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The map label for this gene is coxB [H]

Identifier: 225852003

GI number: 225852003

Start: 486347

End: 487201

Strand: Direct

Name: coxB [H]

Synonym: BMEA_A0503

Alternate gene names: 225852003

Gene position: 486347-487201 (Clockwise)

Preceding gene: 225852000

Following gene: 225852004

Centisome position: 22.88

GC content: 58.36

Gene sequence:

>855_bases
ATGGGCGGCGCTCTGGCAGTGCTGTGGACGACTGGTGCCGCTCTGGCGGACCAGCCGCGACCATGGGAGTGGAGATTTCA
GGACGCTGCAACGGGGATTGCCGAGCAGATTCATTGGTTTGAGCGTTATACGCTCTGGTTTATTATTCCGATTACCTTGC
TGGTTCTGGGCTTGCTGGTCTGGGTGGTTCTCCGTTTTCGCGCGAGCGTGAACCCGGAACCGTCCAAAACCAGCCACAAT
ACGGCGATTGAGGTGATCTGGACTGTCGGTCCGGTCATCATTCTTCTGTTCCTTGCCGTGCCGTCGTTCCAGCTTCTGAC
CGCGCAATATTCGCCGGAAGACCCGACGCTAACCGTCAAGGCGACCGGCTATCAATGGTATTGGGGTTATGAATATCAGG
TCGATAACCCGGTAAGCTTCGATTCGGTCATCCTGAAGGATGACGACCGTGCTGCTGCCGGCAAGGAAGACCGCGCCCGT
TATCCCCGCCTCCTGACGGTGGACAATGAAGTCGTTGTTCCGGTCGGCGAGACGGTCCGTCTGCTGGTGACAGCCTCCGA
CGTGATCCATTCCTGGACTATTCCCGCATTTGGCGTGAAGATGGATGCCGTTCCGGGCCGCATCAACGAAACCTGGTTCA
AGGCCGATAAGGAAGGCCTCTATTACGGCCAGTGCTCGGAGCTTTGCGGCAAGGATCACGGTTTCATGCCGATCGCCGTC
CGCGTCGTTTCAAAGGACCAGTATCAGAACTGGCTGTCAGCGGCCGCGACGGATCTGCCGGGGGCAAACAAGGCTCTTCT
GCAGGCTGAAGGCGAAGGCAGTGCGAACGATAAGGTGGCTGCGGCGGGGCTGTAA

Upstream 100 bases:

>100_bases
CGACGGGGATAAGGCCGTCCTTAAGACCGGCGTCCAGCCTGAAAGGGCGAAAAGGGAGAGAGTTCTGGTGGATAAGATTG
TTGCCGCAACGAGGGGCGCC

Downstream 100 bases:

>100_bases
ATCCCGCTGGAGCGCCGCGCGCCGTCTGATGCGCGCAATGGCGTTCTGAGCATTAGACCTGCGCACCGGGCTTTGCGAAG
CCTATCCGGTTTCCGGGCCG

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MGGALAVLWTTGAALADQPRPWEWRFQDAATGIAEQIHWFERYTLWFIIPITLLVLGLLVWVVLRFRASVNPEPSKTSHN
TAIEVIWTVGPVIILLFLAVPSFQLLTAQYSPEDPTLTVKATGYQWYWGYEYQVDNPVSFDSVILKDDDRAAAGKEDRAR
YPRLLTVDNEVVVPVGETVRLLVTASDVIHSWTIPAFGVKMDAVPGRINETWFKADKEGLYYGQCSELCGKDHGFMPIAV
RVVSKDQYQNWLSAAATDLPGANKALLQAEGEGSANDKVAAAGL

Sequences:

>Translated_284_residues
MGGALAVLWTTGAALADQPRPWEWRFQDAATGIAEQIHWFERYTLWFIIPITLLVLGLLVWVVLRFRASVNPEPSKTSHN
TAIEVIWTVGPVIILLFLAVPSFQLLTAQYSPEDPTLTVKATGYQWYWGYEYQVDNPVSFDSVILKDDDRAAAGKEDRAR
YPRLLTVDNEVVVPVGETVRLLVTASDVIHSWTIPAFGVKMDAVPGRINETWFKADKEGLYYGQCSELCGKDHGFMPIAV
RVVSKDQYQNWLSAAATDLPGANKALLQAEGEGSANDKVAAAGL
>Mature_283_residues
GGALAVLWTTGAALADQPRPWEWRFQDAATGIAEQIHWFERYTLWFIIPITLLVLGLLVWVVLRFRASVNPEPSKTSHNT
AIEVIWTVGPVIILLFLAVPSFQLLTAQYSPEDPTLTVKATGYQWYWGYEYQVDNPVSFDSVILKDDDRAAAGKEDRARY
PRLLTVDNEVVVPVGETVRLLVTASDVIHSWTIPAFGVKMDAVPGRINETWFKADKEGLYYGQCSELCGKDHGFMPIAVR
VVSKDQYQNWLSAAATDLPGANKALLQAEGEGSANDKVAAAGL

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=224, Percent_Identity=37.5, Blast_Score=164, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6226540, Length=254, Percent_Identity=38.9763779527559, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 31454; Mature: 31323

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGALAVLWTTGAALADQPRPWEWRFQDAATGIAEQIHWFERYTLWFIIPITLLVLGLLV
CCCEEEEEEECCCHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVLRFRASVNPEPSKTSHNTAIEVIWTVGPVIILLFLAVPSFQLLTAQYSPEDPTLTVK
HHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEE
ATGYQWYWGYEYQVDNPVSFDSVILKDDDRAAAGKEDRARYPRLLTVDNEVVVPVGETVR
ECCEEEEEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHCCEEEEECCEEEEECCCEEE
LLVTASDVIHSWTIPAFGVKMDAVPGRINETWFKADKEGLYYGQCSELCGKDHGFMPIAV
EEEEEHHHHHHCCCCCCCEEEECCCCCCCHHHHHCCCCCCEECCHHHHCCCCCCCEEEEE
RVVSKDQYQNWLSAAATDLPGANKALLQAEGEGSANDKVAAAGL
EEECHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCC
>Mature Secondary Structure 
GGALAVLWTTGAALADQPRPWEWRFQDAATGIAEQIHWFERYTLWFIIPITLLVLGLLV
CCEEEEEEECCCHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVLRFRASVNPEPSKTSHNTAIEVIWTVGPVIILLFLAVPSFQLLTAQYSPEDPTLTVK
HHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEE
ATGYQWYWGYEYQVDNPVSFDSVILKDDDRAAAGKEDRARYPRLLTVDNEVVVPVGETVR
ECCEEEEEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHCCEEEEECCEEEEECCCEEE
LLVTASDVIHSWTIPAFGVKMDAVPGRINETWFKADKEGLYYGQCSELCGKDHGFMPIAV
EEEEEHHHHHHCCCCCCCEEEECCCCCCCHHHHHCCCCCCEECCHHHHCCCCCCCEEEEE
RVVSKDQYQNWLSAAATDLPGANKALLQAEGEGSANDKVAAAGL
EEECHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA