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The map label for this gene is ribB [H]

Identifier: 225851965

GI number: 225851965

Start: 449835

End: 450950

Strand: Direct

Name: ribB [H]

Synonym: BMEA_A0462

Alternate gene names: 225851965

Gene position: 449835-450950 (Clockwise)

Preceding gene: 225851964

Following gene: 225851966

Centisome position: 21.16

GC content: 60.22

Gene sequence:

>1116_bases
ATGAGCTATAATCAGAAACAGGTCGTTGATGCGATTTGCGCTTTTGAACGCGGTGAAATCGTCGTGGTCATGGATGACGA
CGGTCGCGAAAACGAAGGCGATCTGATCGTCGCCGCCGTGCATTGCACACCGGAAAAGATGGCCTTCATCGTGCGCCATA
CGTCCGGCATTGTCTGCACGCCGATGACGCGTGAGGAAGCCAAGCGCCTCAACCTGACGCCGATGGTGGCGGAAAACGAA
TCCGCTCACACGACCGCTTTTACGGTCACGGTCGATTATCGCCATGGCACCACGACCGGCATTTCAGCCGAAGACCGCAC
GCTGACCGTGCGCAACCTGGCCAATCCCAATGCCGGTGCTTCGGATTTCGTGCGCCCCGGCCATATTTTCCCGCTGGTTG
CCCGTGAGGGCGGTGTGCTGATGCGCTCCGGCCATACGGAAGCCGCCGTTGATCTGTGCAAGCTCGCCAACCTGCCGCCC
ATCGGCGTTATCTGCGAACTCGTCAACGATGACGGCACGGTCATGCGCGGTCCCGATGTGGCGGCTTTCGCCGAGGAGCA
CAAATTGCACCGCGTCACGGTTGCCGATCTCATCGCCTATCGCCAGCGCAAGGAAACGCTGGTCAGGCGCATTGGCGATG
CGCCTGTCGAAACCTGTGCTGGCAAGGCTCATGCCTATAGTTATGAACTGCCGTGGGAGCCGATGCAGCATGTGGCGGTT
GTCTTCGGCGATATTCGCGACGGTGAGGAAGTGCCGGTCCGTCTCCATCGCGAGGATGTGCTGAACGATGTTTTCGGCAA
GGGCGGCAGCAATCTCGATGCCATCATGCAGCGCATGGGGCAGGAGGGCCGGGGCATTCTGGTCTATCTGCGTGAAGGCT
CCGTCGGCGTGCGTTCGGATCATCGCGATGCCCGCGCCCGTGAGGCGCTGCAAGGCGAGCATGAAGCCCATGCGGAAGCC
GTTGCCCGCGAGGAAGAATGGCGCCAGATCGGCCTTGGCGCGCAGATTTTGAAGGATCTCGGCGTTTCCTCCATCGTGCT
TCTGGCCTCGCGTGAGCGCCACTATGTCGGCCTTGAAGGTTTCGGCATTTGCATCACGCGTACGGAAATTATCTAA

Upstream 100 bases:

>100_bases
GTGGGGCCAGATTGGCCGCGCCTGAAAATAATAGGGCCAACCGGCCCCTTATGACGAGCAATGCGGCCATACCGGCCGCA
TTTGAAATATCGAGGTCGAA

Downstream 100 bases:

>100_bases
TGCATGTCTCCCAAAAGCGGGAACCGGTTTTGGGATGAAAACATGCATAAAAACAAAAGTTTCGTGTCGTAAGAGTACGA
TAAAACGCGGCGCGCTTTAA

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSYNQKQVVDAICAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCTPMTREEAKRLNLTPMVAENE
SAHTTAFTVTVDYRHGTTTGISAEDRTLTVRNLANPNAGASDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCKLANLPP
IGVICELVNDDGTVMRGPDVAAFAEEHKLHRVTVADLIAYRQRKETLVRRIGDAPVETCAGKAHAYSYELPWEPMQHVAV
VFGDIRDGEEVPVRLHREDVLNDVFGKGGSNLDAIMQRMGQEGRGILVYLREGSVGVRSDHRDARAREALQGEHEAHAEA
VAREEEWRQIGLGAQILKDLGVSSIVLLASRERHYVGLEGFGICITRTEII

Sequences:

>Translated_371_residues
MSYNQKQVVDAICAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCTPMTREEAKRLNLTPMVAENE
SAHTTAFTVTVDYRHGTTTGISAEDRTLTVRNLANPNAGASDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCKLANLPP
IGVICELVNDDGTVMRGPDVAAFAEEHKLHRVTVADLIAYRQRKETLVRRIGDAPVETCAGKAHAYSYELPWEPMQHVAV
VFGDIRDGEEVPVRLHREDVLNDVFGKGGSNLDAIMQRMGQEGRGILVYLREGSVGVRSDHRDARAREALQGEHEAHAEA
VAREEEWRQIGLGAQILKDLGVSSIVLLASRERHYVGLEGFGICITRTEII
>Mature_370_residues
SYNQKQVVDAICAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCTPMTREEAKRLNLTPMVAENES
AHTTAFTVTVDYRHGTTTGISAEDRTLTVRNLANPNAGASDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCKLANLPPI
GVICELVNDDGTVMRGPDVAAFAEEHKLHRVTVADLIAYRQRKETLVRRIGDAPVETCAGKAHAYSYELPWEPMQHVAVV
FGDIRDGEEVPVRLHREDVLNDVFGKGGSNLDAIMQRMGQEGRGILVYLREGSVGVRSDHRDARAREALQGEHEAHAEAV
AREEEWRQIGLGAQILKDLGVSSIVLLASRERHYVGLEGFGICITRTEII

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=51, Blast_Score=200, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=50.4950495049505, Blast_Score=198, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40759; Mature: 40628

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNQKQVVDAICAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCT
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHEEEEEEECCCEEEC
PMTREEAKRLNLTPMVAENESAHTTAFTVTVDYRHGTTTGISAEDRTLTVRNLANPNAGA
CCCHHHHHHCCCCEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCH
SDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCKLANLPPIGVICELVNDDGTVMRGPDV
HHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHEEEEECCCCCEEECCCH
AAFAEEHKLHRVTVADLIAYRQRKETLVRRIGDAPVETCAGKAHAYSYELPWEPMQHVAV
HHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCHHHHHEE
VFGDIRDGEEVPVRLHREDVLNDVFGKGGSNLDAIMQRMGQEGRGILVYLREGSVGVRSD
EEECCCCCCCCCEEECHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCC
HRDARAREALQGEHEAHAEAVAREEEWRQIGLGAQILKDLGVSSIVLLASRERHYVGLEG
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCEECCCC
FGICITRTEII
CEEEEEEEECC
>Mature Secondary Structure 
SYNQKQVVDAICAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCT
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHEEEEEEECCCEEEC
PMTREEAKRLNLTPMVAENESAHTTAFTVTVDYRHGTTTGISAEDRTLTVRNLANPNAGA
CCCHHHHHHCCCCEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCH
SDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCKLANLPPIGVICELVNDDGTVMRGPDV
HHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHEEEEECCCCCEEECCCH
AAFAEEHKLHRVTVADLIAYRQRKETLVRRIGDAPVETCAGKAHAYSYELPWEPMQHVAV
HHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCHHHHHEE
VFGDIRDGEEVPVRLHREDVLNDVFGKGGSNLDAIMQRMGQEGRGILVYLREGSVGVRSD
EEECCCCCCCCCEEECHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCC
HRDARAREALQGEHEAHAEAVAREEEWRQIGLGAQILKDLGVSSIVLLASRERHYVGLEG
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCEECCCC
FGICITRTEII
CEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA