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The map label for this gene is cyoE

Identifier: 225852005

GI number: 225852005

Start: 489225

End: 490172

Strand: Direct

Name: cyoE

Synonym: BMEA_A0505

Alternate gene names: 225852005

Gene position: 489225-490172 (Clockwise)

Preceding gene: 225852004

Following gene: 225852006

Centisome position: 23.01

GC content: 58.97

Gene sequence:

>948_bases
ATGTCTCTGGTGGAAAAAAACACGGCTTCCGAGGATGCCTTCGCTCTCTCCGAGGCGACGGCGCGGGATTATCTCGTTCT
TCTGAAGCCCCGCGTGATGTCGCTTGTGGTCTTCACGGGGCTGGTCGGGCTTGTGCTCGCACCGGGGCATATGAACCCGG
TTCTGGCCGTAATCAGCATCCTTTGCATTGCGGTCGGCGCGGGCGCGTCGGGCGCGCTCAATATGTGGTACGATGCCGAT
ATCGACGCGGTGATGAAGCGCACGCGCAAGCGTCCTATTCCCGCTGGCATCATCGCCCCCAATCAGGTTCTGGCCTTCGG
CCTCACCCTTTCCGCCTTCTCGGTCATGACGCTCGGCCTCATGGTCAACTGGCTGGCAGCGGCCCTTCTGGCTTTCACCA
TCTTCTTTTATGCCGTCATCTATACGATGTGGCTAAAGCGGTCGACACCGCAGAACATCGTCATTGGCGGTGCTGCCGGC
GCCTTTCCGCCCATGATTGGATGGGCTGCCGCGACGGGTGAAATCACCTGGGACAGTCTTGTTCTGTTCATGATTATCTT
CCTGTGGACCCCGCCGCATTTCTGGGCGCTGTCGCTGTTCACAACGAATGATTATGAAGCCGCGCGCATTCCGATGATGC
CTAATGTGAAGGGTGAGCTTTCGACCCGCCGTCAGGCCCTGTTCTATGCCGTTCTCATGGCGCCGGTCGGTGTTCTGCCG
TGGGTCATGGGTTTTGCGGGCATGTTCTATGGTGTGGTGTCCACGCTTCTGGGGCTTGCCTTCGTCTATTATGCCTGGCG
CCTGTGGGCTGCGGATTCGCAGCCGCAGATGCTGGCTGCGGCGCGCAAGCTGTTCCGTTTTTCGCTGCTTTACCTTGCGG
GTATTTTCGCTGTGCTGCTCTTCGAGGCGCTGACGTTCAAGCTGCTCGCGGCCTTTGGAGTATTTTGA

Upstream 100 bases:

>100_bases
GGGAACAGTATGGTTTCCGGGAGGTATGTTCGTGGTGGTTGCCGATGCGTGAGTAGGGACACGCAGTCGGGCCGGTGAAT
TCGAGGTTTTTGAAGTTAAA

Downstream 100 bases:

>100_bases
TGGACAAGACTGCACACAAGCCGGTGCATGAGAAACTGGAGCTGGTCGTCCCGACCGAGCAACAGAAAAAGGCCCAGCGC
AACCGTTCATGGGGCCTTGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSLVEKNTASEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIAVGAGASGALNMWYDAD
IDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAAALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAG
AFPPMIGWAAATGEITWDSLVLFMIIFLWTPPHFWALSLFTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMAPVGVLP
WVMGFAGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLLFEALTFKLLAAFGVF

Sequences:

>Translated_315_residues
MSLVEKNTASEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIAVGAGASGALNMWYDAD
IDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAAALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAG
AFPPMIGWAAATGEITWDSLVLFMIIFLWTPPHFWALSLFTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMAPVGVLP
WVMGFAGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLLFEALTFKLLAAFGVF
>Mature_314_residues
SLVEKNTASEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIAVGAGASGALNMWYDADI
DAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAAALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAGA
FPPMIGWAAATGEITWDSLVLFMIIFLWTPPHFWALSLFTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMAPVGVLPW
VMGFAGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLLFEALTFKLLAAFGVF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=204, Percent_Identity=34.3137254901961, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786631, Length=271, Percent_Identity=30.2583025830258, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=273, Percent_Identity=30.7692307692308, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=287, Percent_Identity=28.9198606271777, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI19921064, Length=287, Percent_Identity=29.616724738676, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_BRUC2 (A9M8Z3)

Other databases:

- EMBL:   CP000872
- RefSeq:   YP_001592328.1
- GeneID:   5785223
- GenomeReviews:   CP000872_GR
- KEGG:   bcs:BCAN_A0475
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- ProtClustDB:   PRK04375
- BioCyc:   BCAN483179:BCAN_A0475-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 34405; Mature: 34274

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20ffbbcc)-; HASH(0x20c2780c)-; HASH(0x2072ac90)-; HASH(0x20f9744c)-; HASH(0x206ed8b0)-; HASH(0x20f7ab08)-; HASH(0x213f320c)-; HASH(0x206b6c50)-; HASH(0x20df9a34)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVEKNTASEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISI
CCCCCCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LCIAVGAGASGALNMWYDADIDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGL
HHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MVNWLAAALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAAATGEITWDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHH
VLFMIIFLWTPPHFWALSLFTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMAPVGVLP
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WVMGFAGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FEALTFKLLAAFGVF
HHHHHHHHHHHHCCH
>Mature Secondary Structure 
SLVEKNTASEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISI
CCCCCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LCIAVGAGASGALNMWYDADIDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGL
HHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MVNWLAAALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAAATGEITWDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHH
VLFMIIFLWTPPHFWALSLFTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMAPVGVLP
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WVMGFAGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FEALTFKLLAAFGVF
HHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA