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The map label for this gene is degP [H]

Identifier: 225852136

GI number: 225852136

Start: 620113

End: 621654

Strand: Direct

Name: degP [H]

Synonym: BMEA_A0649

Alternate gene names: 225852136

Gene position: 620113-621654 (Clockwise)

Preceding gene: 225852135

Following gene: 225852137

Centisome position: 29.17

GC content: 60.38

Gene sequence:

>1542_bases
ATGTCCAGAGCCAGGATTTCCAACTATCGCAAAGGCGTTGCCGCCGTCGCGCTTTCCGCAGCGCTTGCCGGCGCATTCGT
CGTAACCGGCCCGCTTGGTGCGCTGAACGAAGCCCGCGCCGAAGCGGTGCATGTGACGCCGCCGCAGCAGGCTGGCTTTG
CCGATCTGGTGGAAAAGGTTCGCCCTGCGGTCGTCAGCGTCCGCGTCAAGAAGGACGTGCAGGAGACTTCCAACCGTGGT
CCGCAGTTCTTCGGCCCTCCCGGCTTCGACCAGTTGCCGGACGGTCATCCGCTGAAGCGATTTTTCCGTGATTTTGGTAT
GGAGCCGCGTGGCGATTCACGCTCCGATAACCGTCGCGGCAAGGCCAACAAGCCGCGCCCGGGCCATGAACGCCCTGTTG
CACAAGGATCGGGCTTCGTCATTTCCGAAGATGGCTATGTCGTTACTAACAACCATGTCGTTTCCGATGGCGATGCCTAT
ACCGTCGTGCTGGACGACGGCACCGAACTTGATGCCAAGCTGATTGGTGCTGATCCGCGCACGGACCTGGCCGTGTTGAA
AATCAACGCTCCGAAGCGCAAGTTCGTCTATGTCGCCTTTGGCGACGATAATAAGGTGCGCGTCGGTGATTGGGTTGTCG
CAGTTGGCAATCCGTTCGGCCTTGGTGGCACGGTGACTTCCGGTATCGTTTCGGCCCGTGGCCGAGACATCGGCGCAGGC
CCCTATGACGATTTCATCCAGATTGATGCCGCCGTGAACAAGGGCAATTCCGGTGGTCCGGCTTTCGACCTTTCCGGCGA
AGTCATCGGCATCAACACCGCCATCTTCTCGCCATCTGGCGGCAGCGTGGGCATTGCTTTTGCAATTCCGTCCTCCACCG
CCAAGCAGGTCGTGGACCAGCTCATCAAGAAGGGTTCCGTCGAGCGCGGCTGGATCGGCGTCCAGATACAGCCTGTGACC
AAGGATATCGCCGCTTCGCTCGGTCTTGCCGAGGAAAAGGGTGCGATCGTGGCCTCGCCGCAGGATGATGGCCCGGCTGC
CAAGGCTGGCATCAAGGCGGGCGATGTGATTACGGCTGTCAATGGCGAAACGGTTCAGGACCCGCGTGACCTGGCGCGCA
AGGTTGCCAATATCGCCCCTGGTGAAAAGGCGGCCCTGACCGTCTGGCGCAAGAACAAGGCCGAGGAAATCAACGTCACG
ATTGCTGCCATGCCCAATGACAAGGGGAAGAGCGGCAGCCAGTCCAACGACAATGACGGCGGACAGGGTGAAACGCTCGA
CTCCTACGGCTTGACCGTCGTTCCGTCTGAAGACGGTAAGGGCGTGGTCGTTACCGATGTGGACCCGGACAGCGATGCGG
CTGACCGTGGCATCCGCTCCGGCGATGTGATCGTGAGCGTCAACAACCAGACGGTAAAGACCGCTGGCGATATCAACAAG
GCCATCACGGCAGCCGAAAAGTCAGGCCGTAAGGCGGTGCTGCTGCAATTGCAGAGCAATGATCAGAGCCGCTTCGTGGC
GCTGCCGATCAATCAGGAATGA

Upstream 100 bases:

>100_bases
CGGAAATTGAACGGTAAGGTAGCTCTAACTATCTTGCTCTCATAGAAAATTACGAGGCCAGAAATTCCTGGCCCGGATTA
CTGCTCGCAAGGAGAAACAG

Downstream 100 bases:

>100_bases
TCGGCGCCTCGCAGGGAAACTGATCGAATTCCGATGCCAGGCGGGTAACTGCCTGGCATCGCCTTATCGCTGAACGGAAC
CTATAGTAGCGCCATGAAAA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSRARISNYRKGVAAVALSAALAGAFVVTGPLGALNEARAEAVHVTPPQQAGFADLVEKVRPAVVSVRVKKDVQETSNRG
PQFFGPPGFDQLPDGHPLKRFFRDFGMEPRGDSRSDNRRGKANKPRPGHERPVAQGSGFVISEDGYVVTNNHVVSDGDAY
TVVLDDGTELDAKLIGADPRTDLAVLKINAPKRKFVYVAFGDDNKVRVGDWVVAVGNPFGLGGTVTSGIVSARGRDIGAG
PYDDFIQIDAAVNKGNSGGPAFDLSGEVIGINTAIFSPSGGSVGIAFAIPSSTAKQVVDQLIKKGSVERGWIGVQIQPVT
KDIAASLGLAEEKGAIVASPQDDGPAAKAGIKAGDVITAVNGETVQDPRDLARKVANIAPGEKAALTVWRKNKAEEINVT
IAAMPNDKGKSGSQSNDNDGGQGETLDSYGLTVVPSEDGKGVVVTDVDPDSDAADRGIRSGDVIVSVNNQTVKTAGDINK
AITAAEKSGRKAVLLQLQSNDQSRFVALPINQE

Sequences:

>Translated_513_residues
MSRARISNYRKGVAAVALSAALAGAFVVTGPLGALNEARAEAVHVTPPQQAGFADLVEKVRPAVVSVRVKKDVQETSNRG
PQFFGPPGFDQLPDGHPLKRFFRDFGMEPRGDSRSDNRRGKANKPRPGHERPVAQGSGFVISEDGYVVTNNHVVSDGDAY
TVVLDDGTELDAKLIGADPRTDLAVLKINAPKRKFVYVAFGDDNKVRVGDWVVAVGNPFGLGGTVTSGIVSARGRDIGAG
PYDDFIQIDAAVNKGNSGGPAFDLSGEVIGINTAIFSPSGGSVGIAFAIPSSTAKQVVDQLIKKGSVERGWIGVQIQPVT
KDIAASLGLAEEKGAIVASPQDDGPAAKAGIKAGDVITAVNGETVQDPRDLARKVANIAPGEKAALTVWRKNKAEEINVT
IAAMPNDKGKSGSQSNDNDGGQGETLDSYGLTVVPSEDGKGVVVTDVDPDSDAADRGIRSGDVIVSVNNQTVKTAGDINK
AITAAEKSGRKAVLLQLQSNDQSRFVALPINQE
>Mature_512_residues
SRARISNYRKGVAAVALSAALAGAFVVTGPLGALNEARAEAVHVTPPQQAGFADLVEKVRPAVVSVRVKKDVQETSNRGP
QFFGPPGFDQLPDGHPLKRFFRDFGMEPRGDSRSDNRRGKANKPRPGHERPVAQGSGFVISEDGYVVTNNHVVSDGDAYT
VVLDDGTELDAKLIGADPRTDLAVLKINAPKRKFVYVAFGDDNKVRVGDWVVAVGNPFGLGGTVTSGIVSARGRDIGAGP
YDDFIQIDAAVNKGNSGGPAFDLSGEVIGINTAIFSPSGGSVGIAFAIPSSTAKQVVDQLIKKGSVERGWIGVQIQPVTK
DIAASLGLAEEKGAIVASPQDDGPAAKAGIKAGDVITAVNGETVQDPRDLARKVANIAPGEKAALTVWRKNKAEEINVTI
AAMPNDKGKSGSQSNDNDGGQGETLDSYGLTVVPSEDGKGVVVTDVDPDSDAADRGIRSGDVIVSVNNQTVKTAGDINKA
ITAAEKSGRKAVLLQLQSNDQSRFVALPINQE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=292, Percent_Identity=36.6438356164384, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI22129776, Length=275, Percent_Identity=35.6363636363636, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7019477, Length=269, Percent_Identity=37.9182156133829, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI24308541, Length=259, Percent_Identity=33.976833976834, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI1786356, Length=482, Percent_Identity=37.1369294605809, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1789629, Length=455, Percent_Identity=39.3406593406593, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1789630, Length=275, Percent_Identity=40, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24646839, Length=267, Percent_Identity=31.4606741573034, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53514; Mature: 53383

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRARISNYRKGVAAVALSAALAGAFVVTGPLGALNEARAEAVHVTPPQQAGFADLVEKV
CCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHCCCEEEECCCCCCCHHHHHHHH
RPAVVSVRVKKDVQETSNRGPQFFGPPGFDQLPDGHPLKRFFRDFGMEPRGDSRSDNRRG
CCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
KANKPRPGHERPVAQGSGFVISEDGYVVTNNHVVSDGDAYTVVLDDGTELDAKLIGADPR
CCCCCCCCCCCCCCCCCCEEEECCCEEEECCEEEECCCEEEEEECCCCCCCEEEECCCCC
TDLAVLKINAPKRKFVYVAFGDDNKVRVGDWVVAVGNPFGLGGTVTSGIVSARGRDIGAG
CCEEEEEECCCCEEEEEEEECCCCEEEECCEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
PYDDFIQIDAAVNKGNSGGPAFDLSGEVIGINTAIFSPSGGSVGIAFAIPSSTAKQVVDQ
CCCCEEEEEEEECCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEEECCHHHHHHHHH
LIKKGSVERGWIGVQIQPVTKDIAASLGLAEEKGAIVASPQDDGPAAKAGIKAGDVITAV
HHHCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEE
NGETVQDPRDLARKVANIAPGEKAALTVWRKNKAEEINVTIAAMPNDKGKSGSQSNDNDG
CCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCC
GQGETLDSYGLTVVPSEDGKGVVVTDVDPDSDAADRGIRSGDVIVSVNNQTVKTAGDINK
CCCCEECCCCEEEEECCCCCEEEEECCCCCCCHHHCCCCCCCEEEEECCCEEECCCHHHH
AITAAEKSGRKAVLLQLQSNDQSRFVALPINQE
HHHHHHHCCCEEEEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure 
SRARISNYRKGVAAVALSAALAGAFVVTGPLGALNEARAEAVHVTPPQQAGFADLVEKV
CCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHCCCEEEECCCCCCCHHHHHHHH
RPAVVSVRVKKDVQETSNRGPQFFGPPGFDQLPDGHPLKRFFRDFGMEPRGDSRSDNRRG
CCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
KANKPRPGHERPVAQGSGFVISEDGYVVTNNHVVSDGDAYTVVLDDGTELDAKLIGADPR
CCCCCCCCCCCCCCCCCCEEEECCCEEEECCEEEECCCEEEEEECCCCCCCEEEECCCCC
TDLAVLKINAPKRKFVYVAFGDDNKVRVGDWVVAVGNPFGLGGTVTSGIVSARGRDIGAG
CCEEEEEECCCCEEEEEEEECCCCEEEECCEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
PYDDFIQIDAAVNKGNSGGPAFDLSGEVIGINTAIFSPSGGSVGIAFAIPSSTAKQVVDQ
CCCCEEEEEEEECCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEEECCHHHHHHHHH
LIKKGSVERGWIGVQIQPVTKDIAASLGLAEEKGAIVASPQDDGPAAKAGIKAGDVITAV
HHHCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEE
NGETVQDPRDLARKVANIAPGEKAALTVWRKNKAEEINVTIAAMPNDKGKSGSQSNDNDG
CCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCC
GQGETLDSYGLTVVPSEDGKGVVVTDVDPDSDAADRGIRSGDVIVSVNNQTVKTAGDINK
CCCCEECCCCEEEEECCCCCEEEEECCCCCCCHHHCCCCCCCEEEEECCCEEECCCHHHH
AITAAEKSGRKAVLLQLQSNDQSRFVALPINQE
HHHHHHHCCCEEEEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]