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The map label for this gene is pyrD [H]

Identifier: 225630899

GI number: 225630899

Start: 1307169

End: 1308236

Strand: Direct

Name: pyrD [H]

Synonym: WRi_012150

Alternate gene names: 225630899

Gene position: 1307169-1308236 (Clockwise)

Preceding gene: 225630898

Following gene: 225630900

Centisome position: 90.41

GC content: 35.49

Gene sequence:

>1068_bases
ATGGTAAAAAATAAACTAAAAATAAGCAAAGTGTTTTACAAACGTAATTTACTATTTTTACTACCGCCCGAAGTTGCTCA
CTCTTTGGCAATTATGGCATTAAAGAAAATGCCTTATAAGAATCCTATAGAGCTACCAGAATCTTTGAGTGTGAATTTTT
TTGGTAATAAGCTCAGAAGCCCCATAGGTCTGGCTGCAGGTTTTGACAAGAATGCAGAAGTTATAAGGCCTATGCTCTCA
TTTGGTTTTGGGTTTATTGAAACTGGTACTGTAACTCGTAATCCACAATATGGAAACAAAAAGCCAAGAATTTTTCGGTT
AATTAAAGATCAAGGGGTAATTAACAGATTGGGATTTAACAATAAAGGAATAGACTATTTTCTTAAACAAATAGGTGAAA
CCAAGCTTGATGACTGCATTTTTGGCATCAACATAGGAAAAAACAGTACATCAAAGGACCAAATCAGCGATTATGTTGAC
TTAATAAAGATAGTATATGGAAAGAGCAATTATATAGTGCTGAACATCTCATCCCCAAACACGCCTAATTTACGCAATCT
GCACAATAAGCAAGAATTATCGGAATTGTTGAAATCCGTAACTCTAACCCGAAAATCAATTGATAATTCTAAATCCATAC
CAATAATATTAAAAATCTCACCAGATGTAGATCAGCAAACGAAAGAAAATATCGCTGAGCTTGCGTTGGAATATAAGATT
GACGGATTAACAGTAAGCAACACTACGGTAAGTAGAGATAATCTGCATTCTCACCATAATGAGAGTGGTGGGTTGAGTGG
CAAACCGCTGTTTAAACTTTCAACCGAGTTATTGGGCGATATGTACAAATTTACTAAGGGCAAAATATTATTGATAGGGT
GCGGAGGAATCTCAAGTGGTGCTGATGCATATAAAAAAATAAAGGCAGGAGCTTCTTTGGTGCAGTTGTACACTGCTCTC
ATATACCACGGACCTCAAGTTGTAAACAAAATTAATCTAGAACTTGCAGAACTAATAAGGAGAGATGGATTTAGTAACAT
TAGTGAGGTGGTGGGTTGTATACATTAA

Upstream 100 bases:

>100_bases
AAAAGTTAACAGTAGCTTTAAGTGTGTAACCTATAGAGAAAGCTTGTCCATAGTAAAATCAATTTCTTTTCAAGTTATGG
TTATACTCTTATAGCGTTTC

Downstream 100 bases:

>100_bases
TTTTGGAAGTTGGTGGTATTATTTTAATAAAATAAAACTAATTCTCTGGTATAAAGGTGGTAGAAAGTGCTTTTCTTTTA
AATAATTGGTATGAAGAGTT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MVKNKLKISKVFYKRNLLFLLPPEVAHSLAIMALKKMPYKNPIELPESLSVNFFGNKLRSPIGLAAGFDKNAEVIRPMLS
FGFGFIETGTVTRNPQYGNKKPRIFRLIKDQGVINRLGFNNKGIDYFLKQIGETKLDDCIFGINIGKNSTSKDQISDYVD
LIKIVYGKSNYIVLNISSPNTPNLRNLHNKQELSELLKSVTLTRKSIDNSKSIPIILKISPDVDQQTKENIAELALEYKI
DGLTVSNTTVSRDNLHSHHNESGGLSGKPLFKLSTELLGDMYKFTKGKILLIGCGGISSGADAYKKIKAGASLVQLYTAL
IYHGPQVVNKINLELAELIRRDGFSNISEVVGCIH

Sequences:

>Translated_355_residues
MVKNKLKISKVFYKRNLLFLLPPEVAHSLAIMALKKMPYKNPIELPESLSVNFFGNKLRSPIGLAAGFDKNAEVIRPMLS
FGFGFIETGTVTRNPQYGNKKPRIFRLIKDQGVINRLGFNNKGIDYFLKQIGETKLDDCIFGINIGKNSTSKDQISDYVD
LIKIVYGKSNYIVLNISSPNTPNLRNLHNKQELSELLKSVTLTRKSIDNSKSIPIILKISPDVDQQTKENIAELALEYKI
DGLTVSNTTVSRDNLHSHHNESGGLSGKPLFKLSTELLGDMYKFTKGKILLIGCGGISSGADAYKKIKAGASLVQLYTAL
IYHGPQVVNKINLELAELIRRDGFSNISEVVGCIH
>Mature_355_residues
MVKNKLKISKVFYKRNLLFLLPPEVAHSLAIMALKKMPYKNPIELPESLSVNFFGNKLRSPIGLAAGFDKNAEVIRPMLS
FGFGFIETGTVTRNPQYGNKKPRIFRLIKDQGVINRLGFNNKGIDYFLKQIGETKLDDCIFGINIGKNSTSKDQISDYVD
LIKIVYGKSNYIVLNISSPNTPNLRNLHNKQELSELLKSVTLTRKSIDNSKSIPIILKISPDVDQQTKENIAELALEYKI
DGLTVSNTTVSRDNLHSHHNESGGLSGKPLFKLSTELLGDMYKFTKGKILLIGCGGISSGADAYKKIKAGASLVQLYTAL
IYHGPQVVNKINLELAELIRRDGFSNISEVVGCIH

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=359, Percent_Identity=44.0111420612813, Blast_Score=298, Evalue=6e-81,
Organism=Escherichia coli, GI1787177, Length=330, Percent_Identity=38.7878787878788, Blast_Score=227, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17509475, Length=367, Percent_Identity=42.7792915531335, Blast_Score=277, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6322633, Length=326, Percent_Identity=24.8466257668712, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281361352, Length=342, Percent_Identity=45.906432748538, Blast_Score=304, Evalue=5e-83,
Organism=Drosophila melanogaster, GI17137316, Length=342, Percent_Identity=45.906432748538, Blast_Score=304, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39427; Mature: 39427

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKNKLKISKVFYKRNLLFLLPPEVAHSLAIMALKKMPYKNPIELPESLSVNFFGNKLRS
CCCCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHCC
PIGLAAGFDKNAEVIRPMLSFGFGFIETGTVTRNPQYGNKKPRIFRLIKDQGVINRLGFN
CCCEECCCCCCHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCEEEEEHHCCHHHHCCCC
NKGIDYFLKQIGETKLDDCIFGINIGKNSTSKDQISDYVDLIKIVYGKSNYIVLNISSPN
CCCHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
TPNLRNLHNKQELSELLKSVTLTRKSIDNSKSIPIILKISPDVDQQTKENIAELALEYKI
CCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEE
DGLTVSNTTVSRDNLHSHHNESGGLSGKPLFKLSTELLGDMYKFTKGKILLIGCGGISSG
CCEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
ADAYKKIKAGASLVQLYTALIYHGPQVVNKINLELAELIRRDGFSNISEVVGCIH
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MVKNKLKISKVFYKRNLLFLLPPEVAHSLAIMALKKMPYKNPIELPESLSVNFFGNKLRS
CCCCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHCC
PIGLAAGFDKNAEVIRPMLSFGFGFIETGTVTRNPQYGNKKPRIFRLIKDQGVINRLGFN
CCCEECCCCCCHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCEEEEEHHCCHHHHCCCC
NKGIDYFLKQIGETKLDDCIFGINIGKNSTSKDQISDYVDLIKIVYGKSNYIVLNISSPN
CCCHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
TPNLRNLHNKQELSELLKSVTLTRKSIDNSKSIPIILKISPDVDQQTKENIAELALEYKI
CCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEE
DGLTVSNTTVSRDNLHSHHNESGGLSGKPLFKLSTELLGDMYKFTKGKILLIGCGGISSG
CCEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
ADAYKKIKAGASLVQLYTALIYHGPQVVNKINLELAELIRRDGFSNISEVVGCIH
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA