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The map label for this gene is hemA [H]

Identifier: 225630982

GI number: 225630982

Start: 1394759

End: 1395967

Strand: Direct

Name: hemA [H]

Synonym: WRi_013060

Alternate gene names: 225630982

Gene position: 1394759-1395967 (Clockwise)

Preceding gene: 225630981

Following gene: 225630987

Centisome position: 96.46

GC content: 37.8

Gene sequence:

>1209_bases
TTGGTAAACTACGAAGAAATATTCTTAAATAAAATCAAAGATATAAAAGAGGAGGGGCGCTACCGTGAATTTACGCACTT
TGCGTCATTGCCAGGTAGGCTCCCCCACATTATGGACTATGAAAGAAATAGGGAAGTAATAGTCTGGTGCAGTAATAACT
ATTTGGGAATGTCACAAAATGAGAGTGTAATTGCCGCTATCCAAAATTCATCTGTTGGCGCTGGAGGAACAAGAAATATA
TCTGGTACAACAAAAGAGGTTGTCGAACTTGAAAAATCCTTAGCTTGTTTGCATAAAAAAGAGGCTGCTTTAACTTTTGC
TTGTGGCTACCTCGCTAACCAGACAACACTTAGCACTTTATCGTCTGTTATTCCTGGCGTAGTAATTTTTTCAGACGAGA
AGAACCATTCTTCGATGATAGAAGGCATAAAATCAGGAAAAAGGCCAAAACATATATTTAAACACAATAATGTTAATCAT
CTAGAGCAGTTACTCAAGTCTATAGACAAAAAGACACCAAAAATAATAGCACTTGAATCCGTATATTCAATGGATGGCGA
TATAGCGCCGCTTGAAGCGATATGTGATCTTGCAGATCAACATAATGCAATTACCTATTTGGATGAGGTGCACGCAGTTG
GCATGTATGGTTCACATGGTGGCGGAATTGCAGAAAGAGAAGGTCTGATGGATAGAATAACCGTTATTCAAGGTACACTA
TCGAAGGCTTTTGGAGTGATGGGTGGGTATATAGCATCTTCAAAGAGCTTGGTAGATGTAATAAGAAGTTCCGCTCCAGG
ATTTATTTTTACCACTGCTATGTCGCCTGTTTTAGCAGCGGCAGCAAAGGCAAGCGTTGAACACCTAAAATCAAGCAACA
TTGAAAGGGAAAAGCAAAAGCAAGTCGTTGAAAAAGTAAAAAACTCACTGAGAAATGCAGGAATTAACTTCATTCCAACA
GAAACTCATATAATTCCAATAATAATTGGCAACTCAGAGTTATCCAAAAAAGCATCAAAATTATTATTTGATGAGTATGG
AATATACGTTCAACATATAAATTACCCGACAGTTCCAAGAGGAACTGAGCGTTTCCGTATTACCCCTACACCTTATCATA
CCGATGAAATGATAGAGCATTTAACAGAATCTCTTGTAAAAGTTTTTGAGAAGTTGTCTATCTCTTTAGCCTGTTTATGC
TATAGCTAG

Upstream 100 bases:

>100_bases
AACACGAAGGAAGCATCTACTACCGTATCTGTATAATAAATATTGTAGTTTACCATTTAATAATTTATTATAATTATATT
AATTATTAGCGAATAAAAAC

Downstream 100 bases:

>100_bases
TACAGCCCTACGTCATACCGCGATTTATTCGCGGTATCTCAGCATGGATTCCGCTAACAAGTAGCGGAATGACGAGTTTT
ACGCTTATCAAATTGTAGGT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MVNYEEIFLNKIKDIKEEGRYREFTHFASLPGRLPHIMDYERNREVIVWCSNNYLGMSQNESVIAAIQNSSVGAGGTRNI
SGTTKEVVELEKSLACLHKKEAALTFACGYLANQTTLSTLSSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFKHNNVNH
LEQLLKSIDKKTPKIIALESVYSMDGDIAPLEAICDLADQHNAITYLDEVHAVGMYGSHGGGIAEREGLMDRITVIQGTL
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQKQVVEKVKNSLRNAGINFIPT
ETHIIPIIIGNSELSKKASKLLFDEYGIYVQHINYPTVPRGTERFRITPTPYHTDEMIEHLTESLVKVFEKLSISLACLC
YS

Sequences:

>Translated_402_residues
MVNYEEIFLNKIKDIKEEGRYREFTHFASLPGRLPHIMDYERNREVIVWCSNNYLGMSQNESVIAAIQNSSVGAGGTRNI
SGTTKEVVELEKSLACLHKKEAALTFACGYLANQTTLSTLSSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFKHNNVNH
LEQLLKSIDKKTPKIIALESVYSMDGDIAPLEAICDLADQHNAITYLDEVHAVGMYGSHGGGIAEREGLMDRITVIQGTL
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQKQVVEKVKNSLRNAGINFIPT
ETHIIPIIIGNSELSKKASKLLFDEYGIYVQHINYPTVPRGTERFRITPTPYHTDEMIEHLTESLVKVFEKLSISLACLC
YS
>Mature_402_residues
MVNYEEIFLNKIKDIKEEGRYREFTHFASLPGRLPHIMDYERNREVIVWCSNNYLGMSQNESVIAAIQNSSVGAGGTRNI
SGTTKEVVELEKSLACLHKKEAALTFACGYLANQTTLSTLSSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFKHNNVNH
LEQLLKSIDKKTPKIIALESVYSMDGDIAPLEAICDLADQHNAITYLDEVHAVGMYGSHGGGIAEREGLMDRITVIQGTL
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQKQVVEKVKNSLRNAGINFIPT
ETHIIPIIIGNSELSKKASKLLFDEYGIYVQHINYPTVPRGTERFRITPTPYHTDEMIEHLTESLVKVFEKLSISLACLC
YS

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=406, Percent_Identity=45.320197044335, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI83977440, Length=406, Percent_Identity=45.320197044335, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI83977442, Length=406, Percent_Identity=45.320197044335, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI4502025, Length=404, Percent_Identity=45.2970297029703, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI40316939, Length=404, Percent_Identity=45.2970297029703, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=30.2798982188295, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI284448556, Length=372, Percent_Identity=32.5268817204301, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI119220554, Length=374, Percent_Identity=29.144385026738, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=28.2258064516129, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=28.8537549407115, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1790046, Length=356, Percent_Identity=31.7415730337079, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=30.8571428571429, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=31.75, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=28.9189189189189, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=358, Percent_Identity=27.6536312849162, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=358, Percent_Identity=27.6536312849162, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=231, Percent_Identity=29.8701298701299, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=231, Percent_Identity=29.8701298701299, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=418, Percent_Identity=44.4976076555024, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320267, Length=426, Percent_Identity=25.5868544600939, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=289, Percent_Identity=25.2595155709343, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=47.5124378109453, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24662918, Length=396, Percent_Identity=29.040404040404, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17136286, Length=377, Percent_Identity=26.790450928382, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=25.9927797833935, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=25.9927797833935, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=25.9927797833935, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44448; Mature: 44448

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNYEEIFLNKIKDIKEEGRYREFTHFASLPGRLPHIMDYERNREVIVWCSNNYLGMSQN
CCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCEEEEECCCEECCCCC
ESVIAAIQNSSVGAGGTRNISGTTKEVVELEKSLACLHKKEAALTFACGYLANQTTLSTL
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFKHNNVNHLEQLLKSIDKKTPKIIALES
HHHHCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEHH
VYSMDGDIAPLEAICDLADQHNAITYLDEVHAVGMYGSHGGGIAEREGLMDRITVIQGTL
HHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQK
HHHHHHHHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QVVEKVKNSLRNAGINFIPTETHIIPIIIGNSELSKKASKLLFDEYGIYVQHINYPTVPR
HHHHHHHHHHHHCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
GTERFRITPTPYHTDEMIEHLTESLVKVFEKLSISLACLCYS
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
>Mature Secondary Structure
MVNYEEIFLNKIKDIKEEGRYREFTHFASLPGRLPHIMDYERNREVIVWCSNNYLGMSQN
CCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCEEEEECCCEECCCCC
ESVIAAIQNSSVGAGGTRNISGTTKEVVELEKSLACLHKKEAALTFACGYLANQTTLSTL
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SSVIPGVVIFSDEKNHSSMIEGIKSGKRPKHIFKHNNVNHLEQLLKSIDKKTPKIIALES
HHHHCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEHH
VYSMDGDIAPLEAICDLADQHNAITYLDEVHAVGMYGSHGGGIAEREGLMDRITVIQGTL
HHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
SKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNIEREKQK
HHHHHHHHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QVVEKVKNSLRNAGINFIPTETHIIPIIIGNSELSKKASKLLFDEYGIYVQHINYPTVPR
HHHHHHHHHHHHCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
GTERFRITPTPYHTDEMIEHLTESLVKVFEKLSISLACLCYS
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]