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The map label for this gene is hemN [H]

Identifier: 225852176

GI number: 225852176

Start: 666194

End: 667528

Strand: Direct

Name: hemN [H]

Synonym: BMEA_A0692

Alternate gene names: 225852176

Gene position: 666194-667528 (Clockwise)

Preceding gene: 225852175

Following gene: 225852178

Centisome position: 31.34

GC content: 57.3

Gene sequence:

>1335_bases
ATGCATGACGACGCGATAAGACGCTACGCAGCACTGGCTGTTCCTCGTTATACTTCCTATCCTACTGCGGCGGATTTCGT
GCCGGTCGGCATGGATACCACGCGCCGTTGGCTGCGCCAGATCGGGCCGGAAGAAAGCGTTTCGCTTTATATCCATGTGC
CGTATTGCAGTCAGATATGCCACTATTGCGGCTGCAACGCAAAAATGGCGATACGTGAGGATGTGATCGAAAATTTCGTA
AATGCGCTTCTTGGAGAAATCCGGACTGTGAGCGCAAGCCTTACGGCGCGTCCCCGCGTTGCCCATCTTCACTGGGGCGG
CGGCACACCCTCCATTCTCAATGCCGGGCAATTTCAGACTGTTCTGGCCGCAATCCGCACGGCGTTTGATTTCGATCTCT
CGATGGAACACGCCATAGAGCTTGATCCACGCACGGTAACACCGCTTTTGGCGAAGACGCTTGCCGAAATGGGTGTAAAT
CGCGCAAGCCTCGGTGTGCAGGATGTGGACAGCAGGGTGCAAATGGCCATCGGTCGCGTTCAGCCGATTGAAACGGTTGC
CGAGGCTACAAGGCTCCTGCGTGAGGTGGGTATCAACCGCATCAATTTCGACCTGATCTATGGTCTGCCTTTGCAGACGG
TCGAGACATTGCGCGAAACCTGCGAGCGCGTTGTGACGCTCTCACCGGATCGGGTTGCCTGCTATGGCTATGCGCATCTG
CCGCAGCGCCGTGCAAATCAGCGTCTCATCGATGAAAACACGCTGCCTGACGCGGACGAGCGTTTCCGTCAGGCCCGCAT
CGTAACGGACAGCTTCATTGGTTTCGGCTATCAGCCGGTTGGTATCGACCATTTTGCGCTGCCGGATGACGATCTTGCGA
TCGCTGCGCGCGAAGGCACTCTGAATCGCAATTTTCAGGGCTATACCAACGACCGTTGCGGAACCCTGATCGGGTTTGGC
CCGTCATCGATCTCGCAGTTTCCGGGCGGTTATGCGCAGAATATTTCCGATGTCGGGCAATATCGCAAGCGCGTGGAAGC
CGGCGAGCTGGCGACGGTTCGCGGCTACACGCTGCGTGACGCAGACCGTATCCGCTCCGCCATCATCTCCGCGCTCATGT
GCAATTTCTGCGTCGATCTGAACGCGGTCGCGCCGGGCATGGAATTTTCCGACGAGTTTGCGCTGCTGCGCCCTCTTGTT
GCCGATGGTCTGGTGGCGGTCGAGGGCCGTACGATCCGCGCCACGGAAAATGGCAAGTCGCTGATCCGTCTTGTTGCGGC
AGCTTTTGATGAGTTTAGGAGAGATAGCGTACACGGCTTCAGTTTTGCAGTGTGA

Upstream 100 bases:

>100_bases
CGTATTGTGCTTCCACGCCCCACAAAATGCTCGTCTTCAGCCAGTATTCCTGCGCCGGGCGAACTCCTCCCGCAGCGCCA
GTTGGGTGGAGTGATGCGCC

Downstream 100 bases:

>100_bases
GATTGCTGCAGAACAAAGAAGTTGGGGGCCAATTGCCCTATCAAGAATGTGCCGCTGCACCGGGCCGTCAAAAGGTCAGT
GGCATGGGAGCACCGCACGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MHDDAIRRYAALAVPRYTSYPTAADFVPVGMDTTRRWLRQIGPEESVSLYIHVPYCSQICHYCGCNAKMAIREDVIENFV
NALLGEIRTVSASLTARPRVAHLHWGGGTPSILNAGQFQTVLAAIRTAFDFDLSMEHAIELDPRTVTPLLAKTLAEMGVN
RASLGVQDVDSRVQMAIGRVQPIETVAEATRLLREVGINRINFDLIYGLPLQTVETLRETCERVVTLSPDRVACYGYAHL
PQRRANQRLIDENTLPDADERFRQARIVTDSFIGFGYQPVGIDHFALPDDDLAIAAREGTLNRNFQGYTNDRCGTLIGFG
PSSISQFPGGYAQNISDVGQYRKRVEAGELATVRGYTLRDADRIRSAIISALMCNFCVDLNAVAPGMEFSDEFALLRPLV
ADGLVAVEGRTIRATENGKSLIRLVAAAFDEFRRDSVHGFSFAV

Sequences:

>Translated_444_residues
MHDDAIRRYAALAVPRYTSYPTAADFVPVGMDTTRRWLRQIGPEESVSLYIHVPYCSQICHYCGCNAKMAIREDVIENFV
NALLGEIRTVSASLTARPRVAHLHWGGGTPSILNAGQFQTVLAAIRTAFDFDLSMEHAIELDPRTVTPLLAKTLAEMGVN
RASLGVQDVDSRVQMAIGRVQPIETVAEATRLLREVGINRINFDLIYGLPLQTVETLRETCERVVTLSPDRVACYGYAHL
PQRRANQRLIDENTLPDADERFRQARIVTDSFIGFGYQPVGIDHFALPDDDLAIAAREGTLNRNFQGYTNDRCGTLIGFG
PSSISQFPGGYAQNISDVGQYRKRVEAGELATVRGYTLRDADRIRSAIISALMCNFCVDLNAVAPGMEFSDEFALLRPLV
ADGLVAVEGRTIRATENGKSLIRLVAAAFDEFRRDSVHGFSFAV
>Mature_444_residues
MHDDAIRRYAALAVPRYTSYPTAADFVPVGMDTTRRWLRQIGPEESVSLYIHVPYCSQICHYCGCNAKMAIREDVIENFV
NALLGEIRTVSASLTARPRVAHLHWGGGTPSILNAGQFQTVLAAIRTAFDFDLSMEHAIELDPRTVTPLLAKTLAEMGVN
RASLGVQDVDSRVQMAIGRVQPIETVAEATRLLREVGINRINFDLIYGLPLQTVETLRETCERVVTLSPDRVACYGYAHL
PQRRANQRLIDENTLPDADERFRQARIVTDSFIGFGYQPVGIDHFALPDDDLAIAAREGTLNRNFQGYTNDRCGTLIGFG
PSSISQFPGGYAQNISDVGQYRKRVEAGELATVRGYTLRDADRIRSAIISALMCNFCVDLNAVAPGMEFSDEFALLRPLV
ADGLVAVEGRTIRATENGKSLIRLVAAAFDEFRRDSVHGFSFAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=290, Percent_Identity=26.551724137931, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082341, Length=437, Percent_Identity=39.3592677345538, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI1789325, Length=245, Percent_Identity=29.7959183673469, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49092; Mature: 49092

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDDAIRRYAALAVPRYTSYPTAADFVPVGMDTTRRWLRQIGPEESVSLYIHVPYCSQIC
CCHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEECCHHHHHH
HYCGCNAKMAIREDVIENFVNALLGEIRTVSASLTARPRVAHLHWGGGTPSILNAGQFQT
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHCCCCHHHH
VLAAIRTAFDFDLSMEHAIELDPRTVTPLLAKTLAEMGVNRASLGVQDVDSRVQMAIGRV
HHHHHHHHHCCCCCHHHHEECCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCC
QPIETVAEATRLLREVGINRINFDLIYGLPLQTVETLRETCERVVTLSPDRVACYGYAHL
CHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHEECCCCCEEEEEEHHC
PQRRANQRLIDENTLPDADERFRQARIVTDSFIGFGYQPVGIDHFALPDDDLAIAAREGT
CHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCC
LNRNFQGYTNDRCGTLIGFGPSSISQFPGGYAQNISDVGQYRKRVEAGELATVRGYTLRD
CCCCCCCCCCCCCCEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEECC
ADRIRSAIISALMCNFCVDLNAVAPGMEFSDEFALLRPLVADGLVAVEGRTIRATENGKS
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHCCEEEECCEEEEECCCHHH
LIRLVAAAFDEFRRDSVHGFSFAV
HHHHHHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure
MHDDAIRRYAALAVPRYTSYPTAADFVPVGMDTTRRWLRQIGPEESVSLYIHVPYCSQIC
CCHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEECCHHHHHH
HYCGCNAKMAIREDVIENFVNALLGEIRTVSASLTARPRVAHLHWGGGTPSILNAGQFQT
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHCCCCHHHH
VLAAIRTAFDFDLSMEHAIELDPRTVTPLLAKTLAEMGVNRASLGVQDVDSRVQMAIGRV
HHHHHHHHHCCCCCHHHHEECCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCC
QPIETVAEATRLLREVGINRINFDLIYGLPLQTVETLRETCERVVTLSPDRVACYGYAHL
CHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHEECCCCCEEEEEEHHC
PQRRANQRLIDENTLPDADERFRQARIVTDSFIGFGYQPVGIDHFALPDDDLAIAAREGT
CHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCC
LNRNFQGYTNDRCGTLIGFGPSSISQFPGGYAQNISDVGQYRKRVEAGELATVRGYTLRD
CCCCCCCCCCCCCCEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEECC
ADRIRSAIISALMCNFCVDLNAVAPGMEFSDEFALLRPLVADGLVAVEGRTIRATENGKS
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHCCEEEECCEEEEECCCHHH
LIRLVAAAFDEFRRDSVHGFSFAV
HHHHHHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]