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The map label for this gene is mutL

Identifier: 225631007

GI number: 225631007

Start: 1419589

End: 1421406

Strand: Direct

Name: mutL

Synonym: WRi_013350

Alternate gene names: 225631007

Gene position: 1419589-1421406 (Clockwise)

Preceding gene: 225631006

Following gene: 225631008

Centisome position: 98.18

GC content: 36.52

Gene sequence:

>1818_bases
ATGGCAATAATTCTTTTAGACACAAAAACCATAAACCGTATAGCAGCGGGGGAGGTGATAGAAAGGCCAGCAAGTGTAGT
AAAGGAATTAGTGGAAAATGCAATAGATGCTGGAAGTTTAGAAATAGAGATTAAAATAGAAAGTGGTGGGCGTAACCTTA
TTATTGTGACAGATGATGGTAACGGAGTAGAAAAAAACGATTTAGAACTTGCGTTTATGCGCCATGCTACTTCAAAATTG
AGCGATAGTGAGTTGATAGAAATCAAGCATCTTGGCTTTAGAGGAGAAGCTCTGCCTTCAATTGCAGCAGTAAGTAGGAT
AAAATTATCGTCTAAGGCAAGAGAAGCAAGTGAAGCATGGTCTATAAGTTATGAGGGTGGAGAGAAAATAGGGGAGCAAA
CTCCTTACTCTTTATCGCAAGGGACACATATTGAAGTACGAGATTTATTTTTTGCCACTCCAAATAGACTAAAATTTCTA
AAAACCGAAAGAGCAGAAACTCAAAGCATTGTTGATATTGTAAACAACCTAGCAATGATTAACTATCATATAGGGTTTAC
TCTCACTTCAGGTAATAAAAAGCTCTTAAAATACGCTAAGCAGACTTCGTTATTTCATAGATTGTGTGAAGTAGAAGAAG
AATTTCAGGGCAGTTCTCTGGAGATTAATGAAGAAGAAGACGGCATTAAACTTACGGGACACATCTGTAAGCCGACCGTC
AATCGTGGTAAGTCCACTCAGATCTATACGTTTGTTAATGGAAGGCCAATCAAAGATAATCTACTTATTGGCGCAGTTAG
GTATGCATATCATGATTTTATTCCAAGCGATAGGTATCCTTTCGCAGCGTTACATTTAGAGATACCTTATGATCAAGTAG
ATGTAAATGTGCATCCAAATAAGTCAGAAGTAAGGTTTCAGAATAAGAAGCTCATATATGAGATAATGACAAGAGGATTA
ATTAAAGCATTGTCAAGAAGGATAGGCACCTTTCCAGCGCATGACCAGAAAATGGATTCAACATTGCCAGATCCTTTTGA
TAAACCTGATGTTCAAAATGAAAGAAGGCCAAGTCCTTTTGAAAATCAACTAATAAAAGAATTTGCTTCTCCAAATGAAA
AAGCAAAAGGCTTATCAGAACAGTCAAAATCGTTTGATTATACCGGCATACAGAAATTCCCAGCACAAGCGGAGGCTATG
GTTCTAGAAAAAAAGGTGTTAGAGCAAGTTGATTTGATAGAGAGCCACCCGCTCGGGTTTGCACGCTGTCAGGTCTATAA
TACTTATATTATTGCAGAGGTAAGAGACAAATTGATTATAGTCGATCAGCATGCAGCCCACGAGAGATTAGTATATGAAT
GCCTAAAACAAAAATCAAGTATAAAAAGACAAAAACTACTTCTTCCTGAAACGGTTGAAATCAAAAATCAAGCCGGAATG
GAGATGATTGAAATCTATAAAGATAAGTTATTTGAAATGGGTTTTGATATTGAAATCAAATCAGAGAATAAAGTGATAGT
AAAAGAAATCCCTGCAATTTTGGGAGCAATAGATGTGAAAGAGATGCTAATTAACATAATTGATAGATTAACGGAAATAG
AAGATACATTGCCAGTAGAAGATAAAGTGAACAAAATATTGGCCACTATCGCTTGTCATGGATCAATTAGAGCGGGTAGA
AAAATGAGGTTAGATGAAATGAATGAGCTGCTGAGACAAATGGAAAAAACACCATATTCCGGGCAATGCAACCACGGAAG
ACCAACTTATATAGAAATGAAACTCAGTGATATTGAAAAACTTTTTGAGCGTAGGTAA

Upstream 100 bases:

>100_bases
ATATTGTCAATTTCCAACAGTGAAATTGCAGGTAGGTTAAAAAAGTGGAGAGAGAAACAGACCAAAGAAGTAAAAGAAAA
ACCAGTTTCATAATAAATCT

Downstream 100 bases:

>100_bases
TGAGGTTGCCATAAATATGTAACCTCGTCATCCAAGTAGCTCATAGAAACGGATTAAACGAAAAAACTTCCTTGACAAAC
TCCGTCAGCCCCCTTATCAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSLEIEIKIESGGRNLIIVTDDGNGVEKNDLELAFMRHATSKL
SDSELIEIKHLGFRGEALPSIAAVSRIKLSSKAREASEAWSISYEGGEKIGEQTPYSLSQGTHIEVRDLFFATPNRLKFL
KTERAETQSIVDIVNNLAMINYHIGFTLTSGNKKLLKYAKQTSLFHRLCEVEEEFQGSSLEINEEEDGIKLTGHICKPTV
NRGKSTQIYTFVNGRPIKDNLLIGAVRYAYHDFIPSDRYPFAALHLEIPYDQVDVNVHPNKSEVRFQNKKLIYEIMTRGL
IKALSRRIGTFPAHDQKMDSTLPDPFDKPDVQNERRPSPFENQLIKEFASPNEKAKGLSEQSKSFDYTGIQKFPAQAEAM
VLEKKVLEQVDLIESHPLGFARCQVYNTYIIAEVRDKLIIVDQHAAHERLVYECLKQKSSIKRQKLLLPETVEIKNQAGM
EMIEIYKDKLFEMGFDIEIKSENKVIVKEIPAILGAIDVKEMLINIIDRLTEIEDTLPVEDKVNKILATIACHGSIRAGR
KMRLDEMNELLRQMEKTPYSGQCNHGRPTYIEMKLSDIEKLFERR

Sequences:

>Translated_605_residues
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSLEIEIKIESGGRNLIIVTDDGNGVEKNDLELAFMRHATSKL
SDSELIEIKHLGFRGEALPSIAAVSRIKLSSKAREASEAWSISYEGGEKIGEQTPYSLSQGTHIEVRDLFFATPNRLKFL
KTERAETQSIVDIVNNLAMINYHIGFTLTSGNKKLLKYAKQTSLFHRLCEVEEEFQGSSLEINEEEDGIKLTGHICKPTV
NRGKSTQIYTFVNGRPIKDNLLIGAVRYAYHDFIPSDRYPFAALHLEIPYDQVDVNVHPNKSEVRFQNKKLIYEIMTRGL
IKALSRRIGTFPAHDQKMDSTLPDPFDKPDVQNERRPSPFENQLIKEFASPNEKAKGLSEQSKSFDYTGIQKFPAQAEAM
VLEKKVLEQVDLIESHPLGFARCQVYNTYIIAEVRDKLIIVDQHAAHERLVYECLKQKSSIKRQKLLLPETVEIKNQAGM
EMIEIYKDKLFEMGFDIEIKSENKVIVKEIPAILGAIDVKEMLINIIDRLTEIEDTLPVEDKVNKILATIACHGSIRAGR
KMRLDEMNELLRQMEKTPYSGQCNHGRPTYIEMKLSDIEKLFERR
>Mature_604_residues
AIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSLEIEIKIESGGRNLIIVTDDGNGVEKNDLELAFMRHATSKLS
DSELIEIKHLGFRGEALPSIAAVSRIKLSSKAREASEAWSISYEGGEKIGEQTPYSLSQGTHIEVRDLFFATPNRLKFLK
TERAETQSIVDIVNNLAMINYHIGFTLTSGNKKLLKYAKQTSLFHRLCEVEEEFQGSSLEINEEEDGIKLTGHICKPTVN
RGKSTQIYTFVNGRPIKDNLLIGAVRYAYHDFIPSDRYPFAALHLEIPYDQVDVNVHPNKSEVRFQNKKLIYEIMTRGLI
KALSRRIGTFPAHDQKMDSTLPDPFDKPDVQNERRPSPFENQLIKEFASPNEKAKGLSEQSKSFDYTGIQKFPAQAEAMV
LEKKVLEQVDLIESHPLGFARCQVYNTYIIAEVRDKLIIVDQHAAHERLVYECLKQKSSIKRQKLLLPETVEIKNQAGME
MIEIYKDKLFEMGFDIEIKSENKVIVKEIPAILGAIDVKEMLINIIDRLTEIEDTLPVEDKVNKILATIACHGSIRAGRK
MRLDEMNELLRQMEKTPYSGQCNHGRPTYIEMKLSDIEKLFERR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=321, Percent_Identity=35.202492211838, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=29.3103448275862, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=29.3103448275862, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI4505911, Length=330, Percent_Identity=29.3939393939394, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI189458898, Length=330, Percent_Identity=29.3939393939394, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=29.1139240506329, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=27.6666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI263191589, Length=230, Percent_Identity=30, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992162, Length=352, Percent_Identity=23.5795454545455, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI91992160, Length=352, Percent_Identity=23.5795454545455, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790612, Length=338, Percent_Identity=39.9408284023669, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=316, Percent_Identity=31.9620253164557, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=354, Percent_Identity=25.7062146892655, Blast_Score=119, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=35.4354354354354, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=358, Percent_Identity=26.2569832402235, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=404, Percent_Identity=25.990099009901, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325093, Length=172, Percent_Identity=29.6511627906977, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136968, Length=308, Percent_Identity=33.4415584415584, Blast_Score=175, Evalue=9e-44,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=24.5714285714286, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_WOLWR (C0R515)

Other databases:

- EMBL:   CP001391
- RefSeq:   YP_002727798.1
- ProteinModelPortal:   C0R515
- SMR:   C0R515
- EnsemblBacteria:   EBWOLT00000001700
- GeneID:   7670044
- GenomeReviews:   CP001391_GR
- KEGG:   wri:WRi_013350
- GeneTree:   EBGT00050000031443
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 68702; Mature: 68571

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSLEIEIKIESGGRNLIIVTDDG
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCC
NGVEKNDLELAFMRHATSKLSDSELIEIKHLGFRGEALPSIAAVSRIKLSSKAREASEAW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHE
SISYEGGEKIGEQTPYSLSQGTHIEVRDLFFATPNRLKFLKTERAETQSIVDIVNNLAMI
EEEECCCHHCCCCCCCCCCCCCEEEEEHEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEE
NYHIGFTLTSGNKKLLKYAKQTSLFHRLCEVEEEFQGSSLEINEEEDGIKLTGHICKPTV
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCC
NRGKSTQIYTFVNGRPIKDNLLIGAVRYAYHDFIPSDRYPFAALHLEIPYDQVDVNVHPN
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCC
KSEVRFQNKKLIYEIMTRGLIKALSRRIGTFPAHDQKMDSTLPDPFDKPDVQNERRPSPF
CHHEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHH
ENQLIKEFASPNEKAKGLSEQSKSFDYTGIQKFPAQAEAMVLEKKVLEQVDLIESHPLGF
HHHHHHHHCCCCHHHCCCHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCE
ARCQVYNTYIIAEVRDKLIIVDQHAAHERLVYECLKQKSSIKRQKLLLPETVEIKNQAGM
EEEEEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCH
EMIEIYKDKLFEMGFDIEIKSENKVIVKEIPAILGAIDVKEMLINIIDRLTEIEDTLPVE
HHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DKVNKILATIACHGSIRAGRKMRLDEMNELLRQMEKTPYSGQCNHGRPTYIEMKLSDIEK
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHH
LFERR
HHHCC
>Mature Secondary Structure 
AIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSLEIEIKIESGGRNLIIVTDDG
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCC
NGVEKNDLELAFMRHATSKLSDSELIEIKHLGFRGEALPSIAAVSRIKLSSKAREASEAW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHE
SISYEGGEKIGEQTPYSLSQGTHIEVRDLFFATPNRLKFLKTERAETQSIVDIVNNLAMI
EEEECCCHHCCCCCCCCCCCCCEEEEEHEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEE
NYHIGFTLTSGNKKLLKYAKQTSLFHRLCEVEEEFQGSSLEINEEEDGIKLTGHICKPTV
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCC
NRGKSTQIYTFVNGRPIKDNLLIGAVRYAYHDFIPSDRYPFAALHLEIPYDQVDVNVHPN
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCC
KSEVRFQNKKLIYEIMTRGLIKALSRRIGTFPAHDQKMDSTLPDPFDKPDVQNERRPSPF
CHHEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHH
ENQLIKEFASPNEKAKGLSEQSKSFDYTGIQKFPAQAEAMVLEKKVLEQVDLIESHPLGF
HHHHHHHHCCCCHHHCCCHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCE
ARCQVYNTYIIAEVRDKLIIVDQHAAHERLVYECLKQKSSIKRQKLLLPETVEIKNQAGM
EEEEEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCH
EMIEIYKDKLFEMGFDIEIKSENKVIVKEIPAILGAIDVKEMLINIIDRLTEIEDTLPVE
HHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DKVNKILATIACHGSIRAGRKMRLDEMNELLRQMEKTPYSGQCNHGRPTYIEMKLSDIEK
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHH
LFERR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA