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The map label for this gene is 225851966

Identifier: 225851966

GI number: 225851966

Start: 451166

End: 452116

Strand: Direct

Name: 225851966

Synonym: BMEA_A0463

Alternate gene names: NA

Gene position: 451166-452116 (Clockwise)

Preceding gene: 225851965

Following gene: 225851967

Centisome position: 21.22

GC content: 58.15

Gene sequence:

>951_bases
ATGACGACACGGCTTTACTGGCATCCGATCTATCTCGAACACCTGACGCCGCCCGGCCACCCGGAACGCCCCGACCGCAT
TCGCGCGTTGATGAGCGAGCTGGAGGGGCCGGATTTCTACCGCCTTGACCGGGTGGAAGCGCCGCATGCCGGTGAGGCGG
CGATCCTGCTTGCCCACCCGGAAGAACATCTGGAAGCGGTGCGGTCGAAAATTCCCGAACCTGTTGAGGACGGGGAAGCG
TCCCAGCCCATCGTGAAACTTGATGGTGATACCTATGTCAGCCCGAAAAGCATGGATGCGGCGCTGACAGCCATTGGCGC
GGCGATGGCCGCGGTCGATGATGTCATGTCGGGTGCTGCGGACAATGTTTTCGTGGCATCGCGCCCGCCTGGCCACCATG
CCGAGCGCAGCAGGGCCATGGGCTTTTGCGTTTTCAACAATATTGCGATTGCGGCGCGCCATGCGCAGCGCCATCATGGG
CTGGAACGCATCGCAATTGTCGATTGGGATGTACACCACGGCAATGGCACGCAGGATATTTTCAAGGATGATCCAGGCGT
AATGTTCTGTTCGACGCACCAGTTCCCGCTCTATCCGGGAAGTGGTGACAAGCACGAAACGGGCGTGGGCAATATCGTCA
ATGCGCCGCTTTCGCCCAATACGGGCAGTCGCGAGTTTCGTGAGGCGTTCAATAGTCGTATTTTACCGGCCCTGGACAAT
TTCCGGCCAGATTTGATCCTTATTTCGGCTGGCTTCGATGCCCATTTTCGCGACCCTCTGGCCGAGATCAATCTCGATGA
GTCGGATTTCGATTGGGCGACGGGCAAGCTCATGGAGCGGGCAGAAAGGTTCTGCGATCACCGACTGGTGAGTGTGCTTG
AAGGTGGATATGATCTAGAGGGCTTGTCGCAGTCCGCATCTGTGCATATTACGCGGCTGTTGAAAGGATGA

Upstream 100 bases:

>100_bases
AGGCGGCCTCGCGGCGGGGCCGCCTGTTTTTTCTTCCATGCATTTTCCGGGCCGAAGGCGTTTCACATATTTTTTGCGGA
AAATGCTTTATAGTGGATGC

Downstream 100 bases:

>100_bases
ATTAATGGTGACTGAACCGTCCAACGCCGACATTGCAGTAATGAGCTTCGAGGATGCGCTGAAGCAGCTCGAAAAGATCG
TTGACGATCTGGAGCGGGGC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTTRLYWHPIYLEHLTPPGHPERPDRIRALMSELEGPDFYRLDRVEAPHAGEAAILLAHPEEHLEAVRSKIPEPVEDGEA
SQPIVKLDGDTYVSPKSMDAALTAIGAAMAAVDDVMSGAADNVFVASRPPGHHAERSRAMGFCVFNNIAIAARHAQRHHG
LERIAIVDWDVHHGNGTQDIFKDDPGVMFCSTHQFPLYPGSGDKHETGVGNIVNAPLSPNTGSREFREAFNSRILPALDN
FRPDLILISAGFDAHFRDPLAEINLDESDFDWATGKLMERAERFCDHRLVSVLEGGYDLEGLSQSASVHITRLLKG

Sequences:

>Translated_316_residues
MTTRLYWHPIYLEHLTPPGHPERPDRIRALMSELEGPDFYRLDRVEAPHAGEAAILLAHPEEHLEAVRSKIPEPVEDGEA
SQPIVKLDGDTYVSPKSMDAALTAIGAAMAAVDDVMSGAADNVFVASRPPGHHAERSRAMGFCVFNNIAIAARHAQRHHG
LERIAIVDWDVHHGNGTQDIFKDDPGVMFCSTHQFPLYPGSGDKHETGVGNIVNAPLSPNTGSREFREAFNSRILPALDN
FRPDLILISAGFDAHFRDPLAEINLDESDFDWATGKLMERAERFCDHRLVSVLEGGYDLEGLSQSASVHITRLLKG
>Mature_315_residues
TTRLYWHPIYLEHLTPPGHPERPDRIRALMSELEGPDFYRLDRVEAPHAGEAAILLAHPEEHLEAVRSKIPEPVEDGEAS
QPIVKLDGDTYVSPKSMDAALTAIGAAMAAVDDVMSGAADNVFVASRPPGHHAERSRAMGFCVFNNIAIAARHAQRHHGL
ERIAIVDWDVHHGNGTQDIFKDDPGVMFCSTHQFPLYPGSGDKHETGVGNIVNAPLSPNTGSREFREAFNSRILPALDNF
RPDLILISAGFDAHFRDPLAEINLDESDFDWATGKLMERAERFCDHRLVSVLEGGYDLEGLSQSASVHITRLLKG

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=323, Percent_Identity=35.9133126934984, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI13128864, Length=299, Percent_Identity=38.1270903010033, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI17158039, Length=345, Percent_Identity=34.4927536231884, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI30795202, Length=345, Percent_Identity=34.4927536231884, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI30795204, Length=345, Percent_Identity=34.4927536231884, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI153085395, Length=345, Percent_Identity=33.9130434782609, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI62750349, Length=347, Percent_Identity=32.2766570605187, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI62750347, Length=347, Percent_Identity=32.2766570605187, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI169234807, Length=244, Percent_Identity=39.344262295082, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI148539870, Length=244, Percent_Identity=39.344262295082, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI226529806, Length=323, Percent_Identity=33.4365325077399, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI13128860, Length=255, Percent_Identity=26.6666666666667, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI293336691, Length=255, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI13128862, Length=306, Percent_Identity=24.1830065359477, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI8923769, Length=251, Percent_Identity=25.4980079681275, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI262073088, Length=140, Percent_Identity=30, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI262073092, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540334, Length=306, Percent_Identity=38.562091503268, Blast_Score=193, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI193206283, Length=306, Percent_Identity=38.562091503268, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17540332, Length=306, Percent_Identity=38.562091503268, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI193209491, Length=319, Percent_Identity=33.2288401253918, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25154020, Length=301, Percent_Identity=30.8970099667774, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25154022, Length=301, Percent_Identity=30.5647840531561, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17537347, Length=311, Percent_Identity=30.5466237942122, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17508561, Length=293, Percent_Identity=25.5972696245734, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534739, Length=258, Percent_Identity=28.6821705426357, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17561978, Length=253, Percent_Identity=24.901185770751, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324307, Length=330, Percent_Identity=32.4242424242424, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325141, Length=299, Percent_Identity=28.0936454849498, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=255, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321244, Length=257, Percent_Identity=25.2918287937743, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=138, Percent_Identity=29.7101449275362, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24642144, Length=313, Percent_Identity=36.1022364217252, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24642146, Length=313, Percent_Identity=36.1022364217252, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281360899, Length=313, Percent_Identity=36.1022364217252, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24642142, Length=313, Percent_Identity=36.1022364217252, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24641720, Length=344, Percent_Identity=33.7209302325581, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281360799, Length=344, Percent_Identity=33.7209302325581, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281360801, Length=344, Percent_Identity=33.7209302325581, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24657891, Length=303, Percent_Identity=26.7326732673267, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24644244, Length=307, Percent_Identity=24.7557003257329, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 34858; Mature: 34727

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRLYWHPIYLEHLTPPGHPERPDRIRALMSELEGPDFYRLDRVEAPHAGEAAILLAHP
CCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEECC
EEHLEAVRSKIPEPVEDGEASQPIVKLDGDTYVSPKSMDAALTAIGAAMAAVDDVMSGAA
HHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCC
DNVFVASRPPGHHAERSRAMGFCVFNNIAIAARHAQRHHGLERIAIVDWDVHHGNGTQDI
CCEEEECCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHH
FKDDPGVMFCSTHQFPLYPGSGDKHETGVGNIVNAPLSPNTGSREFREAFNSRILPALDN
HCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCCHHHC
FRPDLILISAGFDAHFRDPLAEINLDESDFDWATGKLMERAERFCDHRLVSVLEGGYDLE
CCCCEEEEECCCCCHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GLSQSASVHITRLLKG
CCCCCHHEEEEEECCC
>Mature Secondary Structure 
TTRLYWHPIYLEHLTPPGHPERPDRIRALMSELEGPDFYRLDRVEAPHAGEAAILLAHP
CCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEECC
EEHLEAVRSKIPEPVEDGEASQPIVKLDGDTYVSPKSMDAALTAIGAAMAAVDDVMSGAA
HHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCC
DNVFVASRPPGHHAERSRAMGFCVFNNIAIAARHAQRHHGLERIAIVDWDVHHGNGTQDI
CCEEEECCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHH
FKDDPGVMFCSTHQFPLYPGSGDKHETGVGNIVNAPLSPNTGSREFREAFNSRILPALDN
HCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCCHHHC
FRPDLILISAGFDAHFRDPLAEINLDESDFDWATGKLMERAERFCDHRLVSVLEGGYDLE
CCCCEEEEECCCCCHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GLSQSASVHITRLLKG
CCCCCHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]