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The map label for this gene is purE [H]

Identifier: 225631006

GI number: 225631006

Start: 1419090

End: 1419581

Strand: Direct

Name: purE [H]

Synonym: WRi_013340

Alternate gene names: 225631006

Gene position: 1419090-1419581 (Clockwise)

Preceding gene: 225630996

Following gene: 225631007

Centisome position: 98.15

GC content: 37.2

Gene sequence:

>492_bases
ATGACAAAAATAAAAAAAGATGTTGCTGTTATTATGGGAAGTGAGTCAGATTACACCACTATGGTCCATACTGTTGATAT
GTTAAAAGCATTAGAAGTTTCACATGATATATTCATAATATCTGCACATAGAACACCAGAAAGGCTCTTCAATTTTGCTA
AATCTGCACAAGAAGAAGGTTTTAAGGTTATTATAGCTGGTGCAGGAGGTGCAGCTCATTTACCTGGTATGGTTGCGTCA
CTAACTTGTTTACCAGTTATCGGCGTTCCTGTGCATAGTAAACAATTAAATGGGCTGGACAGCCTACTCTCTATAGTTCA
AATGCCAAAGGGTGTTCCAGTTGCAACCATGTCTATAGGAGAAAATGGAGCATATAATGCTGCCATTACTGCCGTATCTA
TATTGTCAATTTCCAACAGTGAAATTGCAGGTAGGTTAAAAAAGTGGAGAGAGAAACAGACCAAAGAAGTAAAAGAAAAA
CCAGTTTCATAA

Upstream 100 bases:

>100_bases
TTTAACGAGAATTCTATATATTATATTTATAATATAATTTAAATATTTGTTGCTTTTTAGCTGGAACATTATTTAGTTAG
TAAGTAAAATTGTGTTGAAT

Downstream 100 bases:

>100_bases
TAAATCTATGGCAATAATTCTTTTAGACACAAAAACCATAAACCGTATAGCAGCGGGGGAGGTGATAGAAAGGCCAGCAA
GTGTAGTAAAGGAATTAGTG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MTKIKKDVAVIMGSESDYTTMVHTVDMLKALEVSHDIFIISAHRTPERLFNFAKSAQEEGFKVIIAGAGGAAHLPGMVAS
LTCLPVIGVPVHSKQLNGLDSLLSIVQMPKGVPVATMSIGENGAYNAAITAVSILSISNSEIAGRLKKWREKQTKEVKEK
PVS

Sequences:

>Translated_163_residues
MTKIKKDVAVIMGSESDYTTMVHTVDMLKALEVSHDIFIISAHRTPERLFNFAKSAQEEGFKVIIAGAGGAAHLPGMVAS
LTCLPVIGVPVHSKQLNGLDSLLSIVQMPKGVPVATMSIGENGAYNAAITAVSILSISNSEIAGRLKKWREKQTKEVKEK
PVS
>Mature_162_residues
TKIKKDVAVIMGSESDYTTMVHTVDMLKALEVSHDIFIISAHRTPERLFNFAKSAQEEGFKVIIAGAGGAAHLPGMVASL
TCLPVIGVPVHSKQLNGLDSLLSIVQMPKGVPVATMSIGENGAYNAAITAVSILSISNSEIAGRLKKWREKQTKEVKEKP
VS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=55.8441558441558, Blast_Score=164, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324702, Length=154, Percent_Identity=51.9480519480519, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17442; Mature: 17310

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKKDVAVIMGSESDYTTMVHTVDMLKALEVSHDIFIISAHRTPERLFNFAKSAQEEG
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCC
FKVIIAGAGGAAHLPGMVASLTCLPVIGVPVHSKQLNGLDSLLSIVQMPKGVPVATMSIG
CEEEEECCCCCHHCCHHHHHHHHHHEECCCCCCHHHCCHHHHHHHHHCCCCCCEEEEECC
ENGAYNAAITAVSILSISNSEIAGRLKKWREKQTKEVKEKPVS
CCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKIKKDVAVIMGSESDYTTMVHTVDMLKALEVSHDIFIISAHRTPERLFNFAKSAQEEG
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCC
FKVIIAGAGGAAHLPGMVASLTCLPVIGVPVHSKQLNGLDSLLSIVQMPKGVPVATMSIG
CEEEEECCCCCHHCCHHHHHHHHHHEECCCCCCHHHCCHHHHHHHHHCCCCCCEEEEECC
ENGAYNAAITAVSILSISNSEIAGRLKKWREKQTKEVKEKPVS
CCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]