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The map label for this gene is ffh [H]

Identifier: 225630810

GI number: 225630810

Start: 1203918

End: 1205261

Strand: Reverse

Name: ffh [H]

Synonym: WRi_011140

Alternate gene names: 225630810

Gene position: 1205261-1203918 (Counterclockwise)

Preceding gene: 225630811

Following gene: 225630809

Centisome position: 83.36

GC content: 35.71

Gene sequence:

>1344_bases
ATGTTTAAGTCGTTAACCGAAAGTTTAAATTCTGTATTTAGTAAACTAAGAGGAAAGTCAATCATTTCTGAAGATGATTT
TAATCTTGCCATGCGTGAAATACGCATAGCCTTAATTGAAGCTGACGTTTCACTTGAAGTTGCAAAAAAATTCATCAACG
ACATTAAAGATAAAGTGATTGGGGAAAAAGTCATAAAAAGCGTTTCTCCAGCACAAATGATAATCAAAATTGTGCAGGAT
AATTTAGTTGCAGTTCTCGGATCAGAGAAAAGTGACTTAAATCTAGCAGTTAAACCCCCTGCTGTGATTATGATGGTGGG
CTTACAAGGTGCAGGTAAAACAACTACCTCAGGAAAGCTTGCTTTAAAGCTAAAAAAGCAAAAGAAAAAAGTGATGCTTG
CCTCTTTAGACATTTATAGGCCGGCTGCCCAAAAACAACTTGAAGTGCTAGGTAAACAAATAGATGTGCAAACTTTACCT
GTAGTAATAGACGAGAAGCCCATTACAATTACAAAAAGGGCACTGGCAGCAGCAAAGAACGATAATTATGATGTATTAAT
ACTAGATACCGCAGGCAGGCTTCATATTGACAATAATATGATGAATGAGTTGAAAGCCGTAAAGGAAATAGCTTCACCTG
CAGAAGTTATTTTAGTAGCCGACGCAATGATAGGCCAGGATGCGGTCAACATTGCCAAATCATTCAATGAGGTAATAGGT
GTAACCGGCATTATTCTTACCCGTGTTGATGGTGATGCACGTGGTGGTGCTGCTCTTTCTATGAAAATGATCGCCGATTG
TCCAATTAAATTTATTGCTTGTGGTGAAAAATTAAGTGACCTCGATGATTTTTATCCAGATAGAATTGCAAAAAGAATAC
TTAGCATGGGTGATGTTGTCTCATTGGTTGAAAAAGCTGCTGAGATTGTTGGTCAGGAAGAAATTGATAAGTTACAAAAG
AAAGTGAAAAAAGGTAAATTCGACCTAAACGACCTAGTGGGAATGTTAAAAACTCTGAGTAAAATGGATGGCATTAGCAA
CATAATGAAATTCATTCCTAGTTCATTTACAAAAAAGCTAAGTAGCAGTGTGCCAGATGACAATAAAGTGAAAAAATATA
TAGCCATCATAAACTCAATGACTGAAAAAGAAAGGCAAAATCCAGATATTTTAAATGGCAAAAGAAGACTTAGAATTTCT
AAGGGGTCCGGAACAACTGTAACTGACATTAATCTTCTAATTAAGCAGTATAATCAAATGAGCTCTATGGTAAATAAGTT
CAGTAAAGTTGACCATAGTAAACTCAAAGAATCTGATTTGATGAATATGCTAAGCAGAAAGTAA

Upstream 100 bases:

>100_bases
TTGATAATATTACTAAACTTAAGGAAGTGCTGGGTTATAACTCAGTGAGTTTTGTTTCAGCTTCTTCTCTCTTTTTAATG
AGTATTCTACTAATGCTATT

Downstream 100 bases:

>100_bases
GTCAGCAGGTAGTGGAATGAGACAAATCATCAGTAAACCTTTAGCTATATCAAAAGCGGCTTAGGTCTCGCAAAAAAATT
TACAGCTTCTTGCTAGCCAA

Product: Signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFKSLTESLNSVFSKLRGKSIISEDDFNLAMREIRIALIEADVSLEVAKKFINDIKDKVIGEKVIKSVSPAQMIIKIVQD
NLVAVLGSEKSDLNLAVKPPAVIMMVGLQGAGKTTTSGKLALKLKKQKKKVMLASLDIYRPAAQKQLEVLGKQIDVQTLP
VVIDEKPITITKRALAAAKNDNYDVLILDTAGRLHIDNNMMNELKAVKEIASPAEVILVADAMIGQDAVNIAKSFNEVIG
VTGIILTRVDGDARGGAALSMKMIADCPIKFIACGEKLSDLDDFYPDRIAKRILSMGDVVSLVEKAAEIVGQEEIDKLQK
KVKKGKFDLNDLVGMLKTLSKMDGISNIMKFIPSSFTKKLSSSVPDDNKVKKYIAIINSMTEKERQNPDILNGKRRLRIS
KGSGTTVTDINLLIKQYNQMSSMVNKFSKVDHSKLKESDLMNMLSRK

Sequences:

>Translated_447_residues
MFKSLTESLNSVFSKLRGKSIISEDDFNLAMREIRIALIEADVSLEVAKKFINDIKDKVIGEKVIKSVSPAQMIIKIVQD
NLVAVLGSEKSDLNLAVKPPAVIMMVGLQGAGKTTTSGKLALKLKKQKKKVMLASLDIYRPAAQKQLEVLGKQIDVQTLP
VVIDEKPITITKRALAAAKNDNYDVLILDTAGRLHIDNNMMNELKAVKEIASPAEVILVADAMIGQDAVNIAKSFNEVIG
VTGIILTRVDGDARGGAALSMKMIADCPIKFIACGEKLSDLDDFYPDRIAKRILSMGDVVSLVEKAAEIVGQEEIDKLQK
KVKKGKFDLNDLVGMLKTLSKMDGISNIMKFIPSSFTKKLSSSVPDDNKVKKYIAIINSMTEKERQNPDILNGKRRLRIS
KGSGTTVTDINLLIKQYNQMSSMVNKFSKVDHSKLKESDLMNMLSRK
>Mature_447_residues
MFKSLTESLNSVFSKLRGKSIISEDDFNLAMREIRIALIEADVSLEVAKKFINDIKDKVIGEKVIKSVSPAQMIIKIVQD
NLVAVLGSEKSDLNLAVKPPAVIMMVGLQGAGKTTTSGKLALKLKKQKKKVMLASLDIYRPAAQKQLEVLGKQIDVQTLP
VVIDEKPITITKRALAAAKNDNYDVLILDTAGRLHIDNNMMNELKAVKEIASPAEVILVADAMIGQDAVNIAKSFNEVIG
VTGIILTRVDGDARGGAALSMKMIADCPIKFIACGEKLSDLDDFYPDRIAKRILSMGDVVSLVEKAAEIVGQEEIDKLQK
KVKKGKFDLNDLVGMLKTLSKMDGISNIMKFIPSSFTKKLSSSVPDDNKVKKYIAIINSMTEKERQNPDILNGKRRLRIS
KGSGTTVTDINLLIKQYNQMSSMVNKFSKVDHSKLKESDLMNMLSRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=433, Percent_Identity=29.3302540415704, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI226371618, Length=336, Percent_Identity=31.25, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI23308697, Length=309, Percent_Identity=27.1844660194175, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI295424842, Length=309, Percent_Identity=27.1844660194175, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI89061728, Length=143, Percent_Identity=33.5664335664336, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=48.4705882352941, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1789874, Length=299, Percent_Identity=36.4548494983278, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17539958, Length=433, Percent_Identity=27.0207852193995, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI193206261, Length=316, Percent_Identity=30.0632911392405, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=419, Percent_Identity=31.980906921241, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=25.6410256410256, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17647949, Length=441, Percent_Identity=28.3446712018141, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641198, Length=303, Percent_Identity=26.0726072607261, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49151; Mature: 49151

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSLTESLNSVFSKLRGKSIISEDDFNLAMREIRIALIEADVSLEVAKKFINDIKDKVI
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GEKVIKSVSPAQMIIKIVQDNLVAVLGSEKSDLNLAVKPPAVIMMVGLQGAGKTTTSGKL
HHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCEE
ALKLKKQKKKVMLASLDIYRPAAQKQLEVLGKQIDVQTLPVVIDEKPITITKRALAAAKN
EEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEECEEECCCCCHHHHHHHHHHCC
DNYDVLILDTAGRLHIDNNMMNELKAVKEIASPAEVILVADAMIGQDAVNIAKSFNEVIG
CCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCHHEEEEEHHHHCHHHHHHHHHHHHHHH
VTGIILTRVDGDARGGAALSMKMIADCPIKFIACGEKLSDLDDFYPDRIAKRILSMGDVV
HHHEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHCHHHHHHHHHHHHHHH
SLVEKAAEIVGQEEIDKLQKKVKKGKFDLNDLVGMLKTLSKMDGISNIMKFIPSSFTKKL
HHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SSSVPDDNKVKKYIAIINSMTEKERQNPDILNGKRRLRISKGSGTTVTDINLLIKQYNQM
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
SSMVNKFSKVDHSKLKESDLMNMLSRK
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKSLTESLNSVFSKLRGKSIISEDDFNLAMREIRIALIEADVSLEVAKKFINDIKDKVI
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GEKVIKSVSPAQMIIKIVQDNLVAVLGSEKSDLNLAVKPPAVIMMVGLQGAGKTTTSGKL
HHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCEE
ALKLKKQKKKVMLASLDIYRPAAQKQLEVLGKQIDVQTLPVVIDEKPITITKRALAAAKN
EEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEECEEECCCCCHHHHHHHHHHCC
DNYDVLILDTAGRLHIDNNMMNELKAVKEIASPAEVILVADAMIGQDAVNIAKSFNEVIG
CCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCHHEEEEEHHHHCHHHHHHHHHHHHHHH
VTGIILTRVDGDARGGAALSMKMIADCPIKFIACGEKLSDLDDFYPDRIAKRILSMGDVV
HHHEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHCHHHHHHHHHHHHHHH
SLVEKAAEIVGQEEIDKLQKKVKKGKFDLNDLVGMLKTLSKMDGISNIMKFIPSSFTKKL
HHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SSSVPDDNKVKKYIAIINSMTEKERQNPDILNGKRRLRISKGSGTTVTDINLLIKQYNQM
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
SSMVNKFSKVDHSKLKESDLMNMLSRK
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA