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The map label for this gene is ubiA [H]

Identifier: 225631016

GI number: 225631016

Start: 1435714

End: 1436571

Strand: Reverse

Name: ubiA [H]

Synonym: WRi_013460

Alternate gene names: 225631016

Gene position: 1436571-1435714 (Counterclockwise)

Preceding gene: 225631017

Following gene: 225631011

Centisome position: 99.36

GC content: 36.36

Gene sequence:

>858_bases
ATGCATTTCAATCGTTACTTTTCATTAATGAGGTTGCACAGTTTAACGGGTTTGTGGCTTGTGCTATTTCCCAGTTTGAG
CGGTATTCTTTTAGCCTCAACTTCTCTATCATATCAGGCTCTTTTTCTCCTTGTTTTGTTTACTATAGGTGCATTTTTAA
TGAGACCCGCAGGGTGCATAATCAATGATATCTTCGATAGAAAAATAGATGCGCACGTTGAACGAACAAAATATAGGCCA
CTTGCAAGTGGTGCATTAAACATAAAGCAGGCTTTGGCTTTACTTTCACTGCTACTGTCTATTGCCCTGGTAATCTTATT
ATTAACTAATAAAACTACACTCATACTTGGAATAATCTCAATGTGTATGATAGCTACTTACCCTTTATTAAAGCGGTATG
TTTGGTGGCCACAATTGTTCTTAGGGTTTACCTTCAATATGGGATCGCTCATGGGCTCAGCAGCAATAACAAACCAGATC
AGTATAGAATCCTTGCTGTTTTATATAGGATGCGTCTTTTGGACGCTTAGTTATGACACCATATACGCCCATCAAGATAA
AAAAGATGATGAAAAACTCGGGATGAAATCTACCGCATTATATTTTGGTGATACAACAAAATCTTGGTTGAAAAGATTTT
ATTTAATATCTCTTATGACGTGGCTATATGCTGGTATTTTATCATCATTAAATAACATTTTTTATATTGCTCTACTTGCC
GTAGGGTTCATATTTCACCGCCAATGCAAAAATTTCAATCCTGACGATCCCAGTCAATGCATGTCCATATTTAAAAATAA
CTCCTACGTAGGGTTGCTGCTCTTTTTCGGCATTCTTTTAGATAGAATTATCACCTAG

Upstream 100 bases:

>100_bases
TGTTGATTTGCGATTTATACCTGAACTAGTTTTCAAGCCTGACTTAGCGTTCGATAATTTTGTTAATGTAAGCAAAATAT
TACATAATCACACTTAATTA

Downstream 100 bases:

>100_bases
GTCTCAAGAGTTTCGGCTCTAATGAAATCAATAGACTCAGGTAGCCCGCAGAAACAAAAAAACTTGCTTGACAAACTCCG
CCAGCCCACTTATCATGATA

Product: 4-hydroxybenzoate polyprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MHFNRYFSLMRLHSLTGLWLVLFPSLSGILLASTSLSYQALFLLVLFTIGAFLMRPAGCIINDIFDRKIDAHVERTKYRP
LASGALNIKQALALLSLLLSIALVILLLTNKTTLILGIISMCMIATYPLLKRYVWWPQLFLGFTFNMGSLMGSAAITNQI
SIESLLFYIGCVFWTLSYDTIYAHQDKKDDEKLGMKSTALYFGDTTKSWLKRFYLISLMTWLYAGILSSLNNIFYIALLA
VGFIFHRQCKNFNPDDPSQCMSIFKNNSYVGLLLFFGILLDRIIT

Sequences:

>Translated_285_residues
MHFNRYFSLMRLHSLTGLWLVLFPSLSGILLASTSLSYQALFLLVLFTIGAFLMRPAGCIINDIFDRKIDAHVERTKYRP
LASGALNIKQALALLSLLLSIALVILLLTNKTTLILGIISMCMIATYPLLKRYVWWPQLFLGFTFNMGSLMGSAAITNQI
SIESLLFYIGCVFWTLSYDTIYAHQDKKDDEKLGMKSTALYFGDTTKSWLKRFYLISLMTWLYAGILSSLNNIFYIALLA
VGFIFHRQCKNFNPDDPSQCMSIFKNNSYVGLLLFFGILLDRIIT
>Mature_285_residues
MHFNRYFSLMRLHSLTGLWLVLFPSLSGILLASTSLSYQALFLLVLFTIGAFLMRPAGCIINDIFDRKIDAHVERTKYRP
LASGALNIKQALALLSLLLSIALVILLLTNKTTLILGIISMCMIATYPLLKRYVWWPQLFLGFTFNMGSLMGSAAITNQI
SIESLLFYIGCVFWTLSYDTIYAHQDKKDDEKLGMKSTALYFGDTTKSWLKRFYLISLMTWLYAGILSSLNNIFYIALLA
VGFIFHRQCKNFNPDDPSQCMSIFKNNSYVGLLLFFGILLDRIIT

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=279, Percent_Identity=41.9354838709677, Blast_Score=207, Evalue=9e-54,
Organism=Escherichia coli, GI1790473, Length=273, Percent_Identity=36.2637362637363, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17553718, Length=279, Percent_Identity=43.010752688172, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI32565247, Length=280, Percent_Identity=41.4285714285714, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17553720, Length=336, Percent_Identity=35.7142857142857, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=45.3900709219858, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=45, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324370, Length=285, Percent_Identity=35.7894736842105, Blast_Score=162, Evalue=7e-41,
Organism=Drosophila melanogaster, GI21355567, Length=276, Percent_Identity=43.1159420289855, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32422; Mature: 32422

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFNRYFSLMRLHSLTGLWLVLFPSLSGILLASTSLSYQALFLLVLFTIGAFLMRPAGCI
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
INDIFDRKIDAHVERTKYRPLASGALNIKQALALLSLLLSIALVILLLTNKTTLILGIIS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MCMIATYPLLKRYVWWPQLFLGFTFNMGSLMGSAAITNQISIESLLFYIGCVFWTLSYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYAHQDKKDDEKLGMKSTALYFGDTTKSWLKRFYLISLMTWLYAGILSSLNNIFYIALLA
EEECCCCCCHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGFIFHRQCKNFNPDDPSQCMSIFKNNSYVGLLLFFGILLDRIIT
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHFNRYFSLMRLHSLTGLWLVLFPSLSGILLASTSLSYQALFLLVLFTIGAFLMRPAGCI
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
INDIFDRKIDAHVERTKYRPLASGALNIKQALALLSLLLSIALVILLLTNKTTLILGIIS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MCMIATYPLLKRYVWWPQLFLGFTFNMGSLMGSAAITNQISIESLLFYIGCVFWTLSYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYAHQDKKDDEKLGMKSTALYFGDTTKSWLKRFYLISLMTWLYAGILSSLNNIFYIALLA
EEECCCCCCHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGFIFHRQCKNFNPDDPSQCMSIFKNNSYVGLLLFFGILLDRIIT
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA