Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 225852556

GI number: 225852556

Start: 1041418

End: 1042446

Strand: Direct

Name: cysK [H]

Synonym: BMEA_A1094

Alternate gene names: 225852556

Gene position: 1041418-1042446 (Clockwise)

Preceding gene: 225852555

Following gene: 225852557

Centisome position: 48.99

GC content: 58.02

Gene sequence:

>1029_bases
ATGTTCAATTCGGTACTCGACACAATCGGCAACACGCCGTTGATCCGCCTCAGCAAGGCTTCCGAGCTCACAGGATGCGA
TATTTACGGGAAAGCAGAGTTTCTCAATCCGGGCCAGTCGGTCAAGGACCGTGCGGCGCTCTACATTATCCGCGATGCGG
AAAAACGCGGGCTTTTGCGGCCCGGAGGCGTGATTGTGGAAGGAACCGCGGGCAATACCGGCATTGGCCTCACGATGGTC
GCCAAGGCATTGGGCTACCGCACGGCGATCGTGATTCCTGAAACGCAGAGCCAGGAAAAAAAGGAAGCCTTGCGCCTGCT
CGGTGCAGAGCTGATCGAGGTTCCCGCCGCCCCCTATCGCAACCCGAACAATTATGTGCGCCTTTCAGGGCGTCTTGCCG
AGCAACTGGCCAAAACCGAGCCGAATGGCGCAATATGGGCCAATCAGTTCGACAATACGGTCAACCGGCAAGCCCATATC
GAGACCACGGCGCAGGAAATCTGGCGCGATACAAGCGACCAGATCGATGGTTTTGTGGCCGCTGTGGGATCTGGCGGTAC
GCTTGCCGGAACGGCGATTGGCCTGAAGGAACGGAACCACAATATCAAAATTGCTCTGGCGGACCCGCATGGCGCGGCGC
TTCACGCCTTCTATACGACCGGCGAATTGAAGGCAGAAGGCGATTCGATCACCGAAGGCATCGGGCAGGGGCGCATCACC
GCCAATCTTGAAGGCTTCACCCCTGATTTTTCCTACCAGATTCCCGATGCGGAGGCGCTCGATATCCTGTTTGCCCTCGT
GGAAGAGGAGGGGCTTTGCCTCGGCGGCTCGTCCGGCATCAACATTGCCGGTGCAATCCGGCTTGCAAAAGATCTCGGGC
CGGGCCACACAATTGTGACCGTGCTTTGTGACTACGGTAATCGTTACCAGTCAAAGCTGTTCAATCCCGCCTTCCTCCGC
GGCAAGAGCCTGCCCGTGCCGCGCTGGCTGGAGAAGAAAACCGAAATAGACATACCGTTCGAGGGGTAA

Upstream 100 bases:

>100_bases
AGTTTCAGTTTGCCCTTTGGCGTGGAAAATTATTCCATACTTGCTTGAAGGGCAGGGCGCTTCCCCATAACTTCGCCTTC
AAACAGAAAGGACGGAAGCC

Downstream 100 bases:

>100_bases
TCATGGCATACGAGACTGAGGCGCTTTTTCGCGAAGATTCCTATCTTTCAACTGCGGAGGGCACAGTTCTCGCCATCGCC
GGAAATGGCGGCATTATCCT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MFNSVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRPGGVIVEGTAGNTGIGLTMV
AKALGYRTAIVIPETQSQEKKEALRLLGAELIEVPAAPYRNPNNYVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHI
ETTAQEIWRDTSDQIDGFVAAVGSGGTLAGTAIGLKERNHNIKIALADPHGAALHAFYTTGELKAEGDSITEGIGQGRIT
ANLEGFTPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIAGAIRLAKDLGPGHTIVTVLCDYGNRYQSKLFNPAFLR
GKSLPVPRWLEKKTEIDIPFEG

Sequences:

>Translated_342_residues
MFNSVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRPGGVIVEGTAGNTGIGLTMV
AKALGYRTAIVIPETQSQEKKEALRLLGAELIEVPAAPYRNPNNYVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHI
ETTAQEIWRDTSDQIDGFVAAVGSGGTLAGTAIGLKERNHNIKIALADPHGAALHAFYTTGELKAEGDSITEGIGQGRIT
ANLEGFTPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIAGAIRLAKDLGPGHTIVTVLCDYGNRYQSKLFNPAFLR
GKSLPVPRWLEKKTEIDIPFEG
>Mature_342_residues
MFNSVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRPGGVIVEGTAGNTGIGLTMV
AKALGYRTAIVIPETQSQEKKEALRLLGAELIEVPAAPYRNPNNYVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHI
ETTAQEIWRDTSDQIDGFVAAVGSGGTLAGTAIGLKERNHNIKIALADPHGAALHAFYTTGELKAEGDSITEGIGQGRIT
ANLEGFTPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIAGAIRLAKDLGPGHTIVTVLCDYGNRYQSKLFNPAFLR
GKSLPVPRWLEKKTEIDIPFEG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=325, Percent_Identity=37.2307692307692, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI295821200, Length=325, Percent_Identity=37.2307692307692, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4557415, Length=325, Percent_Identity=37.2307692307692, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI11345492, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI2367138, Length=317, Percent_Identity=35.6466876971609, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=38.6075949367089, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=35.5048859934853, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562970, Length=305, Percent_Identity=36.3934426229508, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=36.3934426229508, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17534315, Length=332, Percent_Identity=35.2409638554217, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=334, Percent_Identity=33.8323353293413, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=35.0819672131148, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17561720, Length=324, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=31.5068493150685, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=364, Percent_Identity=24.4505494505494, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=39.4578313253012, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321594, Length=334, Percent_Identity=33.8323353293413, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24643623, Length=327, Percent_Identity=35.7798165137615, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129101, Length=327, Percent_Identity=35.7798165137615, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36715; Mature: 36715

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNSVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLR
CCHHHHHHHCCCCEEEEECCCCCCCCEEECCCEECCCCCCCCCCEEEEEEEEHHHCCCCC
PGGVIVEGTAGNTGIGLTMVAKALGYRTAIVIPETQSQEKKEALRLLGAELIEVPAAPYR
CCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
NPNNYVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHIETTAQEIWRDTSDQIDGFVA
CCCCEEEECHHHHHHHHHCCCCCCEECCCCCCCCCCEEEHHHHHHHHHCCCHHHHCEEEE
AVGSGGTLAGTAIGLKERNHNIKIALADPHGAALHAFYTTGELKAEGDSITEGIGQGRIT
EECCCCEEEEEEEEEEECCCEEEEEEECCCCCEEEEEEECCEEEECCCHHHHCCCCCEEE
ANLEGFTPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIAGAIRLAKDLGPGHTIVT
EEECCCCCCCCEECCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHEEEHHHCCCCCEEEE
VLCDYGNRYQSKLFNPAFLRGKSLPVPRWLEKKTEIDIPFEG
EEECCCCHHHHHCCCHHHHCCCCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFNSVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLR
CCHHHHHHHCCCCEEEEECCCCCCCCEEECCCEECCCCCCCCCCEEEEEEEEHHHCCCCC
PGGVIVEGTAGNTGIGLTMVAKALGYRTAIVIPETQSQEKKEALRLLGAELIEVPAAPYR
CCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
NPNNYVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHIETTAQEIWRDTSDQIDGFVA
CCCCEEEECHHHHHHHHHCCCCCCEECCCCCCCCCCEEEHHHHHHHHHCCCHHHHCEEEE
AVGSGGTLAGTAIGLKERNHNIKIALADPHGAALHAFYTTGELKAEGDSITEGIGQGRIT
EECCCCEEEEEEEEEEECCCEEEEEEECCCCCEEEEEEECCEEEECCCHHHHCCCCCEEE
ANLEGFTPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIAGAIRLAKDLGPGHTIVT
EEECCCCCCCCEECCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHEEEHHHCCCCCEEEE
VLCDYGNRYQSKLFNPAFLRGKSLPVPRWLEKKTEIDIPFEG
EEECCCCHHHHHCCCHHHHCCCCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]