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The map label for this gene is czcD [H]

Identifier: 225852034

GI number: 225852034

Start: 518751

End: 519644

Strand: Direct

Name: czcD [H]

Synonym: BMEA_A0535

Alternate gene names: 225852034

Gene position: 518751-519644 (Clockwise)

Preceding gene: 225852033

Following gene: 225852036

Centisome position: 24.4

GC content: 58.17

Gene sequence:

>894_bases
ATGGGCGCCGATCACGAACATGCCGATGTGAAGAACACGCCGATTTCCCGATTATGGATCGCTTTCGGCCTGACCGGCAT
CTTCATGATTGCCGAAGTCATCGGCAGCTTTGCCACCGGCAGTCTGGCGCTTCTTTCAGACGCCATGCACATGGCGACCG
ATGCATTCGCCCTCTTGCTGGCGCTGATCGCCATCTATCTGGGGCGCCGCCCGGCCGATGTTCTGCGCACCTATGGCTAT
GCGCGGTTCGAGATATTGGCGGCGGCGTTCAATGCGCTCCTGCTGCTGGGTGTTGCCTTCTATATTCTCTATGAAGCCTG
GGAGCGCCTGTCCGAACCGGCCGATGTCCAGTCTCTCGGCATGTTGGCGGTGGCTATCGTCGGGCTGGTCATGAACTTCA
TCTCCATGCGGATACTGACCGTGCACAAGGATGACAGCCTGAACGTCAAGGGCGCTTATCTGGAAGTCTGGGCCGATATG
CTGGGCTCTGTCGGGGTGATCGCCGCTGCAATCATCATCTATCTGACTGGCTGGGAATGGGTCGATTCAGCCATCGCGGT
CGGTATCGGCTTCATGGTTTTTCCACGCACATGGGTTTTGCTCAAGGAATGTATCAACATTCTTCTGGAAGGTGTGCCGG
CAGGGGGCGACGTGAAAAAGCTCGAAGCTGCAATCCTTGCCGTGCCGGGTGTCGCCTCCGTCCACGACCTCCATGTCTGG
TCGCTCACCAAGACCGAGCACTCGCTGACCGCACATCTCGTGCTGGCGCAGGAAGCCGATGGCGAAACGGTGCGCCGTGC
CGTGGAACATGTGCTCCAGAACGATTATGACCTGCACCACACGACCTTGCAGACCGAAAAAGTGACCTGCGCGGCGAAGG
AACTAATCCATTGA

Upstream 100 bases:

>100_bases
ACCATGGGTGAGCAAGGGGTGAGCCAGCTTGTCTCGGTCGATCTTCAAACGGCGGAGCAGCTACGCGAGGCAAGTTGACT
TTTCTATAATGGGAGGATGC

Downstream 100 bases:

>100_bases
GTGCTGCCTGATAGCGGGCTCGCTGCGATACGGGGCATTTGCAGGCTCCGCCCGCAGCGAGCCGCCATCCAGTCCCGCGA
CAAACCGGCGAGACTGATGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGADHEHADVKNTPISRLWIAFGLTGIFMIAEVIGSFATGSLALLSDAMHMATDAFALLLALIAIYLGRRPADVLRTYGY
ARFEILAAAFNALLLLGVAFYILYEAWERLSEPADVQSLGMLAVAIVGLVMNFISMRILTVHKDDSLNVKGAYLEVWADM
LGSVGVIAAAIIIYLTGWEWVDSAIAVGIGFMVFPRTWVLLKECINILLEGVPAGGDVKKLEAAILAVPGVASVHDLHVW
SLTKTEHSLTAHLVLAQEADGETVRRAVEHVLQNDYDLHHTTLQTEKVTCAAKELIH

Sequences:

>Translated_297_residues
MGADHEHADVKNTPISRLWIAFGLTGIFMIAEVIGSFATGSLALLSDAMHMATDAFALLLALIAIYLGRRPADVLRTYGY
ARFEILAAAFNALLLLGVAFYILYEAWERLSEPADVQSLGMLAVAIVGLVMNFISMRILTVHKDDSLNVKGAYLEVWADM
LGSVGVIAAAIIIYLTGWEWVDSAIAVGIGFMVFPRTWVLLKECINILLEGVPAGGDVKKLEAAILAVPGVASVHDLHVW
SLTKTEHSLTAHLVLAQEADGETVRRAVEHVLQNDYDLHHTTLQTEKVTCAAKELIH
>Mature_296_residues
GADHEHADVKNTPISRLWIAFGLTGIFMIAEVIGSFATGSLALLSDAMHMATDAFALLLALIAIYLGRRPADVLRTYGYA
RFEILAAAFNALLLLGVAFYILYEAWERLSEPADVQSLGMLAVAIVGLVMNFISMRILTVHKDDSLNVKGAYLEVWADML
GSVGVIAAAIIIYLTGWEWVDSAIAVGIGFMVFPRTWVLLKECINILLEGVPAGGDVKKLEAAILAVPGVASVHDLHVWS
LTKTEHSLTAHLVLAQEADGETVRRAVEHVLQNDYDLHHTTLQTEKVTCAAKELIH

Specific function: Necessary for activation of the czc determinant [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=30.2931596091205, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI289803013, Length=281, Percent_Identity=33.0960854092527, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI289803009, Length=281, Percent_Identity=33.0960854092527, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI289803007, Length=281, Percent_Identity=33.0960854092527, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI289803003, Length=281, Percent_Identity=33.0960854092527, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI64762489, Length=280, Percent_Identity=33.2142857142857, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI21359890, Length=311, Percent_Identity=29.903536977492, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI21361112, Length=297, Percent_Identity=28.956228956229, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI20070323, Length=303, Percent_Identity=26.4026402640264, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=29.1666666666667, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI52351208, Length=159, Percent_Identity=31.4465408805031, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI52352803, Length=128, Percent_Identity=41.40625, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI222080086, Length=112, Percent_Identity=34.8214285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40255009, Length=112, Percent_Identity=34.8214285714286, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=280, Percent_Identity=38.9285714285714, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=310, Percent_Identity=29.6774193548387, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI32564488, Length=301, Percent_Identity=30.5647840531561, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555794, Length=296, Percent_Identity=28.3783783783784, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=275, Percent_Identity=29.0909090909091, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550442, Length=124, Percent_Identity=33.8709677419355, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=124, Percent_Identity=33.8709677419355, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320411, Length=165, Percent_Identity=35.7575757575758, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=127, Percent_Identity=37.007874015748, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=154, Percent_Identity=29.8701298701299, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583858, Length=312, Percent_Identity=25.9615384615385, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24585900, Length=124, Percent_Identity=33.0645161290323, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585898, Length=124, Percent_Identity=33.0645161290323, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585896, Length=124, Percent_Identity=33.0645161290323, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921672, Length=124, Percent_Identity=33.0645161290323, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=38.5321100917431, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584409, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=28.9655172413793, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24656728, Length=149, Percent_Identity=30.2013422818792, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656724, Length=149, Percent_Identity=30.2013422818792, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656720, Length=149, Percent_Identity=30.2013422818792, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656715, Length=149, Percent_Identity=30.2013422818792, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21357035, Length=149, Percent_Identity=30.2013422818792, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32315; Mature: 32184

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGADHEHADVKNTPISRLWIAFGLTGIFMIAEVIGSFATGSLALLSDAMHMATDAFALLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ALIAIYLGRRPADVLRTYGYARFEILAAAFNALLLLGVAFYILYEAWERLSEPADVQSLG
HHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MLAVAIVGLVMNFISMRILTVHKDDSLNVKGAYLEVWADMLGSVGVIAAAIIIYLTGWEW
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHH
VDSAIAVGIGFMVFPRTWVLLKECINILLEGVPAGGDVKKLEAAILAVPGVASVHDLHVW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHEEEE
SLTKTEHSLTAHLVLAQEADGETVRRAVEHVLQNDYDLHHTTLQTEKVTCAAKELIH
EECCCCHHHEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GADHEHADVKNTPISRLWIAFGLTGIFMIAEVIGSFATGSLALLSDAMHMATDAFALLL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ALIAIYLGRRPADVLRTYGYARFEILAAAFNALLLLGVAFYILYEAWERLSEPADVQSLG
HHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MLAVAIVGLVMNFISMRILTVHKDDSLNVKGAYLEVWADMLGSVGVIAAAIIIYLTGWEW
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHH
VDSAIAVGIGFMVFPRTWVLLKECINILLEGVPAGGDVKKLEAAILAVPGVASVHDLHVW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHEEEE
SLTKTEHSLTAHLVLAQEADGETVRRAVEHVLQNDYDLHHTTLQTEKVTCAAKELIH
EECCCCHHHEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]