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The map label for this gene is hemE [H]

Identifier: 225630691

GI number: 225630691

Start: 1056377

End: 1057393

Strand: Direct

Name: hemE [H]

Synonym: WRi_009840

Alternate gene names: 225630691

Gene position: 1056377-1057393 (Clockwise)

Preceding gene: 225630689

Following gene: 225630692

Centisome position: 73.06

GC content: 36.48

Gene sequence:

>1017_bases
TTGGAAAGCGGCAAAACAACAATAGCGAAAATTATTAAGAGAAATGAGCCGGGTGGAAGAGTGCCTATCTGGCTAATGCG
TCAGGCTGGCAGGTCTCTTCCTGAGTACCGCAAAGCAGTAGAAAATATGAATAATTTTATGGAGATATGCTACAACACAG
ATTTAGTGACAGAATTGACGTTACAGCCGGTGACAAGATTTGACATGGATGCGGCGATAATTTTTTCAGACATTTTAATA
ATAGCTGATGTTTTGGGTTGTGACGTGAATTTCGTACGCGGTGTAGGTCCAATAATAAAACCCGTGGAAAGTCCTAAGGA
ATTGAAGGGTCCACAAGAAATTGAAACTAAAACCTTACCAATTCTAAACGCTATAAAAAAAGTCAGAAGCCAATTACCAA
AAGAAAAATCTCTCATAGGATTTGCTGGTGGACCATGGACAGTAGCCTCATACATCATAGAAGGTGGGAGCAGCAAAACT
TTTTCCAAAGTATTAAATTTTTATCCTTCGTGTTTGAAGGAAATAATTGAACGAATAACGGAAGTAACGATTATTTATCT
AATTAAACAGATAGAATTTGGAGCAGATGTTATTCAGCTATTTGACAGTAATGCTGGTGCGTTATCGGAACCATTGTTTA
AAGAATATGTTATCGAACCAACAAAGAGAATTATCTTGGCAATAAAGGATAGATTTTCTGATTTTCCAATAATAGGTTTT
CCAAGGTCTGCTGGAAATCTTTATAAAGATTACTGCGAACAAACAGGTGTATCTGCAGTAAGTATAGATTATAATGTTCC
AATAAAATGGGCGAAAGCGAATCTAAACATCCCTCTACAAGGAAACCTTGATCCTAATCTTTTAGCCTATAATAAAACGG
AAGCAATCAAAGAAGCAAAACGTATAATAGATTGCTTTAGAGATTTACCCTTCATATTTAATCTCGGACATGGAGTACTC
CCTGATACTCCAGTTGAAAATATTGCTGCGTTGGTAAACCTGGTAAAAAGCTACTAA

Upstream 100 bases:

>100_bases
AACAACGCCAATTTTTACTGAATTTTAAGTTAGTAACAAGTTATTGATAGAACTATTATTATTACTATACTTTAATATAC
AAAAGAATAAATAGAATAGA

Downstream 100 bases:

>100_bases
TACAATACACAAAATTCCTAGCTTTTTTGTTGTACGGGGTTTATCATTTAAATTTAGCTTCAGTAAAATATGTCAGACCT
TGCAAAAAGAATGTTCCTAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MESGKTTIAKIIKRNEPGGRVPIWLMRQAGRSLPEYRKAVENMNNFMEICYNTDLVTELTLQPVTRFDMDAAIIFSDILI
IADVLGCDVNFVRGVGPIIKPVESPKELKGPQEIETKTLPILNAIKKVRSQLPKEKSLIGFAGGPWTVASYIIEGGSSKT
FSKVLNFYPSCLKEIIERITEVTIIYLIKQIEFGADVIQLFDSNAGALSEPLFKEYVIEPTKRIILAIKDRFSDFPIIGF
PRSAGNLYKDYCEQTGVSAVSIDYNVPIKWAKANLNIPLQGNLDPNLLAYNKTEAIKEAKRIIDCFRDLPFIFNLGHGVL
PDTPVENIAALVNLVKSY

Sequences:

>Translated_338_residues
MESGKTTIAKIIKRNEPGGRVPIWLMRQAGRSLPEYRKAVENMNNFMEICYNTDLVTELTLQPVTRFDMDAAIIFSDILI
IADVLGCDVNFVRGVGPIIKPVESPKELKGPQEIETKTLPILNAIKKVRSQLPKEKSLIGFAGGPWTVASYIIEGGSSKT
FSKVLNFYPSCLKEIIERITEVTIIYLIKQIEFGADVIQLFDSNAGALSEPLFKEYVIEPTKRIILAIKDRFSDFPIIGF
PRSAGNLYKDYCEQTGVSAVSIDYNVPIKWAKANLNIPLQGNLDPNLLAYNKTEAIKEAKRIIDCFRDLPFIFNLGHGVL
PDTPVENIAALVNLVKSY
>Mature_338_residues
MESGKTTIAKIIKRNEPGGRVPIWLMRQAGRSLPEYRKAVENMNNFMEICYNTDLVTELTLQPVTRFDMDAAIIFSDILI
IADVLGCDVNFVRGVGPIIKPVESPKELKGPQEIETKTLPILNAIKKVRSQLPKEKSLIGFAGGPWTVASYIIEGGSSKT
FSKVLNFYPSCLKEIIERITEVTIIYLIKQIEFGADVIQLFDSNAGALSEPLFKEYVIEPTKRIILAIKDRFSDFPIIGF
PRSAGNLYKDYCEQTGVSAVSIDYNVPIKWAKANLNIPLQGNLDPNLLAYNKTEAIKEAKRIIDCFRDLPFIFNLGHGVL
PDTPVENIAALVNLVKSY

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=332, Percent_Identity=34.0361445783133, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI2367337, Length=333, Percent_Identity=33.6336336336336, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320252, Length=322, Percent_Identity=35.0931677018634, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19921920, Length=337, Percent_Identity=37.3887240356083, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI221330099, Length=337, Percent_Identity=37.3887240356083, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37744; Mature: 37744

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGKTTIAKIIKRNEPGGRVPIWLMRQAGRSLPEYRKAVENMNNFMEICYNTDLVTELT
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LQPVTRFDMDAAIIFSDILIIADVLGCDVNFVRGVGPIIKPVESPKELKGPQEIETKTLP
HHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCCCCHHCCCCHHHHHHHHH
ILNAIKKVRSQLPKEKSLIGFAGGPWTVASYIIEGGSSKTFSKVLNFYPSCLKEIIERIT
HHHHHHHHHHHCCCHHCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVTIIYLIKQIEFGADVIQLFDSNAGALSEPLFKEYVIEPTKRIILAIKDRFSDFPIIGF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEC
PRSAGNLYKDYCEQTGVSAVSIDYNVPIKWAKANLNIPLQGNLDPNLLAYNKTEAIKEAK
CCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCEEECCCCCCEEEECHHHHHHHHH
RIIDCFRDLPFIFNLGHGVLPDTPVENIAALVNLVKSY
HHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MESGKTTIAKIIKRNEPGGRVPIWLMRQAGRSLPEYRKAVENMNNFMEICYNTDLVTELT
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LQPVTRFDMDAAIIFSDILIIADVLGCDVNFVRGVGPIIKPVESPKELKGPQEIETKTLP
HHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCCCCHHCCCCHHHHHHHHH
ILNAIKKVRSQLPKEKSLIGFAGGPWTVASYIIEGGSSKTFSKVLNFYPSCLKEIIERIT
HHHHHHHHHHHCCCHHCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVTIIYLIKQIEFGADVIQLFDSNAGALSEPLFKEYVIEPTKRIILAIKDRFSDFPIIGF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEC
PRSAGNLYKDYCEQTGVSAVSIDYNVPIKWAKANLNIPLQGNLDPNLLAYNKTEAIKEAK
CCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCEEECCCCCCEEEECHHHHHHHHH
RIIDCFRDLPFIFNLGHGVLPDTPVENIAALVNLVKSY
HHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA