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The map label for this gene is moeZ [H]

Identifier: 225851550

GI number: 225851550

Start: 5070

End: 5852

Strand: Direct

Name: moeZ [H]

Synonym: BMEA_A0004

Alternate gene names: 225851550

Gene position: 5070-5852 (Clockwise)

Preceding gene: 225851549

Following gene: 225851561

Centisome position: 0.24

GC content: 61.17

Gene sequence:

>783_bases
ATGTTTGCAGGCATGAATGTATCATCCAGACCATTTTCGCCCGAAGAACTTGAACGCTATGCACGCCATATCGTGCTGCC
GGTAATTGGCGGTCCGGGCCAGCAAAAGCTGAAGGCTGCCCGTGTGCTTGTCGTTGGCGCAGGCGGACTGGGCGCGCCGG
TGCTGCAATATCTGGCGGCGGCAGGCGTCGGCACGCTCGGCATCGTCGATGACGATACGGTGTCGCTGTCGAACCTGCAA
CGGCAGATCATCCATGATACGGACAGTATCGGGCAGCCCAAGGTGGAAAGCGCGCTTGCCTCCATCGCGCGCATCAACCC
GCATGTGAAGGTGGAAGGCCACCAGCTGCGTCTCGACGCGCATAATGCCGAGGCGCTCATTGCCGGTTTCGATGTCGTGG
TGGACGGTTCGGACAATTTCGCCACGCGCTATGTGCTGGCCGATGCTGCTGCTAAGGTGGGAAGGCCCCTCGTAACGGGC
GCCATGGGCCGTTTCGATGGCACGGTGACGGTGTTGATGCCCTATGCGAACGGCCCGGACGGCGCAAAGAACCCGTCCTA
TCGCGATCTTTTCCCGGATGCGCCGCCGCCGGGAACGGTCCCTTCCTGCGCCGAAGCGGGTGTGCTGGGTGTCCTGCCGG
GTGTGATCGGCAGCCTGCAGGCCATGGAAGTCATCAAGCTTGTCACCGGCATCGGCGAACCGCTGGTCGGGCGGCTTCTT
CTCTACAATGCGCTGAATGTCCGTTTTGAAACCATCCGCTACAAGGCCCGCAAACCAAAATAA

Upstream 100 bases:

>100_bases
GATGCGCTTGCTGGCGATGCGCAGTTTTTCAACGTGTCGGCCGGGCAATTGACAGGGATATAAGGCAAAATAGTTGCTGA
CAGCGCGGTTCGGGCAGCCT

Downstream 100 bases:

>100_bases
TTGAGCATTTTCAGGCTCAATACTGGGTTGAACGGTCCACCACATGCTCCAGGGTGCCGTCGCGCTCGAATGCCTCGATC
TGGCGGATGATCTGGGGCAC

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MFAGMNVSSRPFSPEELERYARHIVLPVIGGPGQQKLKAARVLVVGAGGLGAPVLQYLAAAGVGTLGIVDDDTVSLSNLQ
RQIIHDTDSIGQPKVESALASIARINPHVKVEGHQLRLDAHNAEALIAGFDVVVDGSDNFATRYVLADAAAKVGRPLVTG
AMGRFDGTVTVLMPYANGPDGAKNPSYRDLFPDAPPPGTVPSCAEAGVLGVLPGVIGSLQAMEVIKLVTGIGEPLVGRLL
LYNALNVRFETIRYKARKPK

Sequences:

>Translated_260_residues
MFAGMNVSSRPFSPEELERYARHIVLPVIGGPGQQKLKAARVLVVGAGGLGAPVLQYLAAAGVGTLGIVDDDTVSLSNLQ
RQIIHDTDSIGQPKVESALASIARINPHVKVEGHQLRLDAHNAEALIAGFDVVVDGSDNFATRYVLADAAAKVGRPLVTG
AMGRFDGTVTVLMPYANGPDGAKNPSYRDLFPDAPPPGTVPSCAEAGVLGVLPGVIGSLQAMEVIKLVTGIGEPLVGRLL
LYNALNVRFETIRYKARKPK
>Mature_260_residues
MFAGMNVSSRPFSPEELERYARHIVLPVIGGPGQQKLKAARVLVVGAGGLGAPVLQYLAAAGVGTLGIVDDDTVSLSNLQ
RQIIHDTDSIGQPKVESALASIARINPHVKVEGHQLRLDAHNAEALIAGFDVVVDGSDNFATRYVLADAAAKVGRPLVTG
AMGRFDGTVTVLMPYANGPDGAKNPSYRDLFPDAPPPGTVPSCAEAGVLGVLPGVIGSLQAMEVIKLVTGIGEPLVGRLL
LYNALNVRFETIRYKARKPK

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=238, Percent_Identity=47.8991596638655, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI23510338, Length=187, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI23510340, Length=187, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI38045942, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38045944, Length=155, Percent_Identity=30.9677419354839, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38045948, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI150417996, Length=208, Percent_Identity=30.2884615384615, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=44.8979591836735, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=39.1836734693878, Blast_Score=151, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17540406, Length=249, Percent_Identity=42.570281124498, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=141, Percent_Identity=26.9503546099291, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71984476, Length=153, Percent_Identity=28.7581699346405, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=259, Percent_Identity=40.9266409266409, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320598, Length=152, Percent_Identity=29.6052631578947, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24582879, Length=249, Percent_Identity=45.3815261044177, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28573937, Length=195, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24660640, Length=140, Percent_Identity=30.7142857142857, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI20129973, Length=182, Percent_Identity=30.2197802197802, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27304; Mature: 27304

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAGMNVSSRPFSPEELERYARHIVLPVIGGPGQQKLKAARVLVVGAGGLGAPVLQYLAA
CCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCHHHHHEEEEEEEECCCCCHHHHHHHHH
AGVGTLGIVDDDTVSLSNLQRQIIHDTDSIGQPKVESALASIARINPHVKVEGHQLRLDA
CCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEC
HNAEALIAGFDVVVDGSDNFATRYVLADAAAKVGRPLVTGAMGRFDGTVTVLMPYANGPD
CCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCCC
GAKNPSYRDLFPDAPPPGTVPSCAEAGVLGVLPGVIGSLQAMEVIKLVTGIGEPLVGRLL
CCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LYNALNVRFETIRYKARKPK
HHHHHHCEEEEEEEECCCCC
>Mature Secondary Structure
MFAGMNVSSRPFSPEELERYARHIVLPVIGGPGQQKLKAARVLVVGAGGLGAPVLQYLAA
CCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCHHHHHEEEEEEEECCCCCHHHHHHHHH
AGVGTLGIVDDDTVSLSNLQRQIIHDTDSIGQPKVESALASIARINPHVKVEGHQLRLDA
CCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEC
HNAEALIAGFDVVVDGSDNFATRYVLADAAAKVGRPLVTGAMGRFDGTVTVLMPYANGPD
CCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCCC
GAKNPSYRDLFPDAPPPGTVPSCAEAGVLGVLPGVIGSLQAMEVIKLVTGIGEPLVGRLL
CCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LYNALNVRFETIRYKARKPK
HHHHHHCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]