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The map label for this gene is dapA [H]

Identifier: 225852167

GI number: 225852167

Start: 658159

End: 659040

Strand: Direct

Name: dapA [H]

Synonym: BMEA_A0683

Alternate gene names: 225852167

Gene position: 658159-659040 (Clockwise)

Preceding gene: 225852165

Following gene: 225852168

Centisome position: 30.96

GC content: 57.03

Gene sequence:

>882_bases
ATGCTGAAGGGCTCAATTACCGCACTTGTCACGCCGTTCGACCGTGAAGGGGCGTTCGACGAAAAAGCCTTTCGTGCATT
CGTCAACTGGCAGATCGAAGAGGGGACGAAAGGTCTCGTTCCGGTTGGCACGACCGGCGAAACGCCGACCCTTTCCCATG
ATGAACATAAGCGTGTGATCGAAGTCTGCATTGAAGTCGCCGCTGGCCGTGTGCCAGTGATTGCGGGTGCCGGCTCGAAC
AATACGGTGGAAGCGATCGAACTGGCGCAGCACGCCGAAAAAGCGGGCGCGGATGCGGTTCTGGTTGTCACACCTTATTA
CAACAAGCCGAATCAGCGTGGCCTCTACGAGCATTTTTCGCGCGTTGCCCGCTCTATCTCGATCCCGCTGGTGATCTATA
ACGTTCCGGGCCGGTCCATTATCGACATGACGCCGGAAACCATGGGCGCTCTCGTTCGCGACTGTAAGAATATTGTCGGC
GTCAAGGATGCGACCGGCAAGATCGAGCGTGTTTCCGAACAGCGCGCGATCTGTGGCAAGGAGTTCATCCAGCTTTCCGG
TGAAGACGCCACGGCGCTTGGCTTCAATGCTCATGGCGGGGTGGGGTGCATTTCGGTAACGTCCAACATTGCGCCGCGTC
TTTGCGCGGAATTTCAGGAAGCCTGCCAGGCTGGTAATTTCGCCAAGGCGCTGGAATTGCAGGACCGTTTGATGCCGCTG
CACAAGGCGCTGTTCCTGGAACCCAATCCTTCCGGCCCGAAATATGCGCTTTCGCGCCTGGGTCGTATTGAAAATGTTCT
GCGTTCACCAATGGTTACGATCGAAGCGGCGACGGCGGAAAAGATCGACCATGCCATGAAGCACGCGGTCCTCATCAACT
GA

Upstream 100 bases:

>100_bases
CGTGGCAAGACTATGGTGCAACGCCTCACGCATAATCCGATGAAGCCCGAAGGGGGCTTTGCTGCGTGGGGTCCCGTCTA
TCTGTTTCAGGAGTTCACGA

Downstream 100 bases:

>100_bases
CCCGGTATATTTGCCAATCCGGCGAATTTTACGCTCCCGTCGCTGCGGGAGCGTTTTCATTTCCGGCATTCCACATTATA
TGGTGCCATCATGAACAAGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLKGSITALVTPFDREGAFDEKAFRAFVNWQIEEGTKGLVPVGTTGETPTLSHDEHKRVIEVCIEVAAGRVPVIAGAGSN
NTVEAIELAQHAEKAGADAVLVVTPYYNKPNQRGLYEHFSRVARSISIPLVIYNVPGRSIIDMTPETMGALVRDCKNIVG
VKDATGKIERVSEQRAICGKEFIQLSGEDATALGFNAHGGVGCISVTSNIAPRLCAEFQEACQAGNFAKALELQDRLMPL
HKALFLEPNPSGPKYALSRLGRIENVLRSPMVTIEAATAEKIDHAMKHAVLIN

Sequences:

>Translated_293_residues
MLKGSITALVTPFDREGAFDEKAFRAFVNWQIEEGTKGLVPVGTTGETPTLSHDEHKRVIEVCIEVAAGRVPVIAGAGSN
NTVEAIELAQHAEKAGADAVLVVTPYYNKPNQRGLYEHFSRVARSISIPLVIYNVPGRSIIDMTPETMGALVRDCKNIVG
VKDATGKIERVSEQRAICGKEFIQLSGEDATALGFNAHGGVGCISVTSNIAPRLCAEFQEACQAGNFAKALELQDRLMPL
HKALFLEPNPSGPKYALSRLGRIENVLRSPMVTIEAATAEKIDHAMKHAVLIN
>Mature_293_residues
MLKGSITALVTPFDREGAFDEKAFRAFVNWQIEEGTKGLVPVGTTGETPTLSHDEHKRVIEVCIEVAAGRVPVIAGAGSN
NTVEAIELAQHAEKAGADAVLVVTPYYNKPNQRGLYEHFSRVARSISIPLVIYNVPGRSIIDMTPETMGALVRDCKNIVG
VKDATGKIERVSEQRAICGKEFIQLSGEDATALGFNAHGGVGCISVTSNIAPRLCAEFQEACQAGNFAKALELQDRLMPL
HKALFLEPNPSGPKYALSRLGRIENVLRSPMVTIEAATAEKIDHAMKHAVLIN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=252, Percent_Identity=26.984126984127, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI13540533, Length=242, Percent_Identity=25.6198347107438, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=44.7098976109215, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI87082415, Length=289, Percent_Identity=32.5259515570934, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1786463, Length=253, Percent_Identity=32.0158102766798, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789620, Length=237, Percent_Identity=30.8016877637131, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31599; Mature: 31599

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGSITALVTPFDREGAFDEKAFRAFVNWQIEEGTKGLVPVGTTGETPTLSHDEHKRVI
CCCCCEEEEECCCCCCCCCHHHHHHHHHCEEECCCCCCCEECCCCCCCCCCCCHHHHHHH
EVCIEVAAGRVPVIAGAGSNNTVEAIELAQHAEKAGADAVLVVTPYYNKPNQRGLYEHFS
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHH
RVARSISIPLVIYNVPGRSIIDMTPETMGALVRDCKNIVGVKDATGKIERVSEQRAICGK
HHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
EFIQLSGEDATALGFNAHGGVGCISVTSNIAPRLCAEFQEACQAGNFAKALELQDRLMPL
HHHHCCCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
HKALFLEPNPSGPKYALSRLGRIENVLRSPMVTIEAATAEKIDHAMKHAVLIN
HHHEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MLKGSITALVTPFDREGAFDEKAFRAFVNWQIEEGTKGLVPVGTTGETPTLSHDEHKRVI
CCCCCEEEEECCCCCCCCCHHHHHHHHHCEEECCCCCCCEECCCCCCCCCCCCHHHHHHH
EVCIEVAAGRVPVIAGAGSNNTVEAIELAQHAEKAGADAVLVVTPYYNKPNQRGLYEHFS
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHH
RVARSISIPLVIYNVPGRSIIDMTPETMGALVRDCKNIVGVKDATGKIERVSEQRAICGK
HHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
EFIQLSGEDATALGFNAHGGVGCISVTSNIAPRLCAEFQEACQAGNFAKALELQDRLMPL
HHHHCCCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
HKALFLEPNPSGPKYALSRLGRIENVLRSPMVTIEAATAEKIDHAMKHAVLIN
HHHEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA