Click here to switch to the map view.

The map label for this gene is cusR [H]

Identifier: 225852137

GI number: 225852137

Start: 621748

End: 622455

Strand: Direct

Name: cusR [H]

Synonym: BMEA_A0650

Alternate gene names: 225852137

Gene position: 621748-622455 (Clockwise)

Preceding gene: 225852136

Following gene: 225852138

Centisome position: 29.25

GC content: 60.03

Gene sequence:

>708_bases
ATGAAAATTCTCGTTATCGAAGATGACCGCGAAGCGGCCCGTTATCTGGAAAAGGCCTTTGCCGAGGCAGGGCATTCGGC
CGATATCGCGGGCGACGGCGAAACCGGCTACGCACTTGCCGAAAACGGCAATTACGATGTGCTGGTGGTGGACCGTATGC
TGCCCAAACGCGACGGCCTTTCCGTTGTGGCGGGCCTGCGCGCCAAGGGCATGGAAACGCCGGTCCTGATCCTGTCGGCG
CTTGGCGAGGTGGATGACCGCGTGACCGGTCTGCGCGCTGGGGGCGATGATTATCTCACCAAGCCCTATGCTTTTTCCGA
ACTTCTGGCGCGTGTCGAGGTCTTGCAGCGCCGCTCAAGCCCGCGCGAGGCGGATACGATCTACCGCGTCGGCGATCTGG
AGCTTGACCGCCTTACGCATACTGCGCGCCGCCAGAGTGTTGATATTACGCTTCAACCGCGAGAATTTCGTCTTCTCGAA
TATCTCATGCGCCATGCCGGGCAGGTCGTCACCCGCACCATGCTGCTTGAAAACGTCTGGGATTACCACTTCGACCCGCA
GACCAATGTGATCGATGTTCACATTTCGCGGCTGCGCTCCAAGATTGAAAAGGGCTTTGACGAGCCGCTGCTTCATACGG
TGCGCGGGGCTGGCTATATGCTGAAGGCGGGCCGGGGCAAGCAATCCGCTGCCGCAAGGGCGGAATGA

Upstream 100 bases:

>100_bases
GGAATGATCGGCGCCTCGCAGGGAAACTGATCGAATTCCGATGCCAGGCGGGTAACTGCCTGGCATCGCCTTATCGCTGA
ACGGAACCTATAGTAGCGCC

Downstream 100 bases:

>100_bases
TGAGCCGGTTTTCCGCACTCATGCGCACCACCGCGGCGCGGCTTTCCGCGCTTTATCTCCTGCTCTTTGCAGTGGGCGCG
GTTGCACTTGTCTTTTACAT

Product: transcriptional activator protein copR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKILVIEDDREAARYLEKAFAEAGHSADIAGDGETGYALAENGNYDVLVVDRMLPKRDGLSVVAGLRAKGMETPVLILSA
LGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLQRRSSPREADTIYRVGDLELDRLTHTARRQSVDITLQPREFRLLE
YLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIEKGFDEPLLHTVRGAGYMLKAGRGKQSAAARAE

Sequences:

>Translated_235_residues
MKILVIEDDREAARYLEKAFAEAGHSADIAGDGETGYALAENGNYDVLVVDRMLPKRDGLSVVAGLRAKGMETPVLILSA
LGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLQRRSSPREADTIYRVGDLELDRLTHTARRQSVDITLQPREFRLLE
YLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIEKGFDEPLLHTVRGAGYMLKAGRGKQSAAARAE
>Mature_235_residues
MKILVIEDDREAARYLEKAFAEAGHSADIAGDGETGYALAENGNYDVLVVDRMLPKRDGLSVVAGLRAKGMETPVLILSA
LGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLQRRSSPREADTIYRVGDLELDRLTHTARRQSVDITLQPREFRLLE
YLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHISRLRSKIEKGFDEPLLHTVRGAGYMLKAGRGKQSAAARAE

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=44.4933920704846, Blast_Score=213, Evalue=7e-57,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=39.9103139013453, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=38.4279475982533, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.6363636363636, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=33.6283185840708, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.7180616740088, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=32.2727272727273, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=31.4159292035398, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=31.1111111111111, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.5087719298246, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=29.0598290598291, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=26.9911504424779, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=31.6831683168317, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26281; Mature: 26281

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVIEDDREAARYLEKAFAEAGHSADIAGDGETGYALAENGNYDVLVVDRMLPKRDGL
CEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCH
SVVAGLRAKGMETPVLILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLQRRSS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PREADTIYRVGDLELDRLTHTARRQSVDITLQPREFRLLEYLMRHAGQVVTRTMLLENVW
CCCHHHEEEECCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPQTNVIDVHISRLRSKIEKGFDEPLLHTVRGAGYMLKAGRGKQSAAARAE
HCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKILVIEDDREAARYLEKAFAEAGHSADIAGDGETGYALAENGNYDVLVVDRMLPKRDGL
CEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCH
SVVAGLRAKGMETPVLILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLQRRSS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PREADTIYRVGDLELDRLTHTARRQSVDITLQPREFRLLEYLMRHAGQVVTRTMLLENVW
CCCHHHEEEECCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPQTNVIDVHISRLRSKIEKGFDEPLLHTVRGAGYMLKAGRGKQSAAARAE
HCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]