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The map label for this gene is nuoD [H]

Identifier: 225852321

GI number: 225852321

Start: 802516

End: 803706

Strand: Direct

Name: nuoD [H]

Synonym: BMEA_A0847

Alternate gene names: 225852321

Gene position: 802516-803706 (Clockwise)

Preceding gene: 225852320

Following gene: 225852322

Centisome position: 37.75

GC content: 58.02

Gene sequence:

>1191_bases
ATGGCTGAGACTCAGGTCCGCAATTTCAATATCAACTTCGGCCCGCAGCATCCTGCCGCGCACGGCGTGTTGCGTCTGGT
GCTGGAGCTTGACGGCGAAGTGGTCGAGCGCGTCGATCCGCATATCGGTCTGCTGCATCGCGGCACCGAAAAGCTGATGG
AAGCCAAGACCTATCTTCAGGCTGTGCCTTATCTCGACCGCCTCGACTATGTGGCGCCGATGAATCAGGAACATGCCTAT
GCGCTTGCCGTCGAACGTCTTCTGGATATCGAAGTGCCGAAGCGCGGCCAGCTAATCCGCGTTCTCTATTCGGAAATCGG
CCGTATCCTGAACCACCTTCTCAACGTGACCACGCAGGCCATGGACGTCGGCGCGCTGACGCCGCCGCTTTGGGGCTTCG
AGGAGCGTGAAAAGCTGATGGTGTTTTATGAGCGCGCCTGCGGCGCGCGTATGCACGCAGCCTATTTCCGTCCGGGCGGT
GTTCACCAGGACCTGCCGGACCAGTTGATCGAAGATATCGGCAAATGGATCGATCCATTCTTCACGACGTTGAAGAATCT
CGATGATCTCATCACGCCGAACCGCATTTTCAAGCAGCGTAACGTCGATATCGGCGTTGTGAAGCTGGAAGACGCATGGG
CATGGGGCTTCTCCGGCGTCATGGTTCGCGGTTCGGGCGCTGCATGGGATCTGCGCAAGTCGCAGCCCTACGAGTGCTAT
AGCGAGATGGAATTCGACATTCCGGTCGGCAAGAACGGCGATTGCTATGATCGCTATCTGATCCGCATGGAAGAAATGCG
CCAGTCGGCGCGTATCATGCGCCAGTGCGTTGATCTGCTTCTGGGCAAGGAGCGTGTCGGCCCCGTTTCCAATACGGATC
ACAAGATCGTGCCGCCCAAGCGCGGCGAGATGAAGCGCTCGATGGAGGCGCTCATCCATCACTTCAAGCTTTACACGGAA
GGCTACCACGTGCCTGCCGGTGAAGTTTATGCGGCAGTGGAAGCCCCGAAGGGCGAGTTTGGCGTCTATCTGGTTTCGGA
TGGCTCCAACAAGCCTTATCGCTGCAAGCTGCGCGCTCCGGGCTTTGCCCATCTTCAAGCCATGGATTTCCTTTGCCGGG
GCCACATGCTGGCCGACGTTTCGGCAATTCTTGGCTCGCTCGATATCGTGTTTGGTGAGGTTGACCGCTGA

Upstream 100 bases:

>100_bases
AATTCCGCAATTTCGATTTTCTCTCGCCGTGGGAAGGAACGGATTACGTTCTGCCCGGTGATGAGAAAGCAAAGACGAAC
TGAGCGACAGGAAGCTGAAC

Downstream 100 bases:

>100_bases
TGTCCGTTCGCCGTCTCGCAGATGATGCCGTCCAGCCAGCCACTTTCGCGTTTAACGCGGAAAATGAGGCTTGGGCACAC
AAGACGATCGCAAAATATCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAETQVRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLMEAKTYLQAVPYLDRLDYVAPMNQEHAY
ALAVERLLDIEVPKRGQLIRVLYSEIGRILNHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGG
VHQDLPDQLIEDIGKWIDPFFTTLKNLDDLITPNRIFKQRNVDIGVVKLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
SEMEFDIPVGKNGDCYDRYLIRMEEMRQSARIMRQCVDLLLGKERVGPVSNTDHKIVPPKRGEMKRSMEALIHHFKLYTE
GYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKLRAPGFAHLQAMDFLCRGHMLADVSAILGSLDIVFGEVDR

Sequences:

>Translated_396_residues
MAETQVRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLMEAKTYLQAVPYLDRLDYVAPMNQEHAY
ALAVERLLDIEVPKRGQLIRVLYSEIGRILNHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGG
VHQDLPDQLIEDIGKWIDPFFTTLKNLDDLITPNRIFKQRNVDIGVVKLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
SEMEFDIPVGKNGDCYDRYLIRMEEMRQSARIMRQCVDLLLGKERVGPVSNTDHKIVPPKRGEMKRSMEALIHHFKLYTE
GYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKLRAPGFAHLQAMDFLCRGHMLADVSAILGSLDIVFGEVDR
>Mature_395_residues
AETQVRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLMEAKTYLQAVPYLDRLDYVAPMNQEHAYA
LAVERLLDIEVPKRGQLIRVLYSEIGRILNHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGGV
HQDLPDQLIEDIGKWIDPFFTTLKNLDDLITPNRIFKQRNVDIGVVKLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECYS
EMEFDIPVGKNGDCYDRYLIRMEEMRQSARIMRQCVDLLLGKERVGPVSNTDHKIVPPKRGEMKRSMEALIHHFKLYTEG
YHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKLRAPGFAHLQAMDFLCRGHMLADVSAILGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=394, Percent_Identity=65.4822335025381, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI260898743, Length=388, Percent_Identity=64.6907216494845, Blast_Score=516, Evalue=1e-146,
Organism=Escherichia coli, GI145693162, Length=390, Percent_Identity=40, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1789076, Length=391, Percent_Identity=26.3427109974425, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788832, Length=389, Percent_Identity=25.9640102827763, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=60.1522842639594, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=59.8984771573604, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=63.4517766497462, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=56.7357512953368, Blast_Score=473, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44983; Mature: 44852

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETQVRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLMEAKTYLQ
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AVPYLDRLDYVAPMNQEHAYALAVERLLDIEVPKRGQLIRVLYSEIGRILNHLLNVTTQA
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGGVHQDLPDQLIEDIGKWIDPF
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCHHHHHHHHHHHHHHH
FTTLKNLDDLITPNRIFKQRNVDIGVVKLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
HHHHHHHHHHCCCHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCEECCCCCCCCHHH
SEMEFDIPVGKNGDCYDRYLIRMEEMRQSARIMRQCVDLLLGKERVGPVSNTDHKIVPPK
HCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCEECCCC
RGEMKRSMEALIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKLRAP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQAMDFLCRGHMLADVSAILGSLDIVFGEVDR
CHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
AETQVRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLMEAKTYLQ
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AVPYLDRLDYVAPMNQEHAYALAVERLLDIEVPKRGQLIRVLYSEIGRILNHLLNVTTQA
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGGVHQDLPDQLIEDIGKWIDPF
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCHHHHHHHHHHHHHHH
FTTLKNLDDLITPNRIFKQRNVDIGVVKLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
HHHHHHHHHHCCCHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCEECCCCCCCCHHH
SEMEFDIPVGKNGDCYDRYLIRMEEMRQSARIMRQCVDLLLGKERVGPVSNTDHKIVPPK
HCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCEECCCC
RGEMKRSMEALIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKLRAP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQAMDFLCRGHMLADVSAILGSLDIVFGEVDR
CHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA