BacMap

Definition	Brucella melitensis ATCC 23457 chromosome chromosome I, complete sequence.
Accession	NC_012441
Length	2,125,701

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The map label for this gene is ccmA [H]

Identifier: 225851633

GI number: 225851633

Start: 100096

End: 100743

Strand: Direct

Name: ccmA [H]

Synonym: BMEA_A0099

Alternate gene names: 225851633

Gene position: 100096-100743 (Clockwise)

Preceding gene: 225851628

Following gene: 225851634

Centisome position: 4.71

GC content: 58.49

Gene sequence:

>648_bases
ATGCGGCTTGAAGCCGAAAATCTGGCAGGCGAACGTGGCGGCGAAACCATCTTCTCGCACTTGTCGTTCACCATTGGCAC
AGGTCAAGCACTCGTTGTGACCGGACCGAACGGTTCTGGCAAATCCACATTGCTGCGAATCATCTGCGGCCTCCTCGCTC
CCGAAGCGGGCGAGGTGAAACTGACCGAGGGAACGCAGATTGTGCCCGTGCGTGCTGCCTGCCACTATCTGGGTCATCAA
AATGCAATGAAGCCCGCGCTCAGCGTGCGCGAGAACCTCCTGTTCTGGCAGAAGTTCAACGGCGGTGAAGCCCTCGATAT
CGGCGCGGCACTGGAGGCGGTGGATTTGGCGGGTGTGGAACACCTGCCTTTCGGCTATCTTTCCACCGGACAGAAACGGC
GTGTTTCCATTGCCAAGCTGCTTGTGAGCCATCGCCCGCTCTGGATTGTCGATGAACCGACTGCCGGTCTCGACAAGGCG
TCCGAAGCCCGCTTTGCAGAACTTATGCGCGAACATATGCGCCAGGACGGCATGATTATCGCCGCGACCCATATTCCGTT
AGGGCTGGACGGCGCCATTTCGACAACGGGTAACGGGCTGGTGCGTTCGCTTGATATGGCCGCTTTTTCGGTTGAGGATA
TCGCCTGA

Upstream 100 bases:

>100_bases
GGCGAAATGTTGCGATATGTTCGGGGAGCTGCGGTTCAATCGATTTGGGCGCCCCGATCAGGTCTGAAACGGGGTTTGCG
TGGGGTTTAAAGTGGTAGAG

Downstream 100 bases:

>100_bases
TGCTGGCCCTGTTCCTTCGCGATATGCGCCTTGGTTTGCGCGCTGGCGGCGGCGCGCTGATCGGCATCCTGTTCTTCCTC
GCGGTGATTTCTGTGATGCC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVKLTEGTQIVPVRAACHYLGHQ
NAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVEHLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKA
SEARFAELMREHMRQDGMIIAATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA

Sequences:

>Translated_215_residues
MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVKLTEGTQIVPVRAACHYLGHQ
NAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVEHLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKA
SEARFAELMREHMRQDGMIIAATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA
>Mature_215_residues
MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVKLTEGTQIVPVRAACHYLGHQ
NAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVEHLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKA
SEARFAELMREHMRQDGMIIAATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=192, Percent_Identity=29.6875, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI27436953, Length=149, Percent_Identity=28.8590604026846, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI46592915, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592956, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI46592898, Length=183, Percent_Identity=28.9617486338798, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI46592978, Length=183, Percent_Identity=28.9617486338798, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI46592964, Length=183, Percent_Identity=28.9617486338798, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI46592971, Length=183, Percent_Identity=28.9617486338798, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI215820660, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI20143975, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27262624, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI27262626, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI105990541, Length=182, Percent_Identity=31.3186813186813, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27881501, Length=175, Percent_Identity=23.4285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI30795238, Length=175, Percent_Identity=23.4285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI31657092, Length=181, Percent_Identity=26.5193370165746, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI27477115, Length=176, Percent_Identity=26.7045454545455, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI116734710, Length=172, Percent_Identity=27.3255813953488, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI150417984, Length=172, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082064, Length=191, Percent_Identity=41.3612565445026, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI87081709, Length=191, Percent_Identity=29.3193717277487, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786253, Length=182, Percent_Identity=30.2197802197802, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788165, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994943, Length=194, Percent_Identity=33.5051546391753, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790467, Length=189, Percent_Identity=30.1587301587302, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786563, Length=187, Percent_Identity=29.9465240641711, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081791, Length=171, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1786803, Length=193, Percent_Identity=32.1243523316062, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1790739, Length=196, Percent_Identity=27.0408163265306, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081782, Length=192, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789593, Length=190, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1790544, Length=205, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787370, Length=188, Percent_Identity=30.3191489361702, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788225, Length=199, Percent_Identity=27.6381909547739, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1787029, Length=194, Percent_Identity=28.3505154639175, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786698, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI2367384, Length=165, Percent_Identity=31.5151515151515, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081834, Length=181, Percent_Identity=28.1767955801105, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788761, Length=186, Percent_Identity=29.5698924731183, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI87082267, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1789873, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787041, Length=160, Percent_Identity=30.625, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787792, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788210, Length=179, Percent_Identity=27.9329608938547, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787112, Length=194, Percent_Identity=28.8659793814433, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787712, Length=213, Percent_Identity=26.7605633802817, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787089, Length=187, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787164, Length=175, Percent_Identity=29.1428571428571, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17543740, Length=192, Percent_Identity=30.2083333333333, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533592, Length=185, Percent_Identity=30.2702702702703, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17533971, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646699, Length=180, Percent_Identity=30, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=184, Percent_Identity=29.3478260869565, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71992285, Length=197, Percent_Identity=28.4263959390863, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320874, Length=179, Percent_Identity=27.3743016759777, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920532, Length=175, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24580930, Length=175, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574744, Length=192, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221500365, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007184, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076682, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161076684, Length=185, Percent_Identity=28.6486486486486, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581617, Length=185, Percent_Identity=28.6486486486486, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581615, Length=185, Percent_Identity=28.6486486486486, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574533, Length=189, Percent_Identity=29.1005291005291, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI85724858, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85724856, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580547, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580551, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580549, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580545, Length=181, Percent_Identity=26.5193370165746, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24581191, Length=172, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581189, Length=172, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581193, Length=172, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581195, Length=172, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648314, Length=229, Percent_Identity=25.764192139738, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724864, Length=187, Percent_Identity=30.4812834224599, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580555, Length=187, Percent_Identity=30.4812834224599, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85816269, Length=187, Percent_Identity=30.4812834224599, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580553, Length=187, Percent_Identity=30.4812834224599, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85726357, Length=164, Percent_Identity=30.4878048780488, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581407, Length=199, Percent_Identity=26.6331658291457, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45552199, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22909; Mature: 22909

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVK
CCCCCCCCCCCCCCHHHHHHHEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
LTEGTQIVPVRAACHYLGHQNAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVE
ECCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHCCCC
HLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKASEARFAELMREHMRQDGMII
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEE
AATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA
EEEECCCCCCCCCCCCCCHHHHHHHHHHEEHHHCC
>Mature Secondary Structure
MRLEAENLAGERGGETIFSHLSFTIGTGQALVVTGPNGSGKSTLLRIICGLLAPEAGEVK
CCCCCCCCCCCCCCHHHHHHHEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
LTEGTQIVPVRAACHYLGHQNAMKPALSVRENLLFWQKFNGGEALDIGAALEAVDLAGVE
ECCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHCCCC
HLPFGYLSTGQKRRVSIAKLLVSHRPLWIVDEPTAGLDKASEARFAELMREHMRQDGMII
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEE
AATHIPLGLDGAISTTGNGLVRSLDMAAFSVEDIA
EEEECCCCCCCCCCCCCCHHHHHHHHHHEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA