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The map label for this gene is mce [H]

Identifier: 225852334

GI number: 225852334

Start: 818318

End: 818722

Strand: Direct

Name: mce [H]

Synonym: BMEA_A0860

Alternate gene names: 225852334

Gene position: 818318-818722 (Clockwise)

Preceding gene: 225852333

Following gene: 225852335

Centisome position: 38.5

GC content: 57.28

Gene sequence:

>405_bases
ATGCTTGAACGCTTGAACCATGTGGCGATAGCCGTTCCCGATCTTGAAGCCGCAACCGCGCTTTATCGCGGTAAGCTTGG
CGCCACGGTCACAGAGCCGGAGGCTCTGCCGGAACATGGCGTAACGGTGGTTTTCATAGACGTCGGCAATACCAAGATCG
AACTTCTGGAACCTCTGGGCGAGGGCTCGCCGATTGCTGCCTTTCTTGAGAAGAACCCTTCGGGCGGCATGCATCATCTG
TGCTATGAGGTTGCCGATATCATCGCCGCGCGCGATCGTCTCAAGGCGGAAGGCGCCCGCATTCTTGGCAATGGCGAGCC
GAAGATTGGCGCGCATGGCAAGCCGGTTCTGTTTTTGCATCCCAAGGATTTCAACGGCACGCTGATCGAACTCGAAGAGG
TCTGA

Upstream 100 bases:

>100_bases
GGCAAATGAAGCCTGGGGCAAAAAGCCGGTAGTGACCGTCTTCGTGAATAGGATACGGTAATCCTGCGAAATTGCGAACT
GACTGGCATGGGAGGTGCTT

Downstream 100 bases:

>100_bases
TCATGTCTCTCTTTTCCGGCATTGCGATCTATTTCATCATCTGGTGGACAGCACTTTTTGCGCTGCTGCCTTTTGGTTTG
CGCACGCAGGCCGAGGAAAA

Product: methylmalonyl-CoA epimerase

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MLERLNHVAIAVPDLEAATALYRGKLGATVTEPEALPEHGVTVVFIDVGNTKIELLEPLGEGSPIAAFLEKNPSGGMHHL
CYEVADIIAARDRLKAEGARILGNGEPKIGAHGKPVLFLHPKDFNGTLIELEEV

Sequences:

>Translated_134_residues
MLERLNHVAIAVPDLEAATALYRGKLGATVTEPEALPEHGVTVVFIDVGNTKIELLEPLGEGSPIAAFLEKNPSGGMHHL
CYEVADIIAARDRLKAEGARILGNGEPKIGAHGKPVLFLHPKDFNGTLIELEEV
>Mature_134_residues
MLERLNHVAIAVPDLEAATALYRGKLGATVTEPEALPEHGVTVVFIDVGNTKIELLEPLGEGSPIAAFLEKNPSGGMHHL
CYEVADIIAARDRLKAEGARILGNGEPKIGAHGKPVLFLHPKDFNGTLIELEEV

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI188035928, Length=132, Percent_Identity=64.3939393939394, Blast_Score=166, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17506387, Length=133, Percent_Identity=59.3984962406015, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR018146
- InterPro:   IPR017515 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 14336; Mature: 14336

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLNHVAIAVPDLEAATALYRGKLGATVTEPEALPEHGVTVVFIDVGNTKIELLEPLG
CCCCCCEEEEEECCCHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCEEEEEECCC
EGSPIAAFLEKNPSGGMHHLCYEVADIIAARDRLKAEGARILGNGEPKIGAHGKPVLFLH
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEC
PKDFNGTLIELEEV
CCCCCCEEEEEECC
>Mature Secondary Structure
MLERLNHVAIAVPDLEAATALYRGKLGATVTEPEALPEHGVTVVFIDVGNTKIELLEPLG
CCCCCCEEEEEECCCHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCEEEEEECCC
EGSPIAAFLEKNPSGGMHHLCYEVADIIAARDRLKAEGARILGNGEPKIGAHGKPVLFLH
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEC
PKDFNGTLIELEEV
CCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]