: 1065024-1065443 (Clockwise)

Preceding gene: 225852576

Following gene: 225852578

Centisome position: 50.1

GC content: 57.38

Gene sequence:

>420_bases
ATGAGCATTTTTCCTGCCCAGCCTTCCGACAAGAAGGCCGTTGAAGAAGGCGCGGCATTCATGCCGCGCTTTGATGCATC
CGGCCTCATTACAGCGATCGTCACTGATGCGCGCGATGGCGAATTGCTGATGGTCGCGCATATGAACGAGGAAGCCCTGC
GCCTTACACTGGAAACCGGCATTGCCCATTATTGGTCGCGCTCGCGCAAGACGCTATGGAAAAAGGGCGAAACCTCCGGC
AACCTGCAAAGCGTGGTCGAATTGCGCACGGATTGCGATCAGGATGCACTCTGGCTGAAAGTGCACGTCGCCGGTGACGG
CCCGACATGCCATACGGGGCGTCGTTCGTGCTTCTATCGTCAGGTCGTTTCGTCGGGTGGCAAGGTGGCGCTGACAATGG
CAAGCGATCACGATCAATAA

Upstream 100 bases:

>100_bases
ATCACCACCACCTTTACCGGCGATTTCAAGGAAAAGGCGGACCAGCAGGTTCGCTTCATGACCCTGATCCGCACTTGAAC
ACAGCATTCAGGCATAGACG

Downstream 100 bases:

>100_bases
TTCCTTTCAAAATGATGTGAAGAGACGAATAAGGCTCGCGTCATCAATTCGCAGTATTTATTGTCTGGATACCAAGTTTC
GCCAAAGCATGTCTCCCAAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MSIFPAQPSDKKAVEEGAAFMPRFDASGLITAIVTDARDGELLMVAHMNEEALRLTLETGIAHYWSRSRKTLWKKGETSG
NLQSVVELRTDCDQDALWLKVHVAGDGPTCHTGRRSCFYRQVVSSGGKVALTMASDHDQ

Sequences:

>Translated_139_residues
MSIFPAQPSDKKAVEEGAAFMPRFDASGLITAIVTDARDGELLMVAHMNEEALRLTLETGIAHYWSRSRKTLWKKGETSG
NLQSVVELRTDCDQDALWLKVHVAGDGPTCHTGRRSCFYRQVVSSGGKVALTMASDHDQ
>Mature_138_residues
SIFPAQPSDKKAVEEGAAFMPRFDASGLITAIVTDARDGELLMVAHMNEEALRLTLETGIAHYWSRSRKTLWKKGETSGN
LQSVVELRTDCDQDALWLKVHVAGDGPTCHTGRRSCFYRQVVSSGGKVALTMASDHDQ

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=49.4505494505495, Blast_Score=92, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=39.5604395604396, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_BRUA1 (B2S5T1)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935002.1
- ProteinModelPortal:   B2S5T1
- SMR:   B2S5T1
- GeneID:   6328567
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I10190
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15280; Mature: 15149

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFPAQPSDKKAVEEGAAFMPRFDASGLITAIVTDARDGELLMVAHMNEEALRLTLETG
CCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEEHHHH
IAHYWSRSRKTLWKKGETSGNLQSVVELRTDCDQDALWLKVHVAGDGPTCHTGRRSCFYR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
QVVSSGGKVALTMASDHDQ
HHHHCCCCEEEEECCCCCC
>Mature Secondary Structure 
SIFPAQPSDKKAVEEGAAFMPRFDASGLITAIVTDARDGELLMVAHMNEEALRLTLETG
CCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEEHHHH
IAHYWSRSRKTLWKKGETSGNLQSVVELRTDCDQDALWLKVHVAGDGPTCHTGRRSCFYR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
QVVSSGGKVALTMASDHDQ
HHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA